Clinical trials: Gut Microbiome Dysbiosis
Dysbiosis
Impact of Dysbiosis-inducing Drugs on Effectivity of Immune Checkpoint Inhibitor in Non-small Cell Lung Cancer Patients
Lung cancer is the leading cancer in France in terms of mortality. The prognosis of the disease is closely correlated with the diagnostic stage and the majority of patients are diagnosed at a metastatic stage.
- Trial name
- ICI (NCT07191171)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Strasbourg, France
C. Difficile Enteritis
Support of Colonization Resistance of the Gut Microbiota with the Synbiotic Food Supplement Nagasin®
Double blind, placebo-controlled, parallel, multicentric trial to investigat whether Nagasin® can support the colonization resistance against C.difficile.
- Trial name
- NCT05800704
- Testing
- Nagasin, maltodextrin
- Where
- 6 sites in Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
HIV
Fecal Microbiota Transplantation in HIV
Even in individuals treated for HIV, chronic immune activation persists and is associated with increased cardiovascular disease, liver disease, and mortality.
- Trial name
- FMT-HIV (NCT02256592)
- Testing
- Fecal Microbiota
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, San Francisco
Alcoholic Hepatitis
Effect of Saturated Fat (Desi Ghee) on Gut-Liver Axis in Alcoholic Hepatitis
The pathogenesis of the alcoholic liver disease (ALD) is a complex interplay of various etiopathological factors other than direct alcohol toxicity.
- Trial name
- SFAH (NCT04084522)
- Testing
- Saturated Fat- Desi Ghee (Clarified Butter), Soyabean Oil
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Dysbiosis, Gastroesophageal Reflux Disease (GERD)
Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users
Proton-pump inhibitors (PPIs) are widely used to treat acid-related stomach problems, such as heartburn and acid reflux. Long-term use of PPIs has been linked to changes in the gut bacteria and fungi (called the gut microbiota)…
- Trial name
- NCT07852676
- Testing
- Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI)
- Where
- 3 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
H.Pylori Gastrointestinal Disease
Second Line Bismuth Containing Quadruple Therapy With Supplementary Probiotic
This study is designed to evaluate the clinical outcome of second line Bismuth containing quadruple therapy with supplementary probiotic for Helicobacter pylori eradication
- Trial name
- NCT05577572
- Testing
- Probiotics packets
- Where
- 4 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Dysbiosis, Cardiometabolic Health Indicators
Almonds, Gut Microbiome and Kids
This 8-week parallel-arm randomized controlled trial (N=70; ages 6-13) will determine the impact of daily almond butter consumption on gut microbiome composition and function, intestinal barrier integrity, and cardiometabolic…
- Trial name
- NCT07636850
- Testing
- Creamy Richards 100% Almonds! Creamy Natural Almond Butter, Cadbury Milk Chocolate Spread
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida State University
Spondyloarthritis, Ruminococcus Gnavus
The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in…
- Trial name
- RUMINOSPA (NCT04853212)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Drug Resistant Epilepsy
Role of the Gut Microbiota in Pediatric Epilepsy
Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children.
- Trial name
- EPBiome (NCT04705298)
- Testing
- Prebiotic
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- British Columbia Children's Hospital
Functional Gastrointestinal Disorders (FGIDs), Weight Loss
Effects of Multi-strain Bacillus Spore Probiotics on Growth, Digestive Function, and Gut Microbiota in Cesarean-Delivered Neonates
Infants born by cesarean section commonly show early weight loss and slower recovery of birth weight, together with characteristic patterns of gut microbiota dysbiosis marked by reduced Bifidobacterium and Bacteroides and…
- Trial name
- NCT07320287
- Testing
- RO water, LiveSpo PREG-MOM, LiveSpo CONSY
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Cancer
Correlates of CRCI and Gut Microbiome Dysbiosis; a Pilot Study
The aim of this study is to characterize the microbiome and assess fatigue and cognition of patients with cancer undergoing standard of care treatment.
- Trial name
- NCT06098404
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Dysbiosis
Association Between Fecal Microbiota Composition, Metabolite Concentrations, and Indoxyl Sulfate Levels
Gut dysbiosis is frequently characterized by decreased microbial diversity and alterations in the abundance of certain microbial species.
- Trial name
- NCT06877585
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Clostridioides Difficile Infection
Clostridioides Difficile: Understanding Responses and Treatment Effects
The goal of this observational study is to learn how different treatments for Clostridioides difficile infection (CDI) work, and which biological mechanisms are involved in recovery.
- Trial name
- CURE-CDI (NCT07374094)
- Testing
- Antibiotic treatment, Fecal microbiota transplantation (FMT)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Aging
Can Synbiotic Use Effect Gut Bacteria and the Immune Response in Older People
The objectives of this study are to use a nutritional change in the diet to improve gut health in older people. Ageing can result in major changes in the composition and activities of the bacteria in your gut, leading to a higher…
- Trial name
- NCT01226212
- Testing
- Synbiotic (Synergy 1/B. longum)
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Probiotic, Ocular Surface Disease
Efficacy and Safety of Oral Probiotics on Ocular Symptoms and Gut Microbiome of Children with Vernal Keratoconjunctivitis
The primary goal of this study is to determine the effects of oral probiotics on the severity of ocular symptoms and the alterations of the gut microbiome of children (4-18 years old) with vernal keratoconjunctivitis.
- Conditions
- Probiotic, Ocular Surface Disease, Ocular Diseases, Ocular Dryness
- Trial name
- NCT06793514
- Testing
- Probiotic
- Volunteers
- 32 people
- Sponsor
- Mohsen Pourazizi
Central Serous Chorioretinopathy
the Study of the Association Between the Gut Microbiota and Central Serous Chorioretinopathy
To investigate the potential association between gut microbiota and central serous chorioretinopathy (CSC), clinical observations have indicated that patients with CSC frequently present with chronic gastrointestinal symptoms.
- Trial name
- NCT06527326
- Testing
- Live Combined Bifidobacterium
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Psoriasis
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis.
- Trial name
- INGUTSKIN (NCT05971992)
- Testing
- Chicory-derived inulin-type β-fructans, Maltodextrin
- Where
- 2 sites in Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Weight Gain, Pregnancy, Microbial Colonization
Microbiome and Malnutrition in Pregnancy (MMiP)
Nutritional status during pregnancy plays an important role in maternal health and birth outcomes. While few factors impacting nutritional status during pregnancy have been identified, studies of undernutrition in children have…
- Conditions
- Weight Gain, Pregnancy, Microbial Colonization, Pregnancy Related, Pregnancy Loss
- Trial name
- MMiP (NCT05108675)
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- Aga Khan University
Dysbiosis
Effect of Agave Consumption on Performance and Gut Microbiota in Adults Undergoing Physical Training
The purpose of this study is to analyze changes in the gut microbiota of healthy adult athletes, both men and women, before and after supplementation with a dietary fiber (agavins).
- Trial name
- NCT07828093
- Testing
- Agavins
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- National Polytechnic Institute, Mexico