Clinical trials: H Pylori Infection
Helicobacter Pylori Infection, Intestinal Bacteria Flora Disturbance
Fucoidan Assisted Eradication of Helicobacter Pylori
The purpose of this study is to investigate whether the eradication rate of H.pylori will be improved when adding fucoidan to the duplex scheme combination of amoxicillin and vonoprazan, and to explore the effect of fucoidan on…
- Trial name
- NCT05461508
- Testing
- Amoxicillin combined with vonoprazan and fucoidan, Amoxicillin combined with vonoprazan
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Helicobacter Pylori Infection
Esomeprazole/Vonoprazan Combined With High-dose Amoxicillin Dual Therapy for Primary Eradication of Helicobacter Pylori Infection
This study intends to collect the clinical data of patients with Helicobacter pylori infection, and to observe and count the high-dose double therapy and the traditional quadruple / triple therapy ( i.e., esomeprazole +…
- Trial name
- NCT06250634
- Testing
- esomeprazole + amoxicillin, esomeprazole + amoxicillin + clarithromycin + colloidal bismuth tartrate agent, Vonoprazan + amoxicillin
- Where
- China
- Volunteers
- 806 people
- Sponsor
- The Third Xiangya Hospital of Central South University
HELICOBACTER PYLORI INFECTIONS
to Assess the Eradication Rate of 14-day Bismuth/Amoxicillin/PCAB Triple Therapy for the Treatment of Helicobacter Pylori Infection
To assess the efficacy and safety of 14-day bismuth/amoxicillin/PCAB triple therapy for the treatment of Helicobacter pylori infection in Taiwan
- Trial name
- NCT07142798
- Testing
- Bismuth amoxilillin potassium
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University
Gastritis
A Multi-center Study for Eradication of Refractory Helicobacter Pylori
Recently studies showed that the eradication rate of H. pylori fail to exceed 80% and even falls into an unacceptable range. A major cause of treatment failure is associated with antibiotic resistance and poor patient compliance.
- Trial name
- NCT02741414
- Testing
- The result of H pylori culture based on gram staining and enzyme activity testing, The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole, The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
- Where
- China
- Volunteers
- 4,428 people
- Sponsor
- Taizhou Hospital
Nephrotic Syndrome, Glomerulonephritis
The Effects of Helicobacter Pylori Eradication on Proteinuria in Patients With Membranous Nephropathy
Membranous nephropathy (MN) may also be secondary to many other diseases (e.g., infections, drugs, neoplasms and autoimmune diseases). In this study, the presence of Helicobacter Pylori (H.
- Conditions
- Nephrotic Syndrome, Glomerulonephritis, Membranous Nephropathy
- Trial name
- NCT00983034
- Testing
- lansoprazole, amoxicillin, clarithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul University
Helicobacter Pylori Infection, Peptic Ulcer Hemorrhage
Diagnostic Performance of CIM for Helicobacter Pylori Infection in Patients With Peptic Ulcer Bleeding
The goal of this cross-sectional study is to evaluate the efficacy of current infection marker (CIM) method for H. pylori detection. The main questions it aims to answer are: To evaluate the efficacy of CIM method for H.
- Trial name
- CIM (NCT06273384)
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Helicobacter Pylori Infection
Saccharomyces Boulardii as Pretreatment Before Rescue Therapy of Helicobacter Pylori
The increasing rate of drug resistance in often leads to eradication failure and the need for rescue therapy, and it is of great significance to explore new rescue therapeutic regimens.
- Trial name
- NCT05191875
- Testing
- Saccharomyces Boulardii 250 MG, Ilaprazole.Doxycycline. Furazolidone. Colloidal Bismuth Tartrate
- Where
- China
- Volunteers
- 106 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Gastric Cancer, Helicobacter Pylori Infection
Gastric Cancer Prevention in the Family Members by Helicobacter Pylori Eradication
This study evaluate whether treatment of Helicobacter pylori infection reduces the incidence of gastric cancer in subjects with family history of gastric cancer.
- Conditions
- Gastric Cancer, Helicobacter Pylori Infection, Family Members
- Trial name
- NCT01678027
- Testing
- LAC triple therapy
- Where
- South Korea
- Volunteers
- 1,838 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Helicobacter Pylori Infection
Triple Therapy Versus Quadruple Therapies in the First Line Therapy of Helicobacter Pylori Infection
Whether non-bismuth quadruple therapy (concomitant therapy) is more effective than bismuth quadruple therapy or triple therapy for 14 days remains unknown.
- Trial name
- NCT01906879
- Testing
- triple, quadruple, non-bismuth quadruple therapy
- Where
- 10 sites in Taiwan
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection, Children, Only
Treatment Adherence And Influencing Factors in Children With Helicobacter Pylori Infection During Eradication Therapy
The aim of this study is to describe the current status of treatment adherence in children with Helicobacter pylori infection, understand the medication literacy, medication beliefs of the children, knowledge of H.
- Trial name
- NCT06396780
- Where
- China
- Volunteers
- 233 people
- Sponsor
- Wei XIA, PhD
Neoplasm, Stomach, H. Pylori Infection
Early Detection and Screening Strategy of Gatric Cancer in Sichuan Province-A Prospective Cohort Study (WCH-GC-SIGES-01)
To establish prospective cohort of healthy population and corresponding serum sample bank in Sichuan province to provide platform for exploring early diagnosis and screening strategy of gastric cancer by a prospective cohort…
- Conditions
- Neoplasm, Stomach, H. Pylori Infection, Chronic Atrophic Gastritis
- Trial name
- SIGES-01 (NCT03597672)
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Jian-Kun Hu
Duodenal Ulcer, Helicobacter Pylori Infection
Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection
The aims of this study are (1) to evaluate the prevalence rate of PM of CYP2C19 in our country; (2) to evaluate the efficacy of dual therapy with different dose of omeprazole and amoxicillin; (3) to judge the relationship of…
- Trial name
- NCT00854451
- Testing
- omeprazole plus amoxicillin
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- National Taiwan University Hospital
Inflammatory Bowel Diseases, Helicobacter Pylori Infection
The Relationship Between Helicobacter Pylori Infection and Inflammatory Bowel Diseases: A Real-life Observation
Numerous epidemiological studies have investigated the association between Helicobacter pylori (H. pylori) infection and inflammatory bowel disease (IBD) with various conflicting results.
- Trial name
- NCT04708405
- Testing
- Observation
- Where
- Egypt
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa
The GAstric Precancerous Conditions Study
Gastric cancer afflicts 27,000 Americans annually and carries a dismal prognosis. One reason for poor outcomes is late diagnosis, as the majority of gastric cancers in the United States are diagnosed at a relatively advanced…
- Conditions
- Gastric Cancer, Intestinal Metaplasia of Gastric Mucosa, Helicobacter Pylori Infection, Atrophic Gastritis
- Trial name
- GAPS (NCT04191551)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Stanford University
Helicobacter Pylori Infection
Influence of Oral Hp Infection and Oral Related Factors on Gastric Hp Infection and Eradication Therapy
Helicobacter pylori (H. pylori) is closely related to the occurrence of gastric cancer and other diseases. The discovery and eradication of H. pylori is of great significance for the prevention and treatment of related diseases.
- Trial name
- Hp (NCT05455372)
- Testing
- PPI quadruple therapy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Helicobacter Pylori Infection
Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication
The researchers collect treatment-naive H.pylori-positive patients from the outpatient clinic. The subjects were randomized to receive a 10-day or 14-day course of quadruple eradication therapy.
- Trial name
- NCT05049902
- Testing
- Amoxicillin, Clarithromycin, Tetracycline
- Where
- 6 sites in China
- Volunteers
- 1,300 people
- Sponsor
- Shandong University
Helicobacter Pylori Infection
The Effect of Broccoli Sprout Extract and Probiotics for Eradication of Helicobacter Pylori
In Korea, the first-line therapy to treat Helicobacter pylori (Hp) consists of a proton pump inhibitor (PPI) and two antibiotics for one week.
- Trial name
- NCT03220542
- Testing
- Probiotics, Broccoli, Esomeprazole
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Kyunghee University Medical Center
Helicobacter Pylori Infection, Peptic Ulcer
Effectiveness of GastimunHp Plus in Supporting the Treatment of Peptic Ulcer Disease With Helicobacter Pylori Infection
Challenges in the treatment of Helicobacter pylori (H. pylori) include increasing antimicrobial resistance and patient's low tolerance to some regimens. Lactobacillus johnsonii (L.
- Trial name
- GasHp (NCT04025983)
- Testing
- GastimunHp Plus
- Where
- Vietnam
- Volunteers
- 190 people
- Sponsor
- Institute of Gastroenterology and Hepatology, Vietnam
Helicobacter Pylori Infection
Efficacy of Nitazoxanide Based Therapy vs Standard Triple Therapy in H-pylori in Children
This study aimed at comparing the efficacy of nitazoxanide-based triple therapy versus standard triple therapy for eradication of Helicobacter pylori infection in children at a tertiary care hospital.
- Trial name
- NCT07086937
- Testing
- Nitazoxanide, Metronidazole, PPI
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Muhammad Aamir Latif
Helicobacter Infection
The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection
As increasing the antibiotics resistance, the effectiveness of traditional Helicobacter pylori (H. pylori) therapies has been declined coincidentally. In this study, the investigators evaluated the efficacy of H.
- Trial name
- NCT02359331
- Testing
- H. pylori culture and antimicrobial susceptibility testing, 14 days empirical bismuth quadruple therapy (Proton pump inhibitor), Metronidazole
- Where
- South Korea
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital