Clinical trials: HEALTHY VOLUNTEERS
Healthy
Effect of External Heat on a Transdermal Granisetron Patch in Pharmacokinetics (PK) of Healthy Subjects
The purpose of this study is to determine the effect of heat applied to a granisetron transdermal patch in healthy subjects.
- Trial name
- NCT01073696
- Testing
- granisetron IV, granisetron patch
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Magnetic Resonance Imaging
Quantitative T1rho Magnetic Resonance Imaging in Healthy Subjects
T1rho imaging is a new MRI technique that has strong potential in neuroimaging. This technique does not require exogenous contrast agents and has high spatial resolution.
- Trial name
- NCT04993196
- Testing
- T1rho imaging
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Haemofiltration
Clinical Investigation of the Safety of the MediSieve Magnetic Haemofiltration System in Healthy Volunteers
This is a single-centre, non-randomised, prospective study to assess the safety of the MediSieve blood filtration system in healthy volunteers
- Trial name
- NCT05713188
- Testing
- MediSieve Magnetic Haemofiltration System
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- MediSieve Limited
Healthy Volunteers
Effects of Bifidobacterium Longum BB536 on Incidence of Acute Diarrhea and/or Respiratory- Related Illnesses in Children
This project aims to study the benefits of probiotics namely Bifidobacterium longum BB536 in prevention of acute diarrhea and/or respiratory-related illnesses, which are found common among children in Malaysia aged from 2 to 6…
- Trial name
- NCT02434042
- Testing
- BB536
- Where
- Malaysia
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Healthy Volunteers
A Phase 1 MAD Study of KINE-101 in Healthy Volunteers
This is a randomized, single-center, single-blind, placebo-controlled, dose-escalation Phase 1 clinical trial designed to evaluate the safety, tolerability, pharmacokinetic, and pharmacodynamic characteristics of multiple…
- Trial name
- NCT07324642
- Testing
- KINE-101
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kine Sciences Co., Ltd.
Type 2 Diabetes
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Healthy Subjects
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01454973
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Foundation for the National Institutes of Health
Hyperglycaemia (Diabetic), Healthy Volunteers
The Assessment of Single-Dose Safety,Tolerability, Pharmacokinetics and Pharmacodynamic of Globalagliatin Hydrochloride
This is a phase 1 randomized,double-blind,placebo-controlled study with single oral dose of globalagliatin hydrochloride (SY-004) administered to chinese healthy subjects to evaluated the safety, tolerability, pharmacokinetics…
- Trial name
- NCT03171623
- Testing
- globalagliatin hydrochloride
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yabao Pharmaceutical Group
Healthy Volunteers
Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN3918 in Healthy Volunteers
To evaluate the safety and tolerability of single ascending intravenous (IV) and subcutaneous (SC) doses and a multiple dose regimen.
- Trial name
- NCT03115996
- Testing
- REGN3918
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Health, Subjective
Benapenem PK Phase Ib Multiple-dose Study
A single-center, randomized, open-label, three-period and three-crossover trial design is adopted in the single-dose pharmacokinetic study. 12adult volunteers, are assigned to 3 groups, B1（250mg), B2 (500mg), and B3 (1000mg).
- Trial name
- NCT03578588
- Testing
- Banapenem
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sihuan Pharmaceutical Holdings Group Ltd.
Healthy
Pharmacokinetics, Mass Balance, and Metabolism of [14C]HSK31679 in Healthy Adult Male Volunteers.
This is a single-center, nonrandomized, and open design study to investigate the pharmacokinetics, mass balance, metabolism and excretion of HSK31679 in healthy male subjects.
- Trial name
- NCT06258746
- Testing
- [14C]HSK31679
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Xizang Haisco Pharmaceutical Co., Ltd
Healthy Volunteer Study
Pharmacokinetics of Tranexamic Acid After Oral, Intramuscular or Intravenous Administration: a Prospective, Randomised, Cross-over Trial in Healthy Volunteers.
This is a Phase 1 study which aims to determine the pharmacokinetics and local and systemic tolerance of tranexamic acid in healthy volunteers using a population approach after oral, intramuscular or intravenous administration.
- Trial name
- PharmacoTXA (NCT03777488)
- Testing
- Tranexamic Acid 1 gram intravenously, Tranexamic acid 2 grams oral solution, Tranexamic acid 1 gram intramuscular
- Where
- 2 sites in France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Safety
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of PRV-3279 in Healthy Subjects
This Phase 1b study will evaluate the safety of PRV-3279 in healthy adult subjects
- Trial name
- PREVAIL1 (NCT03955666)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Provention Bio, Inc.
Healthy Volunteers
A Drug-drug Interaction Study Evaluating the PK Effects of Obicetrapib on Atorvastatin and Rosuvastatin
A study to evaluate impact of Obicetrapib on PK levels of Atorvastatin and Rosuvastatin
- Trial name
- NCT06081166
- Testing
- Obicetrapib, Atorvastatin Calcium, Rosuvastatin Calcium
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- NewAmsterdam Pharma
Non-invasive Ventilation, High-frequency Ventilation
Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.
The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer, Lung Diseases
- Trial name
- ANIV (NCT02712190)
- Testing
- High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy Volunteers
Relative Bioavailability Study
To investigate relative bioavailability of crushed tablets suspended in apple sauce or water
- Trial name
- NCT02159313
- Testing
- Riociguat(Adempas,BAY63-2521)
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bayer
Infection, Human Immunodeficiency Virus
A Study of the Relative Bioavailability of BMS-626529 Administered as BMS-663068 From 150mg Low-dose Extended-release Tablets Compared to 600mg Reference Extended-release Tablets in Healthy Subjects
An oral dose in healthy subjects to determine the relative bioavailabilty of BMS-626529 administered as BMS-663068
- Trial name
- NCT02859259
- Testing
- BMS-663068 (1 tablet at 600 mg), BMS-663068 (4 tablets at 150 mg each tablet)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Depressive Disorder
PAXIL CR Bioequivalence Study
This study is to determine if controlled release paroxetine tablets manufactured at two different sites behave similarly in healthy volunteers.
- Trial name
- NCT00749359
- Testing
- Paxil CR
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Psoriatic Arthritis, Rheumatoid Arthritis
Activating the Cholinergic Anti-Inflammatory Pathway in Healthy Volunteers and People With Inflammatory Arthritis
This study is designed to investigate whether non-invasive ultrasound (US) that is optimized for stimulation and can elicit an anti-inflammatory response in people with Inflammatory Arthritis as compared to a sham intervention.
- Conditions
- Psoriatic Arthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- NCT06555562
- Testing
- Ultrasound Stimulation, Non-active ultrasound stimulation
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Surf Therapeutics
Healthy
Effect of Different Food Compositions on Bioavailability of BIIL 284 BS in Healthy Male Volunteers
food effect, relative bioavailability, pharmacokinetics, safety and tolerability
- Trial name
- NCT02273427
- Testing
- BIIL 284 BS, high fat meal, low fat meal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypercholesterolaemia
A Study of PCSK9 Inhibitor AK102 in Healthy Subjects
This is a first-in-human,randomized, double-blind, placebo-controlled, single dose escalation, phase 1 study to evaluate the safety, tolerability, PK/PD and immunogenicity of AK102 administered subcutaneously in healthy subjects.
- Trial name
- NCT04169386
- Testing
- AK102
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Akeso
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