Clinical trials: Gynecology
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
ERAS, Gynecologic Cancer
Adherence and Compliance to ERAS in Gynecological Surgery
The aim of the study is to investigate the association between early non-compliance to ERAS in postoperative day 2 (POD2) with the rate of postoperative complications.
- Conditions
- ERAS, Gynecologic Cancer, Post Operative Pain, Ovarian Cancer
- Trial name
- ERASGYNBS002 (NCT05738902)
- Testing
- Assessment of compliance to ERAS.
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Surgery, Anesthesia
Compliance With Enhanced Recovery After Surgery Protocol (ERAS) in Surgical Patients
The concept of "enhanced recovery" was introduced by European anesthesiologists and surgeons who challenged traditional clinical practices involved in peri-operative care in 1990s.
- Trial name
- NCT03968666
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Augusta University
ENT Surgery, Gynecological Surgery
Medico-economic Evaluation of Subcutaneous Automatic Resorbable Staples Device
A surgery made by an external incision requires to stitch the subcutaneous plans, usually performed using absorbable synthetic sutures hold on wire needle.
- Conditions
- ENT Surgery, Gynecological Surgery, Plastic Surgery
- Trial name
- S2CARA (NCT01546272)
- Testing
- Insorb resorbable staples, Monocryl resorbable wire
- Where
- 24 sites in France
- Volunteers
- 664 people
- Sponsor
- Nantes University Hospital
Gynecological Survey
Gynecological Presentations Following Supracervical Hysterectomy
Supracervical hysterectomy is widely common and had many complications either immediate or delayed. In these patients bleeding, infection, chronic pelvic pain are common.
- Trial name
- GPH (NCT03606772)
- Testing
- Questionanniare
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Tanta University
Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder
Gene and Molecular Pathways of Ozone Treatment Response in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Cancer Treatment
Gynecological cancers, including those affecting the ovaries, uterus, and cervix, represent a significant health burden for women.
- Conditions
- Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy
- Trial name
- OzoGynEpigen (NCT06816095)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Bernardino Clavo, MD, PhD
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Curcumin Use for Gynecological Conditions
Curcumin Supplementation for Gynecological Diseases
To use curcumin supplementation as an additive treatment to induce clinical, biochemical response and remission in patients with suspected Pelvic inflammatory disease, Tubo ovarian abcess, Endometritis, wound infection.
- Trial name
- NCT03016039
- Testing
- Curcumin supplementation
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Meir Medical Center
Recurrent or Metastatic MSI-H/dMMR Gynecological Malignancies
SKB264 Plus KL-A167 in MSI-H/dMMR Advanced Gynecological Malignancies
This is a prospective, open-label, multicenter, single-arm Phase II study designed to evaluate the efficacy and safety of sacituzumab tirumotecan (sac-TMT/SKB264) in combination with tagitanlimab (KL-A167) as second-line or later…
- Trial name
- NCT07738757
- Testing
- Sacituzumab Tirumotecan (Sac-TMT), Tagitanlimab
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Ovarian Carcinoma, Cervical Carcinoma
Contribution of Oncovascular Surgery in the Treatment of Gynecological Advanced Malignant Diseases.
Multicenter ambispective observational study (prospective/retrospective)
- Conditions
- Ovarian Carcinoma, Cervical Carcinoma, Endometrial Carcinoma, Vulvar Carcinoma
- Trial name
- NCT07267780
- Where
- 2 sites in Italy
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute, Naples
Simulation Training
Impact of Simulation Training for Obstetrics-gynecology Residents.
The main objective of the study is to evaluate the benefit of simulator training for learning external cephalic version (ECV) or vacuum assisted vaginal delivery (hereafter vacuum extraction [VE]) for obstetrics-gynecology…
- Trial name
- NCT03848975
- Testing
- Simulation training for ECV, Simulation training for VE
- Where
- Switzerland
- Volunteers
- 68 people
- Sponsor
- University Hospital, Geneva
Gynecologic Operations, Anti-Mullerian Hormone
The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH)
Besides the removal of lesions, the purpose of surgeries has been extended to the improvement of quality of life after procedures. Minimally invasive surgeries enabled women to experience less pain, less hospital days.
- Conditions
- Gynecologic Operations, Anti-Mullerian Hormone, Ovarian Reserve
- Trial name
- NCT00928044
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Gynecology, Gynecology/Obstetrics Conditions
Gynaecological Examination Gown and Patient Satisfaction
The attitude of the health personnel before, during and after the examination and the positive examination experience of the person have a significant impact on ensuring the continuity of the subsequent examination and increasing…
- Trial name
- NCT06324019
- Testing
- putting on an examination gown
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ayşegül muslu
Intra-uterine Device Placement
Weighted Blankets for IUD Insertion
When having an intrauterine device placed in an outpatient clinic, patients frequently feel anxiety related to the procedure. This study is designed to determine if the use of a small, weighted blanket, placed over the patient's…
- Trial name
- NCT06969365
- Testing
- 10-pound weighted lap-pad, blanket
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Saint Luke's Health System
Breast Cancer, Genitourinary Cancer
Inflammatory Response and Tissue Fibrosis/ Lymphatico-venous Bypass
The goal of this clinical research study is to measure the amount of inflammatory proteins inside the body before and after lymphatico-venular bypass surgery.
- Conditions
- Breast Cancer, Genitourinary Cancer, Malignant Female Reproductive System Neoplasm, Melanoma
- Trial name
- NCT01433302
- Testing
- Punch Biopsy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Vaginal Fistula
Non-inferiority of Short-term Catheterization Following Fistula Repair Surgery
This facility-based, multi-center randomized controlled trial (RCT) will test the non-inferiority of short-term (7 day) urethral catheterization compared to longer-term (14 day) urethral catheterization in terms of predicting…
- Trial name
- NCT01428830
- Testing
- 7-day catheterization following fistula repair surgery, 14 day catheterization
- Where
- 8 sites in Democratic Republic of the Congo, Ethiopia and 6 more
- Volunteers
- 524 people
- Sponsor
- EngenderHealth
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Stibium Metallicum Praeparatum D6 Versus Placebo in the Reduction of Paclitaxel-induced Peripheral Neurotoxicity
Chemotherapy induced peripheral neuropathy (CIPN) is one of the most limiting side effects of chemotherapy and often leads to adaptations in the protocol of the chemotherapy including dose reduction or even discontinuation of…
- Trial name
- STING-CIPN (NCT04715542)
- Testing
- Stibium metallicum praeparatum 6x
- Volunteers
- 86 people
- Sponsor
- University of Bern
Emergencies
Artificial Intelligence (IA) Advanced Triage Tool for G&O Emergencies
Triage represents the first opportunity to classify patients who come to an Emergency Department (ED) and to be able to identify, prioritize high-risk patients and efficiently allocate the limited resources that are available.
- Trial name
- TIAGO (NCT05382000)
- Testing
- Advanced triage tool for Gynecology and Obstetrics emergencies based on artificial intelligence algorithms.
- Where
- Spain
- Volunteers
- 450 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Ovarian Cancer Recurrent, Endometrial Cancer Recurrent
A Study to Explore Personalized Treatment for Patients With Recurrent Gynecological Malignancies Based on MTB
This is a non-interventional, real-world study divided into two parts: a retrospective study and a prospective study. The main question it aims to answer is: Will genomic sequencing and molecular tumor boards lead to clinical…
- Conditions
- Ovarian Cancer Recurrent, Endometrial Cancer Recurrent, Cervical Cancer Recurrent
- Trial name
- RWS-MTB (NCT06781151)
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University