Clinical trials: HBV Reactivation, active
Resolved Hepatitis B, CD20 Positive B-cell Lymphoma
Entecavir Prophylaxis for Hepatitis B Reactivation for CD20 Positive B-cell Lymphoma Patients With Resolved Hepatitis B (Negative Hepatitis B Surface Antigen, Positive Hepatitis B Core Antibody)
This phase 2 trial aims to evaluate the efficacy of entecavir prophylacxis for hepatitis B virus (HBV) reactivation that continues until 6 months after completing CD20 monoclonal antibody therapy in patients with CD20-positive…
- Trial name
- REHEB (NCT05453435)
- Testing
- Entecavir
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Sun Yat-sen University
Occult Hepatitis B Infection in Cancer Patients
Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy.
The goal of this observational study is to evalue the cumulative proportion of patients with OBI who do not develop HBsAg seroreversion and/or an increase of serum HBV DNA by at least 1 log above the lower limit of detection of…
- Trial name
- NCT06347588
- Testing
- Observational: Blood sample of HVB-specific Elispot assay, HBSAg, HBV-DNA
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Hepatitis B Reactivation, Hematopoietic Stem Cell Transplantation
Prophylactic Entecavir for HBV Reactivation in Past HBV Infected Patients With Hematopoietic Stem Cell Transplantation
This study is a randomized, prospective, comparative study of the effectiveness of prophylactic entecavir treatment for HBV reactivation in past HBV infected patients (HBsAg-, HBcIgG+) with allogeneic hematopoietic stem cell…
- Conditions
- Hepatitis B Reactivation, Hematopoietic Stem Cell Transplantation, Antiviral Drug, HBV
- Trial name
- NCT04942886
- Testing
- Baracle Tab.®
- Where
- South Korea
- Volunteers
- 226 people
- Sponsor
- Seoul St. Mary's Hospital
HBV Reactivation, HSCT
HBV Reactivation Prediction Model in Allo-HSCT
Hepatitis B virus (HBV) reactivation is a serious complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT), particularly in patients with resolved HBV infection (HBsAg-negative, anti-HBc-positive).
- Trial name
- HBV-post HSCT (NCT07644026)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 300 people
- Sponsor
- Xiao Hui Zhang
HBV
HBV Reactivation in Immunocompromised Patients (REANT STUDY)
Background/Objective: Comorbidities represent a critical risk factor in the prognosis of patients receiving immunosuppressive therapy.
- Trial name
- NCT07529171
- Testing
- Antiviral
- Where
- 16 sites in Turkey (Türkiye)
- Volunteers
- 490 people
- Sponsor
- Yaşar Bayındır, MD
HBV (Hepatitis B Virus), HIV Infection
Occult Hepatitis B Virus Infection and HBV Reactivation After Switching to Long Acting Therapy in Patients With HIV-1
The primary objective of the present project will be to investigate the risk of HBV reactivation (from virological reactivation to overt HBV infection) in HIV-1 carriers with occult HBV infection (OBI, is characterized by the…
- Trial name
- OBILART (NCT06728917)
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Hepatitis B Reactivation
TAF to Prevent HBV Reactivation in Cancer Patients
Tenofovir alafenamide (TAF) has been approved to prevent HBV reactivation for HBsAg-positive cancer patients receiving chemotherapy. However, the real-world effectiveness and safety of TAF for cancer patients was lacing.
- Trial name
- NCT04619082
- Testing
- Tenofovir alafenamide
- Where
- 5 sites in Taiwan
- Volunteers
- 102 people
- Sponsor
- Chiayi Christian Hospital
Chronic Hepatitis b, Hepatitis B Reactivation
Chronic Hepatitis b Patients Switch to tAf After Discontinuation of Nucleoside Analogue
We will conduct a phase 4, multicenter, open-label trial at 8 academic centers in Taiwan. Chronic hepatitis B patients receiving oral antiviral therapy (entecavir [ETV], tenofovir disoproxil fumarate [TDF]) for at least 1 year…
- Trial name
- CHANGE (NCT04496882)
- Testing
- Vemlidy
- Where
- 8 sites in Taiwan
- Volunteers
- 260 people
- Sponsor
- National Taiwan University Hospital