Clinical trials: Gynecologic Tumor
Gynecologic Cancer, Surgery
GO SOAR1: Post-Operative Morbidity and Mortality Following Gynaecological Oncology Surgery
The Global Gynaecological Oncology Surgical Outcomes Collaborative (GO SOAR) will develop a network of gynaecological oncology surgeons, surgical departments and other interested parties that will have the long-term ability to…
- Conditions
- Gynecologic Cancer, Surgery, Surgery--Complications
- Trial name
- GO SOAR1 (NCT04579861)
- Testing
- Prospective data collection following gynaecological oncology surgery
- Where
- United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Faiza Gaba
Cancer of the Ovary Treated as 2nd Line Therapy, Muellerian Mixed Tumours
Combination Chemotherapy Consisting of Pegylated Liposomal Doxorubicin and Carboplatin in Malignant Gynecologic Tumours
Pegylated Liposomal Doxorubicin as well as Carboplatin have been showed efficacy in monotherapy as in combination therapy of gynaecologic tumours.
- Conditions
- Cancer of the Ovary Treated as 2nd Line Therapy, Muellerian Mixed Tumours, Tumours of the Uterus, Cervical Cancers
- Trial name
- NCT00189410
- Testing
- Pegylated Liposomal Doxorubicin and Carboplatin
- Where
- 19 sites in Germany
- Volunteers
- 140 people
- Sponsor
- AGO Study Group
Gynecologic Cancer, Carcinoma
Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma
Immunotherapy has gained a significant amount of attention recently, but its efficacy as a single agent in gynecological cancers has been disappointing.
- Conditions
- Gynecologic Cancer, Carcinoma, Uterine Cancer, Endometrial Cancer
- Trial name
- NCT05559879
- Testing
- Cabo + Dostarlimab
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Alabama at Birmingham
Hypotension, Hemodynamic Instability
Perioperative Hypotension in Gynaecologic Oncologic Surgery: HPI-ClearSight Versus Arterial Waveform Analysis
Background Intraoperative hypotension is associated with increased morbidity and mortality. The Hypotension Prediction Index (HPI) is an advancement of the arterial waveform analysis to predict intraoperative hypotension minutes…
- Conditions
- Hypotension, Hemodynamic Instability, Gynecologic Cancer
- Trial name
- NCT05354661
- Testing
- Hypotension Prediction Index
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Neoplasms, Abdominal Neoplasms
Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy
Pulse pressure variation (PPV) is a well-known and widely used dynamic preload indicator based on heart-lung interaction to predict fluid responsiveness.
- Trial name
- NCT02653469
- Testing
- Augmented ventilation, Fluid loading
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Samsung Medical Center
Surgical Site Infection, Gynecologic Cancer
Effectiveness of Wound Drains for the Prevention Of Surgical sITe infectION
The aim of the present randomized trial is to assess the efficacy of wound drains in terms of reducing the rates of surgical site infection in obese patients with gynecological cancer.
- Conditions
- Surgical Site Infection, Gynecologic Cancer, Wound Drain
- Trial name
- POSITION (NCT05179122)
- Testing
- Surgical drain
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Malignant Female Reproductive System Neoplasm
Electroencephalographic Changes Under General Anesthesia in Patients With Gynecologic Cancers With and Without History of Chemotherapy
This study compares changes in brain waves in women with gynecologic cancers who have or have not received chemotherapy and who are scheduled to receive surgery as part of their standard care.
- Trial name
- NCT04593550
- Testing
- Biospecimen Collection, BrainCheck Cognitive Assessment, Cognitive Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Wound Infection, Gynecologic Cancer
Prophylactic Negative Pressure Wound Therapy (VAC) in Gynecologic Oncology (G.O.)
A prospective controlled randomized study aimed to prospectively evaluate, the impact and effectiveness of clean incision prophylactic vacuum negative pressure therapy on wound healing (ciNPWT) in women at high risk of developing…
- Trial name
- GO-VAC (NCT04584957)
- Testing
- VAC therapy
- Where
- Italy
- Volunteers
- 196 people
- Sponsor
- Catholic University of the Sacred Heart
Intestines Cancer, Pulmonary Cancer
A Retrospective Cohort Study for Main Postoperative Complications After SARS-CoV-2 Infection
To explore the relationship between SARS-CoV-2 infection in different time before operation and postoperative main complications (mortality, main pulmonary and cardiovascular complications) 30 days after operation; To determine…
- Conditions
- Intestines Cancer, Pulmonary Cancer, Liver Cancer, Trauma
- Trial name
- NCT05781581
- Testing
- no intervention
- Volunteers
- 50,000 people
- Sponsor
- RenJi Hospital
Gynaecologic or Digestive Pelvic Cancer
Study Comparing Isolated Pelvic Perfusion With TNF-α 0.3 mg and Melphalan 1.5 mg/kg Versus Standard Treatment in Patients With Non Resectable, Recurrent Gynaecologic or Digestive Pelvic Cancer
Randomised phase 3 trial comparing 2 arms: an experimental treatment (Isolated pelvis perfusion) and a standard treatment (systemic chemotherapy +/- radiotherapy +/- surgery).
- Trial name
- NCT00949039
- Testing
- Isolated pelvis perfusion, radiotherapy, Surgery
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Quality of Life, Gynecologic Neoplasm
Effects of Therapeutic Touch in Patients With Female Genital Neoplasia: a Randomized Controlled Clinical Trial
This is a randomized controlled prospective study on the use of therapeutic touch in patients diagnosed with gynecological cancer.
- Conditions
- Quality of Life, Gynecologic Neoplasm, Gynecologic Cancer, Palliative Care
- Trial name
- NCT03142477
- Testing
- Questionnaires, Therapeutic touch
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Federal University of Minas Gerais
Cervical Cancer, Endometrial Cancer
PET-CT vs. Integrated MR-PET Scanning of GYN Cancers
This research study is an imaging pilot study. Imaging pilot studies explore the potential benefit of one imaging approach compared to another clinically accepted approach.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT01779128
- Testing
- PET-CT, MR-PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Gynecologic Cancer, Adjustment
Yoga for Psychological Distress in Gynecologic, Gastrointestinal, or Thoracic Cancer
This study will test the feasibility and acceptability of a yoga program for women with gynecologic, gastrointestinal (GI), or thoracic malignancies.
- Conditions
- Gynecologic Cancer, Adjustment, Gastrointestinal Cancer, Thoracic Cancer
- Trial name
- NCT03385577
- Testing
- Stilling the Waters of Uncertainty: A yoga program for women with gynecologic, gastrointestinal (GI), or thoracic cancer
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Florida
Gynaecologic Cancer, Cervical Cancer
GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries
The purpose of study is to compare the side effects of two different forms of radiation for endometrial and cervical cancer. If you decide to enroll in this study, you will be randomized to one of two treatment groups.
- Conditions
- Gynaecologic Cancer, Cervical Cancer, Radiation Therapy
- Trial name
- NCT07415681
- Testing
- Volume Modulated Arc Therapy (VMAT), Intensity Modulated Proton Therapy (IMPT)
- Where
- 5 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Maryland, Baltimore
Gynecologic Cancer, Skin Cancer
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This is a randomized open-label multicentre Phase III superiority study of the effect of adding SBRT to the standard of care treatment on overall survival in patients with rare oligometastatic cancers.
- Conditions
- Gynecologic Cancer, Skin Cancer, Head and Neck Cancer, Sarcoma
- Trial name
- OligoRARE (NCT04498767)
- Testing
- Stereotactic body radiotherapy, Palliative RT
- Where
- 13 sites in Belgium, France and 5 more
- Volunteers
- 200 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Vulvar Intraepithelial Neoplasia, Condylomata Acuminata
Cavitronic Ultrasonic Surgical Aspiration (CUSA) Women's Health Study
The study is a single arm, retrospective, single-center, post market registry. The purpose of this Registry is to collect data to demonstrate the safety and performance of CUSA® for the treatment of Vulvar Intraepithelial…
- Trial name
- NCT06297187
- Testing
- CUSA (Cavitronic Ultrasonic Surgical Aspirator)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Integra LifeSciences Corporation
Advanced Solid Tumors, Advanced Breast Cancer
Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors
Phase 1/2, open-label study of ETX-636 in participants with advanced solid tumors
- Trial name
- NCT06993844
- Testing
- ETX-636 dose escalation, ETX-636 dose escalation in combination with fulvestrant, ETX-636 dose expansion in combination with fulvestrant
- Where
- 15 sites in United States, China
- Volunteers
- 233 people
- Sponsor
- Ensem Therapeutics
Gynecologic Cancer
Massage, Oncology, Pain, Anxiety, Feasibility
The goal of this clinical trial is to determine the feasibility of studying massage therapy in patients with gynecologic cancers while receiving infusion treatments.
- Trial name
- IMPACT (NCT07502157)
- Testing
- Massage Therapy, Attention Control
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Jill Cole
Pelvic Cancer, Ovarian Cancer
Ultrasound-guided Tru-Cut Biopsy in Pelvic Masses.
In a transvaginal tru-cut biopsy, guided by ultrasound, a needle is inserted through the vaginal wall into a pelvic lesion and a few pieces of tissue are obtained for examination.
- Conditions
- Pelvic Cancer, Ovarian Cancer, Cervical Cancer, Uterus Cancer
- Trial name
- NCT05610501
- Testing
- Ultrasound guided tru-cut biopsy
- Where
- 4 sites in Belgium, Czechia and 2 more
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven