Clinical trials: Gynecologic Cancer
Female Reproductive System Neoplasm, Malignant Female Reproductive System Neoplasm
EHealth Mindful Movement and Breathing in Improving Outcomes in Participants Undergoing Gynecologic Surgery
This trial determines how well eHealth mindful movement and breathing works to improve outcomes in participants undergoing gynecologic surgery.
- Conditions
- Female Reproductive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Uterine Neoplasm, Ovarian Carcinoma
- Trial name
- NCT03379376
- Testing
- Questionnaire Administration, Supportive Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Gynecologic Cancer
The HOPE Trial and the SMART Study
This research study is evaluating a new smartphone application named the "Helping Our Patients Excel (HOPE)" app with a Fitbit device. The SMART Study is a sub-study of the HOPE Trial.
- Trial name
- NCT03022032
- Testing
- Fitbit Zip, HOPE App, Standard of Care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Dana-Farber Cancer Institute
Gynecologic Malignancies
Weight-based Dosing for Dense Weekly Paclitaxel and Carboplatin in Overweight Patients w/ Body Surface Area (BSA) > 2.0
The purpose of this study is to evaluate the side effects and effectiveness of giving standard paclitaxel chemotherapy in doses based on actual body surface area in combination with standard dosed carboplatin chemotherapy for…
- Trial name
- NCT02756013
- Testing
- Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Gynecologic Cancer
Evaluating Smoking Cessation Protocols in Cancer Patients: NRT, MI, CBT or Hypnotherapy
This trial offers support and assistance to patients wishing to quit smoking in order to increase the success rate of smoking cessation and all the benefits associated with it.
- Conditions
- Breast Cancer, Gynecologic Cancer, Digestive Cancer, Melanoma
- Trial name
- RESPIRE (NCT04899492)
- Testing
- Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT), Hypnotherapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Institut Cancerologie de l'Ouest
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer, Uterine Endometrial Cancer
Implementation of a Rapid Recovery Program in Gynecologic Oncology Surgery: A Pilot Study
Over 600,000 hysterectomies are performed annually in the United States. Despite increasing use of less invasive approaches, the majority of hysterectomies are still performed via traditional laparotomy, which can be associated…
- Conditions
- Cervical Cancer, Uterine Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT01705288
- Testing
- Laparotomy, intravenous narcotics, standard anesthesia
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Ovarian Neoplasms
Paclitaxel, Carboplatin and Vorinostat for the Treatment of Advanced Stage Ovarian Carcinoma
Since the mortality rates for patients with advanced ovarian carinoma are high, the most likely way to improve progression free and overall survival is with maximal "upfront" therapy (Morrow \& Curtin, 1998).
- Trial name
- NCT00976183
- Testing
- Vorinostat
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Gynecologic Oncology Associates
Gynecologic Neoplasms, Epithelial Ovarian Cancer
PLX2853 as a Single Agent in Advanced Gynecological Malignancies and in Combination With Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer
The purpose of this research study is to evaluate safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of the investigational drug PLX2853 in Advanced Gynecological Malignancies with a Known ARID1A Mutation and…
- Trial name
- NCT04493619
- Testing
- PLX2853, Carboplatin
- Where
- 9 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Opna Bio LLC
Clear Cell Tumor, Gynecologic Cancer
A Study of Pembrolizumab in Patients With Advanced Gynaecological Clear Cell Cancer
PEACOCC is a multi-centre, single arm, single stage phase II trial. The overall aim is to determine whether treatment with pembrolizumab is effective in patients with advanced clear cell gynaecological cancer.
- Conditions
- Clear Cell Tumor, Gynecologic Cancer, Advanced Cancer
- Trial name
- PEACOCC (NCT03425565)
- Testing
- Pembrolizumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Cervical Carcinoma, Endometrioid Adenocarcinoma
Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers
This phase I trial studies the side effects and best dose of adavosertib when given together with external beam radiation therapy and cisplatin in treating patients with cervical, vaginal, or uterine cancer.
- Conditions
- Cervical Carcinoma, Endometrioid Adenocarcinoma, Malignant Female Reproductive System Neoplasm, Recurrent Cervical Carcinoma
- Trial name
- NCT03345784
- Testing
- Adavosertib, Cisplatin, External Beam Radiation Therapy
- Where
- 8 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer, Uterine Cancer
Gynecologic Brachytherapy-Specific Educational Video
Brachytherapy is a highly technical and integral component of the definitive treatment of gynecologic cancers [1]. To enhance provider communication and patient engagement, our study investigates a video consent on impact of…
- Trial name
- NCT04363957
- Testing
- Brachytherapy video, Standard Brachytherapy Consent Process
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Locally Advanced/Metastatic or Recurrent Ovarian Cancer, Fallopian Tube Cancer,, Primary Peritoneal Cancer or Endometrial Cancer
A Study of MM-121 in Combination With Paclitaxel in Patients With Advanced Gynecologic and Breast Cancers
This study was a Phase 1 and pharmacologic open-labeled dose-escalation trial of MM-121 in combination with paclitaxel using a "3+3" design.
- Conditions
- Locally Advanced/Metastatic or Recurrent Ovarian Cancer, Fallopian Tube Cancer,, Primary Peritoneal Cancer or Endometrial Cancer, Locally Advanced/Metastatic Her2 Non Overexpressing Breast Cancer
- Trial name
- NCT01209195
- Testing
- MM-121, Paclitaxel
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Merrimack Pharmaceuticals
Cancer of the Cervix, Cervical Neoplasms
Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial)
The purpose of this study is to determine the maximum tolerated dose of integrated boost radiation therapy when given with concurrent chemotherapy (cisplatin).
- Trial name
- IDEAL (NCT01627288)
- Testing
- Boost radiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Cervical Cancer, Endometrial Cancer
Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer
RATIONALE: Fondaparinux may help prevent blood clots from forming in patients who are undergoing surgery for gynecologic cancer.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00381888
- Testing
- fondaparinux sodium
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Gynecologic Cancer, Colorectal Cancer
Patient-Centered Intervention to Reduce Cancer Patients' Financial Toxicity
The purpose of this study is to incorporate feedback from cancer patients and providers to adapt, implement, and test an intervention.
- Conditions
- Gynecologic Cancer, Colorectal Cancer, Lung Cancer
- Trial name
- NCT04314284
- Testing
- I Can PIC, Historical control survey, Post-intervention survey (I Can PIC participants)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Washington University School of Medicine
Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients
The primary objective of this study is to determine if metformin administered in combination with chemotherapy to women with advanced ovarian, primary peritoneal or fallopian tube cancer will improve recurrence-free survival at…
- Trial name
- NCT01579812
- Testing
- Metformin
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Michigan Rogel Cancer Center
Malignant Neoplasms of Female Genital Organs, Gynecologic Cancer
Wound Infiltration With Liposomal Bupivacaine vs. Standard Wound Infiltration With Bupivacaine in Patient's Undergoing Open Gynecologic Surgery on an Enhanced Recovery Pathway
Bupivacaine is a drug that is traditionally given as an injection to numb surgical sites. Liposomes are molecules that are similar to fats.
- Trial name
- NCT02740114
- Testing
- Bupivacaine, Liposomal Bupivacaine, Oxycodone
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer Debulking, Enlarged Uterus
Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
To determine if opioid consumption postoperatively among patients undergoing non-emergent laparotomy by the gynecologic oncology service who receive intrathecal morphine with intraoperative lidocaine (IML) infusion are lower than…
- Conditions
- Cancer Debulking, Enlarged Uterus, Fibroid Uterus, Adnexal Mass
- Trial name
- NCT05017246
- Testing
- Bupivacaine, Morphine, Lidocaine
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Washington University School of Medicine
Gastrointestinal and Gynecologic Malignancies
Laparoscopic Narrow Band Imaging for Detection of Occult Cancer Metastases
Adult patients evaluated at Lahey Clinic with known or suspected gastrointestinal or gynecologic malignancies and with an indication for diagnostic laparoscopy will be offered participation in the study.
- Trial name
- NCT01944930
- Testing
- Laparoscopic narrow band imaging, Standard white-light laparoscopy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Lahey Clinic
Ovarian Cancer, Breast Cancer
A Crossover Bioequivalence Study of Olaparib Tablets, 150 mg (Lek Pharmaceuticals d.d.) and Lynparza® (Olaparib) Tablets 150 mg (AstraZeneca Pharmaceuticals LP), in Patients With Breast Cancer Gene (BRCA) Mutated Ovarian Cancer, Recurrent Ovarian Cancer or Metastatic Breast Cancer
This is a two-way crossover bioequivalence study between test and reference product in patients diagnosed with BRCA mutated ovarian cancer, recurrent ovarian cancer or metastatic breast cancer.
- Trial name
- NCT05258747
- Testing
- Olaparib tablets, 150 mg, Lynparza® (olaparib) tablets 150 mg
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sandoz