Clinical trials: HIV/AIDS, Medication Adherence
Adherence, Medication, Risk Behavior
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03387462
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV-1-infection
Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa
This is a prospective observational cohort study enrolling participants in South Africa and Uganda who are prescribed an HIV treatment regimen containing lamivudine, tenofovir, and dolutegravir, which is known as TLD.
- Trial name
- DISCO (NCT04066036)
- Testing
- This is an observational study only.
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 999 people
- Sponsor
- Massachusetts General Hospital
HIV, Alcohol Use Disorder
Naltrexone for Medication Compliance Among HIV-infected Men With Alcohol Use Disorder
This study will recruit 159 HIV-infected men with alcohol use disorders (AUDs). Men will be randomized to receive either oral naltrexone for the treatment of alcohol use disorder or placebo.
- Trial name
- NCT01377168
- Testing
- oral naltrexone
- Where
- Peru
- Volunteers
- 159 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV Infections
A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
Anti-HIV drug therapy works best when the drugs are taken exactly as prescribed by a doctor. Because anti-HIV therapy often involves multiple drugs, some people have difficulty taking them all correctly.
- Trial name
- NCT00036452
- Testing
- lopinavir/ritonavir, emtricitabine, stavudine
- Where
- 29 sites in United States, Puerto Rico and 1 more
- Volunteers
- 402 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adherence, Medication
Life-Steps Counseling to Enhance Adherence and Engagement in PrEP Care
The purpose of this study is to test how different types of interventions may affect how someone takes their pre-exposure prophylaxis (PrEP) medication.
- Trial name
- NCT04316715
- Testing
- Lifesteps for PrEP, Daily text message reminders
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Adherence, Medication, Risk Behavior
DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03771638
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
HIV Infection Primary
Assessing Differential Adherence to Medications and Quality of Life Among People Living With HIV and Comorbidities
The investigators propose to utilize quantitative and qualitative methodology to better understand the impact of multiple drug use (polypharmacy) on medication adherence as well as the driving forces behind differential adherence…
- Trial name
- TEAMH (NCT03387397)
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Northwell Health
HIV-1-infection, Non-Adherence, Medication
Outcomes of the PLHIV With Suboptimal Viral Suppression to Injectable Long-acting Antiretrovirals
This study aims to determine whether people living with HIV (PLHIV) with suboptimal medical adherence can achieve better viral suppression with long-acting antiretrovirals (LA) compared to all-oral antiretrovirals.
- Trial name
- SUPLA (NCT06507059)
- Testing
- cabotegravir/rilpivirine (600mg/ 900mg), Antiretroviral Combinations
- Where
- 4 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
HIV Seropositivity, Adherence, Medication
Supporting Health Behavior Among Persons Living With HIV Using Tech, MOST, and Behavioral Economics
The present study focuses on adult persons living with HIV in the New York City and Newark, New Jersey metropolitan areas who are not highly adherent to HIV medication and who do not evidence undetectable HIV viral load (the…
- Trial name
- SCAP2 (NCT04518241)
- Testing
- MI sessions, TMQQ, Type of compensation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- New York University
HIV Infection, Pregnancy
Antiretroviral Adherence Evaluation in HIV Pregnant and Postpartum Women
The purpose of this study is to compare adherence to antiretroviral therapy during pregnancy and postpartum, and to record adherence barriers and facilitators.
- Trial name
- NCT01621347
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
HIV, Substance Use
Adherence Intervention for HIV-infected Drug Users
Many people living with HIV use illicit drugs, which leads to worsened health outcomes and increased transmission of HIV due to poor adherence to medication regimens.
- Trial name
- NCT02907697
- Testing
- Life Steps-Drug Use, General Health Education
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Texas at Austin
Medication Adherence
China Adherence Through Technology Study
The CATS project is designed to increase understanding of interventions that are feasible and effective in helping injection drug users (IDU) or other patients at high risk of poor medication adherence who are HIV-positive to…
- Trial name
- CATS (NCT01722552)
- Testing
- adherence feedback, standard of care
- Where
- 2 sites in United States, China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV, Tuberculosis
Evaluation of South Africa's National Adherence Strategy
NOTE THAT THE STUDY IS LED BY SOUTH AFRICA NATIONAL DEPARTMENT OF HEALTH AND WORLD BANK WITH SUPPORT FROM BOSTON UNIVERSITY. The South Africa National Department of Health (NDOH) intends to launch its newly developed National…
- Conditions
- HIV, Tuberculosis, Diabetes, Hypertension
- Trial name
- ENHANCE (NCT02536768)
- Testing
- Minimum package of interventions to improve ART adherence
- Where
- South Africa
- Volunteers
- 8,020 people, healthy volunteers welcome
- Sponsor
- Boston University
Human Immunodeficiency Virus, Alcohol-Related Disorders
Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa
The purpose of this study is to test the effectiveness and implementation of a brief, integrated behavioral intervention for HIV medication adherence and substance use in the HIV care setting in South Africa.
- Conditions
- Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use
- Trial name
- NCT03529409
- Testing
- Project Khanya
- Where
- 2 sites in United States, South Africa
- Volunteers
- 66 people
- Sponsor
- University of Maryland, College Park
HIV/AIDS, Medication Adherence
Centralized Off-Site Adherence Enhancement Program
Our proposal "Centralized Off-Site Adherence Enhancement Program" or "CARE" will develop and test an effective behavioral adherence intervention program for HIV patients with alcohol and/or substance abuse problems.
- Trial name
- CARE (NCT01409655)
- Testing
- cognitive-behavioral therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, Los Angeles
Medication Adherence
Provider and Peer Support Intervention to Improve ART Adherence Among Kenyan Men Who Have Sex With Men
Antiretroviral therapy (ART) can improve health, prevent complications due to HIV infection, and prevent HIV transmission by making people less infectious.
- Trial name
- Shikamana (NCT02301533)
- Testing
- Shikamana Intervention, Standard Care
- Where
- Kenya
- Volunteers
- 60 people
- Sponsor
- University of Washington
HIV Infections
Pediatric Impact: Promoting Adherence to Medications Among HIV-infected Children
The purpose of the study is to develop and evaluate an intervention to promote adherence to HIV medications among children 5-12 years of age.
- Trial name
- NCT00134602
- Testing
- Needs assessment followed by tailored intervention
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections, Depression
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression.
- Trial name
- NCT00338767
- Testing
- Directly Observed Therapy (DOT), Fluoxetine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
HIV Infections
Observational Study of Nevirapine Extended Release in Human Immunodeficiency Virus (HIV) Patients in Daily Clinical Practice
This Post Marketing Surveillance study will be performed as an open-label, prospective, non-interventional, uncontrolled study in Human immunodeficit Virus-1 (HIV-1) infected patients.
- Trial name
- NCT01524900
- Where
- 53 sites in Austria, Poland and 1 more
- Volunteers
- 398 people
- Sponsor
- Boehringer Ingelheim
Human Immunodeficiency Virus Infection (HIV), HIV-1 Infection in Adults
Long-Term Real-World Evidence Study to Evaluate Effectiveness, Persistence, Adherence, Safety and Tolerability of Long-acting Cabotegravir Plus Rilpivirine.
The RELATIVITY study is a nationwide, multicenter, ambispective observational cohort evaluating the long-term effectiveness, safety, persistence, and tolerability of long-acting injectable cabotegravir plus rilpivirine (CAB+RPV…
- Trial name
- NCT07703748
- Where
- Spain
- Volunteers
- 3,346 people
- Sponsor
- FUNDACIÓN HOSPITAL UNIVERSITARIO INFANTA LEONOR Y DEL HOSPITAL UNIVERSITARIO DEL SURESTE