Clinical trials: Gynecological Disease
Ovarian Cancer, Cervical Cancer
Ensuring Communication in Hospice by Oncology Study (ECHO)
The goal of this study is to determine if scheduled communication with the oncology team through phone calls is helpful to caregivers with the transition to hospice care.
- Conditions
- Ovarian Cancer, Cervical Cancer, Uterine Cancer, Head and Neck Cancer
- Trial name
- NCT02069769
- Testing
- communication with oncology team
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Endometriosis
Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial.
Endometriosis is a chronic condition affecting approximately 10% of women. It is frequently associated with persistent or recurrent pelvic and abdominal pain.
- Trial name
- ENDPAIN (NCT07881562)
- Testing
- Esketamine
- Volunteers
- 1,000 people
- Sponsor
- Region Skane
Superior Hypogastric Plexus Block, Hysterectomy
Superior Hypogastric Plexus Blockade in Laparoscopic Hysterectomy
The primary indication for superior hypogastric plexus (SHP) block is visceral pelvic pain, most commonly from malignancy of the ovary, uterus, cervix, bladder, rectum or prostate.
- Conditions
- Superior Hypogastric Plexus Block, Hysterectomy, Minimally Invasive Surgery, Laparoscopy
- Trial name
- NCT03427840
- Testing
- Procedure/Surgery: superior hypogastric block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Derince Training and Research Hospital
Polycystic Ovary Syndrome (PCOS)
A Randomized Controlled Trial of Acupuncture for Insulin Resistance in Patients With Polycystic Ovary Syndrome
To determine the efficacy and safety of 2 different treatment modalities: 1) acupuncture plus lifestyle management (treatment group), 2) placebo plus lifestyle management (control group) in the treatment of insulin resistance in…
- Trial name
- NCT06306417
- Testing
- lifestyle intervention, acupuncture
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Endometriosis, Stem Cell Transplant
Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning
Background: Some transplant recipients have been found to have cells in their uterus that come from the donor. Researchers want to study uterine tissue from three different groups of women: (1) healthy volunteers, (2) people who…
- Conditions
- Endometriosis, Stem Cell Transplant, Healthy Volunteers
- Trial name
- NCT01468935
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Anemia
Accuracy of Non Invasive Hemoglobin Measure by SpHb Device in Post Operative Anemia Diagnosis
Non invasive Hemoglobin monitoring by SpHb device had been developed to assess Hemoglobin level during hemorrhagic surgery. It's accuracy to detect post operative anemia on a single post operative measure has been recently…
- Trial name
- SpHb_gyneco (NCT06497335)
- Testing
- non invasive hemoglobin measure
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Gynecological Disorder
Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain
Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals.
- Trial name
- NCT04547608
- Testing
- The difference of the timing of rocuronium administration after propofol injection
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Pulmonary Atelectasis
Ultrasound-guided Alveolar Recruitment in Laparoscopic Gynecological Surgery
The study aims to compare the degree of atelectasis between ultrasound-guided alveolar recruitment group and conventional alveolar recruitment group in patients receiving laparoscopic gynecologic surgery
- Trial name
- NCT03607240
- Testing
- lung ultrasound-guided alveolar recruitment, conventional alveolar recruitment
- Where
- 2 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Anal Cancer, Bladder Cancer
Low-Fiber Diet or High-Fiber Diet in Preventing Bowel Side Effects in Patients Undergoing Radiation Therapy for Gynecological Cancer, Bladder Cancer, Colorectal Cancer, or Anal Cancer
RATIONALE: Fiber may lessen bowel side effects caused by radiation therapy. It is not yet known whether a high-fiber diet is more effective than a low-fiber diet in preventing bowel side effects caused by radiation therapy.
- Conditions
- Anal Cancer, Bladder Cancer, Cervical Cancer, Colorectal Cancer
- Trial name
- NCT01170299
- Testing
- dietary intervention, laboratory biomarker analysis, gastrointestinal complications management/prevention
- Where
- United Kingdom
- Volunteers
- 177 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Postmenopausal Bleeding, Endometrial Cancer
Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity
Postmenopausal bleeding (PMB) is the occurrence of vaginal bleeding 12 months following a woman's last menstrual cycle. PMB represents one of the most common reasons for referral to gynaecology services.
- Conditions
- Postmenopausal Bleeding, Endometrial Cancer, Endometrial Hyperplasia
- Trial name
- NCT05378152
- Testing
- Pipelle biopsy catheter
- Where
- Ireland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Gynecologic Cancer
High-frequency Ultrasound for Intraoperative Lymph Node Assessment in Gynecological Cancer: From Surgery to Radiomics
Lymph node assessment is crucial in gynecological cancers (ovarian, endometrial, cervical, and vulvar), as nodal involvement significantly impacts prognosis and treatment.
- Trial name
- RHINOCERUS (NCT06906705)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Renal Cell Carcinoma, Urothelial Carcinoma
Famitinib Plus Anti-PD1 Therapy for Advanced Urinary System Tumor, Advanced Gynecological Tumors
Phase II multi-chort, adaptive two-stage, open label, nonrandomized study. The aim of our study is to evaluate the efficacy and safety of anti-PD-1 antibody SHR-1210(Camrelizumab) in combination with a small-molecule multikinase…
- Conditions
- Renal Cell Carcinoma, Urothelial Carcinoma, Cervical Cancer, Ovarian Cancer Recurrent
- Trial name
- NCT03827837
- Testing
- SHR-1210, Famitinib
- Where
- China
- Volunteers
- 265 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus
Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic…
- Conditions
- Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus, Endometriosis, Endometrial Cancer
- Trial name
- NCT07860203
- Testing
- DEX 0.2 μg/kg/h., SGB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Catherin Zhang
Toxicity, Radiation Toxicity
The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study
The purpose of this study is to assess and compare GI toxicity from RT between subjects who receive therapeutic SCFA and those who receive placebo, in hopes of identifying a safe, low-cost therapeutic to reduce GI toxicity from…
- Trial name
- NCT04700527
- Testing
- Short Chain Fatty Acid, Tapioca Flour
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Neoplasms, Ovarian Neoplasms
Cognitive-Existential Group Therapy to Reduce Fear of Cancer Recurrence: A RCT Study
Studies show that cancer survivors have unmet needs, the most frequently cited being fear of recurrence (FCR). Moderate to high levels of FCR have been reported by as much as 49% of cancer patients and are more prevalent among…
- Conditions
- Breast Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Uterine Cervical Neoplasms
- Trial name
- NCT03270995
- Testing
- Cognitive Existential Therapy Group 1, Supportive Therapy Group 2
- Where
- 3 sites in Canada
- Volunteers
- 144 people
- Sponsor
- McGill University
Gynecologic Disease
Laparoscopic Lens Defogging Using Anti-fog Solution, waRm Saline, and Chlorhexidine Solution
The aim of this study is to compare three popular methods of minimizing or reducing laparoscopic lens fogging (LLF) by heating lens using warm saline, applying anti-fog agent to lens, and rubbing lens with chlorhexidine in…
- Trial name
- CLEAR (NCT03438890)
- Testing
- Warm saline, anti-fog agent, chlorhexidine
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Kangbuk Samsung Hospital
Cervical Cancer, Transgender Persons
Gynecology Beyond Gender: Cervical Cancer Screening in Transgender Men in France
In France, cervical cancer screening is the subject of a national screening programme organized for all asymptomatic individuals aged 25 to 65 years with a cervix.
- Conditions
- Cervical Cancer, Transgender Persons, Health Services for Transgender Persons
- Trial name
- GYDECAT (NCT05924217)
- Testing
- Survey questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Endometriosis, Ovarian Cyst
PerClot Compared to Usual Care in Gynaecology Procedures
This study is a post market, multi-centre, randomised study evaluating PerClot compared to usual care. PerClot is a CE marked device and is currently used as a haemostat in gynaecological surgery throughout Europe.
- Conditions
- Endometriosis, Ovarian Cyst, Menorrhagia, Cancer
- Trial name
- NCT02835391
- Testing
- PerClot, Floseal, Surgicel, Surgiflo, Arista, Electrocautery/Diatermy
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- CryoLife Europa
Pelvic Inflammatory Diseases
A Clinical Study on Kangfu Anti-inflammatory Suppository of Gynaecology Combined With Antibiotics for Pelvic Inflammatory Diseases (Evidence of Dampness and Heat Accumulation)
To evaluate the efficacy and safety of Kangfu Xiaoyan Suppository in the treatment of pelvic inflammatory diseases (dampness-heat accumulation syndrome) and its influence on the sequelae of pelvic inflammatory diseases, and to…
- Trial name
- NCT04035785
- Testing
- Kangfu Anti-inflammatory Suppository
- Volunteers
- 240 people
- Sponsor
- China Academy of Chinese Medical Sciences
Breast Cancer, Ovarian Cancer
Intermittent Fasting Accompanying Chemotherapy in Gynecological Cancers
The aim of this trial is an evaluation of the effectiveness of intermittent fasting as a supplementary therapy in patients with breast cancer and ovarian cancer in respect to quality of life, reduction of side effects and…
- Trial name
- FIT2 (NCT03162289)
- Testing
- Fasting, Vegan
- Where
- 8 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany