Clinical trials: HF - Heart Failure
Sarcopenia, Exercise Intolerance
Prehabilitation for Cardiac Surgery in Patients With Reduced Exercise Tolerance
Among patients awaiting cardiac surgery, a significant proportion are patients with severe angina, heart failure (HF) and peripheral atherosclerosis.
- Conditions
- Sarcopenia, Exercise Intolerance, Heart Failure, Peripheral Artery Disease
- Trial name
- NCT04545268
- Testing
- Neuromuscular electrical stimulation (NMES), Transcutaneous electrical stimulation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Heart Failure
Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF
This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before…
- Trial name
- NCT07347925
- Testing
- Prehospital ARNI use, No prehospital ARNI use
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Future University in Egypt
Dilated Cardiomyopathy
Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy
This study is designed to assess the safety profile and the efficacy of cardiac repair cells (CRCs) administered via catheter in treating patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT01020968
- Testing
- Ixmyelocel-T, Vehicle Control
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Vericel Corporation
Cardiovascular Diseases, Chronic Heart Failure
The Effectiveness of Surgical Treatment of Patients With Ischemic Cardiomyopathy
The study focuses on the development of a new personalized approach to diagnostics and surgical treatment of patients with ischemic cardiomyopathy.
- Conditions
- Cardiovascular Diseases, Chronic Heart Failure, Ischemic Cardiomyopathy
- Trial name
- NCT04489355
- Testing
- coronary artery bypass graft (CABG) with surgical ventricular restoration (SVR) and mitral repair (MR)
- Where
- Russia
- Volunteers
- 260 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Sarcopenia in Elderly, Chronic Heart Failure
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure
The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.
- Trial name
- NCT06785168
- Testing
- Machine-based Resistance Training
- Where
- 2 sites in Vietnam
- Volunteers
- 146 people
- Sponsor
- Kieu Dang Phuong Nguyen
Heart Failure, Cancer, Therapy-Related
Identification of Anticancer Drugs Associated With Cancer Therapy-related Cardiac Dysfunction: a Pharmacovigilance Study
Therapeutic advances have significantly improved the survival of patients with cancer. However, these novel therapies are associated with a concomitant increase in the prevalence of toxicity, including cardiovascular…
- Trial name
- NCT06268535
- Testing
- Cancer therapy with FDA and/or European Medicines Agency approval on the 30th September 2023
- Where
- France
- Volunteers
- 36,580,288 people
- Sponsor
- University Hospital, Caen
Healthy Volunteers, Heart Failure
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict…
- Conditions
- Healthy Volunteers, Heart Failure, Aortic Stenosis, Ischemic Heart Disease
- Trial name
- NCT00830726
- Testing
- Pharmacologic and mechanical heart failure treatment, Aortic valve replacement, Revascularisation in Acute Coronary Syndrome
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Chronic Heart Failure
South Korean Pitavastatin Heart Failure Study
We want to evaluate the utility of statins on heart function according to potency. Patients with chronic ischemic heart failure are administered pitavastatin 4mg or pravastatin 10mg for 52 weeks.
- Trial name
- SAPHIRE (NCT00701285)
- Testing
- pitavastatin, pravastatin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- JW Pharmaceutical
Heart Failure
Bio-signal Telemonitoring Using Electronic Textiles in a Pediatric Population
There is a need for developing reliable and convenient technologies for telemonitoring of physiological signals such as respiration, cardiac function, and activity level in children and especially for those with heart disease.
- Trial name
- NCT04305340
- Testing
- Myant SKIIN Device
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aamir Jeewa
Chronic Heart Failure
Evaluation of NT PRO BNP Guided Therapy on Hospitalization Rate and Mortality in Patients With Chronic HF NYHA II-IY
To use continuous measurement of NT Pro BNP level as guide in therapy patients with CHF.
- Trial name
- NCT00469001
- Testing
- Treatment according NT Pro BNP level
- Where
- Israel
- Volunteers
- 108 people
- Sponsor
- Hillel Yaffe Medical Center
Heart Failure
Mobile Application for Patient Engagement and Physician-Directed Remote Management of Heart Failure
The ENGAGE-HF mobile application tracks three key features over time: (1) heart failure health status, (2) vital signs (e.g., blood pressure, heart rate) and weight, and (3) the quality of heart failure medication therapy.
