Clinical trials: Gynecologic Tumor
Gynecologic Cancers
Alveolar Recruitment in Obese Patients in Major Gynaecological Cancer Surgery
In this study, the investigators planned to evaluate the effect of alveolar recruitment strategy primarily on postoperative pulmonary complications in obese patients undergoing lung protective ventilation in major open…
- Trial name
- NCT06619626
- Testing
- alveolar recruitment strategy applied group, group without alveolar recruitment strategy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Metastatic Malignant Female Reproductive System Neoplasm
Single Fraction or Multi-fraction Palliative Radiation Therapy for the Improvement of Quality of Life in Patients With Metastatic Gynecologic Cancers
This phase II trial studies if a single session of palliative radiation therapy can help improve symptoms of gynecologic cancers that have spread to other places in the body (metastatic) and that affect quality of life as well or…
- Trial name
- NCT04516135
- Testing
- 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Genital Neoplasm Malignant Female, Surgical Procedure, Unspecified
A Trial Comparing Surgeon-administered TAP Block With Placebo After Midline Laparotomy in Gynecologic Oncology
Multimodal opioid-sparing analgesia is recommended in order to prevent post-operative complications and shorten length of stay. Administration by the surgeon of local anesthetics in the abdominal wall after surgery for a…
- Trial name
- NCT04202874
- Testing
- Surgeon-administered transversus abdominis plane (TAP)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McMaster University
Ovarian Cancer, Cervical Cancer
A Prospective Study to Evaluate the Clinical Performance and Safety of the SIRIUS Endoscope System in Laparoscopic Gynecological Surgery.
Precision Robotics' Sirius Robotic Flexible Endoscopic System is a new fully integrated compact 3D laparoscopic camera system with a disposable single-use flexible tip that can change its viewing direction.
- Conditions
- Ovarian Cancer, Cervical Cancer, Gynecologic Cancer
- Trial name
- NCT05318625
- Testing
- Gynaecological laparoscopic surgery (Sirius System)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Precision Robotics (Hong Kong) Limited
Female Reproductive System Neoplasm, Malignant Female Reproductive System Neoplasm
EHealth Mindful Movement and Breathing in Improving Outcomes in Participants Undergoing Gynecologic Surgery
This trial determines how well eHealth mindful movement and breathing works to improve outcomes in participants undergoing gynecologic surgery.
- Conditions
- Female Reproductive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Uterine Neoplasm, Ovarian Carcinoma
- Trial name
- NCT03379376
- Testing
- Questionnaire Administration, Supportive Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Gynecologic Cancers
Homoeriodictyol Sodium Mouthwash to Reduce Chemotherapy Induced Bitter Taste Disorders
Background: More than 75% of women with cancer experience taste disorders during adjuvant chemotherapy. Bitter phantogeusia is particularly limiting.
- Trial name
- HED (NCT07573787)
- Testing
- homoeriodictyol sodium
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Christoph Grimm
Advanced Endometrial Cancer, Cervical Cancer and Ovarian Cancer
A Study of TQ-B3525 Tablets in Subjects With PIK3CA and/or PIK3R1/2 Gene-altered Recurrent/Metastatic Advanced Gynecologic Tumors
This is a study to evaluate the efficacy and safety of TQ-B3525 in subjects with recurrent / metastatic advanced endometrial cancer, cervical cancer and ovarian cancer with PIK3CA and / or PIK3R1 / 2 gene-altered (mutation or…
- Trial name
- NCT04836663
- Testing
- TQ-B3525 tablet
- Where
- 5 sites in China
- Volunteers
- 90 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Gynecologic Cancer, Ovarian Cancer
Journey Ahead: Enhancing Coping and Communication for Women Diagnosed With Gynecological Cancer
This study looks at how well the Journey Ahead intervention works in improving coping and communication skills in participants with gynecologic cancers.
- Conditions
- Gynecologic Cancer, Ovarian Cancer, Endometrial Cancer, Fallopian Tube Cancer
- Trial name
- NCT05220033
- Testing
- Informational intervention, survey administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey
Gynecologic Cancers
Geriatric Patients Undergoing Gynaecological Cancer Surgery
Sınce old age includes variables such as genetics, chronic diseases, lifestyle, aging can be classified as chronological, social, physiological and psychological.
- Trial name
- NCT07077629
- Testing
- morbidity and mortality
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Breast Cancer, Gynecologic Cancer
Food Supplements Based on Nettle and Peppermint to Control Signs and Symptoms Induced by Cancer Therapies
The main purpose of this study is to evaluate the impact of food supplements (herbal remedies) on sign and symptoms induced by cancer therapies: Nettle will be administered for improvement of anemia and fatigue; Peppermint will…
- Trial name
- GALENO 1 (NCT04474951)
- Testing
- Stinging Nettle, Peppermint
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Recurrent Platinum Resistant Epithelial Ovarian Carcinoma, Recurrent Epithelial Endometrial Carcinoma
Sacituzumab Govitecan for Relapsed Ovarian, Endometrial, and Cervical Carcinomas
Background: Cancers of the female reproductive organs often come back after treatment. A drug called sacituzumab govitecan (SG) has been approved for use in other types of cancers.
