Clinical trials: HIV/AIDS, completed
HIV-1
Dermal HIV-1 Immunization During Anti-retroviral Therapy Followed by Repeated Treatment Interruptions
In this study, the investigators evaluated a therapeutic HIV-1 DNA vaccine administered with a novel topical application method to 12 chronically HIV-infected cART treated patients.
- Trial name
- Vac09 (NCT01140139)
- Testing
- HIV DNA Vaccine
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Swedish Institute for Infectious Disease Control
Inflammation, Fibrosis
Losartan to Reduce Inflammation and Fibrosis Endpoints in HIV Trial
The purpose of this study is to evaluate the potential effectiveness of losartan (100mg daily) for reducing inflammation and improving immune recovery.
- Trial name
- LIFE-HIV (NCT02049307)
- Testing
- Losartan 100mg daily
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- Hennepin Healthcare Research Institute
HIV Infections
Observational Study of Nevirapine Extended Release in Human Immunodeficiency Virus (HIV) Patients in Daily Clinical Practice
This Post Marketing Surveillance study will be performed as an open-label, prospective, non-interventional, uncontrolled study in Human immunodeficit Virus-1 (HIV-1) infected patients.
- Trial name
- NCT01524900
- Where
- 53 sites in Austria, Poland and 1 more
- Volunteers
- 398 people
- Sponsor
- Boehringer Ingelheim
Opioid-use Disorder
Intervention to Facilitate MMT/HIV Service Decentralization in Vietnam
Vietnam is currently decentralizing its methadone maintenance therapy (MMT) dispensing network to its local commune health centers (CHC), which provides a window of opportunity to study decentralization of harm reduction and…
- Trial name
- NCT04798534
- Testing
- Service decentralization facilitation intervention
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
HIV Infections
A Multicenter Dose Ranging Clinical Trial of 2',3'-Dideoxycytidine in the Treatment of Patients With AIDS and Advanced ARC.
To evaluate the long-term safety and effectiveness of the drug 2',3'-dideoxycytidine ( zalcitabine; ddC ) in treating patients with AIDS or advanced AIDS related complex ( ARC ).
- Trial name
- NCT00000704
- Testing
- Zalcitabine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, Stimulant Use Disorders
RCT of an Integrative Intervention for Non-Treatment-Seeking Meth Users
In the era of HIV treatment as prevention (TasP), efforts are needed to identify evidence-based combination prevention approaches that achieve greater decreases HIV viral load among populations that are more likely to engage in…
- Trial name
- ARTEMIS (NCT01926184)
- Testing
- Affect Regulation Treatment to Enhance Meth Intervention Success (ARTEMIS), Contingency Management (CM)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of California, San Francisco
HIV, Metabolic Syndrome
Incidence of HANA Conditions in HIV-infected Individuals
With the availability of effective anti-retroviral therapy, HIV-infected individuals are expected not to die of AIDS and have longer life expectancy.
- Conditions
- HIV, Metabolic Syndrome, Osteopenia, Osteoporosis
- Trial name
- NCT03483584
- Where
- Hong Kong
- Volunteers
- 215 people
- Sponsor
- Chinese University of Hong Kong
HIV, AIDS
Supporting Attendance for Facility Delivery and Infant Health
The goal of this proposed intervention study is to increase the proportion of HIV positive and HIV negative pregnant women who deliver in a facility, the proportion of HIV exposed infants (HEI) who receive nevirapine (NVP) within…
- Trial name
- SAFI (NCT03023033)
- Testing
- mHealth messaging, Transport Payments
- Where
- Tanzania
- Volunteers
- 1,505 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Lymphoma, Non-Hodgkin, HIV Infections
A Phase III Randomized Trial of Low-Dose Versus Standard-Dose mBACOD Chemotherapy With rGM-CSF for Treatment of AIDS-Associated Non-Hodgkin's Lymphoma
To determine the impact of dose intensity on tumor response and survival in patients with HIV-associated non-Hodgkin's lymphoma (NHL). HIV-infected patients are at increased risk for developing intermediate and high-grade NHL.
- Trial name
- NCT00000658
- Testing
- Bleomycin sulfate, Vincristine sulfate, Doxorubicin hydrochloride
- Where
- 22 sites in United States
- Volunteers
- 250 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Spurring Innovation to Promote HIV Testing: An RCT Evaluating Crowdsourcing
Crowdsourcing may be a powerful tool to spur the development of innovative videos to promote HIV testing among key populations such as men who have sex with men (MSM) and transgender (TG) individuals.
