Clinical trials: HFpEF - Heart Failure With Preserved Ejection Fraction
Heart Failure
Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults
The purpose of this research is to see if the drug rapamycin will improve the heart's ability to pump by improving your oxygen consumption.
- Trial name
- NCT04996719
- Testing
- Rapamune
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Heart Failure With Preserved Ejection Fraction, Iron Deficiencies
The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life
This study will address whether the additional use of Ferric Derisomaltose on top of standard care will improve exercise capacity and quality of life in patients with acute heart failure and iron deficiency.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Iron Deficiencies, Acute Heart Failure
- Trial name
- COREVIVE-HFpEF (NCT05991128)
- Testing
- Ferric derisomaltose
- Where
- China
- Volunteers
- 170 people
- Sponsor
- China-Japan Friendship Hospital
Heart Failure，Congestive, Atrial Fibrillation
The Cardio-share Telemedicine Cross-sector Collaboration Model for Managing Vulnerable Patients With Heart Failure
The goal of this observational study is to explore the potential of implementing a telemedicine-based cross-sector collaboration model to manage patients with frequent admissions with decompensated heart failure.
- Trial name
- ADHFQUAL-BFH (NCT06176131)
- Testing
- Telemedicine-based cross-sector collaboration for patient management
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure
Effects of a Multidisciplinary Integrated Care Model on Care Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases and is associated with frequent hospitalizations, poor quality of life, and limited effective treatment options.
- Trial name
- MICM-HFpEF (NCT07798856)
- Testing
- Multidisciplinary Integrated Care Model (MICM), Usual Care
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chimei Medical Center
Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2
Phenotypes and Outcomes of Heart Failure With Preserved Ejection Fraction in Patients With Hypertension and Diabetes
Our study is the first multicenter study in Vietnam on clinical phenotypes of heart failure with preserved ejection fraction (HFpEF) in patients with concurrent type 2 diabetes (T2DM) and hypertension (HTN).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NCT04835194
- Where
- 2 sites in Vietnam
- Volunteers
- 233 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Heart Failure With Preserved Ejection Fraction
Polydiuretic Therapy for HFpEF, a Randomised Controlled Trial
Heart Failure (HF) in Australia affects 1-2% of the population. Heart failure with preserved ejection fraction (HFpEF) refers to a syndrome of clinical heart failure without impairment of systolic cardiac function.
- Trial name
- NCT05129722
- Testing
- Low dose combination polydiuretic therapy, Comparator monotherapy empagliflozin
- Where
- 2 sites in Australia
- Volunteers
- 3 people
- Sponsor
- The George Institute
Heart Failure, Heart Failure With Reduced Ejection Fraction
Effectiveness of CRD-740 in Heart Failure
This is a study evaluating the effectiveness of CRD-740 in patients with either Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Preserved Ejection Fraction (HFpEF) after 12 weeks of treatment.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction, Cardiovascular Diseases
- Trial name
- CARDINAL-HF (NCT05409183)
- Testing
- CRD-740
- Where
- 34 sites in United States, Canada and 2 more
- Volunteers
- 60 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.
Shear Wave Elastography, Heart Failure With Preserved Ejection Fraction
Shear Wave Elastography for Diagnosis of Heart Failure With Preserved Ejection Fraction
The diagnosis of heart failure with preserved ejection fraction (HFpEF) is often complex. Echocardiography has the advantages of being a non-invasive, simple operation, low price, and high repeatability, and is of great value in…
- Trial name
- NCT06282822
- Testing
- Transthoracic echocardiography
- Volunteers
- 800 people
- Sponsor
- First Hospital of China Medical University
Type2diabetes, Heart Failure With Preserved Ejection Fraction
Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF)
The study team is studying how increasing dietary fiber, specifically through adding potato starch to participant's diet, may impact the species of bacteria in participant's gut microbiome.
- Trial name
- NCT06337812
- Testing
- Potato Starch
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Chronic Heart Failure, Preserved Ejection Fraction
Chronic Heart Failure With Preserved Ejection Fraction - COngestion eValuation
Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF.
- Trial name
- CHF-COV-P (NCT05097898)
- Testing
- Clinical examination centered on congestion, Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Blood and urine sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure With Preserved Ejection Fraction, Coronary Microvascular Dysfunction
A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
To evaluate the effect of CS reducer implantation in patients with HFPEF and CMD on myocardial ischemia, measured by stress myocardial perfusion using cardiovascular magnetic resonance (CMR)
- Trial name
- NCT07093528
- Testing
- Cardiovascular Magnetic Resonance (CMR)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Heart Failure, Diastolic
External Body Pressure in Heart Failure With Preserved Ejection Fraction
The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and…
- Trial name
- NCT05764564
- Testing
- Positive or negative pressure
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duke University
Combined Pre- and Post-capillary Pulmonary Hypertension, CpcPH
Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH)
This clinical trial will evaluate whether combination therapy with Dapagliflozin + Macitentan improves outcomes compared to Dapagliflozin + placebo in patients with combined pre- and post-capillary pulmonary hypertension (CpcPH).
- Conditions
- Combined Pre- and Post-capillary Pulmonary Hypertension, CpcPH, HFmrEF, HFpEF
- Trial name
- NCT07147114
- Testing
- Combination therapy, Monotherapy
- Where
- 15 sites in South Korea
- Volunteers
- 64 people
- Sponsor
- Gachon University Gil Medical Center
Heart Failure With Preserved Ejection Fraction
Effort-Lung Ultra Sound
The E-LUS study is a prospective, non randomised, monocenter case-control study. The main objective is to evaluate the association of exercise lung ultrasound data acquired during a stress test on a bicycle ergometer with the…
- Trial name
- E-LUS (NCT04644692)
- Testing
- Lung ultrasound
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Heart Failure With Preserved Ejection Fraction, Malnutrition
A Single-center Retrospective Cohort Study to Explore the Prognostic Significance of CONUT in Elderly CAD Patients With HFpEFand Compare CONUT With Other Objective Nutritional Indices.
HF is an advanced or terminal stage of various heart diseases, with high rehospitalization and mortality rates. In HF patients, undernutrition is not uncommon and represents one of the most significant determinants of poor…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Malnutrition, Aged, Prognosis
- Trial name
- NCT05586828
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Beijing Tongren Hospital
Heart Failure, Diastolic
Exercise Training in Heart Failure With Preserved Ejection Fraction - a Long-term Follow-up
Exercise training is an effective therapy for patients with heart failure with preserved ejection fraction. However, it is unclear, whether a one-year intervention has a sustainable effect beyond the active study phase.
- Trial name
- NCT05162859
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- Technical University of Munich
Heart Failure, Diastolic
Respiratory Muscle Function in Heart Failure
This study is being done because investigators are trying to determine how respiratory muscle and lung function influence the exercise responses in heart failure and healthy participants.
- Trial name
- NCT03924479
- Testing
- PowerBreathe (Breathing muscle training)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease, Heart Failure
HFpEF and 2-year Mortality of COPD Patients
This study was designed to assess potential relationship between heart failure with preserved ejection fraction and 2- year mortality of patients with chronic obstructive pulmonary disease
- Trial name
- THERESE (NCT04277429)
- Testing
- Cardiac function assessment
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Olomouc
Heart Failure
Use of Oxygen in Heart Failure With Preserved Ejection Fraction
Oxygen is routinely given to patients with common conditions such as COPD and heart failure. There is no evidence behind giving oxygen to patients specifically in heart failure due to a stiff heart.
- Trial name
- STOP-EF (NCT02949531)
- Testing
- oxygen
- Volunteers
- 50 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Heart Failure With Preserved Ejection Fraction
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition have recently been reported in two clinical trials.
- Trial name
- NCT05562063
- Testing
- Sotagliflozin
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Juan Badimon