Clinical trials: HEALTHY INDIVIDUALS
Pharmacokinetics
Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 50 μg/ 75 μg Tablets
The purpose of this study is to measure the area under the curve (AUC0-48h; extent of systemic availability) and the maxi-mum concentrations (Cmax) of total serum levothyroxine (TT4, bound and free fraction) after a single…
- Trial name
- NCT01465633
- Testing
- levothyroxine
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Cystic Fibrosis, Bronchiectasis Adult
Bacille Calmette-Guerin (BCG) Vaccine for Immune Protection Against Infections
This is pilot study of the immunologic effects of intradermal Bacille Calmette-Guerin (BCG) vaccination of adults with cystic fibrosis (CF), non-CF bronchiectasis (NCFB), and healthy volunteers.
- Conditions
- Cystic Fibrosis, Bronchiectasis Adult, Non-Tuberculous Mycobacteria
- Trial name
- NCT04884308
- Testing
- BCG TICE Vaccine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV Infections
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Immunogenicity of Recombinant Envelope Protein rgp120/HIV-1SF2 (BIOCINE) Combined With Seven Adjuvants in Healthy HIV-1 Uninfected Individuals
To determine in healthy HIV-negative volunteers the safety and immunogenicity of rgp120/HIV-1SF2 (BIOCINE) formulated with each of seven adjuvants.
- Trial name
- NCT00001042
- Testing
- Aluminum hydroxide, Lipid A, Monophosphoryl, Lipid A, Liposome-encapsulated monophosphoryl
- Where
- 3 sites in United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Lifestyle, Health Behavior
Effects of Online Pilates and Face-To-Face Pilates on Healthy Individuals
Many studies on pilates have shown that these exercises positively affect the endurance of core muscles, mental health, and quality of life in healthy individuals when applied face-to-face.
- Trial name
- COVID (NCT05309486)
- Testing
- Online and Face-to-face Pilates trainings
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Prediabetes
PREPARE: "Prediabetes Research and Education Promoting Activity & Responsible Eating"
The purpose of this study is to determine if a 6-month community-based prediabetes lifestyle and behaviour change intervention (called, PREPARE) for middle and older adults with prediabetes will result in positive lifestyle…
- Trial name
- PREPARE (NCT01396772)
- Testing
- PREPARE education program, standard of care presentation
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Brescia University College
Healthy Male Individuals
A Study of Pharmacokinetics and Safety of Ranolazine PR in Healthy Korean and Caucasian Male Subjects
The purpose of this study is: To assess the pharmacokinetic profile and safety of ranolazine PR in healthy Korean and Caucasian volunteers after oral administration of Ranolazine at the doses of 375, 500, 750mg after single and…
- Trial name
- NCT02817932
- Testing
- Ranolazine
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- A.Menarini Asia-Pacific Holdings Pte Ltd
Healthy
Relationship Between Modified Closed Kinetic Chain Upper Extremity Stability Test and Shoulder Endurance Test in Young Active and Sedentary Individuals
This study is planned to examine the relationship between Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) performance with Posterior Shoulder Endurance Test in healthy young adults.
- Trial name
- NCT06571435
- Testing
- Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), and Posterior Shoulder Endurance Test
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Constipation
Effect of L. Paracasei Strain Shirota on Constipation in Healthy US Adults
The objective of this study is to investigate the efficacy of daily consumption of a fermented milk containing LcS in reducing the frequency of bowel movement with hard or lumpy stools in generally healthy U.S.
- Trial name
- NCT06014008
- Testing
- Test product consumption group
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yakult U.S.A. Inc.
Respiratory Physiology
Expiratory Pressure in Healthy Individuals
The present study aims at enhancing our understanding of the influence of the mouthpiece configuration on the amplitude of oral pressures generated during a maximum expiratory pressure maneuver and on the neuromuscular…
- Trial name
- NCT06435793
- Testing
- MEP measurement - Surface EMG
- Where
- Belgium
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laboratory of Movement, Condorcet, Tournai, Belgium
Obstructive Airway Diseases
Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation
Investigating nasal muco-ciliary clearance by scintigraphy
- Trial name
- NCT04189016
- Testing
- Inhalation from a salt particle inhaler with or without content
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Liita Care ApS
Asthma
Voice Analysis in Asthmatic Patients With Machine Learning Models
Asthma can lead to various factors that impair voice production, including airway restriction, inflammation, and mucus production, resulting in changes in voice frequency and amplitude.
- Trial name
- NCT06820671
- Testing
- Recording voice samples
- Where
- Turkey (Türkiye)
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- MED-CASE
Gene Expression, Cardiometabolic Risk
Effects of Antioxidant Sugar vs Granulated Sugar on Metabolic Outcomes in Healthy and Cardio Metabolic Subjects
Study 1: To investigate the effects of antioxidant-rich sugar as alternative compared to granulated sugar on gene expression and other metabolic parameters in healthy subjects.
- Conditions
- Gene Expression, Cardiometabolic Risk, Metabolic Syndrome
- Trial name
- MSS (NCT04737044)
- Testing
- Study 1: MRBS, Study 2: White sugar & education module, Study 2: MRBS & education module
- Where
- Malaysia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Prehypertension (Elevated Blood Pressure) or Hypertension, Healthy
Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals
In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals.
- Trial name
- ACT-ON-ACUTE (NCT07048509)
- Testing
- Control-no treatment, Exercise
- Where
- Slovenia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Lipidemia, Healthy
Viscosity of Fibre Predicts Cholesterol-lowering in Healthy Individuals
To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals
- Trial name
- NCT03741621
- Testing
- Viscous Fibre Blend, Psyllium, Wheat Bran
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Timing of Meal and Caffeine Intake on Substrate Use and Exercise Efficiency
During the past decades, considerable emphasis has been directed to analyzing the potential role of caffeine on substrate use and exercise performance.
- Trial name
- NCT04106752
- Testing
- Caffeine
- Where
- Lebanon
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Learning, Cognitive Functioning
Dual Orexin Antagonism and Emotion and Affective Processing Study
In this study, the investigators will examine the effects of blocking the orexin system on human behaviour and brain function using daridorexant, a medication that inhibits orexin activity.
- Conditions
- Learning, Cognitive Functioning, Emotional Processing
- Trial name
- DOREA (NCT07267559)
- Testing
- Daridorexant 50 mg
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Awareness of COVID-19 in Turkey
Because COVID-19 is a new virus, it is believed that awareness assessment will inform and guide what steps should be taken and which groups should be targeted in terms of controlling the pandemic.
- Trial name
- NCT04357886
- Where
- Turkey (Türkiye)
- Volunteers
- 2,605 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Hyperbaric Oxygenation, Cardiorespiratory Fitness
Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT
This retrospective observational study evaluates physiological and cognitive changes following a series of 60 hyperbaric oxygen therapy (HBOT) sessions in healthy individuals.
- Conditions
- Hyperbaric Oxygenation, Cardiorespiratory Fitness, Cognition
- Trial name
- HBOT (NCT07596641)
- Testing
- Hyperbaric Oxygen Therapy - HBOT
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Sedentary Behavior / Physical Inactivity, Sedentary Healthy Young Individuals
Variable vs Fixed Auditory-Cued Stepping Training
This study investigates whether stepping training that uses an unpredictable, variable auditory cue - changing both the timing and the direction of each step - improves dynamic balance and stepping adaptability more than stepping…
- Conditions
- Sedentary Behavior / Physical Inactivity, Sedentary Healthy Young Individuals, Sedentary Lifestyle
- Trial name
- NCT07841379
- Testing
- Variable-Timing, Variable-Direction Auditory-Cued Stepping Training, Fixed-Timing, Fixed-Direction Auditory-Cued Stepping Training
- Where
- Egypt
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Beshoy Maher Rezk Hanna
Healthy
The Glycaemic Index of Manuka Honey
Five high methylglyoxal (460-667 mg/kg) Manuka honey samples were selected from different geographical locales around the North Island of New Zealand and tested for glycaemic index (GI) in 10 healthy volunteers in a…
- Trial name
- NCT01615588
- Testing
- Manuka Honey
- Where
- New Zealand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Waiariki Institute of Technology