Clinical trials: Gynecologic Disorders
Gynecologic Disease, Gynecologic Cancer
Enhanced Recovery After Surgery (ERAS) in Gynecological Surgery (ERASGS-01)
Enhanced recovery programs are composed of preoperative, intraoperative and postoperative strategies combined to form a multi-modal pathway.
- Trial name
- ERAS (NCT03629626)
- Testing
- ERAS protocol
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shandong University
Neoplasms, Ovarian Neoplasms
Biobehavioral Intervention in Gynecologic Oncology Patients
Baseline self-report outcome measures will be completed and additional assessments will occur mid-treatment , post-treatment , 3 months following completion of all sessions, and 6 months following completion of all sessions.
- Conditions
- Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Vulva
- Trial name
- NCT02454036
- Testing
- BBI intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Rachel Miller
Breast Cancer, Gynecologic Cancer
Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms
RATIONALE: Dehydroepiandrosterone (DHEA) may help relieve vaginal symptoms in female cancer survivors. PURPOSE: This randomized phase III trial studies DHEA to see how well it works compared to placebo in treating postmenopausal…
- Trial name
- NCT01376349
- Testing
- prasterone
- Where
- 280 sites in United States
- Volunteers
- 464 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Gynecologic Cancer, Cervical Cancer
Hyperpolarized 13C MRI for Cancer Immunotherapy
The investigators aim to develop an advanced imaging platform, such as dynamic nuclear polarization (DNP) 13C-MRI, MR fingerprinting (MRF) and MR Relaxometry, which combines with traditional anatomical contrast CT, MRI and PET…
- Conditions
- Gynecologic Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- DNPSPIO (NCT05805358)
- Testing
- Hyperpolarized 13C-Pyruvate injection
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Nutritional Deficiency, Gynecologic Cancer
Immunonutrition in ERAS Protocols in Gynecologic Oncology
A patient with oncological pathology of any type because of impaired digestion and nutrient absorption, decreased intake, and increased nutrition requirements has an increased risk of malnutrition and moderate to severe weight…
- Conditions
- Nutritional Deficiency, Gynecologic Cancer, ERAS
- Trial name
- NUTRIGO (NCT06103526)
- Testing
- Immunonutrition
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
TNBC - Triple-Negative Breast Cancer, Ovarian Cancer
A Study to Evaluate Safety/Tolerability of Immunotherapy Combinations in Participants With Triple-Negative Breast Cancer or Gynecologic Malignancies
This is a Phase 1/1b, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of etrumadenant (AB928) in combination with…
- Trial name
- NCT03719326
- Testing
- Etrumadenant, IPI-549, Pegylated liposomal doxorubicin (PLD)
- Where
- 27 sites in United States, Australia
- Volunteers
- 35 people
- Sponsor
- Arcus Biosciences, Inc.
Gastrointestinal Cancer, Gynecologic Cancer
BOLSTER: Learning New Skills to Thrive
This research study is evaluating a new program called Building Out Lifelines for Safety, Trust, Empowerment, and Renewal or (BOLSTER), which was designed to support participants with a gynecological or gastrointestinal cancer…
- Conditions
- Gastrointestinal Cancer, Gynecologic Cancer, Advanced Cancer
- Trial name
- BOLSTER (NCT06936878)
- Testing
- BOLSTER Program
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Dana-Farber Cancer Institute
Gynecologic Disease
Effect of Barbed Suture Fascia Closure on Incisional Hernia in Midline Laparotomy for Gynecological Diseases (BARBHER)
Investigators will compare the incidence of incisional hernia in women who underwent midline laparotomy whose abdominal fascia was closed with barbed suture vs. conventional non-barbed suture.
- Trial name
- BARBHER (NCT04643197)
- Testing
- Barbed PDS suture (STRATAFIX Symmetric PDS Plus), Non-barbed PDS suture (PDS Plus)
- Volunteers
- 174 people
- Sponsor
- Seoul National University Hospital
Cervical Cancer, Endometrial Cancer
Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy
This randomized, pilot phase I trial studies whether phone or email reminders increases vaginal dilator use in patients with endometrial, cervical, or vaginal cancers after they undergo brachytherapy.
- Conditions
- Cervical Cancer, Endometrial Cancer, Radiation Toxicity, Vaginal Cancer
- Trial name
- NCT02058550
- Testing
- survey administration, computer-assisted intervention, telephone-based intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Gynecologic Disease
Comparative Study of Blood Loss in Total Laparoscopic Hysterectomy by Ligation the Uterine Arteries in Different Techniques.
Following Caesarean section, hysterectomy is the second most common major gynecological surgery, with approximately 600,000 procedures performed annually in the USA. Since Reich et al.
- Trial name
- NCT06875518
- Testing
- BTLH with bilateral uterine artery ligation from its origin, Conventional TLH
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mostafa Bahaa
Ovarian Carcinoma, Cervical Carcinoma
Contribution of Oncovascular Surgery in the Treatment of Gynecological Advanced Malignant Diseases.
Multicenter ambispective observational study (prospective/retrospective)
- Conditions
- Ovarian Carcinoma, Cervical Carcinoma, Endometrial Carcinoma, Vulvar Carcinoma
- Trial name
- NCT07267780
- Where
- 2 sites in Italy
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute, Naples
Gynecologic Oncological Pelvic/Abdominal Surgery
High-dose Periop Statins for Prevention of DVT
This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation…
- Trial name
- NCT00259662
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Yale University
Malignant Melanoma, Gynecologic Cancer
Carbon Ion Radiation Therapy in the Treatment of Mucous Melanomas of the Female Lower Genital Tract
The present monocentric prospective phase 2 study aims to reproduce the results obtained at NIRS thus offering the possibility of obtaining a promising rate of progression-free survival (PFS) and local control (LC) in patients…
- Trial name
- CYCLE (NCT05478876)
- Testing
- carbon ion radiation therapy CIRT
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Gynecologic Cancer, Breast Neoplasm Female
Impact of the COVID-19 Pandemic in Gynecological Oncology
The current infection with the Coronavirus SARS-CoV-2 (COVID-19) is an exceptional health situation which requires an adaptation of our management practices in gynecological oncology.
- Conditions
- Gynecologic Cancer, Breast Neoplasm Female, Uterine Neoplasms, Ovarian Neoplasms
- Trial name
- COVID-GYN (NCT04351139)
- Testing
- modification of the planned therapeutic management
- Where
- 3 sites in France
- Volunteers
- 205 people
- Sponsor
- Hospices Civils de Lyon
Urinary Incontinence, Urinary Stress Incontinence
Pregnancy After Tension-free Vaginal Tape and Other Mid-urethral Sling Procedures
The purpose of this study is to determine the interactions between pregnancy and urinary stress incontinence in women with a mid-urethral sling (MUS).
- Conditions
- Urinary Incontinence, Urinary Stress Incontinence, Pregnancy Complications
- Trial name
- PregnanT (NCT02999347)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Breast Cancer, Brain Cancer
Study of Insulin-like Growth Factor (IGF)-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
This phase I dose escalation study will evaluate IGF-Methotrexate conjugate (765IGF-MTX) in patients with advanced, previously treated tumors.
- Conditions
- Breast Cancer, Brain Cancer, Gastrointestinal Cancers, Genitourinary Cancers
- Trial name
- NCT02045368
- Testing
- IGF-Methotrexate conjugate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- IGF Oncology, LLC
Gynecologic Cancers, Anxiety
Brief Title- Virtual Reality Glasses in Gynecologic Cancer
It was planned to determine the effect of virtual reality glasses used in female patients diagnosed with gynecological cancer and receiving chemotherapy on treatment compliance and anxiety level.
- Trial name
- NCT06760689
- Testing
- virtual reality glasses, scale
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Fallopian Tube Cancer, Female Reproductive Cancer
Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma
This phase II trial is studying how well ziv-aflibercept works in treating patients with locally advanced, unresectable or metastatic gynecologic soft tissue sarcoma.
- Conditions
- Fallopian Tube Cancer, Female Reproductive Cancer, Ovarian Carcinosarcoma, Ovarian Sarcoma
- Trial name
- NCT00390234
- Testing
- ziv-aflibercept
- Where
- 16 sites in United States, Canada
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Muscle-Invasive Bladder Carcinoma
Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy
Subjects will be randomized into 2 groups (stent or no stent) prior to radical cystectomy with ileal conduit urinary diversion (RCIC). They will follow the standard of care and be enrolled in the study for 12 months post-op.
- Conditions
- Bladder Cancer, Muscle-Invasive Bladder Carcinoma, Urothelial Carcinoma, Pelvic Malignancy
- Trial name
- NCT07234968
- Testing
- Ureteral Stent Placement, No Ureteral Stent, Indocyanine Green with Fluorescence Imaging
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University
Endometrial Neoplasms, Ovarian Neoplasms
Questionnaire Study for Gynecological Cancer Survivors
The purpose of this study is to evaluate the quality of life of long-term gynecologic cancer survivors.
- Conditions
- Endometrial Neoplasms, Ovarian Neoplasms, Uterine Cervical Neoplasms, Vulvar Neoplasms
- Trial name
- NCT00391664
- Testing
- Psychosocial
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- U.S. Army Medical Research and Development Command