Clinical trials: H Pylori Infection
Efficacy, Gastric Microbiota
The Effects Probiotic Has on Gastromicroecology and Combined With Quadruple Regimen for H Pylori Infection
This study assesses the efficacy and safety of treatment with two-week probiotics followed by a 10-day tetracycline- and furazolidone-containing quadruple regimen as rescue treatment for H. pylori infection.
- Conditions
- Efficacy, Gastric Microbiota, Safety
- Trial name
- NCT03377933
- Testing
- Compound Lactobacillus acidophilus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yiqi Du
H. Pylori Infection
Efficacy of 10-day and 14-day Sequential Therapy Versus Triple Therapy on the Eradication of Helicobacter Pylori
Background: Helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. Eradication of H.
- Trial name
- NCT01042184
- Testing
- Sequential therapy for 14 days, Sequential therapy for 10 days, Triple therapy for 14 days
- Where
- Taiwan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Efficacy and Safety of 14-day Concomitant Therapy for Refractory Helicobacter Pylori Infection
The purpose of this study is to evaluate efficacy of a 14-day concomitant therapy for the third-line treatment of Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.
- Trial name
- NCT05133193
- Testing
- three kinds of antibiotics
- Volunteers
- 60 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Rapid Urease Test for Helicobacter Pylori in Population Who Stop Proton Pump Inhibitor Less Than 2 Weeks Compared With Histology
Patients with dyspepsia will have negative impact to their life and common cause is Helicobactor pylori infection. Rapid urease test is the easy available and rapid method to test the infection but the test may be interfered by…
- Trial name
- NCT04233684
- Testing
- rapid urease test
- Where
- Thailand
- Volunteers
- 67 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Helicobacter Pylori Infection
Vonoprazan-based Therapy Versus Standard Regimen for Helicobacter Pylori Infection Management
Appropriately, half of the global population is infected with H. pylori, and it is now recognized that it causes at least 95% of all gastric cancers. Currently, the main challenge in the field of H.
- Trial name
- NCT05614934
- Testing
- standard Clarithromycin triple therapy, Vonoprazan triple therapy, Vonoprazan dual therapy
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Alexandria University
Helicobacter Pylori Infection
Efficacy and Safety of 14-day Concomitant Therapy for Difficult-to-Treat Helicobacter Pylori Infection
The purpose of this study is to evaluate efficacy of a 14-day concomitant therapy for the treatment of Hard-to-treat Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates
- Trial name
- NCT05126121
- Testing
- three kinds of antibiotics including amoxicillin，tetracycline, furazolidone, levofloxacin,clarithromycin,levofloxacin,tinidazole,metronidazol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiuli Zuo
Helicobacter Pylori Infection, Helicobacter Pylori Eradication
The Impact of WeChat Group Patient Education on the Eradication Rate of Helicobacter Pylori
In this study, effects of oral and written education, WeChat education plus oral and written education on Helicobacter pylori eradication will be compared in a randomized way.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Eradication, Patient Education
- Trial name
- NCT04850209
- Testing
- oral and written education, Wechat group
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Shandong University
HELICOBACTER PYLORI INFECTIONS
Efficacy of Vonoprazan-based Rescue Therapy for H. Pylori Eradication
1. This study aims to compare the efficacy of empirical vonoprazan-based therapy versus susceptibility-guided vonoprazan-based therapy for third-line eradication of H. pylori. 2.
- Trial name
- NCT07130253
- Testing
- Vonoprazan based ET, Vonoprazan based SGT
- Where
- Taiwan
- Volunteers
- 220 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection
This study is a multicentra, prospective study. The enrolled patients are HP positive. They are diagnosed as HP positive by rapid urease test and/or 13C urea breath test.
- Trial name
- NCT06561698
- Testing
- Vonoprazan, Amoxicillin, Bismuth Potassium Citrate
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Helicobacter Pylori Rescue Treatment Containing Tetracycline in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of furazolidone-tetracycline-containing and tinidazole-tetracycline-containing quadruple regimens for the rescue treatment of Helicobacter pylori infection in…
- Trial name
- NCT04264663
- Testing
- Furazolidone, Tinidazole
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Dyspepsia
ERADICATE Hp2 - Treating Helicobacter Pylori With RHB-105 Compared to Active Comparator
The "test and treat" strategy for treating dyspeptic patients who are H. pylori positive is rapidly becoming the standard of care. This study will test the effectiveness of RHB-105, a new triple therapy to treat H.
- Trial name
- ERADICATE Hp2 (NCT03198507)
- Testing
- RHB-105, Active Comparator
- Where
- 55 sites in United States
- Volunteers
- 455 people
- Sponsor
- RedHill Biopharma Limited
Helicobacter Pylori Infection
Vonoprazan in Helicobacter Pylori Treatment an RCT
RCT for comparison of Standard Triple therapy (Omeprazole+Amoxil+Clarithromycin) for H Pylori erradication with Vonoprazan+Amoxil dual therapy.
- Trial name
- NCT04901663
- Testing
- Omeprazole 20 MG Capsule; Amoxicillin 1000 MG; Clarithromycin 500 MG, Vonoprazan 20 MG; Amoxicillin 1000 MG
- Where
- Pakistan
- Volunteers
- 179 people
- Sponsor
- Dow University of Health Sciences
Helicobacter Pylori Infection Chronic Gastrit
Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment
The purpose of this study was to evaluate the efficacy and safety of tegoprazan and minocycline dual therapy for Helicobacter pylori initial treatment.
- Trial name
- NCT06523764
- Testing
- tegoprazan, Minocycline, bismuth potassium citrate
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Fourteen-Day Vonoprazan-Based Dual Therapy With Amoxicillin as First-Line Helicobacter Pylori Treatment in Comparison With Extended Sequential Therapy
Background：Helicobacter pylori infection is a well-established risk factor for peptic ulcer disease and gastric cancer. It's now a consensus of experts that H.pylori infection should be treated once it is recognized.
- Trial name
- NCT06156085
- Testing
- Vonoprazan and Amoxicillin, Lansoprazole, Amoxicillin, Clarithromycin and Metronidazole
- Where
- Taiwan
- Volunteers
- 337 people
- Sponsor
- Fu Jen Catholic University Hospital
HELICOBACTER PYLORI INFECTIONS
Fecal Molecular Susceptibility-guided Hp First-line Therapy
The goal of this clinical trial is to evaluate the eradication efficacy and health economic benefits of individualized regimens guided by fecal molecular susceptibility testing with 7-day and 14-day courses in the first-line…
- Trial name
- NCT07405684
- Testing
- 7-day fecal molecular susceptibility-guided therapy, 14-day fecal molecular susceptibility-guided therapy
- Where
- 4 sites in China
- Volunteers
- 544 people
- Sponsor
- Shanghai Zhongshan Hospital
Helicobacter Pylori
A Study Reviewing Medical Records of Adults With Helicobacter Pylori Infections in China
The main aim of the study is to review treatment therapies in people with Helicobacter pylori (H. pylori) infections in standard hospital settings in China.
- Trial name
- NCT05073367
- Where
- 5 sites in China
- Volunteers
- 23,000 people
- Sponsor
- Takeda
Iron Deficiency
Helicobacter Pylori Eradication Trial to Reduce Iron Deficiency in Children
The investigators hypothesize that the Helicobacter pylori bacterium decreases iron from the stomach and that this effect of the infection can be identified among persons with iron deficiency as well as among persons with normal…
- Trial name
- HEIDC (NCT00364104)
- Testing
- Quadruple sequential Helicobacter pylori eradication + iron sulfate, Quadruple sequential Helicobacter pylori eradication therapy, Ferrous sulfate
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Helicobacter Pylori Infection
Diagnosis Ability of Linked Color Imaging for Helicobacter Pylori Infection Compared With White Light Imaging
There are lack of endoscopic criteria for diagnosing Helicobacter pylori (H. pylori) infection by conventional white light imaging (WLI).
- Trial name
- NCT03011437
- Testing
- Esophagogastroduodenoscopy
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kashgar 1st People's Hospital
Helicobacter Pylori Infection
Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication
To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without…
- Trial name
- NCT07439445
- Testing
- Vonoprazan 20 mg twice daily + clarithromycin 500 mg twice daily for 14 days
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
H. Pylori Infection
A Phase Ⅲ Clinical Trial With Oral Recombinant Helicobacter Pylori Vaccine in Chinese Children
Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic bacterium that persistently colonizes the human stomach; more than half the human population is infected worldwide. H.
- Trial name
- NCT02302170
- Testing
- H. pylori vaccine
- Where
- China
- Volunteers
- 4,464 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention