Clinical trials: Gynecologic Disorders, open to volunteers
Colorectal Cancer, Urologic Cancer
Fluid Challenge and Plasma Volume, During Surgery
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique.
- Conditions
- Colorectal Cancer, Urologic Cancer, Gynecologic Cancer, Colorectal Disorders
- Trial name
- FC-VE (NCT05726136)
- Testing
- acetated Ringers, albumin 5%, albumin 20%
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Joachim Zdolsek
Endometriosis, Pelvic Pain Syndrome
Study on the Outcomes of Patients Treated in Gynecological Emergency Departments for Pelvic Endometriosis or Suspected Pelvic Endometriosis
Adult patients consulting the gynecological emergency department of CHI Créteil during the inclusion period for endometriosis or symptoms suggestive of endometriosis
- Conditions
- Endometriosis, Pelvic Pain Syndrome, Chronic Gynaecological Disease
- Trial name
- NCT07472842
- Testing
- Emergency care for endometriosis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Breast Cancer, Lung Cancer
Predicting Cancer Risk With Digital and Molecular Markers
The goal of this study is to identify new markers to predict the risk of developing cancer, primarily breast cancer. For this purpose, researchers will compare data obtained from cancer patients and healthy individuals.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Gynecologic Cancer
- Trial name
- PräDigt (NCT06962670)
- Testing
- Biomaterial collection, BayPass mobile application
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Endometrial Cancer, Cervical Cancer (Early Detection)
Remote Robotic Surgery for Gynecologic Cancer: A Safety and Effectiveness Study
This investigator-initiated, multicenter, single-blind, randomized controlled clinical study is designed to evaluate the safety and effectiveness of the MP2000 thoracoabdominal endoscopic surgical system (Shenzhen Jingfeng…
- Trial name
- RRS-GYN-RCT (NCT07896720)
- Testing
- MP2000 Thoracoabdominal Endoscopic Surgical System
- Volunteers
- 92 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Breast Cancer, Lung Cancer
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study will investigate the effects of atezolizumab on select cancer types in people whose analysis of tumour DNA and RNA indicates they may be sensitive to atezolizumab.
- Conditions
- Breast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- CAPTIV-8 (NCT04273061)
- Testing
- Atezolizumab
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Postoperative Cognitive Dysfunction, Perioperative Neurocognitive Disorder
POCD After Major Gynecologic Surgery
This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery.
- Trial name
- POCD-GYN (NCT07589348)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Fatihhan Zeytun
Ovarian Neoplasms, Uterine Neoplasms
Evaluation of Interactions and Group Processes in Multidisciplinary Tumor Boards in Gynecologic Oncology
Study Title Group Dynamics Evaluation in Gynecologic Multidisciplinary Tumor Boards - GOLD Study Background and Rationale Multidisciplinary Tumor Boards are central to complex oncologic decision-making.
- Trial name
- GOLD (NCT07645716)
- Testing
- Online Survey Assessment of Tumor Board Group Dynamics
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Disease, Adnexal Mass
Assessment of Women's Sexual Quality of Life After Benign Adnexal Surgery Using vNOTES Approach
Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is a recent innovation in minimally invasive surgery which has already proven its non-inferiority to conventional abdominal laparoscopy (CAL) for hysterectomy…
- Conditions
- Gynecologic Disease, Adnexal Mass, Adnexal Cyst, Sexuality
- Trial name
- NCT05761275
- Testing
- Elective cystectomy, Elective oophorectomy, Elective salpingectomy
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Jean Dubuisson
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Fibroid Uterus, Metrorrhagia
A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes
The goal of this randomized clinical trial is to assess the outcomes of total laparoscopic hysterectomy vs subtotal laparoscopic hysterectomy + mini-laparotomy for uterine extraction for benign gynecological conditions in terms…
- Conditions
- Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm
- Trial name
- STORY (NCT06802198)
- Testing
- total hysterectomy, subtotal hysterectomy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer Screening, Gynecologic Cancers
Compliance to Cervical Cancer Chemoradiation Guidelines: A Multicentric Implementation Audit and Resource Assessment Initiative of National Cancer Grid of India
This is a combination of retrospective and prospective observational study that will be performed across NCG and other participating centers to report compliance to chemoradiation for cervical cancer.
- Conditions
- Cervical Cancer Screening, Gynecologic Cancers, Treatment Compliance, Chemoradiotherapy
- Trial name
- NCG-Compliance (NCT07290972)
- Testing
- Not applicable- observational study
- Where
- 2 sites in India
- Volunteers
- 618 people
- Sponsor
- Tata Memorial Hospital
Cervical Dysplasia, Cervical Cancer
Circulating Human Papilloma Virus (HPV) DNA for the Screening and Surveillance of Gynecologic Cancers
Human papilloma virus-related gynecologic malignancies affect over 20,000 women in the United States, and over half a million women globally each year.
- Trial name
- NCT05606133
- Testing
- NavDx(R)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Digestive Cancer, Gynecologic Cancer
Development of Clinical and Biological Database
The BCB is a tool: for research in analytical and public health epidemiology, biological research and for the development of data useful for clinical research and therapeutic trials; to help scientists understand and explain…
- Conditions
- Digestive Cancer, Gynecologic Cancer, Breast Cancer, Sarcoma
- Trial name
- BCBInstitut (NCT03449264)
- Testing
- biological collection
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus
Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic…
- Conditions
- Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus, Endometriosis, Endometrial Cancer
- Trial name
- NCT07860203
- Testing
- DEX 0.2 μg/kg/h., SGB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Catherin Zhang
Pain Management, Outpatient Hysteroscopy
Hysteroscopy Anesthesia for Relief of Pain
This randomized clinical trial aims to evaluate the effect of local anesthesia on pain perception in patients undergoing outpatient diagnostic hysteroscopy.
- Conditions
- Pain Management, Outpatient Hysteroscopy, Local Anesthesia, Procedural Pain Relief
- Trial name
- HARP (NCT07178379)
- Testing
- Local paracervical Anesthesia
- Volunteers
- 70 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Cervical Cancer, Gynecologic Malignancies
The Safety, Tolerability, and Efficacy of KD01 in Gynecologic Malignancies
Recombinant oncolytic adenovirus injection (KD01)is an oncolytic vius product. Its main component is a conditionally replicativerecombinant human type 5 adenovirus, where part of the E3 region has been replaced with the gene…
- Conditions
- Cervical Cancer, Gynecologic Malignancies, Endometrial Cancer
- Trial name
- NCT06552598
- Testing
- KD01(the recombinant oncolytic adenovirus)
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Tongji Hospital
Breast Cancer, Lung Cancer
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
This study will collect, annotate, and sequence biospecimens (blood, tissue, urine, saliva and surgery drainage) from patients across different cancer types to detect molecular residual disease (MRD).
- Conditions
- Breast Cancer, Lung Cancer, Melanoma, Gynecologic Cancer
- Trial name
- SHERLOCK (NCT07524114)
- Where
- Canada
- Volunteers
- 7,000 people
- Sponsor
- University Health Network, Toronto
Esophageal Cancer, Gastrointestinal Cancers
Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.
The goal of clinical trial is to test an FDA approved drug called Pafolacianine that attaches to cancer cells and lights up when seen through a special camera system in adults with a suspected primary diagnosis, or a high…
- Conditions
- Esophageal Cancer, Gastrointestinal Cancers, Gynecologic Cancers
- Trial name
- NCT07039526
- Testing
- CYTALUX™ (pafolacianine) injection preoperatively
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Waters
Ovary Cancer, Endometrial Cancer
Multimedia Aid for Genetic Testing in Gynecologic Oncology
This pilot study aims to estimate rates of genetic testing in patients with ovarian and endometrial cancer before and after the implementation of educational videos about genetic testing.
- Trial name
- NCT07084168
- Testing
- Educational videos, Survey
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center