Clinical trials: Gynecologic Cancers
Breast Cancer, Prostate Cancer
Holistic Acupuncture for Patients With Chemotherapy Induced Nausea
The study explores whether acupuncture as a supplement to conventional antiemetic medicine is superior in reducing the level of chemotherapy induced nausea compared to conventional anitemetic medicine alone.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Gynaecologic Cancer
- Trial name
- NCT07201194
- Testing
- Holistic acupuncture and acupressure, Standard medical treatment
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
Gynecologic Neoplasms, Cognition Disorders
Emerging From the Haze for Gynecologic Cancer Survivors
At Cedars-Sinai Medical Center, the investigators have developed a novel curriculum for a 6-week psycho-educationally-based, cognitive behavioral program to help patients with subjective cognitive complaints after cancer…
- Trial name
- NCT02918461
- Testing
- Emerging from the Haze class
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Ovarian Carcinoma, Cervical Carcinoma
Contribution of Oncovascular Surgery in the Treatment of Gynecological Advanced Malignant Diseases.
Multicenter ambispective observational study (prospective/retrospective)
- Conditions
- Ovarian Carcinoma, Cervical Carcinoma, Endometrial Carcinoma, Vulvar Carcinoma
- Trial name
- NCT07267780
- Where
- 2 sites in Italy
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute, Naples
Advanced Gynecological Malignancies
Phase IIa Study of BRY812 Monotherapy in Advanced Gynecological Malignancies
This study is a single-arm, open-label, multicenter Phase IIa trial designed to evaluate the efficacy, safety, and pharmacokinetic profile of BRY812 for Injection in patients with LIV-1-positive advanced gynecological…
- Trial name
- NCT07311538
- Testing
- BRY812 for injection
- Volunteers
- 56 people
- Sponsor
- BioRay Pharmaceutical Co., Ltd.
Malignant Female Reproductive System Neoplasm, Stage I Cervical Cancer AJCC v8
Sexual Health Counseling Intervention During Radiation Therapy in Improving Quality of Life for Women With Gynecologic Cancer
This phase I trial studies a sexual health counseling intervention during radiation therapy in improving quality of life for women with gynecologic cancer.
- Conditions
- Malignant Female Reproductive System Neoplasm, Stage I Cervical Cancer AJCC v8, Stage I Uterine Corpus Cancer AJCC v8, Stage I Vaginal Cancer AJCC v8
- Trial name
- NCT04269837
- Testing
- Counseling, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Endometrial Cancer, Fallopian Tube Cancer
Combination Chemotherapy in Treating Patients With Endometrial Cancer, Fallopian Tube Cancer, or Sarcoma of the Female Reproductive Tract
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer, Sarcoma
- Trial name
- NCT00003334
- Testing
- paclitaxel, pegylated liposomal doxorubicin hydrochloride
- Where
- 5 sites in United States
- Sponsor
- NYU Langone Health
Postoperative Complications, Obesity
Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients
The purpose of the study is to test whether the use of a new wound closure technique can decrease the rates of wound complications in obese cancer patients.
- Conditions
- Postoperative Complications, Obesity, Gynecologic Neoplasms
- Trial name
- NCT02309944
- Testing
- Standard Wound Closure, Prevena™ Incision Management System
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Neoplasms, Venous Thromboembolism
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Venous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies.
- Conditions
- Gynecologic Neoplasms, Venous Thromboembolism, Low Molecular Weight Heparin, Argatroban
- Trial name
- NCT02935530
- Testing
- s-LMWH, LMWH, Argatroban
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Huazhong University of Science and Technology
Cervical Cancer, Radiation Therapy Complication
Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies
This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation…
- Conditions
- Cervical Cancer, Radiation Therapy Complication, Pelvic Floor Disorders
- Trial name
- NCT07447895
- Testing
- Pelvic floor physical therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Cincinnati
Gynecologic Neoplasms, Epithelial Ovarian Cancer
PLX2853 as a Single Agent in Advanced Gynecological Malignancies and in Combination With Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer
The purpose of this research study is to evaluate safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of the investigational drug PLX2853 in Advanced Gynecological Malignancies with a Known ARID1A Mutation and…
- Trial name
- NCT04493619
- Testing
- PLX2853, Carboplatin
- Where
- 9 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Opna Bio LLC
Nausea, Vomiting
Olanzapine Against Delayed Nausea and Vomiting in Women Receiving Carboplatin Plus Paclitaxel
This randomized, pilot study explores the activity of olanzapine with or without delayed dexamethasone for the prevention of delayed nausea and vomiting in women with gynecologic cancer receiving the combination of carboplatin…
- Trial name
- NCT02290470
- Testing
- Olanzapine, Palonosetron, Dexamethasone, Carboplatin, Paclitaxel, Olanzapine
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Financial Burden, Financial Toxicity
Proactive Costs of Care Study
The Proactive Costs of Care intervention is an educational intervention designed to help patients deal with the cost of cancer care.
