Clinical trials: H Pylori Infection
Helicobacter Pylori Infection
High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment
Dual therapy containing high dose of proton pump inhibitor (PPI) and amoxicillin had showed excellent eradication results with Helicobacter pylori first-line treatment.
- Trial name
- NCT04024527
- Testing
- Esomeprazole, Amoxicillin, Metronidazole
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Treatment of Helicobacter Pylori
Quadruple Therapy for Triple Therapy Resistant Helicobacter Pylori Infection
Triple therapy, a combination of proton pump inhibitor with two antibiotics, is the gold standard for anti-Helicobacter pylori treatment.
- Trial name
- QT-Hp (NCT00520949)
- Testing
- Augmentin (Amoxicillin-clavulanic), Furoxone (furazolidone), Cebes (colloidal bismuth subcitrate)
- Where
- Pakistan
- Volunteers
- 176 people
- Sponsor
- Aga Khan University
MALT Lymphoma of Stomach, Helicobacter Pylori Infection
Orelabrutinib in the Treatment of HP-positive Gastric MALT Lymphoma
Describe the efficacy and safety of Orelabrutinib in the treatment of HP-positive gastric MALT lymphoma
- Trial name
- NCT06228963
- Testing
- Triple therapy for eradication of Helicobacter Pylori and Orelabrutinib, Triple therapy for eradication of Helicobacter Pylori
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Fudan University
Residents of Palau Aged 18 Years or Older
Prevalence of Helicobacter Pylori Infection
1. To investigate the prevalence of Helicobacter pylori infection among adults in Palau using stool antigen testing. 2. To analyze the correlation between H.
- Trial name
- NCT07840833
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Helicobacter Pylori Infection
Concomitant, Sequential, and Standard Triple Therapy for H. Pylori Infection
To simultaneously compare the efficacies of 7-day triple, 10-day sequential and 7-day quadruple therapies for H. pylori infection in Taiwan. Consecutive H.
- Trial name
- NCT01769365
- Testing
- 7-day quadruple therapy, 10-day sequential therapy, 7-day standard triple therapy
- Where
- Taiwan
- Volunteers
- 307 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Helicobacter Pylori Infection
Minocycline for Helicobacter Pylori Rescue Treatment
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy.
- Trial name
- NCT06332599
- Testing
- BQT, PBM4M4, PBM3M3
- Where
- China
- Volunteers
- 823 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hyperemesis Gravidarum
The Association of Helicobacter Pylori in the Pathogenesis of Hyperemesis Gravidarum in Pregnant Women
The purpose of this study to explore the association between Hyperemesis Gravidarum in pregnant women and Helicobacter pylori infection.
- Trial name
- AOHPIPOHGIPW (NCT02830321)
- Testing
- helicopacter pylori stool antigen test (CER TEST BIOTEC)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- rasha fawzy abd el kader
Gastritis, H Pylori Infection
Helicobacter Pylori Eradication With Clostridum Butyricum Capsule and Bacillus Coagulans Tablets
This study aims at evaluating efficacy Clostridum Butyricum Capsule and Bacillus Coagulans Tablets in H. pylori eradication. It is hypothesized that Clostridum Butyricum Capsule , Bacillus Coagulans Tablets monotherapy or…
- Conditions
- Gastritis, H Pylori Infection, Dyspepsia
- Trial name
- NCT03857425
- Testing
- Clostridum Butyricum Capsule, Bacillus Coagulans Tablets, Clostridum Butyricum Capsule plus Bacillus Coagulans Tablets
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
CANHelp Working Group Treatment Trials
The CANHelp Working Group Treatment Trials are part of a comprehensive research program carried out by the Canadian North Helicobacter pylori (CANHelp) Working Group.
- Trial name
- NCT01967329
- Testing
- Standard Triple, Sequential, Quadruple
- Where
- Canada
- Volunteers
- 338 people
- Sponsor
- University of Alberta
Helicobacter Pylori Infection
Sequential Therapy Versus Triple Therapy for Helicobacter Pylori Eradication: a Placebo-controlled Trial
To assess if a sequential treatment regimen better eradicates H. pylori than does a triple drug regimen in adults with dyspepsia or peptic ulcer disease.
- Trial name
- NCT00403364
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Helicobacter Pylori Infection, Tegoprazan
Efficacy and Safety of Tegoprazan Dual Therapy and Furazolidone-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication: A Prospective, Multicenter, Open-label, Randomized Controlled Clinical Study
To compare the efficacy and safety of Tegoprazan-amoxicillin dual therapy and bismuth quadruple therapy based on furazolidone in the treatment of Helicobacter pylori eradication, the eradication rate, patient compliance, and…
- Conditions
- Helicobacter Pylori Infection, Tegoprazan, Furazolidone
- Trial name
- NCT06340334
- Testing
- Tegoprazan-amoxicillin dual therapy
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gastric Cancer Screening, Prevention and Control
Helicobacter Pylori Infection and Gastric Diseases in Lao PDR: First Community-Wide Population-Based Study
This study aims to determine the regional prevalence of Helicobacter pylori infection, bacterial strain differences, and the prevalence of gastric cancer in two provinces of Laos, a multi-ethnic country where these factors may…
- Conditions
- Gastric Cancer Screening, Prevention and Control, Helicobacter Eradication, Helicobacter Infections
- Trial name
- NCT07340593
- Where
- Laos
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Zero Helicobacter IGAN Network
Helicobacter Pylori Infection, Dysbiosis
The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication
Helicobacter pylori (H. pylori) infection is the major cause of gastritis, peptic ulcer disease, and gastric cancer in adults. Bismuth-based quadruple therapy is recommended by a recent review to be the first-line treatment for…
- Conditions
- Helicobacter Pylori Infection, Dysbiosis, Probiotics
- Trial name
- Bsm10 (NCT04527055)
- Testing
- Bismuth Subcitrate 120 MG Oral Tablet, Lactobacillus acidophilus and Bifidobacterium lactis Bb12, Esomeprazole 40mg
- Where
- Taiwan
- Volunteers
- 312 people
- Sponsor
- National Cheng-Kung University Hospital
Helicobacter Pylori Infection
Bag Mode BreathID Hp Validation Versus Endoscopy in Detection of Helicobacter Pylori
A new method of breath collection for testing for Helicobacter Pylori infection has been developed by Exalenz. In this study, it will be compared to the gold standard- endoscopy results to prove its accuracy.
- Trial name
- NCT02010112
- Testing
- Breath Test Collection bags
- Where
- 9 sites in United States
- Volunteers
- 193 people
- Sponsor
- Meridian Bioscience, Inc.
Helicobacter Pylori Infection, Helicobacter Pylori Infected Patients
Study to Evaluate the Efficacy and Safety of DWP14012-based Triple Therapy in Eradication of Helicobacter Pylori
This study is designed to demonstrate the non-inferiority and verify the safety of DWP14012-based triple therapy compared to DWC202301-based triple therapy as the first-line eradication therapy in patients who are positive for…
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Infected Patients, Helicobacter Pylori Infected Subjects
- Trial name
- NCT06751121
- Testing
- DWP14012 40mg, DWC202301 30mg, Amoxicillin 1000mg
- Where
- South Korea
- Volunteers
- 461 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Helicobacter Pylori Infection
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effect of TNP-2198 Capsules After Single Oral Dose in Healthy Participants
This was a single-center, randomized, double-blind, placebo-controlled phase 1 study to evaluate the safety, tolerability, pharmacokinetics of single ascending dose and the food effect on the pharmacokinetics of TNP-2198 capsules…
- Trial name
- NCT06081699
- Testing
- TNP-2198
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Helicobacter Pylori Infection
Adding Bismuth to Rabeprazole-based First-line Triple Therapy Does Not Improve the Eradication of Helicobacter Pylori
This randomized controlled study aimed to evaluate whether adding bismuth to the standard first-line triple therapy could improve the eradication rate of Helicobacter pylori (H. pylori). A total of 162 patients with H.
- Trial name
- NCT03108287
- Testing
- RAK therapy, RBAK therapy
- Volunteers
- 162 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Rescue Therapy for Helicobacter Pylori
Quadruple Therapy Versus Dual Therapy as Rescue Regimens for Helicobacter Pylori Infection
The eradication rates of first-line treatment for Helicobacter pylori(Hp) infection are not satisfactory. The study aims to compare the efficacy and safety between quadruple therapy with furazolidone and dual therapy with high…
- Trial name
- NCT01805934
- Testing
- RBLF, RA
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Vonoprazan-containing Triple Therapy Versus Empiric Bismuth Quadruple Therapy for First-line Helicobacter Pylori Treatment: a Randomized Clinical Trial
Vonoprazan Amoxicillin and metronidazole based triple therapy had achieved a high cure rate in the rescue treatment of helicobacter pylori infection.
- Trial name
- NCT05726734
- Testing
- Vonoprazan, Amoxicillin, Metronidazole, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai East Hospital
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Rifaximin Associated With Classic Triple Therapy for the Eradication of Helicobacter Pylori Infection
Background: A progressive decrease in Helicobacter pylori eradication rates has been described over the years, so new combinations of antibiotics for treatment are needed.
- Trial name
- R+OCA (NCT03124199)
- Testing
- Rifaximin
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa