Clinical trials: H Pylori Eradication
Helicobacter Pylori Infection
Helicobacter Pylori Rescue Treatment in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of furazolidone-tetracycline-containing and metronidazole-tetracycline-containing quadruple regimens for the rescue treatment of Helicobacter pylori infection…
- Trial name
- NCT05135182
- Testing
- Furazolidone, Metronidazole
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Shandong University
Bacterial Infection Due to Helicobacter Pylori (H. Pylori), Eradication Therapy of Helicobacter Pylori
Reinfection After Eradication of Helicobacter Pylori Infection
Helicobacter pylori is closely related with gastritis, peptic ulcer, gastric cancer and gastric MALT lymphoma, and it may participate in a variety of parenteral diseases.
- Conditions
- Bacterial Infection Due to Helicobacter Pylori (H. Pylori), Eradication Therapy of Helicobacter Pylori, Detection of Helicobacter Pylori
- Trial name
- RAEHPI (NCT02674802)
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
H Pylori Gastritis, H Pylori Infection
Efficacy of Carminal in Helicobacter Pylori Gastritis
Eighty patients will be included and randomized in two groups, one group (40 patients) will be administered 30 ml of the supplement Carminal, once a day, plus therapy for HP gastitis and the control group (40 patients) will be…
- Conditions
- H Pylori Gastritis, H Pylori Infection, H Pylori Eradication, Gastritis Associated With Helicobacter Pylori
- Trial name
- NCT07179237
- Testing
- Carminal Oral solution
- Where
- 2 sites in Serbia
- Volunteers
- 80 people
- Sponsor
- Catalysis SL
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment.
- Trial name
- NCT07068607
- Testing
- Vonoprazan, Tetracycline 500mg tid, Minocycline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Stomach Ulcer
Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy
The purpose of this study is to evaluate the ulcer healing efficacy of rebamipide in comparison with omeprazole in Helicobacter pylori-positive gastric ulcer after eradication therapy.
- Trial name
- NCT00272467
- Testing
- Rebamipide, Omeprazole
- Where
- 7 sites in China, South Korea
- Volunteers
- 132 people
- Sponsor
- Korea Otsuka International Asia Arab
Helicobacter Pylori, Drug Resistance, Multiple
14-day Susceptibility-guided Bismuth Quadruple Therapy for Multiple Drug Resistant H. Pylori Infection
The goal of this clinical trial is to learn if the 14-day susceptibility-guided bismuth quadruple therapy works to treat multiple drug resistant Helicobacter pylori (H. pylori) in adults.
- Trial name
- BSUS-2 (NCT06687499)
- Testing
- Bismuth-based susceptibility-guided treatment
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- National Cheng-Kung University Hospital
Helicobacter Pylori Eradication Rate
Optimization of Keverprazan-amoxicillin Dual Therapy for Eradicating Helicobacter Pylori Infection
Eradication of HP can significantly improve and reduce HP-related diseases. A 10-14 day quadruple regimen containing bismuth as first-line treatment, achieving an eradication rate of more than 85%.
- Trial name
- NCT06734260
- Testing
- Keverprazan Hydrochloride tablets + high dose amoxicillin, Keverprazan Hydrochloride tablets + low dose amoxicillin, Keverprazan Hydrochloride tablets + high dose amoxicillin（H-KA-10d）
- Where
- 4 sites in China
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Chemotherapy Effect
Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Management of Locally Advanced Gastric Cancer
This study focuses on patients with H. pylori-positive resectable locally advanced adenocarcinoma of the gastric and oesophagogastric junction. It evaluates the perioperative oxaliplatin with S-1 (SOX) combined H.
- Trial name
- NCT06510010
- Testing
- Oxaliplatin With S-1 (SOX) Combined H. Pylori Eradication (Amoxicillin + clarithromycin + omeprazole + colloidal bismuth subcitrate), Oxaliplatin With S-1 （SOX）
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Helicobacter Pylori Infection, Antibiotic Resistant Strain
Tailored H. Pylori Eradication Based on Clarithromycin Resistance
The investigators investigated the point mutations in the 23S rRNA genes of patients infected with clarithromycin-resistant H. pylori and compared the H.
- Trial name
- NCT03884348
- Testing
- proton pump inhibitor, amoxicillin, clarithromycin, proton pump inhibitor, amoxicillin, metronidazole
- Volunteers
- 431 people
- Sponsor
- Kangdong Sacred Heart Hospital
H. Pylori Infection
Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study
Background: Helicobacter pylori infection, which affects over 50% of the global population, is one of the most prevalent infectious diseases in the world. H.
- Trial name
- vDHp (NCT03142620)
- Testing
- Esomeprazole, Amoxicillin-Potassium Clavulanate Combination, Clarithromycin
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Helicobacter Infection
Clinical Trial to Evaluate the Efficacy of Probit-Based Triple Therapy for Helicobacter Pylori Eradication
This is a single-center, open-label, non-randomized, single-arm clinical study. Eligible participants who provide written informed consent will undergo screening based on inclusion/exclusion criteria.
- Trial name
- NCT07115173
- Testing
- This study aims to evaluate the efficacy and safety of a 14-day triple therapy regimen consisting of Zastaprazan 20 mg, clarithromycin, and amoxicillin for the eradication of Helicobacter pylori.
- Volunteers
- 103 people
- Sponsor
- Samsung Medical Center
Helicobacter Pylori Infection
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H.
- Trial name
- NCT03730766
- Testing
- Esomeprazole, Amoxicillin, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection, Gut Microbiota
Effect of Probiotics on Gut Microbiota During the Helicobacter Pylori Eradication
Helicobacter pylori (H. pylori) is still infecting more than half of the population in many countries, although the prevalence is decreasing. As a main cause of chronic gastritis, peptic ulcer, and malignant gastric tumors, H.
- Trial name
- NCT05662514
- Testing
- Bifidobacterium animalis subsp. lactis BLa80
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
H.Pylori Infection
h.Pylori Ttt With Rebamipide
the primary aim is specially in resistant cases of H.pylori and in promotion of peptic ulcer
- Trial name
- NCT04550858
- Testing
- Rebamipide
- Volunteers
- 60 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection
Additive Effect of Endonase on Eradication Rate of Second Line Therapy for HP Infection
Endonase, a kind of protease, is known to cause both extensive degradation of mucins and a reduction in mucus viscosity. As part of the search for more effective forms of therapy against H.
- Trial name
- NCT01643785
- Testing
- Second-line quadruple therapy with endonase
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Helicobacter Pylori Infection
Efficacy and Safety of Vonoprazan as First-line Treatment for Helicobacter Pylori Eradication
This study aims to evaluate the efficacy of vonoprazan compared with esomeprazole as first-line treatment for Helicobacter Pylori(Hp) eradication, as well as the safety and economic benefits.
- Trial name
- NCT04907747
- Testing
- Vonoprazan, Esomeprazole, Colloidal bismuth pectin
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
Efficacies of HDDT With or Without Bismuth vs Amoxicillin-metronidazole BQT for First-line H Pylori Eradication
Up to know, three is few large-scale, randomized study prospectively and simultaneously comparing the efficacy, adverse effects and patient compliance of high-dose dual therapy (HDDT) with or without bismuth versus…
- Trial name
- NCT03897244
- Testing
- High-dose dual therapy (rabeprazole, amoxicillin), Bismuth High-dose dual therapy (rabeprazole, amoxicillin, tripotassium dicitrate bismuthate), Amoxicillin-Metronidazole Bismuth quadruple therapy
- Where
- Taiwan
- Volunteers
- 603 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia
The Influence of Helicobacter Pylori Eradication on Gastric Pathology: a Long-term, Prospective Cohort Study
Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer.
- Conditions
- Helicobacter Pylori, the Operative Link on Gastric Intestinal Metaplasia, Operative Link on Gastric Intestinal Assessment
- Trial name
- NCT02933229
- Testing
- biopsy, H. pylori eradication
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Infections
The Effect of Probiotics on Gut Microbiotain After Helicobacter Pylori Eradication
The purpose of this study is to evaluate the effect of probiotics during vonoprazan-amoxicillin dual therapy on the gut microbiota in Helicobacter pylori eradication and to investigate whether the eradication rate of H.pylori…
- Conditions
- Helicobacter Pylori Infection, Infections, Intestinal Bacteria Flora Disturbance
- Trial name
- NCT05658055
- Testing
- Vonoprazan, Amoxicillin, probiotics
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Infections
Efficacy and Safety of Basic Triple Therapy Including Ilaprazole on the First Line Eradication Treatment of H.Pylori
This study compared efficacy and safety of basic triple therapy including Ilaprazole 10mg, Levofloxacin 500mg and Amoxicillin 1000mg BID for 10 days on the first line eradication treatment of H.pylori
- Trial name
- NCT02352701
- Testing
- Noltec tab. 10mg, Chongkundang Amoxicillin Cap. 500mg, Cravit Tab. 500mg
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.