- Conditions
- Financial Burden, Financial Toxicity, Financial Stress, Financial Navigation
- Trial name
- PCOC (NCT07217262)
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Endometrioid Endometrial Cancer
Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic Malignancies
This study will assess the safety and efficacy of increasing doses of narazaciclib (ON 123300) in combination with the standard daily dose (2.5mg) of letrozole in patients with Recurrent Metastatic Low-grade Endometrioid…
- Trial name
- NCT05705505
- Testing
- Narazaciclib, Letrozole 2.5mg
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Traws Pharma, Inc.
Cancer of the Gastrointestinal, Genitourinary or Gynecologic Systems
Real Time In-Vivo Body Surface Dosimetry for External Beam Radiation Therapy
This is an observational study. This protocol will determine the feasibility of using a novel nano-material based fiber-optic dosimeter (nanoFOD) device, with dimensions less than 1 mm wide, to measure real-time, pin-point…
- Trial name
- NCT02407977
- Testing
- Novel nano-scintillatorfiber-optic dosimeter ( nanoFOD)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Locally Advanced/Metastatic or Recurrent Ovarian Cancer, Fallopian Tube Cancer,, Primary Peritoneal Cancer or Endometrial Cancer
A Study of MM-121 in Combination With Paclitaxel in Patients With Advanced Gynecologic and Breast Cancers
This study was a Phase 1 and pharmacologic open-labeled dose-escalation trial of MM-121 in combination with paclitaxel using a "3+3" design.
- Conditions
- Locally Advanced/Metastatic or Recurrent Ovarian Cancer, Fallopian Tube Cancer,, Primary Peritoneal Cancer or Endometrial Cancer, Locally Advanced/Metastatic Her2 Non Overexpressing Breast Cancer
- Trial name
- NCT01209195
- Testing
- MM-121, Paclitaxel
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Merrimack Pharmaceuticals
Ovarian Cancer, Chemotherapy
Impact of Disney Movies During Chemotherapy on QOL of Gynecologic Oncology Patients
To evaluate the impact of Disney movies on quality of life (QOL) of gynecologic oncology patients. 25 Patients are watching Disney movies on portable DVD players during chemotherapy, 25 patients are not allowed to watch TV.
- Conditions
- Ovarian Cancer, Chemotherapy, Quality of Life
- Trial name
- NCT03863912
- Testing
- Disney movie, EORTC QLQ-C30 and EORTC QLQ-FA12 surveys
- Where
- Austria
- Volunteers
- 56 people
- Sponsor
- Medical University of Vienna
Gynecologic Disease
GYN-AIDE: Gynecologic Oncology Navigation Through AI-Driven Education
This study seeks to understand how endometrial cancer patients get medical information about cancer care and their satisfaction with those health-seeking methods.
- Trial name
- NCT07279571
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Southern California
Advanced Solid Tumor, Gynecologic Cancer
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor
This is an open-label, Phase 1b/2 study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of…
- Trial name
- NCT04042116
- Testing
- Lucitanib, Nivolumab
- Where
- 27 sites in United States, Austria and 4 more
- Volunteers
- 227 people
- Sponsor
- Clovis Oncology, Inc.
Stage III Gynecologic Cancer, Stage IV Gynecologic Cancer
A Self-Directed Mindfulness Meditation Intervention in Gynecologic Cancer Patients
The current study examines the effects of a 3-week, at-home mindfulness mediation intervention (MMI) to address psychological and physical distress in patients with gynecologic cancer.
- Trial name
- NCT04072406
- Testing
- Mindfulness meditation, Usual care packet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine