Clinical trials: HBP
Eclampsia
Point-of-care Ultrasound Abnormalities in Eclampsia
Preeclampsia (PE) and eclampsia remain leading causes of maternal morbidity and mortality, in both high-, low-and-middle-income countries.
- Trial name
- NCT05678062
- Testing
- Point-of-care ultrasound
- Where
- South Africa
- Volunteers
- 70 people
- Sponsor
- University of Cape Town
Pulmonary Hypertension
FREEDOM - M: Oral Treprostinil as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study was an international, multicenter, randomized (2:1 active:placebo), double-blind, placebo-controlled study in subjects with PAH who were NOT currently receiving approved therapy for their PAH.
- Trial name
- NCT00325403
- Testing
- Oral treprostinil (UT-15C) Sustained Release Tablets
- Where
- 77 sites in United States, Austria and 11 more
- Volunteers
- 349 people
- Sponsor
- United Therapeutics
Hypertension, Systolic
Olive Polyphenols in Cardiovascular Prevention
The aim of this study is to evaluate whether the use of a commercially available standardized olive extract (Tensiofytol®) in individuals with elevated blood pressure 1.
- Trial name
- NCT04874961
- Testing
- Tensiofytol®
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- Nina Hermans
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Hypertension, Fracture
Immediate Fracture Risk After Antihypertensive Drug Initiation
This retrospective observational study aims to evaluate the short-term fracture risk associated with anti-hypertensive medication initiation using a self-controlled case series (SCCS) design and investigate temporal trends of…
- Trial name
- FADI (NCT06964217)
- Testing
- Monotherapy, Combination therapy
- Volunteers
- 10,000,000 people
- Sponsor
- Ajou University School of Medicine
Liver Cirrhosis, Portal Hypertension
Anticoagulation Therapy After Splenectomy in Cirrhosis Patient
1. Inclusion and Exclusion Criteria Inclusion criteria: Inpatients who received laparotomy or laparoscopic splenectomy according to clinical, B-ultrasound scan, CT or MRI diagnosis of cirrhosis and portal hypertension.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Anticoagulant-induced Bleeding, Thrombosis
- Trial name
- ATASICP (NCT04397289)
- Testing
- Heparin and Rivaroxaban
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cardiovascular Diseases, Heart Diseases
ACE Inhibition and Novel Cardiovascular Risk Factors
To determine the effects of an angiotensin converting enzyme inhibitor (ACE inhibitor), fosinopril, on multiple blood markers in 286 adults at high risk for cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00051389
- Testing
- Fosinopril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
- Trial name
- NCT05378750
- Testing
- Diuretic algorithm
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Trial name
- OSA-NORMO (NCT00741520)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pulmonary Hypertension
Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) on pulmonary artery pressure and right heart…
- Trial name
- NCT03637140
- Testing
- Simulated Altitude (FiO2: 15.1%)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Renal Insufficiency, Chronic, Hypertension
Mobile Health Technology for Chronic Kidney Disease Patients: Medication Management
Patients with complex, long-lasting conditions such as chronic kidney disease (CKD) often take multiple medications and frequently have serious medication problems, arising from poor communication between doctors and patients.
- Conditions
- Renal Insufficiency, Chronic, Hypertension, Medication Reconciliation, Mobile Applications
- Trial name
- NCT02905474
- Testing
- Usual Care, Integrated mobile medication app, Commercially available mobile medication app
- Where
- Canada
- Volunteers
- 182 people
- Sponsor
- University Health Network, Toronto
Obstructive Sleep Apnea Syndrome
Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS)
Obstructive sleep apnea syndrome (OSAS) is a common disease, with a prevalence evaluated between 5 - 7% in the general population.
- Trial name
- NCT00874913
- Testing
- measurement of ocular blood flow
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hypertension
Progression Evaluation and Genetic Determinants of Hypertension in Chinese - A Follow-up Study of Taiwan SAPPHIRe
The purpose of this study is to determine the progression evaluation and genetic determinations of hypertension in Chinese
- Trial name
- NCT00260910
- Where
- Taiwan
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Idiopathic Intracranial Hypertension (IIH)
Dural Venous Sinus Stent in Idiopathic Intracranial Hypertension
This study aims to identify clinical determinants and factors that predict outcome including primary outcome and secondary outcome depending on factors in individual patients with Idiopathic intracranial hypertension treated by…
- Trial name
- NCT06833424
- Testing
- Dural venous sinus stenting
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Glaucoma
Steroids Versus Non-steroidal Anti-inflammatory Drugs Following Glaucoma Surgery
This study aims to evaluate the eye pressure response to non-steroidal anti-inflammatory eye drops as compared to steroid eye drops following glaucoma surgery.
- Trial name
- NCT00956462
- Testing
- Ketorolac (NSAID) versus Dexamethasone (steroid)
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University Health Network, Toronto
Peripheral Artery Disease With Intermittent Claudication
Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF)
To study the effect of olmesartan on walking distance and quality of life in peripheral artery disease patients with hypertension treated For intermittent claudication.
- Trial name
- NCT02373462
- Testing
- Olmesartan, other anti-hypertensive drug
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Yonsei University
Severe Preeclampsia
Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia
Severe preeclampsia is a serious pregnancy complication that can lead to severe maternal and fetal outcomes, particularly when blood pressure is not adequately controlled.
- Trial name
- RELAPSE (NCT07547046)
- Where
- 14 sites in France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Cardiovascular Diseases, Heart Diseases
Home-Based Program to Treat High Blood Pressure in African Americans
The purpose of this study is to examine the effectiveness and cost effectiveness of two organizational interventions aimed at improving blood pressure (BP) control among a high-risk, African American home care population.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00139490
- Testing
- Health Education Program, Basic Group, Control Group
- Volunteers
- 846 people
- Sponsor
- Visiting Nurse Service of New York
Esophageal Varices
Cross-section Band Ligation Versus Stepladder Band Ligation of Esophageal Varices
The goal of this randomized controlled trial is to evaluate the cross-section band ligation technique versus the stepladder band ligation technique in esophageal varices prophylaxis.
- Trial name
- NCT06881082
- Testing
- endoscopic band ligation with cross-section technique, Endoscopic band ligation using stepladder technique
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Tanta University
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