Clinical trials: H Pylori Eradication
Peptic Ulcer With H. Pylori Infection, Gastritis With H. Pylori Infection
The Role of CYP2C19 on the Eradication of H. Pylori Infection:Implication of PK/PD Relationships
The objective of this trial is to find the rationale and the optimal dose and duration of regimen for the eradication of H. pylori infection using different proton pump inhibitors.
- Trial name
- NCT00162877
- Testing
- Rabeprazole vs. Esomeprazole
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Efficacy and Safety of Probiotic Treatment as a Supportive Therapy in Eradication of H. Pylori
The aim of the study is to establish efficacy and safety of Normia® probiotic, used as an add-on therapy in treatment of H. Pylori infection with the standard triple therapy approach.
- Trial name
- NCT01969331
- Testing
- Normia
- Where
- Croatia
- Volunteers
- 804 people
- Sponsor
- Goran Hauser
Helicobacter Pylori Eradication Rate
Optimization of Vonoprazan--amoxicillin Dual Therapy for Eradicating Helicobacter Pyloriinfection
Helicobacter pylori infection is closely related to gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer. Eradication of HP can significantly improve and reduce HP-related diseases.
- Trial name
- NCT05719831
- Testing
- vonoprazan fumarate + high dose amoxicillin（H-10d）, vonoprazan fumarate + low dose amoxicillin（L-10d), vonoprazan fumarate + amoxicillin（H-14d)
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Helicobacter Pylori Infection
Efficacy of Low-dose Vonoprazan for Helicobacter Pylori Eradication
The primary objective of this retrospective study was to assess the efficacy and safety of a bismuth quadruple regimen of a low-dose potassium-competitive acid blocker versus a standard-dose potassium-competitive acid blocker and…
- Trial name
- NCT06037122
- Volunteers
- 558 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules
This phase Ⅰb/Ⅱa, single-center, randomized, open-label study was designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary Helicobacter Pylori eradication efficacy in asymptomatic subjects with…
- Trial name
- NCT06076681
- Testing
- TNP-2198, Rabeprazole Sodium, Amoxicillin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
H.Pylori Gastrointestinal Disease
Second Line Bismuth Containing Quadruple Therapy With Supplementary Probiotic
This study is designed to evaluate the clinical outcome of second line Bismuth containing quadruple therapy with supplementary probiotic for Helicobacter pylori eradication
- Trial name
- NCT05577572
- Testing
- Probiotics packets
- Where
- 4 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Eradication Rate
Vonoprazan Fumarate in Combination With Amoxicillin for the First-line Eradication of Helicobacter Pylori -- a Multicenter, Randomized, Parallel Controlled Study
Helicobacter pylori infection is closely related to gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer. Eradication of HP can significantly improve and reduce HP-related diseases.
- Trial name
- NCT05196945
- Testing
- vonoprazan fumarate + amoxicillin, Esomeprazole +Amoxicillin+Clarithromycin+Bismuth potassium citrate
- Volunteers
- 316 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Helicobacter Pylori Infection
Study of the Usefulness of the Probiotic 'Lactobacillus Reuteri' in the Therapy of Quadruple Eradication of Helicobacter Pylori Infection in Usual Clinical Practice.
Helicobacter pylori is a Gram-negative bacterium with a helical bacillus shape that it's able to penetrate and colonize the stomach mucosal lining by infecting it. The eradication treatment of H.
- Trial name
- NCT03150394
- Testing
- GASTRUS
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Dr. Luis Fernandez
Helicobacter Pylori Infections, Atrophic Gastritis
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality
Currently no ideal preventive modalities are available for reducing gastric-cancer caused mortality in organized population-based application.
- Conditions
- Helicobacter Pylori Infections, Atrophic Gastritis, Gastric Cancer
- Trial name
- GISTAR (NCT02047994)
- Testing
- Triple therapy
- Where
- Latvia
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Helicobacter Pylori Infection
Jinghua Weikang Capsule Containing Quadruple Therapy for IgAN With Helicobacter Pylori Infection
This study is to evaluate the efficacy and safety of the Jinghua Weikang Capsule (a Chinese patent medicine for peptic ulcer and gastritis) containing quadruple therapy (Jinghua Weikang Caplsule plus triple therpy) for…
- Trial name
- NCT05320133
- Testing
- JWC containing quadruple therapy, Bismuth-containing quadruple therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Helicobacter Pylori Infection
Efficacy and Safety of Dual Therapy for Helicobacter Pylori Eradication
The purpose of this study was to evaluate the Efficacy and Safety of Vonoprazan- amoxicillin dual therapy for Helicobacter Pylori eradication
- Trial name
- NCT05469685
- Testing
- Vonoprazan, Amoxicillin
- Where
- 10 sites in China
- Volunteers
- 914 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection
5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection
A five day quadruple concomitant therapy is as effective and safe as a 10 day sequential therapy for eradication of H. pylori infection.
- Trial name
- NCT01544517
- Testing
- Eradication therapy (amoxicillin; esomeprazole; tinidazole; levofloxacin)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- University of Campania Luigi Vanvitelli
Eradication Rate for Helicobacter
Comparison of the Efficacy of Levofloxacin-based Sequential Therapy and Triple Therapy as Second Line Therapy
To compare the efficacy and tolerability of levofloxacin-based sequential therapy and triple therapy in the second line therapy for those who fail from one eradication therapy
- Trial name
- NCT01537055
- Testing
- levofloxacin-based sequential therapy, levofloxacin-based triple therapy for 10 days
- Where
- 10 sites in Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Eradication Rate
Modified Non-clarithromycin Triple Therapy in Eradicating Helicobacter Pylori
Helicobacter pylori (H. pylori) infects more than 50% of the population in the world(1), especially 47-66% in China.
- Trial name
- NCT02776371
- Testing
- Modified non-clarithromycin triple therapy, Sequential therapy
- Where
- China
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Helicobacter Pylori Eradication Study
The purpose of this study was to evaluate the efficacy and compliance of tailored therapy which using the polymerase chain reaction for point mutation of clarithromycin, compared to concomitant therapy, in patients without…
- Trial name
- NCT03130452
- Testing
- Lansoprazole 30mg, Amoxicillin 1.0g Tab, Clarithromycin 500mg
- Where
- South Korea
- Volunteers
- 423 people
- Sponsor
- Inje University
Helicobacter Infections
Efficacy and Safety of Quadruple Therapy in Eradication of H. Pylori: A Comparison to Triple Therapy
This study aims at evaluating efficacy and safety of quadruple therapy (bismuth, metronidazole, tetracycline and omeprazole: OBMT) vs triple therapy (amoxicillin, clarithromycin and omeprazole: OAC) in H. Pylori eradication.
- Trial name
- NCT00669955
- Testing
- Omeprazole, amoxicillin, clarithromycin, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole
- Where
- United Kingdom
- Volunteers
- 440 people
- Sponsor
- Forest Laboratories
Helicobacter Pylori Infected Patients, Thyroid Cancer Patients
The Effect of Radioactive Iodine Administration for Thyroid Diseases on H.Pylori Eradication
Because of the high iodine uptake in the stomach, radioactive iodine treatment for thyroid diseases (cancer or hyperthyroidism) or radioactive iodine administered for thyroid scan may be able to eradicate H.pylori infection from…
- Conditions
- Helicobacter Pylori Infected Patients, Thyroid Cancer Patients, Hyperthyroidism
- Trial name
- NCT00822289
- Volunteers
- 120 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori Infection, Eradication
Furazolidone Quadruple Regimen Eradicate H. Pylori Infection
Research protocol: Experimental group: First line solution (furazolidone regimen): esomeprazole magnesium 20 mg +colloidal bismuth pectin 200mg+ amoxicillin 1000 mg + furazolidone 100 mg, twice daily, for 14 days.
- Trial name
- NCT06823791
- Testing
- Furazolidone, Clarithromycin
- Where
- China
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
Helicobacter Pylori Gastrointestinal Tract Infection
Comparison Efficacy of 14-day Concomitant Therapy:Clarithromycin vs.Levofloxacin in Eradication of H.Pylori
Comparison Efficacy of 14-day Concomitant therapy between levofloxacin and Clarithromycin on the Eradication of Helicobacter Pylori in Syrian population
- Trial name
- NCT03021590
- Testing
- Clarithromycin 500Mg Oral Tablet, Levofloxacin 500Mg Oral Tablet
- Where
- Syria
- Sponsor
- Damascus Hospital
Helicobacter Infection
Efficacy of High Dose Dual Therapy, Sequential Therapy and Triple Therapy in H. Pylori Eradication
Up to now, to our knowledge, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of these current recommended 1st-line or 2nd-line regimens for…
- Trial name
- NCT01163435
- Testing
- high dose dual therapy, sequential therapy, clarithromycin-based triple therapy
- Where
- Taiwan
- Volunteers
- 618 people
- Sponsor
- National Taiwan University Hospital