- Trial name
- NCT02248558
- Testing
- Conventional Video, Crowdsourced Video
- Where
- China
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections, Lipodystrophy
Therapeutic Approaches to HAART-Induced Lipodystrophy
To determine the efficacy and safety of 4 therapeutic interventions on HAART-Induced lipodystrophy. The interventions are: 1) Dietary - the effect of a high carbohydrate vs.a high cis-monounsaturated fatty acid diet.
- Trial name
- NCT00461552
- Testing
- Leptin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Texas Southwestern Medical Center
AIDS Related Lymphoma, AIDS-Associated Lymphoma
EPOCH Chemotherapy +/- IL-12 for Previously Untreated and EPOCH Plus Rituximab for Previously Treated Patients With AIDS-Associated Lymphoma
The prognosis of AIDS-related Non-Hodgkin's lymphoma is poor, especially in the relapsed setting. There is no standard treatment, and the few small studies that have been conducted have reported dismal outcomes.
- Trial name
- NCT00001563
- Testing
- Filgrastim, Rituximab, EPOCH
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Cancer Institute (NCI)
Alcohol Consumption, PrEP Uptake
Enhancing HIV Prevention and Reducing Alcohol Use Among People Receiving STI Care in Lilongwe, Malawi
Purpose: To evaluate short-term efficacy and implementation of Treat4All, an alcohol reduction evidence-based intervention, for decreasing heavy drinking and optimizing HIV outcomes (viral suppression among People with HIV (PWH)…
- Conditions
- Alcohol Consumption, PrEP Uptake, Recent Heavy Drinking, HIV Prevention
- Trial name
- Treat4All (NCT06668363)
- Testing
- Treat4All, Standard of care (control arm)
- Where
- Malawi
- Volunteers
- 130 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV, Asthma
Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers
Patients with human immunodeficiency virus (HIV) and respiratory disease commonly require protease inhibitors (PIs) and orally inhaled corticosteroids.
- Trial name
- NCT00936793
- Testing
- Darunavir, Ritonavir, Beclomethasone Dipropionate HFA
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Tuberculosis
Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis
This study will evaluate the ability of 4 antibiotics to kill the bacteria that cause tuberculosis (TB). The antibiotics to be studied are linezolid, gatifloxacin, levofloxacin, and moxifloxacin.
- Trial name
- NCT00396084
- Testing
- Gatifloxacin, Isoniazid, Levofloxacin
- Where
- 2 sites in United States, Brazil
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malignant Neoplasms of Mesothelial and Soft Tissue, Human Immunodeficiency Virus
Non Invasive Oral Cancer Screening Among HIV Infected Individuals
The goal of this clinical research study is to learn how a new method for performing oral (mouth) exams can help doctors check for suspicious lesions (called premalignant and malignant oral lesions [PMOL]) in the mouth of…
- Trial name
- NCT02823847
- Testing
- Screening Interview, Carbon Monoxide Test, Self-Help Materials
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatitis B, Hepatitis C
Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection
Background: Hepatitis B and hepatitis C can cause liver damage. They can also cause serious illness, including liver cancer, and even death. This study will follow people who have hepatitis B or hepatitis C.
- Conditions
- Hepatitis B, Hepatitis C, HIV-HCV Co-Infection
- Trial name
- NCT01350648
- Where
- 2 sites in United States
- Volunteers
- 569 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Acquired Immunodeficiency Syndrome
Improving Uptake of Early Infant Diagnosis of HIV for the Prevention of Mother-to-child Transmission of HIV
Early accurate diagnosis is one of the first crucial steps in care for infants born to HIV-infected mothers. Early initiation of antiretroviral therapy (ART) relies upon early diagnosis and results in significant reductions in…
- Trial name
- SMS4PMTCT (NCT01433185)
- Testing
- Text message
- Where
- Kenya
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, Sexually Transmitted Diseases
Safety, Tolerance and Acceptability Trial of the Invisible Condom® in Healthy Women
The objectives of this clinical study are to evaluate the extended safety, tolerance and acceptability of a vaginal gel formulation when applied in 452 healthy women volunteers.
- Trial name
- NCT00136643
- Testing
- Invisible Condom®
- Where
- Cameroon
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Laval University
Mental Health Issue, Hiv
Walk-in Therapy in Low Barrier Primary Care
The goals of the current research are to adapt an effective walk-in psychotherapy clinic intervention for the context of low-barrier primary care; and conduct a pilot implementation study in a low-barrier primary care clinic…
- Conditions
- Mental Health Issue, Hiv, Substance Use
- Trial name
- NCT06552325
- Testing
- Single Session Narrative Therapy
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Washington