Clinical trials: H Pylori Infection
Helicobacter Pylori [H. Pylori] as the Cause of Diseases
Quadruple and Phytomedicine-based Therapies in H. Pylori Infection
Helicobacter pylori is strongly associated to the development of gastrointestinal disorders. Emerging antibiotic resistance and poor patient compliance of modern therapies has resulted in significant eradication failure.
- Trial name
- NCT02004197
- Testing
- Quadruple Allopathic therapy, Pylorex plus
- Where
- 2 sites in Pakistan
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Hafiz Muhammad Asif
Helicobacter Pylori Infection
Comparison of Different Helicobacter Pylori Detection Methods in Patients With Chronic Atrophic Gastritis
As we know，Helicobacter pylori is closely related to many gastrointestinal diseases such as chronic gastritis, peptic ulcer disease,gastric carcinoma and gastric mucosa-associated lymphoid tissue lymphoma，as well as…
- Trial name
- NCT04923113
- Testing
- Histology，13C urea breath test，Stool antigen test，Serological antibody test for H.pylori and Serologic test with a current infection marker of H.pylori, Rabeprazole，Minocycline，Amoxicillin and Colloidal bismuth pectin
- Where
- 2 sites in China
- Volunteers
- 281 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Infection
Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection
Helicobacter pylori is a bacteria that infects the lining of the stomach and is associated with ulcers. Helicobacter pylori may also increase the long-term risk of developing certain forms of gastric cancer.
- Trial name
- 960025 (NCT00656968)
- Testing
- 10-day sequential treatment, 10-day concomitant therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 232 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection
Triple Therapy With Tegoprazan in H. Pylori Positive Patients_PILOT
This study aims to compare safety and efficacy in an exploratory manner between a Tegoprazan triple therapy and a RAPAE01 triple therapy in H. pylori positive patients.
- Trial name
- NCT04128917
- Testing
- Tegoprazan, RAPAE01
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- HK inno.N Corporation
Helicobacter Pylori Infection
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection, then comparing it with 14-day personal medication…
- Trial name
- NCT03565484
- Testing
- susceptibility guided therapy, personal medication history guided therapy, salvage treatment for failed eradication
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection, Chronic Gastritis
Comparative Effectiveness of Triple Versus Quadruple Therapy in the Treatment of Helicobacter Pylori Induced Gastritis
This randomized controlled trial is designed to compare the efficacy of standard triple therapy versus bismuth-based quadruple therapy for the eradication of Helicobacter pylori-induced gastritis.
- Conditions
- Helicobacter Pylori Infection, Chronic Gastritis, Peptic Ulcer Disease
- Trial name
- HP-THERAPY-TRI (NCT07312721)
- Testing
- Triple Therapy, Quadruple Therapy
- Where
- Pakistan
- Volunteers
- 752 people
- Sponsor
- Azfar Farogh
H Pylori
Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment…
- Trial name
- NCT07040839
- Testing
- Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg
- Where
- Pakistan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Helicobacter Pylori Infection
Optimization of Minocycline for Helicobacter Pylori Rescue Treatment
The efficacy of bismuth-containing quadruple therapy with minocycline and metronidazole was not inferior to classical bismuth quadruple therapy for refractory H.
- Trial name
- NCT06561711
- Testing
- Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole
- Where
- 4 sites in China
- Volunteers
- 480 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Bismuth Quadruple Therapy With Cefuroxime for Helicobacter Pylori Eradication Treatment
To observe the efficacy of cefuroxime-containing bismuth quadruple regimen in the eradication treatment of Helicobacter pylori, and to evaluate whether it can be used as a remedial treatment for Helicobacter pylori after initial…
- Trial name
- NCT04723472
- Testing
- Cefuroxime containing bismuth quadruple treatment, Classic bismuth quadruple treatment
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai East Hospital
Helicobacter Pylori Infection
Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients
Addition of L. reuteri to the standard triple therapy improves H. Pylori treatment outcomes.
- Trial name
- NCT01593592
- Testing
- Lactobacillus reuteri, Omeprazole, Amoxicillin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Zagazig University
Helicobacter Pylori Infection
Rapid Urease Test for Diagnosis Helicobacter Pylori Infection
Nowadays, the gold standard examinations for diagnosing H. pylori infection are histopathology and culture examination. However, those examinations take long preparation so they are not suitable to be applied in daily practice.
- Trial name
- NCT03547544
- Where
- Indonesia
- Volunteers
- 97 people
- Sponsor
- Universitas Indonesia
Helicobacter Pylori Infection
Efficacy of Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests for Helicobacter Pylori Infection
This study aims to evaluate the efficacy and safety of 14-day quadruple therapy based on fecal molecular antimicrobial susceptibility tests for the first-line eradication of H.
- Trial name
- NCT05718609
- Testing
- Rabeprazole, Colloidal Bismuth Pectin Granules, Amoxicillin
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
Influencing Factors of Helicobacter Pylori Infection and Eradication Failure
Helicobacter pylori (H. pylori) is closely related to the occurrence of gastric cancer and other diseases, the discovery and eradication of H.
- Trial name
- NCT05226819
- Testing
- PPI quadruple therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Helicobacter Pylori Infection
Genotypic Resistance-guided Versus Empirical Therapy for H. Pylori Eradication.
This study aims to investigate the efficacy of a 7-day genotypic resistance-guided triple therapy, compared with empirical concomitant therapy, for first-line eradication of H. pylori.
- Trial name
- NCT04090021
- Testing
- Esomeprazole 40mg, Clarithromycin 500mg, Metronidazole 500 mg
- Where
- Greece
- Volunteers
- 304 people
- Sponsor
- Konstantopoulio-Patission General Hospital of Nea Ionia
Helicobacter Pylori
Helicobacter Pylori and Vonoprazan Dual Therapy
Our previous study included 119 Helicobacter pylori(H. pylori)-infected Chinese patients without previous eradication history who were randomized to low-or high-dose amoxicillin-vonoprazan regimens consisting of amoxicillin 1…
- Trial name
- NCT05649709
- Testing
- L-VA dual therapy, H-VA dual therapy
- Where
- China
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Nanchang University
H.Pylori, Gastric Cancer
Helicobacter Pylori Infection and Gastric Disease in Bhutan: First Community-Wide, Population-Based Study
Background: Helicobacter pylori is a major risk factor for gastric cancer, yet in many developing countries, including Bhutan where gastric cancer incidence is high, access to screening and eradication is limited.
- Conditions
- H.Pylori, Gastric Cancer, H Pylori Eradication
- Trial name
- NCT07211880
- Testing
- Rabeprazole Sodium, Amoxicillin Hydrate, Clarithromycin, Upper gastrointestinal endoscopy for the H. pylori and serum pepsinogen positive individuals (high risk group of gastric cancer), Urea Breath Test for the prevalence of H pylori
- Where
- Bhutan
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Zero Helicobacter IGAN Network
Helicobacter Pylori Infection, Helicobacter Pylori Associated Gastrointestinal Disease
Prevalence and Trends of Antimicrobial Resistance of Helicobacter Pylori in Korea
To assess antimicrobial resistance rates and minimal inhibitory concentrations in H. pylori isolated from patients with upper gastrointestinal disease with long-term period.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Associated Gastrointestinal Disease, Helicobacter Pylori Infection, Susceptibility to, Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation
- Trial name
- NCT05247112
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection, Chronic Gastritis
Esomeprazole, Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection
Successful H. pylori eradication therapy remains a challenge in medical practice. Despite promising data for first-line, second-line and rescue treatment options based on clinical trials as well as guidelines and expert…
- Trial name
- ESAMOX (NCT00455806)
- Testing
- esomeprazole, moxifloxacin, amoxicillin
- Where
- 9 sites in Germany
- Volunteers
- 132 people
- Sponsor
- Technische Universität Dresden
Helicobacter Pylori Infection, Intravenous Drug Usage
Intravenous Triple Therapy in the Treatment of Helicobacter Pylori Infection and Related Complications Caused by Active Peptic Ulcer Disease
Helicobacter pylori infection causes active peptic ulcer disease and related complications like bleeding and pyloric obstruction.
- Trial name
- NCT04432233
- Testing
- Esomeprazole, Metronidazole, Levofloxacin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Optimization of Second Line Treatment Protocol for H Pylori Eradication
Sequential Therapy Versus Quadruple Therapy as Second Line Treatment After Failure of the Standard Triple Therapy for H Pylori Infection
The aim of this study is to evaluate the efficacy of sequential therapy, i.e. 5 days of PPI + amoxicillin followed by 5 days of PPI + two antimicrobial drugs( clarithromycin and tinidazole ) versus quadruple drug regimen( i.e.-14…
- Trial name
- NCT01481844
- Testing
- Lansoprazole , Tab Amoxycillin , Tab Clarithromycin ,Tab Tinidazole, Lansoprazole, Bismuth Subsalicylate, Metronidazole, Tetracycline
- Where
- Israel
- Volunteers
- 101 people
- Sponsor
- Soroka University Medical Center