- Conditions
- Recurrent Platinum Resistant Epithelial Ovarian Carcinoma, Recurrent Epithelial Endometrial Carcinoma, Recurrent Epithelial Cervical Carcinoma
- Trial name
- NCT06865677
- Testing
- Sacituzumab Govitecan, EKG, Brain MRI
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Smoking Cessation, Smoking Reduction
Preoperative Smoking Cessation in Patients Undergoing Surgery
Background: At present, effectively implementing smoking cessation programs in the health care system constitutes a major challenge. A unique opportunity to initiate smoking cessation focuses on smokers scheduled for surgery.
- Conditions
- Smoking Cessation, Smoking Reduction, Surgery--Complications, Surgery
- Trial name
- PORTICO (NCT05192837)
- Testing
- Intensive preoperative smoking cessation counselling
- Where
- Switzerland
- Volunteers
- 251 people
- Sponsor
- Luzerner Kantonsspital
Gynecologic Cancer, Pelvic Floor Disorders
Pelvic Floor Dysfunction and Aerobic Training in Gynecological Cancer
The incidence of gynecological cancer and the related death rates in the world are increasing every year. Unfortunately, pelvic floor disorders (PFDs) such as pelvic pain, dyspareunia, vaginal stenosis, and urinary incontinence…
- Conditions
- Gynecologic Cancer, Pelvic Floor Disorders, Aerobic Exercise
- Trial name
- NCT06406322
- Testing
- PFMT, Aerobic Exercise
- Volunteers
- 40 people
- Sponsor
- Atılım University
Gynaecologic Cancer
Improving Sexual Health in Gynecological Cancer Patients
The goal of this clinical trial is to test whether a nurse-led program can improve screening and referral rates for sexual dysfunction and improve sexual health care in individuals with gynecological cancer.
- Trial name
- NCT07144566
- Testing
- Nurse Led Sexual Health Clinical Program Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Cedars-Sinai Medical Center
Cancer Debulking, Enlarged Uterus
Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
To determine if opioid consumption postoperatively among patients undergoing non-emergent laparotomy by the gynecologic oncology service who receive intrathecal morphine with intraoperative lidocaine (IML) infusion are lower than…
- Conditions
- Cancer Debulking, Enlarged Uterus, Fibroid Uterus, Adnexal Mass
- Trial name
- NCT05017246
- Testing
- Bupivacaine, Morphine, Lidocaine
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Washington University School of Medicine
Malignant Peritoneal Neoplasm, Malignant Retroperitoneal Neoplasm
Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis
This phase Ib trial studies the side effects and best dose of nivolumab with or without ipilimumab in treating patients with female reproductive cancer that has come back (recurrent) or is high grade and has spread extensively…
- Conditions
- Malignant Peritoneal Neoplasm, Malignant Retroperitoneal Neoplasm, Metastatic Cervical Carcinoma, Metastatic Endometrial Carcinoma
- Trial name
- NCT03508570
- Testing
- Ipilimumab, Laboratory Biomarker Analysis, Nivolumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Endometrial Cancer
Molecular Staging of Endometrial Cancer
This study, sponsored by NCI and the Gynecologic Oncology Group (GOG), will collect tissue samples from women with cancer of the endometrium (lining of the uterus).
- Trial name
- NCT00340808
- Where
- United States
- Volunteers
- 5,492 people
- Sponsor
- National Cancer Institute (NCI)
Solid Tumors and Advanced Endometrial Cancer, Endometrial Cancer
A Phase II Study to Evaluate the Efficacy of TKI258 for the Treatment of Patients With FGFR2 Mutated or Wild-type Advanced and/or Metastatic Endometrial Cancer
This is a prospective, multi-center, open-label, single-arm, non-randomized, Phase II study to evaluate the efficacy and safety of TKI258 as second-line therapy in patients with either FGFR2 mutated or wild-type advanced and/or…
- Conditions
- Solid Tumors and Advanced Endometrial Cancer, Endometrial Cancer, Second-line Treatment, VEGF
- Trial name
- NCT01379534
- Testing
- TKI258
- Where
- 45 sites in United States, Brazil and 5 more
- Volunteers
- 53 people
- Sponsor
- Novartis Pharmaceuticals
Advanced Solid Tumor, Gynecologic Cancer
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor
This is an open-label, Phase 1b/2 study to determine the recommended dose of lucitanib in combination with nivolumab in patients with an advanced solid tumor (Phase 1b); followed by evaluation of the safety and efficacy of…
- Trial name
- NCT04042116
- Testing
- Lucitanib, Nivolumab
- Where
- 27 sites in United States, Austria and 4 more
- Volunteers
- 227 people
- Sponsor
- Clovis Oncology, Inc.
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University