Clinical trials: HBP
Hypertension, Renal
RENABLATE-II Feasibility Study of Catheter Based Renal Denervation to Treat Resistant Hypertension - 157
This is a prospective, multi-center, non-randomized, feasibility study to assess the safety and effectiveness of renal artery sympathetic denervation using the investigational devices in subjects with resistant hypertension.
- Trial name
- RENABLATE-II (NCT02095691)
- Testing
- Celsius® ThermoCool® Renal Denervation
- Volunteers
- 19 people
- Sponsor
- Biosense Webster, Inc.
Hypertension
Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension
The purpose of this study is to determine Korean red ginseng (KRG)treatment could decrease central blood pressure in subjects with hypertension.
- Trial name
- KRGCBP (NCT02211352)
- Testing
- Korean Red Ginseng Capsules
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Daegu Catholic University Medical Center
Intrahepatic Cholangiocarcinoma (Icc)
Efficacy and Safety of HAIC Combined With Lenvatinib and PD-1 Inhibitors for Advanced Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma (ICC), the second most prevalent primary malignant liver neoplasm, features highly aggressive biological behavior and dismal prognosis.
- Trial name
- LPHAIC for ICC (NCT07646717)
- Testing
- hepatic arterial infusion chemotherapy (Irinotecan liposome plus 5-FU/LV) combined with lenvatinib and PD-1 inhibitors
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Uncontrolled Hypertension
Renal Pelvic Denervation Pilot Trial
The RPD Pilot trial will evaluate the safety and effectiveness of Verve Medical's RPDTM renal denervation system for hypertensive patients with uncontrolled blood pressure despite use of two medications at a therapeutic dose.
- Trial name
- NCT07005050
- Testing
- RPD, Active hypertension medical therapy
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Verve Medical, Inc
Advanced Chronic Liver Disease, Surgery--Complications
Non-invasive Methods and Surgical Risk Stratification in Cirrhotics Undergoing Elective Extrahepatic Surgery
The ELASTO-SURGERY study aims to evaluate the prognostic role of portal hypertension evaluated by non-invasive methods in predicting post-operative morbidity (at 90 days) and mortality (at 365 days) in patients with advanced…
- Trial name
- NCT04615091
- Where
- 37 sites in United States, Austria and 10 more
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pulmonary Hypertension, Pulmonary Hypertension Associated With HFpEF
Percutaneous Pulmonary Artery Denervation (PADN) for the Treatment of Pulmonary Hypertension After Transcatheter Mitral Valve Edge-to-Edge Repair (M-TEER): A Prospective Cohort Study
this study aims to investigate the efficacy and safety of PADN therapy compared with standard medical therapy in patients diagnosed with pulmonary hypertension after M-TEER, thereby providing evidence for clinical treatment…
- Trial name
- NCT07662655
- Testing
- Percutaneous Pulmonary Artery Denervation (PADN), Control group (receiving standard medical therapy alone)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiamen Cardiovascular Hospital, Xiamen University
Pulmonary Hypertension
Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure
A number of 100 patients with pulmonary hypertension associated with the left Heart failure scheduled for elective pulmonary arterial denervation (PADN) are randomized 1:1 to either PADN or control group.
- Trial name
- PADN-5 (NCT02220335)
- Testing
- Pulmonary arterial denervation, Standard treatment
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gastroesophageal Varices Hemorrhage, Gastrointestinal Cancer
Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding
In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.
- Conditions
- Gastroesophageal Varices Hemorrhage, Gastrointestinal Cancer, Received Oxaliplatin-based Chemotherapy
- Trial name
- NCT05141617
- Testing
- Endoscopic treatment, TIPS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Hypertension
Conquering Hypertension in Vietnam: Solutions at Grassroots Level
The objectives of the proposed project are to evaluate the implementation and effectiveness of two multi-faceted community and clinic-based strategies on the control of elevated blood pressure (BP) among adults in Vietnam via a…
- Trial name
- HY-TREC (NCT03590691)
- Testing
- Vietnam National Hypertension Program, Expanded community health worker services, Storytelling intervention
- Where
- Vietnam
- Volunteers
- 671 people
- Sponsor
- Ministry of Health, Vietnam
High-Normal Blood Pressure, Mild Essential Hypertension
Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension
Aspirin (ASA) has been shown to provide marked benefits in the prevention of cardiovascular events, although the potential direct effects of ASA on cardiovascular function remain uncertain.
- Trial name
- NCT00449618
- Testing
- Aspirin 100 mg, Ambulatory blood pressure monitoring, Chronotherapy, timing of medication
- Where
- 5 sites in Spain
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Pulmonary Arterial Hypertension, Heart Defects, Congenital
The Effects of the Otago Exercise Program
The objective of this experimental study is to conduct a comparative evaluation of the effects of a supervised Otago Exercise Program (OEP) functional exercise capacity, blood lactate levels, dyspnea, fatigue, peripheral muscle…
- Trial name
- NCT06172790
- Testing
- Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Pulmonary Hypertension, Familial Persistent, of the Newborn
A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
This study will evaluate whether IV sildenafil can reduce the time on inhaled nitric oxide treatment and reduce the failure rate of available treatments for persistent pulmonary hypertension of the newborn.
- Trial name
- NCT01720524
- Testing
- iv sildenafil
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 59 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Resistant Hypertension
Arterial Stiffness as a Tool to Investigate Adherence in Resistant Hypertension
According to WHO estimates, worldwide, 1.28 billion adults between the age of 30-79 years have hypertension. Furthermore, only 1 in 5 people with hypertension have it under control.
- Trial name
- INSIDE-RH (NCT07207226)
- Testing
- Laser doppler vibrometry
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Retinal Detachment, Optic Neuropathy
Effect of Intraocular Tamponade on Visual Perception
Intraocular tamponade used in vitrectomy operations may affects retinal function in various mechanisms.
- Conditions
- Retinal Detachment, Optic Neuropathy, Glaucoma
- Trial name
- NCT05543018
- Testing
- Electroretinogram, Vitrectomy operation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Idiopathic Pulmonary Arterial Hypertension
Virtual Reality in Patients With Pulmonary Hypertension: A Randomized Controlled Trial
The goal of this research is to investigate the effectiveness of exercise administered via immersive virtual reality in patients with pulmonary hypertension, thereby contributing to the existing literature on this subject.
- Trial name
- NCT07558460
- Testing
- Virtual Reality Group
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Glaucoma, Intraocular Pressure
Impact of Home Intraocular Pressure Telemonitoring on Intraocular Pressure Control and Glaucoma Progression
The goal of this clinical trial is to conduct a study randomizing glaucoma patients to home intra-ocular pressure (IOP) telemonitoring combined with Smart phone-based intervention (Management Paradigm I) or Smart phone-based…
- Conditions
- Glaucoma, Intraocular Pressure, Primary Open Angle Glaucoma
- Trial name
- NCT05940623
- Testing
- Home IOP telemonitoring with smart phone-based intervention, Standard care and smart phone-based intervention
- Where
- Hong Kong
- Volunteers
- 142 people
- Sponsor
- The University of Hong Kong
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes, Hypertension
Free Fatty Acid-Induced Hypertension in Obese Subjects With Type 2 Diabetes
Insulin resistance has been implicated as the central pathogenetic feature of cardiovascular risk factor cluster that includes hypertension, impaired glucose tolerance, diabetes, dyslipidemia, and hemostatic disorders.
- Trial name
- NCT00738023
- Testing
- Rosiglitazone, Normal saline 0.9%, Intralipid 20%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emory University
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