Clinical trials: HIV/AIDS
Tuberculosis, Healthy
Dose-Escalation Study to Evaluate the Safety and Immunogenicity of MTBVAC Vaccine in Comparison With BCG Vaccine.
The purpose of this study is to test the safety and immunogenicity of MTBVAC as a potential substitute for BCG vaccination. BCG vaccination has indeed demonstrated its major limitation in inducing protection against tuberculosis…
- Trial name
- MTBVAC (NCT02013245)
- Testing
- MTBVAC live vaccine, Commercially available BCG live vaccine
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biofabri, S.L
Human Immunodeficiency Virus, Cardiometabolic Risk
The Happy Older Latinos Are Active (HOLA) Health Promotion Study in HIV-Infected Latino Men
The purpose of this study is to examine the feasibility of an intervention to prevent chronic diseases like diabetes, high blood pressure, and obesity in midlife and older Latino adults living with HIV.
- Trial name
- HOLAHIV (NCT03839212)
- Testing
- HOLA Component 1, HOLA Component 2, HOLA Component 3
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Kaposi's Sarcoma
Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS)
The purpose of this pilot study is to determine whether Maraviroc is effective in the treatment of Kaposi's Sarcoma (KS), when it does not remit with standard antiretroviral drug therapy.
- Trial name
- NCT01276236
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
Microbicide Delivery System Perceptibility and Acceptability
Developing Rectal USPE Measures for Suppositories (Project DRUM-S)
The purpose of this study is to (a) adapt existing user sensory perception and experience (USPE) items/instruments generated for rectal gel/cream formulations to include USPEs specific to suppository forms for rectal and vaginal…
- Trial name
- DRUM-S (NCT02744261)
- Testing
- Gel, Suppository 1, Suppository 2
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
MSM, PrEP
A Multilevel Gaming Intervention for Persons on PrEP
This study will develop and test a novel, smartphone based gaming intervention to improve adherence to medication to prevent HIV (known as Pre-exposure Prophylaxis, PrEP) and to decrease HIV risk behaviors among men who have sex…
- Conditions
- MSM, PrEP, HIV Risk
- Trial name
- NCT02611362
- Testing
- IMB Gaming Intervention
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Cervical Cancer, Acquired Immunodeficiency Syndrome
Cisplatin and Radiation Therapy in Treating Patients With HIV-Associated Locally Advanced Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01590017
- Testing
- cisplatin, external beam radiation therapy
- Where
- 2 sites in South Africa, Zimbabwe
- Volunteers
- 41 people
- Sponsor
- AIDS Malignancy Consortium
HIV/AIDS, Chronic Pain
Acceptance and Commitment Therapy for Aging People Living With HIV in Chronic Pain
Chronic pain impacts a large proportion of aging people living with HIV (aPLWH) and involves factors directly related to HIV (neurotoxicity) and psychosocial co-morbidities common in aPLWH (i.e. social isolation and loneliness).
- Trial name
- NCT03699020
- Testing
- Acceptance and Commitment Therapy (ACT), Chronic Pain Education
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alcohol Consumption, Unsafe Sex
Brief Interventions in the Emergency Department for Alcohol and HIV/Sexual Risk
This brief alcohol and sexual risk taking intervention has the potential to influence the public health by reducing alcohol use and sexual risk taking behavior in individuals who are seeking treatment in an Emergency Department.
- Trial name
- SAFER (NCT01351389)
- Testing
- Brief Motivational Intervention (BMI), Brief Advice
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brown University
HIV Infections
Kaletra Sex/Gender Pharmacokinetics (PK) Study
The levels of lopinavir achieved in the blood following oral ingestion of standard doses of Kaletra (lopinavir/ritonavir) in HIV-infected men was compared with those achieved in HIV-infected women receiving the same dose of the…
- Trial name
- LPVGenderPK (NCT00148759)
- Testing
- LPV/r
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
HIV
HIV Prevention Toolkit for HIV-negative Male Couples
Though technology is integrated into the lives of our target population, use of any particular technology will depend on the content delivered, aesthetic appeal, and overall design.
- Trial name
- MCAP (NCT02494817)
- Testing
- Male Couples Agreement Project
- Where
- United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Miami
HIV/AIDS, Adolescent Behavior
Youth Power Action Feasibility Study of Online Support Group Intervention Among Adolescents Living With HIV in Nigeria
This study will examine the feasibility and acceptability of an intervention designed to improve retention in HIV care services and improve anti-retroviral therapy (ART) adherence among adolescents ages 15-19 years living with…
- Conditions
- HIV/AIDS, Adolescent Behavior, Medication Adherence, Health Behavior
- Trial name
- NCT03076996
- Testing
- Online support group
- Where
- Nigeria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Safety and Effectiveness of Emtricitabine, Efavirenz, and Didanosine in HIV Infected Children Who Have Taken Few or No Anti-HIV Drugs
Treatment of HIV-infected patients involves combining drugs from different classes of anti-HIV drugs. One preferred regimen for adults is 2 nucleoside reverse transcriptase inhibitors (NRTIs) and 1 protease inhibitor (PI).
- Trial name
- NCT00016718
- Testing
- Didanosine (ddI), Efavirenz (EFV), Emtricitabine (FTC)
- Where
- 18 sites in United States, Puerto Rico
- Volunteers
- 43 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Exposure, HIV Infection
Early Versus Delayed BCG Vaccination of HIV-exposed Infants
In sub-Saharan Africa (SSA), more than 300,000 babies with HIV die each year. HIV-infected children develop AIDS and die faster in SSA than those in developed countries.
- Trial name
- NCT02062580
- Testing
- BCG
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Human Immunodeficiency Virus, Human Immunodeficiency Virus Transmission
The OPENS Trial: Offering Women PrEP (Aim 2)
To address the significant barriers to pre-exposure prophylaxis (PrEP) implementation for cisgender women and address racial inequities in HIV prevention in the United States (US), a novel approach that accounts for multilevel…
- Conditions
- Human Immunodeficiency Virus, Human Immunodeficiency Virus Transmission, Sexually Transmitted Diseases
- Trial name
- NCT05619497
- Testing
- Clinic-wide Trainings, Clinic-wide Trainings and HIV Prevention Decision Support Tool (DST)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV Infections
Comparison of Liquid Kaletra and Low Dose Kaletra Tablets
Kaletra (a combination drug with lopinavir and ritonavir) is one of a few effective medications that are approved and available for young children who are HIV+.
- Trial name
- NCT00762320
- Testing
- Low dose Kaletra tablets
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Phoenix Children's Hospital
HIV Infections
Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
The First Long-Acting Injectable Regimen (FLAIR) study is being conducted to establish if human immunodeficiency virus type-1 (HIV-1) infected adult participants whose virus is virologically suppressed on an integrase inhibitor…
- Trial name
- NCT02938520
- Testing
- Cabotegravir (CAB) tablet, Rilpivirine (RPV) tablet, Cabotegravir - Injectable Suspension (CAB LA)
- Where
- 108 sites in United States, Canada and 9 more
- Volunteers
- 631 people
- Sponsor
- ViiV Healthcare
HIV
Ibalizumab Plus Optimized Background Regimen in Treatment-Experienced Patients With Multi-Drug Resistant HIV-1
Ibalizumab is a monoclonal antibody that works by blocking HIV entry into the immune system cells (CD4+ or T-cells) the virus typically infects.
- Trial name
- NCT02707861
- Testing
- ibalizumab, Optimized Background Regimen
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 79 people
- Sponsor
- TaiMed Biologics Inc.
Human Immunodeficiency Virus-Infection
Long-term Effectiveness and Safety in Hepatitis-co-infected Patients
The aim of the study is to observe the tolerability and effectiveness of Kaletra in Human Immunodeficiency Virus/Hepatitis-B Virus and Human Immunodeficiency Virus/Hepatitis-C Virus co-infected patients.
- Trial name
- NCT01153269
- Testing
- Lopinavir/Ritonavir (Kaletra)
- Where
- 8 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Abbott
Monkeypox, HIV Coinfection
Morbidity, Mortality And Risk Factors of Mpox in HIV Negative High Risk Sexual Health Clinic Attenders and People Living With HIV
This data collection study aims to describe and compare the outcomes of Mpox on people living with HIV (PLHIV) and HIV-negative individuals who are on pre-exposure prophylaxis (PrEP).
- Trial name
- MASH1 (NCT05965427)
- Testing
- No intervention
- Where
- 9 sites in France, Poland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- NEAT ID Foundation
HIV
Condom Performance in a Longitudinal Enhanced Assessment of User Experiences
This study will enroll 252 men who have sex with men (MSM) and 252 men who have sex with women (MSW) in a double-blind, three-way randomized crossover trial with conditions of fitted, thin, and standard condoms.
- Trial name
- C-PLEASURE (NCT02753842)
- Testing
- 5 Fitted Condoms, 5 Thin Condoms, 5 Standard Condoms
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Global Protection Corp.
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