Clinical trials: HEALTHY VOLUNTEERS
Hyperlipemia
Safety and Tolerability of SHR-1918 in Healthy Subjects
The primary objective of this study is to assess the safety and tolerability of SHR-1918 injection in healthy subjects. In addition, this study will provide information on pharmacokinetics and pharmacodynamics of SHR-1918…
- Trial name
- NCT05432544
- Testing
- SHR-1918
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Healthy Volunteer
A Cardiac Liability Study of Varegacestat in Healthy Participants
This clinical study is designed to study the effect of a single dose of varegacestat on cardiac repolarization in healthy adult participants.
- Trial name
- NCT06855264
- Testing
- varegacestat, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Immunome, Inc.
Healthy
Dose Extension Study of BIIX 1 XX in Healthy Young Male Volunteers
Safety, tolerability and pharmacokinetic study of BIIX 1 XX in healthy male volunteers.
- Trial name
- NCT02198287
- Testing
- BIIX 1 XX inhalation solution
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Isoagglutinin-Mediated Hemolysis, Probiotic Toxicity
Probiotic Ingestion and Isoagglutinin Titers
Background: Probiotics are oral food supplements containing live bacteria that may be beneficial to a person s digestion or general health.
- Trial name
- NCT00891787
- Testing
- Probiotic Supplement
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Volunteers, Hepatic Insufficiency
Ridaforolimus in Patients With Hepatic Insufficiency (MK-8669-046)
This study will evaluate the pharmacokinetics of ridaforolimus including the area under the concentration-time curve (AUC[0-infinity]) and maximum concentration (Cmax) after administration of a single dose of ridaforolimus in…
- Trial name
- NCT01043887
- Testing
- ridaforolimus
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Study In Healthy Adult Volunteers To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of PF-04427429
The purpose is to study the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-04427429 administered intravenously to healthy adult volunteers
- Trial name
- NCT01117233
- Testing
- PF-04427429
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Participants
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants
The purpose of this study is to measure the pharmacokinetics (PK-how the body processes the study drug) of elecoglipron in healthy participants when taken by mouth as different formulations.
- Trial name
- NCT07723833
- Testing
- Elecoglipron Reference Formulation Dose A, Elecoglipron Test formulation 1 Dose A, Elecoglipron Reference Formulation Dose B
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pregnancy, HIV-1-infection
Pre-Exposure Prophylaxis Dosing in Pregnancy to Optimize HIV Prevention (PREP-P)
This trial is a prospective, multi-center, randomized comparison study of 2 Pre-Exposure Prophylaxis (PrEP) pharmacokinetic (PK) dosing regimens from 1st trimester through 12 weeks following delivery (postpartum) to achieve study…
- Trial name
- NCT03834909
- Testing
- Standard dose Truvada®, Pregnancy-adjusted dose Truvada®
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
SARS-CoV-2, Prevention
The Safety and Tolerability of A8G6 COVID-19 Neutralization Antibody Combined With Nasal Spray
This is a randomized, double-blind, placebo-parallel intervention clinical study that will include approximately 108 healthy subjects based on inclusion and exclusion criteria.
- Trial name
- NCT06127498
- Testing
- A8G6 SARS-CoV-2 Neutralization Antibody combination nasal spray, A8G6 SARS-CoV-2 Neutralization Antibody nasal excipient
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Healthy Participants
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD5462 Following Single and Multiple Ascending Dose Administration to Healthy Volunteers
This study will assess the safety, tolerability, and pharmacokinetic (PK) of AZD5462 following single ascending dose (SAD) and multiple ascending dose (MAD) administration in healthy male and female participants and healthy…
- Trial name
- NCT04994106
- Testing
- AZD5462
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
A Study Of GSK679586A When Infused Into Healthy And Mild Asthmatic Volunteers
This is a two part study. Part I is designed to test single doses of GSK678586A in healthy volunteers. Part II is designed to test repeat doses (two doses) of GSK679586A in patients with mild asthma.
- Trial name
- NCT00411814
- Testing
- GSK679586
- Where
- 2 sites in Australia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain, Healthy
To Investigate Safety, Tolerability, and Pharmacokinetics of Treatment With BI 660848 Rising Single Doses (From 2 mg to 600 mg) Administered as Oral Drinking Solution (Powder in Bottle).
As a transition from preclinical investigations to clinical development in this first-in-human trial, safety, tolerability, and pharmacokinetics of BI 660848 will be assessed in human male volunteers using single rising oral…
- Trial name
- NCT01145014
- Testing
- BI 660848
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cholera Vaccination Reaction
Phase 1b Ascending Dose Study of PanChol in Healthy Volunteers
Cholera is a serious diarrheal disease that can be fatal within hours of onset. The current available cholera vaccines to prevent the disease are not very effective.
- Trial name
- PanChol (NCT07107516)
- Testing
- PanChol
- Where
- Zambia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Healthy
Single Rising Dose Study of BI 655088 Administered Intravenously in Healthy Male Volunteers
Investigation of safety and tolerability of BI 655088 following intravenous infusion of single rising doses and exploration of the pharmacokinetics and pharmacodynamics of BI 655088 after single dosing
- Trial name
- NCT02696616
- Testing
- BI 655088
- Where
- Belgium
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Phase 1a Study in Healthy Participants
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Oral HS-10506 in Chinese Healthy Subjects.
- Trial name
- NCT05953506
- Testing
- HS-10506
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Healthy Subjects
Effects of Barley Based Food Products on Metabolism and Gut Microflora
The main objective is to investigate gut microflora composition in relation to cardiometabolic risk markers, and to investigate the effects of 3 days intervention with a barley kernel based product on these variables.
- Trial name
- NCT02427555
- Testing
- Barley kernel bread, white wheat bread
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lund University
Healthy Volunteer
A Study of RG7667 in Healthy Volunteers
This randomized, double-blind, placebo-controlled study will evaluate the safety and pharmacokinetics of RG7667 in healthy volunteers.
- Trial name
- NCT01496755
- Testing
- RG7667
- Where
- 5 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Absolute Bioavailability
Absolute Bioavailability of Reslizumab in Healthy Subjects
The primary objective of this study is to assess the absolute bioavailability of reslizumab following administration of a single subcutaneous (sc) dose to healthy non-Japanese participants
- Trial name
- NCT01990443
- Testing
- Reslizumab IV, Reslizumab SC
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Gastric Emptying, Intestinal Transit Time
Impact of Different Dietary Fibers in Gastric Emptying Time and Intestinal Transit of Healthy Volunteers
The digestive process begins in the mouth and follows in the stomach and intestine. In the stomach the food is mixed with the gastric juices forming the chyme.
- Trial name
- NCT03982836
- Testing
- Soluble Dietary Fibers
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy Volunteers
Cannabis Effects on Electroencephalography
Background: Tetrahydrocannabinol (THC) is a partial CB1/CB2 agonist and causes its pharmacological effects by binding to cannabinoid receptors.
- Trial name
- CEG (NCT04316598)
- Testing
- Cannabis Sativa
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
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