Clinical trials: H Pylori Infection
Helicobacter Pylori Infection, Helicobacter Pylori Eradication Antibiotic
The Impact of Helicobacter Pylori Eradication on the Vaginal Microecology Change
This clinical controlled study enrolled 73 H. pylori（Helicobacter Pylori ）-infected female participants, stratified into reproductive-age and menopausal cohorts, alongside 10 non-infected controls.
- Trial name
- NCT07408271
- Testing
- rabeprazole-based triple therapy plus bismuth H. pylori eradication therapy
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobatcer Pylori, First-Line Eradication
Efficacy And Safety of Bismuth-Tetracycline-Rabeprazole Triple For First-Line Eradication of Helicobacter Pylori Infection
Most international treatment guidelines currently recommend a 14-day bismuth quadruple therapy as the first-line treatment for Helicobacter pylori infection, especially in areas with high clarithromycin resistance.
- Trial name
- NCT07788053
- Testing
- Bismuth, Bismuth quadruple therapy
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chih-An Shih, MD
Gastric Ulcer, Chronic Gastritis
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
This study aims at evaluating efficacy and safety of berberine- amoxicillin containing quadruple therapy(berberine, amoxicillin, esomeprazole and bismuth) versus tetracycline-furazolidone quadruple therapy (tetracycline…
- Conditions
- Gastric Ulcer, Chronic Gastritis, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT03609892
- Testing
- Berberine, Amoxicillin, Esomeprazole
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection, Family History of Stomach Cancer
Comparison of 7-day PPI-based Standard Triple Therapy and 10-day Bismuth Quadruple Therapy for H. Pylori Eradication
In this randomized controlled trial, we investigate the effect of 10-day bismuth quadruple therapy in comparison with that of 7-day PPI-based standard triple as 1st line treatment for H. pylori.
- Trial name
- NCT02557932
- Testing
- Standard triple therapy, Bismuth quadruple therapy
- Where
- South Korea
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Dyspepsia, Helicobacter Pylori Infection
ERADICATE Hp - Treating Helicobacter Pylori With RHB-105
The "test and treat" strategy for treating dyspeptic patients who are H. pylori positive is rapidly becoming the standard of care. This study will test the effectiveness of RHB-105, a new triple therapy to treat H.
- Trial name
- ERADICATE Hp (NCT01980095)
- Testing
- RHB-105
- Where
- 12 sites in United States
- Volunteers
- 119 people
- Sponsor
- RedHill Biopharma Limited
Helicobacter Pylori Infection
A RCT of Triple Therapy With Proton Pump Inhibitor vs Vonoprazan for Helicobacter Pylori Gastritis
Helicobacter pylori (H. pylori) gastritis is a common bacterial infection among the elderly population. H. pylori infection causes chronic progressive gastric inflammation, peptic ulcer disease and gastric cancer.
- Trial name
- TRIVON (NCT03908619)
- Testing
- Omeprazole 20mg, Esomeprazole 20mg, Rabeprazole Sodium 20mg
- Where
- Singapore
- Volunteers
- 252 people
- Sponsor
- Changi General Hospital
Parkinson's Disease, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Study in Parkinson's Disease
It has been hypothesized, based on epidemiological observations, that Helicobacter pylori (HP) infection may play a role in the pathogenesis of Parkinson's Disease (PD).
- Trial name
- NCT02108704
- Testing
- Helicobacter pylori eradication therapy
- Where
- Malaysia
- Volunteers
- 75 people
- Sponsor
- University of Malaya
Helicobacter Pylori Infection
Gastric Swab for Helicobacter Pylori Detection
A randomized controlled trial for comparing the Helicobacter pylori test using the swap method and the method using the conventional biopsy.
- Trial name
- NCT05349578
- Testing
- swab RUT
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Seoul National University Hospital
Helicobacter Pylori Infection
Safety, Efficacy of Pylera BID Dosing in Eradication of H. Pylori
The purpose of this study is to evaluate the effect of Pylera when given twice a day. Pylera approved treatment schedule is 3 pills taken 4 times daily, in addition to omeprazole given twice daily.
- Trial name
- NCT00712413
- Testing
- OBMT
- Where
- 3 sites in United States, Canada
- Sponsor
- Forest Laboratories
Helicobacter Pylori Infection
Helicobacter Pylori First-line Treatment Containing Tetracycline in Patients Allergic to Penicillin
The purpose of this study is to assess and compare the effectiveness of levofloxacin-tetracycline -containing and metronidazole-tetracycline-containing quadruple regimens for the primary treatment of Helicobacter pylori infection…
- Trial name
- NCT05129176
- Testing
- Levofloxacin, Metronidazole
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
P-CABs-based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
Bismuth-containing quadruple therapy was recommended as a first-line treatment for Helicobacter pylori infection. This study aimed to compare real-world outcomes of various potassium-competitive acid blockers (P-CABs) -based…
- Trial name
- PRO-HP (NCT07285096)
- Testing
- Doctors prescribe Helicobacter pylori treatment regimens for patients based on current guidelines and consensus statements, tailored to individual circumstances，not involve any intervention procedures
- Where
- China
- Volunteers
- 1,730 people
- Sponsor
- Yueyue Li
Helicobacter Pylori Infection
Effect of PPIs on Stool DNA Test for H. Pylori
This prospective, self-controlled clinical study aims to evaluate the impact of proton pump inhibitor (PPI) use on the accuracy of stool DNA testing for Helicobacter pylori (H.
- Trial name
- NCT07516262
- Testing
- Proton Pump Inhibitor Discontinuation
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Infection
Standard Triple Therapy vs Sequential Therapy in Treatment of H Pylori Infection
Traditionally, H pylori infection has been treated with conventional triple therapy. This includes amoxicillin, clarithromycin and a proton pump inhibitor all given daily for 10-14 days.
- Trial name
- NCT01723059
- Testing
- Standard Triple Therapy, Sequential Therapy
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Dallas VA Medical Center
H. Pylori Infection
Efficacy of Vonoprazan Based Dual and Triple Therapy for Patient With Helicobacter Pylori Infection
This study aims to assess Efficacy of vonoprazan based dual and triple therapy for naïve patient with Helicopacter Pylori infection in Sohag Government .
- Trial name
- NCT07045688
- Testing
- Efficacy of Vonoprazan based dual therapy for naive patient with Helicobacter Pylori infection, Efficacy of Vonoprazan based triple therapy for naive patient with Helicobacter Pylori infection, Efficacy of PPI based triple therapy for naive patient with Helicobacter Pylori infection
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
H. Pylori Infections, Non-communicable Diseases
Effects of Fermented Rye Bran Products on Helicobacter Pylori (HP) Infection and Metabolic Risk Factors
The investigators hypothesize that long-term fermented high-fibre rye intake may reduce the Helicobacter pylori infection through dampening inflammation and thereby leading to lower adherence of the bacteria to surfaces.The…
- Trial name
- RyeClaim (NCT03103386)
- Testing
- intake of food product with a patented fermented rye bran, intake of food product with common refined wheat
- Where
- China
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Fudan University
HELICOBACTER PYLORI INFECTIONS
High-Dose Dual Therapy for H. Pylori Eradication (RETRO-HP Study)
Background: High-dose dual therapy (HDDT) has emerged as a potential first-line treatment for Helicobacter pylori infection, but its efficacy and safety across different regimens and populations remain unclear.
- Trial name
- RETROHP (NCT07121205)
- Testing
- This study is a retrospective study, and all data have been collected in advance with no active intervention required.
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Liyueyue
Helicobacter Pylori Infection
Head-to-head Study of Tegoprazan 50 mg BID Plus Amoxicillin 1 g TID vs. Vonoprazan 20 mg BID Plus Amoxicillin 1 g TID for H. Pylori Eradication
This study is a randomized, open-label, parallel-group clinical trial designed to compare two 14-day dual therapies for the eradication of Helicobacter pylori (H. pylori) infection.
- Trial name
- TV-HP (NCT07242456)
- Testing
- Tegoprazan, Amoxicillin, Vonoprazan
- Where
- China
- Volunteers
- 240 people
- Sponsor
- First People's Hospital of Hangzhou
Helicobacter Infection
Comparison of 7-day and 14-day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication
At present, triple therapy are recommended by various guidelines for the treatment of Helicobacter pylori (H. pylori) infection.
- Trial name
- NCT00841854
- Testing
- pantoprazole, bismuth, metronidazole
- Where
- South Korea
- Volunteers
- 199 people
- Sponsor
- Asan Medical Center
Helicobacter Pylori Infection
Helicobacter Pylori Eradication According to DPO-PCR Methods (K-CREATE) Study)
Clarithromycin-containing triple therapy is still the primary therapy approved by the Korean government. However, studies of antibiotic resistance have shown that regional resistance patterns to antibiotics such as clarithromycin…
- Trial name
- NCT04147065
- Testing
- Duration of eradication regimen
- Where
- South Korea
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Helicobacter Pylori Infection
Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt
The overall prevalence of H. Pylori in the developing countries is 50.8%, with the highest one presented in Africa (79.1%). Hybrid therapy is supposed to be more effective as a first-line regimen for Helicobacter pylori infection…
- Trial name
- NCT04039412
- Testing
- Hybrid regimen, Reverse hybrid regimen, Levofloxacin quadruple regimen
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Ayman Magd Eldin Mohammad Sadek