Clinical trials: H Pylori Infection
Helicobacter Pylori Infection
Safety and Efficacy Study of a Non-antibiotic Treatment for the Eradication of Helicobacter Pylori
At present, triple therapy is recommended by various guidelines for the treatment of Helicobacter pylori (H.pylori) infection. Recent studies have shown increasing resistance of H.pylori to commonly used antibiotics used in…
- Trial name
- NCT01109381
- Testing
- GT08
- Where
- Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Synergy Pharmaceuticals Pte. Ltd.
HELICOBACTER PYLORI INFECTIONS
Antibiotic Resistance of Helicobacter Pylori in Nanjing: A Cross-Sectional Study
This study aims to provide an updated analysis of the resistance patterns of H. pylori in the Nanjing region, with a focus on characterizing the current status of phenotypic and genotypic resistance to these six antimicrobial…
- Trial name
- NCT07455448
- Testing
- Antimicrobial susceptibility testing
- Where
- China
- Volunteers
- 7,227 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection
Efficacy of Seven-day Combined Rabeprazole Plus Levofloxacin Plus Augmentin for Eradication of Helicobacter Pylori
This prospective controlled randomized open-label clinical trial is designed to determine the eradication rate of 7-day levofloxacin, amoxicillin/clavulanate and rabeprazole regimen compared with 7-day standard triple therapy for…
- Trial name
- NCT01575899
- Testing
- Levofloxacin-Amox/clav., Clarithromycin-Amoxicillin
- Where
- Taiwan
- Volunteers
- 208 people
- Sponsor
- Buddhist Tzu Chi General Hospital
HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection
Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residing in the gastric mucosa and using the mucus layer for protection from the stomach's high acidity.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection, Helicobacter Pylori Infected Patients
- Trial name
- NCT07293910
- Testing
- Vonoparazan, Vitamin D, Probiotic
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tanta University
Helicobacter Pylori Infection
Efficacy and Safety of Dual Therapy as First-line Treatment for Hp Infection
This study aims to evaluate the efficacy of dual therapy compared with bismuth-containing quadruple therapy as first-line treatment for Helicobacter Pylori eradication, as well as the safety and economic benefits.
- Trial name
- NCT05419674
- Testing
- Vonoprazan, Rabeprazole, Amoxicillin
- Where
- China
- Volunteers
- 393 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
Triple Versus Quadruple Therapy for the Eradication of Helicobacter Pylori
The study aimed to compare the efficacy and safety of 7-day and 14-day vonoprazan-amoxicillin-tetracycline triple therapy with 14-day vonoprazan-amoxicillin-tetracycline-bismuth quadruple therapy for the eradication of…
- Trial name
- SHARE2401 (NCT06299605)
- Testing
- Vonoprazan-Amoxicillin-Tetracycline-Bismuth quadruple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 7 days
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Shandong University
HELICOBACTER PYLORI INFECTIONS
Levofloxacin-Based Sequential Therapy Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
This randomized controlled trial aims to compare the efficacy and safety of levofloxacin-based sequential therapy versus bismuth-based quadruple therapy for eradication of Helicobacter pylori infection in adult patients.
- Trial name
- NCT07574983
- Testing
- Levofloxacin-Based Sequential Therapy, Bismuth-Based Quadruple Therapy
- Volunteers
- 90 people
- Sponsor
- University of Health Sciences Lahore
Helicobacter Pylori Infection
Dual-focus Magnification With Narrow-band Imaging in Helicobacter Pylori Infection
Dual-focus with narrow-band imaging (DF-NBI) is a novel technique to improve the quality of images of the irregular mucosal structures and microvessels of gastric neoplasms.
- Trial name
- NCT03973242
- Testing
- Dual focus with narrow band imaging
- Where
- South Korea
- Volunteers
- 292 people
- Sponsor
- Kyunghee University Medical Center
Helicobacter Pylori Infection, Eradication Treatments
Prospective Randomised Trial of First and Second Line Treatments of RCT of First and Second Line H Pylori Treatments in Slovenia
Study is prospective randomised multicentric. The primary objective of the study is to compare the efficacy of two first-line therapy regimens and two second-line therapy regimens (ie, after failure of first-line treatment) in…
- Trial name
- NCT04359966
- Testing
- Esomeprazole 40mg, Clarithromycin 500 mg, Metronidazole 400 mg,, Esomeprazole 40mg, Bismuth subcitrate 120 mg, Amoxicillin 500 mg, Metronidazole 400 mg, Esomeprazole 40mg, Amoxicillin 500 mg, Levofloxacin 500 mg
- Where
- 3 sites in Slovenia
- Volunteers
- 560 people
- Sponsor
- Slovenian Society for Gastroenterology and Hepatology
Helicobacter Pylori Infection
Optimization of Vonoprazan-based Dual Therapy for Helicobacter Pylori
The purpose of this study was to evaluate the efficacy and safety of vonoprazan with different doses of amoxicillin for Helicobacter Pylori.
- Trial name
- NCT05649540
- Testing
- Vonoprazan, Amoxicillin
- Where
- 13 sites in China
- Volunteers
- 900 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial
This study is a multicentre, non-inferiority randomized controlled trial to compare the efficacy and safety of 14-day vonoprazan-based dual therapy with versus quadruple therapy for the eradication of Helicobacter pylori.
- Trial name
- NCT07179159
- Testing
- 14-day vonoprazan-amoxicillin dual therapy, 14-day vonoprazan-amoxicillin-levofloxacin-bismuth quadruple therapy, 14-day vonoprazan-amoxicillin-clarithromycin-bismuth quadruple therapy
- Where
- 2 sites in China
- Volunteers
- 372 people
- Sponsor
- Yanqing Li
Helicobacter Pylori Infection
The Epidemiology and Optimal Treatment of Helicobacter Pylori in Myanmar
This study aims to: 1. Determine the prevalence of Helicobacter infection in Myanmar (this would be the largest ever series in the country) 2.
- Trial name
- NCT04132479
- Testing
- Clarithromycin 500mg, Amoxicillin 500mg, Tinidazole 500mg
- Where
- Burma
- Volunteers
- 313 people
- Sponsor
- Kirby Institute
Helicobacter Pylori Infection
Efficacy of Acetilcysteine in 'Rescue' Therapy for Helicobacter Pylori Infection. Pilot Study
H pylori gastric infection is one of the most prevalent infectious diseases worldwide. The discovery that most upper gastrointestinal diseases are related to H pylori infection and therefore can be treated with antibiotics is an…
- Trial name
- NCT00985608
- Testing
- Group A: NCA 600 mg+antibiotics, Group B: antibiotic treatment (control)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
H Pylori Infection
Screening of Helicobacter Pylori in Children of Positive Infected Mothers
Helicobacter pylori is aspiral shaped gram negative organism that colonized the gastric mucosa.it was showen that intra familial infection play role in transmission of H pylori and mother play the key role in transmission .
- Trial name
- NCT03911791
- Volunteers
- 30 people
- Sponsor
- Assiut University
Helicobacter Pylori Infection
Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori
Comparison Efficacy of 10-days Therapy with Doxycycline with Bismuth Subsalicylate Versus Levofloxacine with Tinadizole on Eradication of Helicobacter Pylori in Syrian population.
- Trial name
- NCT04348786
- Testing
- Doxycycline, Levofloxacin 500mg
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus Hospital
HELICOBACTER PYLORI INFECTIONS
The Clinical Trail to Evaluate the Efficacy and Safety of Anaprazole Sodium Enteric-coated Tablets Combined With Bismuth-containing Quadruple Therapy in Eradicating Helicobacter Pylori
This is a multicenter, randomized, double blind, double-simulated, parallel control of positive drug phase III clinical study to evaluate the efficacy and safety of Anaprazole versus Esomeprazole-containing Bismuth quadruple…
- Trial name
- NCT07606833
- Testing
- Anaprazole Sodium enteric-coated tablet, Esomeprazole magnesium enteric-coated tablets
- Where
- China
- Volunteers
- 556 people
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Helicobacter Pylori Infection
Comparison of Two Dual Therapies in the First-line Treatment of Helicobacter Pylori Infection （SHARE2301）
Helicobacter pylori (H. pylori) infection is a common global infectious disease of the gastrointestinal tract. Helicobacter pylori eradication can effectively prevent the development of stomach cancer.
- Trial name
- NCT05870683
- Testing
- Tegoprazan, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Yanqing Li
H. Pylori Infection, Carcinogenesis
Study on the Probiotics Regulating miRNA in H. Pylori-induced Wnt/β-catenin Gastric Carcinogenesis.
Background. H. pylori has recognized as a type 1 carcinogen for gastric adenocarcinoma. Although H. pylori eradication promises to reduce the risk of gastric cancer, the regression rate of intestinal metaplasia (IM) after…
- Trial name
- NCT05544396
- Testing
- probiotic
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Cheng-Kung University Hospital
H. Pylori Infection
The Efficacy of Treatment for Helicobacter Pylori Infection in Preschooler by Yoghurt With LG21
The goal of this non-randomized, open-label, interventional trial is to study the efficacy of treatment for Helicobacter Pylori Infection in Preschooler aged 4-6 by Meiji Yoghurt with LG21.
- Trial name
- NCT06045494
- Testing
- Meiji Yogurt Group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Meiji China Investment Co.,Ltd
Peptic Ulcer With H. Pylori Infection, Gastritis With H. Pylori Infection
The Role of CYP2C19 on the Eradication of H. Pylori Infection:Implication of PK/PD Relationships
The objective of this trial is to find the rationale and the optimal dose and duration of regimen for the eradication of H. pylori infection using different proton pump inhibitors.
- Trial name
- NCT00162877
- Testing
- Rabeprazole vs. Esomeprazole
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital