Clinical trials: H Pylori Infection
Helicobacter Infection
Efficacy of High Dose Dual Therapy, Sequential Therapy and Triple Therapy in H. Pylori Eradication
Up to now, to our knowledge, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of these current recommended 1st-line or 2nd-line regimens for…
- Trial name
- NCT01163435
- Testing
- high dose dual therapy, sequential therapy, clarithromycin-based triple therapy
- Where
- Taiwan
- Volunteers
- 618 people
- Sponsor
- National Taiwan University Hospital
Caries, Periodontitis
The Effect of Miswak Chewing Sticks on the Oral Helicobacter Pylori Infection
To elucidate the relationship of chewing miswak sticks on the H. Pylori infection in the oral cavity.The study would be conducted at the Faculty of Dentistry, Kuwait University.
- Trial name
- Miswak (NCT02418520)
- Testing
- Miswak
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Gastritis, Gastric Ulcer
A Multi-center Study for Individual Treatment of Helicobacter Pylori Infection
Since the discovery of Helicobacter pylori (H. pylori), many studies have been carried out with the goal of improving H. pylori eradication and therapies have changed from single-antibiotic treatments to the current…
- Trial name
- NCT02689583
- Testing
- Antibiotic selection based on the antibiotic susceptibility testing, PPI selection based on the CYP2C19 gene polymorphism, Probiotics usage based on the 16SrRNA sequencing
- Volunteers
- 3,000 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Helicobacter Pylori Infection in Patients With Chronic Tonsillits
Helicobacter Pylori in Patients With Chronic Tonsillits Prepared for Tonsillectomy
Tonsillar disorders are frequent In both pediatric and adult otolaryngological practice, . Numerous disorders that damage tonsillar tissue necessitate tonsillectomy. Tonsillectomy is typically required for recurrent tonsillitis.
- Trial name
- NCT06117956
- Testing
- Rapid urease test for h pylori
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
H. Pylori Infection
European Registry on the Management of Helicobacter Pylori Infection
The great diversity of regimens and treatment lines, the different efficacy of these, mostly due to the increase in bacterial antibiotic resistance and regional differences, requires a continuous critical analysis of clinical…
- Trial name
- NCT02328131
- Where
- 30 sites in Austria, Belgium and 28 more
- Volunteers
- 10,000 people
- Sponsor
- Javier P. Gisbert
Helicobacter Pylori Infection
ADDITION OF BISMUTH TO THE STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION
H pylori is an important cause of chronic gastritis and other complications. There is a decline in eradication rate for H pylori owing to multiple factors including drug resistance.
- Trial name
- NCT03968302
- Testing
- ARM A Triple therapy for helicobacter pylori, ARM B Quadruple therapy for helicobacter pylori
- Where
- Pakistan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Helicobacter Pylori Infection
Impact of Periodontal Treatment on Gastric Helicobacter Pylori Eradication
The efficacy of conventional systemic antibiotic therapy for eradication of gastric H. pylori has been seriously challenged by antibiotic resistance.
- Trial name
- NCT03654781
- Testing
- Triple therapy, professional periodontal treatment
- Volunteers
- 98 people
- Sponsor
- Ondokuz Mayıs University
Helicobacter Pylori Infection Helicobacter Pylori Eradication Patient Education
Comparison of Keverprazan Hydrochloride-Amoxicillin Dual Therapy and Susceptibility-Guided Quadruple Therapy for Helicobacter Pylori Rescue Treatment
This study aims to evaluate the efficacy and safety of Keverprazan Hydrochloride combined with Amoxicillin in dual therapy compared to susceptibility-guided quadruple therapy in the treatment of Helicobacter pylori (H.
- Trial name
- KHDT-SGT (NCT06760065)
- Testing
- Keverprazan Hydrochloride tablets + high dose amoxicillin, Susceptibility-Guided Quadruple Therapy
- Volunteers
- 316 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Helicobacter
Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP
Objectives: Eradication of H. pylori infection could reduce the occurence or recurrence of gastric cancer and peptic ulcer diseases.
- Trial name
- NCT03148366
- Testing
- Levofloxacin based sequential therapy, bismuth quadruple therapy for 10 days (BQ)
- Where
- 2 sites in Taiwan
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gastritis, Atrophic, Helicobacter Pylori Infection
Diagnosis of Gastritis, H. Pylori Infection and Atrophic Gastritis in Dyspeptic Patients
Gastric cancer is the third most common cause of cancer-related death worldwide (1). Upper endoscopy is necessary to detect neoplastic macroscopic features at an early stage, but subtle abnormalities in the gastric mucosa are…
- Conditions
- Gastritis, Atrophic, Helicobacter Pylori Infection, Intestinal Metaplasia, Gastritis
- Trial name
- NCT04296513
- Testing
- High-Definition white light endoscopy., High-definition magnification with digital chromoendoscopy.
- Where
- Ecuador
- Volunteers
- 150 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Bile Reflux Gastritis, Gastric Cancer
Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.
To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Bile Reflux Gastritis, Gastric Cancer, Helicobacter Pylori Infection, Intestinal Metaplasia
- Trial name
- NCT03976739
- Where
- China
- Volunteers
- 1,162 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Bismuth-containing Quadruple Therapy for Helicobacter Pylori First-line Treatment of Different Tetracycline Doses
The researchers collect treatment-naive H.pylori-positive patients from the outpatient clinic. The subjects were randomized to receive a dose and frequency of tetracycline 500mg tid or qid of bismuth quadruple eradication…
- Trial name
- NCT05431075
- Testing
- Amoxicillin, Tetracycline tid, Tetracycline qid
- Where
- 6 sites in China
- Volunteers
- 406 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Levofloxacin Triple and Bismuth Quadruple Therapies for Rescue Treatment of H Pylori Infection
From the profiles of antibiotic susceptibility data following eradication therapy, tetracycline, amoxicillin and levofloxacin are all good candidates of antibiotics used in the rescue treatment.
- Trial name
- NCT02978157
- Testing
- esomeprazole+amox+levo, esomeprazole+bismuth+tetra+levo
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Persistence of Infection With Helicobacter Pylori
The Role of Cathepsin X in Infection With the Helicobacter Pylori
The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria.
- Trial name
- NCT01137942
- Testing
- clarithromycin, metronidazole, proton pump inhibitor
- Where
- Slovenia
- Volunteers
- 14 people
- Sponsor
- University Medical Centre Ljubljana
Potassium-Competitive Acid Blocker, Proton Pump Inhibitor
Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection
This study aims to compare the eradication rate, safety, and patient adherence between potassium-competitive acid blockers (P-CABs) and proton pump inhibitor-based bismuth quadruple therapy in patients with Helicobacter pylori…
- Conditions
- Potassium-Competitive Acid Blocker, Proton Pump Inhibitor, Bismuth Based Quadruple Therapy, Treatment
- Trial name
- NCT07165444
- Testing
- Potassium-Competitive Acid Blocker, Proton Pump Inhibitor
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Tanta University
Helicobacter Pylori Infection
Investigation on Diagnosis and Treatment of Helicobacter Pylori Infection by Gastroenterologists in Shandong Province
Helicobacter pylori can lead to a variety of digestive system diseases.The eradication of Helicobacter pylori plays an importment role for the treatment of gastrointestinal ulcer and prevention of gastric cancer .Compared with…
- Trial name
- NCT04918134
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
Five Days Quadruple and Clarithromycin Containing Triple Therapy as Treatment for Helicobacter Pylori Eradication
The aim of this randomized trial is to compare the efficacy and tolerability of H. pylori eradication with a 5-day quadruple therapy versus a clarithromycin-containing triple therapy.
- Trial name
- NCT01306786
- Testing
- Quadruple therapy, Triple therapy
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- The University of Hong Kong
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection
The investigators will performed a large-scale multi center trial to compare the efficacy of a high-dose dual therapy (HDDT) with that of standard therapies in treatment-naive (n = 300) patients with Hp infection.
- Trial name
- HDDT (NCT02553083)
- Testing
- Nexium 40 mg, amoxicillin 1.5 gr, doxycycline 200 mg
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rabin Medical Center
Helicobacter Pylori Infection
Assessment of the Adjuvant Role of Dietary Supplementation of Antibiotic-tolerant Probiotics in Standard Therapy for the Eradication of Helicobacter Pylori Infection.
Randomized, double-blind, placebo-controlled clinical study to assess the adjuvant role of dietary supplementation of antibiotic-tolerant probiotics, derived from Lactobacillus acidophilus and Bifidobacterium animalis, in…
- Trial name
- NCT06499649
- Testing
- IBSA Probiotics
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- IBSA Farmaceutici Italia Srl
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of Linarazen Gluconate Capsules Combined With Amoxicillin (Dual-Drug Therapy) Versus Bismuth-Containing Quadruple Therapy for First-Line Eradication of Helicobacter Pylori Infection
This clinical trial aims to compare the efficacy of the dual therapy regimen of linralase glutarate capsules and amoxicillin versus the quadruple therapy regimen containing bismuth for the first-line eradication of Helicobacter…
- Trial name
- NCT07897994
- Testing
- Linalarose Glutarate, Bismuth Quadruple Test
- Where
- 24 sites in China
- Volunteers
- 448 people
- Sponsor
- Yongquan Shi