- Trial name
- ENGAGE-HF (NCT06750549)
- Testing
- ENGAGE-HF Mobile Application
- Where
- 3 sites in United States
- Volunteers
- 134 people
- Sponsor
- University of Michigan
Heart Failure, Ischemic Cardiomyopathy
Scar Location and Acute Haemodynamic Response to MultiPoint Pacing Study in Patients With Ischemic Cardiomyopathy
Cardiac Resynchronization Therapy (CRT) is a proven treatment for heart failure. CRT consists of a special pacemaker with two/three leads (insulated wires which take the electrical impulses from the device to the heart), one in…
- Trial name
- NCT04066738
- Testing
- Cardiac MRI with gadolinium contrast, 3D reconstruction and location of coronary sinus venous system relative to myocardial scar, Acute haemodynamic measurements during CRT implant
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- Oxford University Hospitals NHS Trust
Ventricular Tachycardia, Ventricular Flutter
Feature Assessment Study for Indications Based Programming
The purpose of this evaluation is to assess the acceptance level of specific programming recommendations based on the patient's clinical needs and primary indications when using the feature 'Indications Based Programming' (IBP)…
- Conditions
- Ventricular Tachycardia, Ventricular Flutter, Ventricular Fibrillation, Heart Failure
- Trial name
- FASt-IBP (NCT00711893)
- Testing
- Cognis 100-D, Teligen DR and VR 100 HE
- Where
- 28 sites in Austria, Belgium and 9 more
- Volunteers
- 301 people
- Sponsor
- Boston Scientific Corporation
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
The purpose of this study is to determine possible alterations in cardiac function in patients with Rheumatoid Arthritis and Ankylosing Spondylitis under anti-TNF therapy, without clinical heart disfunction at baseline, using…
- Trial name
- NCT01072058
- Testing
- TNF blockers (infliximab, adalimumab, etanercept)
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Heart Failure
Alert-HF: Early Detection and Intervention on Atrial Fibrillation in Heart Failure Patients
The goal of this clinical trial is to learn if using heart monitoring devices can lower unplanned hospital visits in adults with heart failure (HF).
- Trial name
- Alert-HF (NCT07816458)
- Testing
- Implantable loop recorder, Patient-driven portable ECG monitoring, Usual Care
- Where
- Netherlands
- Volunteers
- 258 people
- Sponsor
- Medisch Spectrum Twente
Heart Failure, Atrial Fibrillation (AF)
Assessment of Medication Adherence in Ccu Admitted Patients
This study aims to assess medication adherence and the appropriateness of prescribed medications among patients admitted to the Coronary Care Unit (CCU).
- Trial name
- NCT07504406
- Testing
- No intervention (observational study)
- Where
- 2 sites in Iraq
- Volunteers
- 250 people
- Sponsor
- AlFayhaa General Hospital
Heart Failure, Ischemic Cardiomyopathy
18F-mFBG Imaging for Myocardial Sympathetic Innervation
This is a Phase 2 study evaluating the positron-emitting radiopharmaceutical 18F-mFBG as an imaging agent for quantification of myocardial sympathetic innervation.
- Conditions
- Heart Failure, Ischemic Cardiomyopathy, ICD Patients
- Trial name
- NCT06965621
- Testing
- 18F-metaFluorobenzylguanidine, Rubidium-82
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)
Hypertension
Finding Early Predictors of Myocardial Dysfunction in Patients With Hypertension
Finding early predictors of myocardial in patients with hypertension 1. Scientific objective The study objective is to clarify the grounds of heart exertional dyspnoea stenocardial pain in patients with well-controlled stage I or…
- Trial name
- dysh (NCT01455714)
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Heart Failure
Strategy to Recognize and Initiate Treatment of Chronic Heart Failure
The purpose of this study is to determine whether a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized (or unestablished) heart failure in primary care will improve the functional capacity…
- Trial name
- STRETCH (NCT01202006)
- Testing
- Training of general practitioners in an uptitration protocol.
- Where
- Netherlands
- Volunteers
- 585 people
- Sponsor
- UMC Utrecht
Heart Failure With Preserved Ejection Fraction, Chronic Pulmonary Thromboembolism (Disorder)
The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
To evaluate the role of exercise hemodynamic testing in the diagnostic workup for patients with dyspnea on exertion referred to the catheterization lab.
- Trial name
- EX_CATH (NCT05490901)
- Testing
- Exercise hemodynamic test
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center