Clinical trials: Gynecologic Cancer, open to volunteers
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma
Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax
This phase Ib trial tests the safety, side effects, and best dose of tumor treating fields therapy in combination with either cabozantinib or nab-paclitaxel and atezolizumab in treating patients with solid tumors involving the…
- Conditions
- Advanced Breast Carcinoma, Advanced Endometrial Carcinoma, Advanced Fallopian Tube Carcinoma, Advanced Hepatocellular Carcinoma
- Trial name
- NCT05092373
- Testing
- Atezolizumab, Cabozantinib S-malate, Nab-paclitaxel
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- M.D. Anderson Cancer Center
Gynecologycal Cancer
Role of Mitochondrial Bioenergetics in Resilience for Gynecologic Cancer
The purpose of this research study is to see if patients with endometrial and ovarian cancer are willing to complete physical and cognitive assessments before treatment and again after treatment has ended.
- Trial name
- MITO-RES (NCT07046936)
- Testing
- muscle sample, blood draw
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Gynecologic Surgery, High-flow Nasal Cannula
A RCT on the Preventive Effect of HFNC on Postoperative Pulmonary Complications in Patients With Gynecologic Neoplasms
Patients at high risk of post-operative pulmonary complications (PPC) will be screened out from gynecological tumor patients undergoing surgical treatment, and randomly assigned into the HFNC group and control group, which uses…
- Conditions
- Gynecologic Surgery, High-flow Nasal Cannula, Post-operative Pulmonary Complications
- Trial name
- NCT05526534
- Testing
- heated humidified high flow nasal cannula oxygen therapy, HFNC, Nasal cannula oxygen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Malignant Female Reproductive System Neoplasm
Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery
This phase IV trial compares methadone versus hydromorphone given in the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord (intrathecal) for postoperative pain relief in patients with…
- Trial name
- NCT06525740
- Testing
- Hydromorphone, Methadone, Questionnaire Administration
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Mayo Clinic
Sexual Dysfunction
Feasibility of Addressing Sexual Dysfunction in Women with Breast and Gynecologic Cancers with a Novel Mobile Application
The purpose of this study is to identify breast and gynecologic cancer patients with sexual dysfunction, to measure sexual dysfunction with the Female Sexual Function Index (FSFI) and to provide Patients with the opportunity…
- Trial name
- NCT06694142
- Testing
- Rosy app
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brachytherapy, Uterine Cervical Neoplasms
Retrospective Study of Brachytherapy
Brachytherapy for gynecological cancers will be studied retrospectively.
- Conditions
- Brachytherapy, Uterine Cervical Neoplasms, Uterine Neoplasms, Vulvar Cancer
- Trial name
- RetroBT (NCT05242861)
- Testing
- Brachytherapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhejiang Cancer Hospital
Advanced Gynecological Cancers
Exploratory Clinical Study of cCTL in Combination With Immunotherapy for Advanced Gynecologic Malignancies
This study is a single-arm, open-label, interventional, and exploratory clinical trial,the goal of which is to evaluate the safety and clinical efficacy of the novel tumor-specific cytotoxic T lymphocyte (cCTL) injection in…
- Trial name
- NCT07434284
- Testing
- cCTL treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Malignant Female Reproductive System Neoplasm, Metastatic Malignant Female Reproductive System Neoplasm
Influencing Next-Generation Oncologic Outcomes Through Rapid Integration of Functional Precision Medicine (NOORI): A Feasibility Study of SmartMatch in Rare Gynecologic Cancers
This study is being done to determine how easy it is to use standard of care (SOC) surgical resections or biopsy for SmartMatch analysis to determine treatment options in advanced gynecological malignancies.
- Conditions
- Malignant Female Reproductive System Neoplasm, Metastatic Malignant Female Reproductive System Neoplasm, Unresectable Malignant Female Reproductive System Neoplasm
- Trial name
- NCT07731880
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center
Gynecologic Cancer
OCRA Distress & Unmet Needs
This study is a prospective longitudinal cohort study with an embedded intervention. It follows participants with gynecologic malignancies and their informal caregivers over a 6-month period to assess caregiver distress, NMDOH…
- Trial name
- NCT07591623
- Testing
- Surveys
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- M.D. Anderson Cancer Center
Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus
Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic…
- Conditions
- Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus, Endometriosis, Endometrial Cancer
- Trial name
- NCT07860203
- Testing
- DEX 0.2 μg/kg/h., SGB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Catherin Zhang
Gynaecologic Cancer
More Representative Vaginal Temperature Measurements With a Hyperthermia Pelotte During Hyperthermia Treatments for Gynaecological Cancer.
The goal of this comparative, cross over single centre study is to to determine whether the average measured vaginal temperature during hyperthermia treatment is (clinically) significant different with the use of a pelotte than…
- Trial name
- ORIENTATE (NCT07235540)
- Testing
- Pelotte
- Where
- Netherlands
- Volunteers
- 27 people
- Sponsor
- Dr. G.H. (Henrike) Westerveld
Breast Cancer, Ovarian Cancer
Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples
The purpose of this study is to try to understand the biology of development of breast, ovarian, fallopian tube, peritoneal or endometrial cancer from persons at high genetic risk for these diseases.
- Conditions
- Breast Cancer, Ovarian Cancer, Gynecologic Cancers, Ovarian/Peritoneal/Fallopian Cancer
- Trial name
- NCT01034033
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Stanford University
Cancer, Cancer Diagnosis
Avera Cancer Sequencing and Analytics Protocol (ASAP)
The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system.
- Conditions
- Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer
- Trial name
- ASAP (NCT05142033)
- Where
- 6 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Prostate Cancer, Gynecologic Cancers
Quality and Safety of Real-Time Brachytherapy Treatments: Clinical Implementation of a Multipoint Scintillation Detector for Treatment Monitoring
This project addresses a key safety gap in High-Dose-Rate (HDR) brachytherapy, where very high, localized radiation doses mean that small geometric deviations in catheter placement or radioactive source positioning can cause…
- Trial name
- (CurieInVivo) (NCT07580651)
- Testing
- Brachytherapy treatment monitoring using a plastic scintillation detector
- Volunteers
- 25 people
- Sponsor
- CISSS de Chaudière-Appalaches
Gynaecologic Cancer, Cervical Cancer
GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries
The purpose of study is to compare the side effects of two different forms of radiation for endometrial and cervical cancer. If you decide to enroll in this study, you will be randomized to one of two treatment groups.
- Conditions
- Gynaecologic Cancer, Cervical Cancer, Radiation Therapy
- Trial name
- NCT07415681
- Testing
- Volume Modulated Arc Therapy (VMAT), Intensity Modulated Proton Therapy (IMPT)
- Where
- 5 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Maryland, Baltimore
Breast Cancer, Ovarian Cancer
Tissue Acquisition and Genomics Analysis of Breast Cancer and Other Gynecologic Malignancies
Background: A person s blood, tissue, and other samples contain DNA. Cancer is a disease of cells that are not working properly. It is caused by changes in DNA that build up.
- Conditions
- Breast Cancer, Ovarian Cancer, Uterine Cancer
- Trial name
- NCT03762733
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Gynecologic Cancers, Surgical Wound Closure Techniques
Effect of Skin Closure Techniques on Body Image in Women Undergoing Gynecologic Surgery
This randomized clinical trial investigates the impact of two different skin closure techniques on body image and mood in women undergoing surgery for gynecologic cancers.
- Conditions
- Gynecologic Cancers, Surgical Wound Closure Techniques, Body Image
- Trial name
- BISGO (NCT07327125)
- Testing
- Continuous Subcuticular Suture, Interrupted Skin Closure
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Gynecologic Cancer, Frailty
Frailty Assessments for Risk Assessment in Gynecologic Oncology Patients
FARGO is a prospective cohort study that aims to determine the performance of preoperative frailty assessment based on the Frailty Phenotype (FP), compared to a perioperative cardiovascular risk assessment based on the…
- Conditions
- Gynecologic Cancer, Frailty, Oncology
- Trial name
- FARGO (NCT05738252)
- Testing
- Clinical Frailty Scale, Frailty Phenotype
- Where
- 4 sites in Canada
- Volunteers
- 280 people
- Sponsor
- Population Health Research Institute
Gynecologic Cancers
Attitudes to Gynae Oncology Care Location - GRACEFUL
Gynaecological oncology (cancer) place of care is often based on evolution of services, along historical professional boundaries, rather than user needs or preferences.
- Trial name
- GRACEFUL (NCT06920342)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Somerset NHS Foundation Trust
Advanced Gynecological Malignancies
Phase IIa Study of BRY812 Monotherapy in Advanced Gynecological Malignancies
This study is a single-arm, open-label, multicenter Phase IIa trial designed to evaluate the efficacy, safety, and pharmacokinetic profile of BRY812 for Injection in patients with LIV-1-positive advanced gynecological…
- Trial name
- NCT07311538
- Testing
- BRY812 for injection
- Volunteers
- 56 people
- Sponsor
- BioRay Pharmaceutical Co., Ltd.