Clinical trials: Gynecological Cancers
Cervical Cancer, Ovarian Cancer
Clinical Study on the Safety, Pharmacokinetics, and Efficacy of ScTIL (Genetically Modified Tumor Infiltrating Lymphocytes) in the Treatment of Gynecological Malignancies
The purpose of this study is to evaluate the safety and clinical efficacy of ScTIL in the treatment of recurrent or refractory cervical cancer, ovarian cancer and malignant trophoblastic tumor, to evaluate the pharmacokinetic…
- Conditions
- Cervical Cancer, Ovarian Cancer, Malignant Trophoblastic Tumor
- Trial name
- NCT05342506
- Testing
- Toripalimab + ScTIL
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Gynecologic Cancer, Chemotherapy Effect
Effect on Adaptation to Cancer of Mobile Application Developed for Gynecological Cancer Patients
Getting a cancer diagnosis, the difficult treatments applied and the side effects that occur completely affect the life of the patient, shaking his future plans and adaptation mechanisms.
- Conditions
- Gynecologic Cancer, Chemotherapy Effect, Mobile Application, Physiological Adaptation
- Trial name
- NCT05131490
- Testing
- A mobile application intervention developed for gynecological cancer patients receiving chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Pamukkale University
Gynecological Cancer
Breathing Exercise Application in Patients With Gynecological Cancer.
The aim of this study is to determine the effects of breathing exercises on nausea, vomiting and anxiety levels in patients with gynecological cancer.
- Trial name
- NCT06777225
- Testing
- breathing exercises, scale, scala
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Anus Neoplasms, Rectal Neoplasms
Alkagin Paste in the Prevention of Radiation Dermatitis
The purpose of this study is to determine whether Alkagin paste is effective at preventing radiodermatitis in patients receiving external beam radiation therapy to the perineal area.
- Conditions
- Anus Neoplasms, Rectal Neoplasms, Urogenital Neoplasms
- Trial name
- NCT01408407
- Testing
- Aveeno cream, Alkagin paste
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Gynecology
An Endometrial Cancer Chemoprevention Study of Metformin
The goal of this clinical research study is to learn about the effects of metformin and/or a program called "lifestyle intervention" on the endometrium (inner lining of the uterus) in post-menopausal women who are also obese…
- Trial name
- NCT01697566
- Testing
- Metformin, Endometrial Biopsy, Lifestyle Intervention
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Solid Tumors
Study of INCB123667 in Subjects With Advanced Solid Tumors
This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCB123667 when administered as monotherapy and in combination with…
- Trial name
- NCT05238922
- Testing
- INCB0123667, Palbociclib, Bevacizumab
- Where
- 41 sites in United States, France and 6 more
- Volunteers
- 291 people
- Sponsor
- Incyte Corporation
Fallopian Tube Cancer, Ovarian Sarcoma
Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies
RATIONALE: Stereotactic radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue. PURPOSE: This clinical trial studies stereotactic radiosurgery using CyberKnife works in treating women with…
- Conditions
- Fallopian Tube Cancer, Ovarian Sarcoma, Ovarian Stromal Cancer, Recurrent Cervical Cancer
- Trial name
- NCT01079832
- Testing
- stereotactic radiosurgery, quality-of-life assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Comprehensive Cancer Center
Gynecologic Cancer
Comparison of Perilipin, Leptin, Adipolipin, Adiponectin, Resistin, Visfatin, Estrone Levels Pre-post Omentectomy
Omentum is adipose tissue lying under inner anterior wall Omentectomy is routine procedure in treatment of gynecological malignancy especially ovarian cancer and some advanced stage endometrial cancer.
- Trial name
- NCT03258307
- Testing
- Preoperative level
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Istanbul Training and Research Hospital
Gynecology
IOTA Versus Pattern Recognition Method in Diagnosis of Ovarian Masses
To compare between the efficacy of IOTA simple rules and pattern recognition method in the differentiating between benign and malignant adnexal masses
- Trial name
- NCT02800031
- Testing
- Transvaginal ultrasonography
- Where
- Egypt
- Volunteers
- 396 people
- Sponsor
- Woman's Health University Hospital, Egypt
Cervical Cancer, Endometrial Cancer，Endometrial Lesion & Adnexal Lesion，Ectopic Pregnancy & Infertility，Pelvic Obstructive Disorder & Genital Tract Deformity
Clinical Application of Laparo-endoscopic Single-site Surgery and Natural Orifice Transluminal Endoscopic in Gynecology
The GLESS registry is a prospective multi-center observational registry. Data from the time of patient admission, operation, discharge, and follow-up will be collected for this registry.
- Trial name
- GLESS (NCT04096872)
- Where
- China
- Volunteers
- 9,000 people
- Sponsor
- Peking Union Medical College Hospital
Ovarian Cancer, Endometrial Cancer
Predictors of Ovarian Cancer and Endometrial Cancer for Artificial-Intelligence-Based Screening Tools
The goal of this observational study is to explore the possible associated factors of ovarian cancer and endometrial cancer in Indonesia and develop screening tools that could predict the risk of both types of cancer The specific…
- Conditions
- Ovarian Cancer, Endometrial Cancer, Endometrial Hyperplasia
- Trial name
- NCT05697601
- Testing
- Artificial-Intelligence Based Screening Tools, Pathology analysis
- Where
- Indonesia
- Volunteers
- 2,905 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Lymphedema of Limb, Sentinel Lymph Node
Early Detection of Lower Extremity Lymphedema After Lymphadenectomy in Gynecological Cancer
This study aims to detect and treat early lower limb lymphedema secondary to lymphadenectomy with the aim of increasing the quality of life of patients with this chronic condition.
- Trial name
- NCT03917771
- Testing
- Early lymphedema detection, Usual follow-up
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Donostia
Pelvic Radiotherapy, Gynecological Cancer
Laser Therapy Following Radiotherapy for Gynecological Cancer
Women with a history of pelvic radiotherapy due to gynecological cancer, will receive laser therapy for the management of genitourinary syndrome of menopause.
- Conditions
- Pelvic Radiotherapy, Gynecological Cancer, Dyspareunia, Vaginal Dryness
- Trial name
- NCT03714581
- Testing
- Microablative Fractional CO2 Laser Therapy
- Where
- Greece
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Endometrial Carcinoma, Ovarian Cancer
AssociatiNG Bevacizumab bEmarituzumab for GynecoLogIcal CAncer
The aim of this study is to determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of bemarituzimab given in combination with a fixed dose of bevacizumab and to assess the clinical activity of the proposed…
- Conditions
- Endometrial Carcinoma, Ovarian Cancer, Cervix Cancer
- Trial name
- ANGELICA (NCT07146919)
- Testing
- Bemarituzumab, Bevacizumab
- Sponsor
- Centre Leon Berard
Cancer
Skin Incision Study - Closure of Skin Incisions in Gynecological Cancer Surgery
The Skin Incision Study evaluates the efficacy of skin closure methods: skin staples and subcuticular sutures at 6 weeks and at 3 months following the operation by measuring cosmesis and pain.
- Trial name
- NCT00107627
- Testing
- Caprosyn subcuticular sutures., Monocryl subcuticular sutures., Skin staples;
- Where
- 2 sites in Australia
- Volunteers
- 90 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Nursing, Gynecological Cancers
Effects of a Self-Regulation Based E-MOTE Program Delivered Via an AI-Assisted Robot and Supported by Mobile Platforms for Newly Diagnosed Gynecologic Cancer Patients
To evaluate the effectiveness of the E-MOTE Emotional Care Program, delivered through the Kebbi robot and the LINE Official Account, for patients newly diagnosed with gynecologic cancer undergoing surgery.
- Conditions
- Nursing, Gynecological Cancers, Psycho-Oncology
- Trial name
- NCT07745478
- Testing
- E-MOTE group
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gynecologic Cancer
Follow-up in Gynecological Cancer Survivors
A cross-sectional prospective study of follow-up in gynecologic cancer patients after primary treatment
- Trial name
- NCT03515993
- Where
- 21 sites in Austria, Belgium and 7 more
- Volunteers
- 1,100 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Gynecologic Cancer
Relationships Among Physical and Psychological Status, Social Support, Resource Utilization, Supportive Care Needs in Patients With Gynecological Cancer
With the advancement of medical treatments and under the trend of prolonging the survival rate of gynecological cancer patients, the use of social resources and the need for supportive care are particularly important! In the…
- Trial name
- NCT05776693
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Genital Diseases, Female, Ovarian Neoplasms
Pharmacokinetic Study on the Administration of Nadroparin Dosing Serum HGF in Gynecological Patients
The purpose of this study is to determine whether HGF serum concentration might be raised in vivo by administering nadroparin given with prophylactic purpose to gynecological patients.
- Conditions
- Genital Diseases, Female, Ovarian Neoplasms, Urogenital Neoplasms
- Trial name
- NCT01523652
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Female Reproductive Cancer
Serum Bovine Immunoglobulin Protein Isolate in Improving Quality of Life and Post-Operative Recovery in Patients With Gynecological Cancer After Undergoing Surgery
This randomized pilot phase II trial studies how well serum bovine immunoglobulin protein isolate works in improving quality of life and post-operative recovery in patients with cancer of the female reproductive tract after…
- Trial name
- NCT01867606
- Testing
- serum-derived bovine immunoglobulin protein isolate, laboratory biomarker analysis, quality-of-life assessment
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic