Clinical trials: H Pylori Infection
H. Pylori Infection
The Efficacy of Sequential Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection - A Pilot Study
Helicobacter pylori infection has been shown to be associated with the development of gastric cancer and peptic ulcer diseases. Eradication of H. pylori infection could reduce the occurence or recurrence of these diseases.
- Trial name
- NCT00885417
- Testing
- Cravit-based sequential therapy
- Where
- Taiwan
- Volunteers
- 142 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Infections
Breath Ammonia Method for H. Pylori Detection: Phase II
The objective is to evaluate the utility of a breath ammonia sensing device. In this study we will assess the effect of H. pylori infection on breath ammonia levels by measuring whether there is a change in the pattern or…
- Trial name
- NCT00194688
- Testing
- H. pylori treatment
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Washington
HELICOBACTER PYLORI INFECTIONS
Feasibility and Performance of FFPE qPCR for Detection of Clarithromycin Resistance in Helicobacter Pylori
This prospective observational study aims to evaluate the feasibility and performance of real-time PCR (qPCR) performed on formalin-fixed, paraffin-embedded (FFPE) gastric biopsies to detect Helicobacter pylori infection and…
- Trial name
- HED-2T (NCT07821294)
- Testing
- q-PCR on FFPE gastric biopsies
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Clinique Bizet
Helicobacter Pylori Infection, Peptic Ulcer Disease
Vonoprazan High-Dose Dual VS Levofloxacin Concomitant
This is a randomized controlled trial comparing the efficacy and safety of two vonoprazan-based regimens: high-dose dual therapy (vonoprazan plus a single antibiotic) versus triple therapy (vonoprazan plus two antibiotics) for…
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer Disease, Gastritis
- Trial name
- NCT07624422
- Testing
- Vonoprazan, Levofloxacin 500mg
- Where
- Syria
- Volunteers
- 150 people
- Sponsor
- Damascus Hospital
Antimicrobial Susceptibility Testing, Triple Therapy
Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT03139253
- Testing
- amoxicillin, clarithromycin, tinidazole
- Volunteers
- 120 people
- Sponsor
- Yanqing Li
Functional Dyspepsia, Epigastric Pain Syndrome
Comparative Study of Epigastric Pain Syndrome and Postprandial Distress Syndrome
The purpose of this study is to compare postprandial distress syndrome and epigastric pain syndrome in demographics psychological features, infection of Helicobacter pylori, gastric emptying and therapeutic response to…
- Conditions
- Functional Dyspepsia, Epigastric Pain Syndrome, Post Prandial Distress Syndrome
- Trial name
- NCT00673972
- Testing
- gastric scintigraphy
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Effectiveness of Once-daily Dose Regimen of 7-day and 14-day High Dose Rabeprazole-levofloxacin Based Quadruple Therapy for H. Pylori Eradication in Thai Patients With Non-ulcer Dyspepsia
H.pylori is an organism which causes gastric inflammation, peptic ulcer disease (PUD), mucosa associated lymphoid tissue (MALT) lymphoma and gastric cancer.
- Trial name
- NCT03397680
- Testing
- 13C Urea Breath Test
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Helicobacter Pylori Infection, Eradication
Furazolidone Quadruple Regimen Eradicate H. Pylori Infection
Research protocol: Experimental group: First line solution (furazolidone regimen): esomeprazole magnesium 20 mg +colloidal bismuth pectin 200mg+ amoxicillin 1000 mg + furazolidone 100 mg, twice daily, for 14 days.
- Trial name
- NCT06823791
- Testing
- Furazolidone, Clarithromycin
- Where
- China
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
Helicobacter Pylori Eradication
Efficacies of Tetracycline-levofloxacin, Standard Bismuth, Amoxicillin-levofloxacin Quadruple Therapy for H.p
1. Compare the efficacy of "Tetracycline combined with levofloxacin quadruple therapy", "standard tincture quadruple therapy" and "amoxicillin combined with levofloxacin quadruple therapy" on the second line of Helicobacter…
- Trial name
- NCT05850117
- Testing
- esomeprazole, tripotassium dicitrate bismuthate, tetracycline and levofloxacin, esomeprazole , tripotassium dicitrate bismuthate, tetracycline 500mg and metronidazole, esomeprazole, tripotassium dicitrate bismuthate , amoxicillin and levofloxacin
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- Kaohsiung Medical University
Helicobacter Pylori Infection
Efficacy and Safety of Dual Therapy for Helicobacter Pylori Eradication
The purpose of this study was to evaluate the Efficacy and Safety of Vonoprazan- amoxicillin dual therapy for Helicobacter Pylori eradication
- Trial name
- NCT05469685
- Testing
- Vonoprazan, Amoxicillin
- Where
- 10 sites in China
- Volunteers
- 914 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection, Resistant Infection
One Sequencing Find All for Helicobacter Pylori Infection
The aim of this study is to Identify antibiotic resistance gene mutations in Helicobacter pylori (HP) and genetic diversity of drug metabolism for antibiotics and proton pump inhibitors (PPIs) in patients with HP infection using…
- Trial name
- NCT03837990
- Testing
- Helicobacter Pylori eradication therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Helicobacter Pylori Infection, Iron Deficiency Anemia
Potential Adverse Developmental and Nutritional Consequences of Helicobacter Pylori Infection in Israeli Children
The investigators believe that there is an association between H. pylori infection and nutritional status and between H. pylori infection and cognitive development.
- Conditions
- Helicobacter Pylori Infection, Iron Deficiency Anemia, Child Development
- Trial name
- NCT02654197
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Helicobacter Pylori Infection
Efficacy and Safety of Tegoprazan Versus Esomeprazole-containing Bismuth Quadruple Therapy for Eradication of Helicobacter Pylori
This study is a multicenter, randomized, double-blind, double-dummy, phase III study to evaluate the efficacy and safety of tegoprazan versus esomeprazole-containing bismuth quadruple therapy in patients infected with…
- Trial name
- NCT05577468
- Testing
- Tegoprazan
- Where
- China
- Volunteers
- 561 people
- Sponsor
- Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
Iron Deficiency Anemia, Helicobacter Pylori Infection
The Effect of H. Pylori Infection on Iron Metabolism
The purpose of this study is to determine if Helicobacter pylori (H. pylori) gastritis results in abnormal iron metabolism in patients with iron deficiency anemia (IDA), and to determine if this is due to strain variations in the…
- Trial name
- NCT00202488
- Testing
- H. pylori treatment
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Helicobacter Pylori Infection
A Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of a new 14-day sequential therapy for the rescue treatment of refractory Helicobacter pylori infection, and whether it is safe while maintaining an ideal eradication rates.
- Trial name
- NCT03658733
- Testing
- esomeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days), rabeprazole, amoxicillin, tetracycline, furazolidone (only for the first 7 days), colloidal bismuth pectin (for the second 7 days)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Helicobacter Pylori Eradication
The Impact of WeChat Group Patient Education on the Eradication Rate of Helicobacter Pylori
In this study, effects of oral and written education, WeChat education plus oral and written education on Helicobacter pylori eradication will be compared in a randomized way.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Eradication, Patient Education
- Trial name
- NCT04850209
- Testing
- oral and written education, Wechat group
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection.
Clarithromycin (CLA)、amoxicillin (AMO)、metronidazole (MET)、levofloxacin (LEV) and tetracycline (TET) are commonly used antibiotics for Helicobacter pylori (Hp) therapy.
- Trial name
- NCT03583476
- Testing
- Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole
- Where
- Taiwan
- Volunteers
- 1,821 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
14-day Double Therapy Versus Bismuth Quadruple Therapy in First-line Treatment of Helicobacter Pylori Infection
The researchers collected untreated H. pylori positive patients from outpatient clinics. Subjects were randomized to 14 days of dual therapy with Tegoprazan or 14 days of quadruple therapy with bismuth for eradication.
- Trial name
- NCT05438550
- Testing
- 14-day high-dose Tegoprazan Dual Therapy (HDDT)
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Intraluminal Clarithromycin Powder Monotherapy for Helicobacter Pylori Infection
Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in humans. The prevalence of H. pylori is about 30~50% in the Western adult population.
- Trial name
- NCT03516669
- Testing
- Clarithromycin, Amoxicillin, Clarithromycin
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Mackay Memorial Hospital
H.Pylori Infection
Comparison of Twice- and Four-times-daily Amoxicillin Administration in 2-week Tegoprazan-based H. Pylori Eradication
Gastric acid depressant play a major role in an H. pylori eradication therapy by (1) increasing the intragastric pH, which improves antibiotic stability and bioavailability; (2) increasing the intragastric pH to 6 or more, which…
- Trial name
- NCT06431737
- Testing
- Amoxicillin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Soonchunhyang University Hospital