Clinical trials: HELICOBACTER PYLORI INFECTIONS, active
Helicobacter Pylori Infection, Colorectal Cancer
European Implementation Study on Simultaneous Screening for Gastric and Colorectal Cancers
The EUGastScreen study is designed as a quality implementation study to explore gastric cancer screening strategies within organised cancer screening frameworks.
- Conditions
- Helicobacter Pylori Infection, Colorectal Cancer, Gastric Cancer
- Trial name
- EUGastScreen (NCT07873580)
- Testing
- Fecal sample acquisition for Helicobacter pylori stool antigen test, Upper endoscopy with biopsies, Colonoscopy with biopsies after bowel cleansing
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Helicobacter Pylori Infection
Vonoprazan-Amoxicillin Dual Therapy for Helicobacter Pylori Infection in United States Adolescents
Helicobacter pylori (H. pylori) is a common bacterial infection of the stomach that can cause chronic stomach inflammation, ulcers, and other digestive problems.
- Trial name
- NCT07860112
- Testing
- Vonoprazan, Amoxicillin
- Volunteers
- 55 people
- Sponsor
- Boston Children's Hospital
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of Second-Line Helicobacter Pylori Eradication
Subjects with persistent H. pylori infection after first-line treatment failure receives either a 14-day PPI-based moxifloxacin triple regimen (esomeprazole, amoxicillin, and moxifloxacin) or a 14-day P-CAB-bismuth-containing…
- Trial name
- NCT07855497
- Testing
- P-CAB-BM quadruple regimen, Moxifloxacin triple regimen
- Where
- South Korea
- Volunteers
- 141 people
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection
Factors Affecting Helicobacter Pylori Infection: Diet and Lifestyle Patterns
This cross-sectional observational study aims to determine the prevalence of Helicobacter pylori (H. pylori) infection among Information Technology (IT) professionals working in Hyderabad, India, and to identify dietary…
- Trial name
- NCT07837401
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Helicobacter Pylori Infection, Gastrointestinal Dysbiosis
Bacillus Probiotics With Bismuth Quadruple Therapy for Helicobacter Pylori Infection
Helicobacter pylori (H. pylori) is a very common gastrointestinal disease that colonises the human gastric mucosa and is a primary risk factor for chronic gastritis, peptic ulcer disease, and gastric cancer.
- Conditions
- Helicobacter Pylori Infection, Gastrointestinal Dysbiosis, Antibiotic-associated Adverse Events
- Trial name
- NCT07827170
- Testing
- RO water, LiveSpo CLAUSY, LiveSpo DIA30
- Where
- Vietnam
- Volunteers
- 336 people
- Sponsor
- Anabio R&D
Erosive Esophagitis, Heartburn
A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their Offspring
The main objective of the study is to compare the maternal, fetal, and infant outcomes of pregnant women who are exposed to vonoprazan during pregnancy with outcomes of an internal comparison cohort of pregnant women who are…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Non-erosive Gastroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06660342
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
HELICOBACTER PYLORI INFECTIONS
Feasibility and Performance of FFPE qPCR for Detection of Clarithromycin Resistance in Helicobacter Pylori
This prospective observational study aims to evaluate the feasibility and performance of real-time PCR (qPCR) performed on formalin-fixed, paraffin-embedded (FFPE) gastric biopsies to detect Helicobacter pylori infection and…
- Trial name
- HED-2T (NCT07821294)
- Testing
- q-PCR on FFPE gastric biopsies
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Clinique Bizet
Helicobacter Pylori Infection
Efficacy and Safety of Black Seed Oil With Vonoprazan Based Triple Therapy in Treatment of Helicobacter Pylori
The aim of this study is to: Evaluation of efficacy and safety of adding black seed oil with vonoprazan triple therapy ( vonoprazan ,clarithromycin and amoxicillin ) in eradication of Helicobacter pylori infection and this will…
- Trial name
- NCT05957432
- Testing
- Black Seed Oil Cap/Tab, Vonoprazan, Amoxicillin and Clarithromycin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
HELICOBACTER PYLORI INFECTIONS
Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori Infection
this Study Evaluating Safety and Effectiveness of (Proton Pump Inhibitor versus Vonoprazan) Based Triple Therapy with or without Zinc to Eradicate H. pylori Infection
- Trial name
- NCT07275827
- Testing
- zinc sulfate, Vonoprazan + amoxicillin + clarithromycin, proton pump inhibitor + amoxicillin
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Tanta University
HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection
Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residing in the gastric mucosa and using the mucus layer for protection from the stomach's high acidity.
- Conditions
- HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection, Helicobacter Pylori Infected Patients
- Trial name
- NCT07293910
- Testing
- Vonoparazan, Vitamin D, Probiotic
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tanta University
Helicobacter Pylori Infection, Gastritis
NLR and PLR in H. Pylori-Associated Gastritis
This cross-sectional study aims to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with Helicobacter pylori-associated gastritis at Assiut…
- Conditions
- Helicobacter Pylori Infection, Gastritis, Dyspepsia
- Trial name
- NCT07805005
- Volunteers
- 90 people
- Sponsor
- Assiut University
Myocardial Infarction, Helicobacter Pylori Infection
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction
Background: Potent antithrombotic therapy has improved prognosis for patients with acute myocardial infarction (MI) significantly, however, at a price of increased bleeding risk. Helicobacter pylori (H.
- Conditions
- Myocardial Infarction, Helicobacter Pylori Infection, GastroIntestinal Bleeding, Cardiovascular Diseases
- Trial name
- HELP-MI (NCT05024864)
- Testing
- Urea breath test (UBT)
- Where
- 35 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Helicobacter Pylori Infection
VA Dual Sequential Therapy
Sequential therapy for Hp was first introduced by Zullo et al. in 2000 and consists of two phases: the first phase involves proton pump inhibitors with one antibiotic, and the second phase involves proton pump inhibitors with two…
- Trial name
- JSHERO3 (NCT06929962)
- Testing
- Vonoprazan and Amoxicillin for the first 7 days, Vonoprazan and Amoxicillin for the first 5 days, Vonoprazan and Amoxicillin for the second 7 days
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
HELICOBACTER PYLORI INFECTIONS
Efficacy and Safety of 14-Day Vonoprazan-Minocycline Dual Therapy for Helicobacter Pylori Eradication
Investigators will enroll treatment-naïve H. pylori-positive patients according to the inclusion and exclusion criteria in the trial.
- Trial name
- NCT07757919
- Testing
- Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Tetracycline Dual Therapy, Vonoprazan-Minocycline Dual Therapy
- Volunteers
- 492 people
- Sponsor
- Qilu Hospital of Shandong University
HELICOBACTER PYLORI INFECTIONS
Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression
Background: Helicobacter pylori (H. pylori) infection affects approximately 50% of the global population and is closely associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Eradication of H.
- Trial name
- NCT07750938
- Testing
- Keverprazan Hydrochloride 20 mg TID, Minocycline 100 mg (10-Day Regimen), Keverprazan Hydrochloride 20 mg BID
- Volunteers
- 316 people
- Sponsor
- Qilu Hospital of Shandong University
Helicobacter Pylori Infection
Metronidazole- Versus Tinidazole-Based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication
This randomized, open-label clinical trial will compare two bismuth-containing quadruple therapies for the first-line treatment of Helicobacter pylori infection. Adults aged 18 years or older with confirmed H.
- Trial name
- NCT07746934
- Testing
- Metronidazole, Tinidazole 500mg, tetracyline
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Helicobacter Pylori Infection, Dyspepsia
Pylori Duo for Adjunctive Treatment and Prevention of Recurrence of Helicobacter Pylori Infection
This randomized, double-blind, placebo-controlled, single-center clinical trial will evaluate the efficacy and safety of Pylori Duo as an adjunctive treatment in adult patients with confirmed Helicobacter pylori infection.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Adverse Effects
- Trial name
- NCT07729293
- Testing
- Omeprazole, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole, Pylori Duo
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Gala Servicios Clinicos S.L.
Helicobacter Pylori Infection
Study on the Effect of Fecal Microbiota Transplantation on Eradication of Refractory Helicobacter Pylori Infection
To determine whether regulating the gut microbiota can contribute to the eradication of refractory H. pylori infection.
- Trial name
- NCT07704255
- Testing
- transanal fecal bacteria transplant
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Sichuan Provincial People's Hospital
Helicobacter Pylori Infection, Premalignant Lesion
Application of Artificial Intelligence on the Diagnosis of Helicobacter Pylori Infection and Premalignant Gastric Lesion
The aim of this study is to evaluate the impact of artificial intelligence (AI) assistance during routine upper endoscopy on gastric cancer-specific mortality.
- Trial name
- NCT05762991
- Testing
- Routine endoscopy with artificial intelligence-assisted interpretation
- Where
- Taiwan
- Volunteers
- 6,000 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection, Peptic Ulcer Disease
Vonoprazan High-Dose Dual VS Levofloxacin Concomitant
This is a randomized controlled trial comparing the efficacy and safety of two vonoprazan-based regimens: high-dose dual therapy (vonoprazan plus a single antibiotic) versus triple therapy (vonoprazan plus two antibiotics) for…
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer Disease, Gastritis
- Trial name
- NCT07624422
- Testing
- Vonoprazan, Levofloxacin 500mg
- Where
- Syria
- Volunteers
- 150 people
- Sponsor
- Damascus Hospital