Clinical trials: HIV Dementia
AIDS Dementia Complex, HIV Infections
An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts
To provide accurate and complete neurologic assessment of the course of the AIDS dementia complex in patients treated with zidovudine (AZT).
- Trial name
- NCT00000709
- Testing
- Zidovudine
- Where
- 12 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS Dementia Complex, HIV Infections
A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex
To evaluate the benefit of adding 1592U89 to current antiretroviral therapies for AIDS dementia complex and to assess the safety and tolerance of the treatment regimens.
- Trial name
- NCT00002163
- Testing
- Abacavir sulfate
- Where
- 9 sites in United States, Canada
- Sponsor
- Glaxo Wellcome
HIV Infections, Coronary Disease
HIV-HEART Aging Study
The HIV/HEART Aging study (HIVH) is an ongoing, prospective, multicentre trial that was conducted to assess the incidence, the prevalence and the clinical course of cardiovascular diseases (CVD) in HIV-infected patients.
- Conditions
- HIV Infections, Coronary Disease, Myocardial Infarction, HIV Encephalopathy
- Trial name
- HIVH (NCT04330287)
- Where
- 5 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Essen
Methamphetamine Abuse, HIV/AIDS
The Getting Off App for Methamphetamine-Using Gay and Bisexual Men
A commonly used manualized outpatient methamphetamine intervention for gay and bisexual men, "Getting Off," is being translated into a mobile phone application (i.e., app) available for download through common app marketplaces.
- Trial name
- NCT03884946
- Testing
- Getting Off App
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Friends Research Institute, Inc.
HIV-Associated Cognitive Motor Complex, Aging
Individualized Cognitive Training in HIV
Over 50% of adults with HIV have some form of HIV-Associated Neurocognitive Disorder (HAND) which represents a significant symptom that interferes with everyday functioning and quality of life.
- Conditions
- HIV-Associated Cognitive Motor Complex, Aging, Cognitive Impairment, Cognitive Decline
- Trial name
- TOPS (NCT03122288)
- Testing
- Individualized Cognitive Training, No-Contact Control
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of Alabama at Birmingham
Alzheimer Disease, HIV
F 18 T807 PET (Positron Emission Tomograph )Scan for HIV Infected & Uninfected
This project will collect quantitative pilot data that will allow the characterization of uptake and binding of 18F-AV-1451 (also known as F 18 T807, also known as T807, also known as…
- Trial name
- NCT03279523
- Testing
- F 18 T807
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tammie L. S. Benzinger, MD, PhD
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
ALS, Autism Spectrum Disorder
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
This is an observational study of medical marijuana manufactured and dispensed by Ilera and given as standard treatment for a variety of approved serious medical conditions as defined by individual state law.
- Conditions
- ALS, Autism Spectrum Disorder, Cancer, Spasticity, Muscle
- Trial name
- Ilera (NCT03886753)
- Testing
- Registry, PK microsampling of blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
HIV-Dementia, HIV-Associated Cognitive Motor Complex
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)
The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.
- Conditions
- HIV-Dementia, HIV-Associated Cognitive Motor Complex, AIDS Encephalopathy, AIDS Dementia Complex
- Trial name
- NCT00459693
- Testing
- [11C]PBR28
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Hiv, HIV/AIDS
AllyQuest: Engaging HIV+ YMSM in Care Through Social Networking and Gamification
AllyQuest is a novel, high impact secondary prevention intervention delivered via mobile phones to improve linkage and engagement in care among newly diagnosed HIV+ young men who have sex with men (YMSM).
- Trial name
- AQ (NCT03090958)
- Testing
- AllyQuest
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis)
ALS Research Collaborative
The goal of this natural history study is to learn more about the biological and clinical aspects of amyotrophic lateral sclerosis (ALS).
- Conditions
- Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis), ALS With Frontotemporal Dementia (ALS/FTD), Motor Neuron Disease
- Trial name
- ARC (NCT06885918)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- ALS Therapy Development Institute
AIDS-Related Dementia Complex
Evaluation of the Role of OCT in the Detection of HIV-associated Neurocognitive Disorder
The purpose of this study is to determine the sensitivity and specificity of the use of optical coherence tomography to detect HIV-associated neurocognitive disorder compared to MRI and usual cognitive screening tools.
- Trial name
- OCT-HIV (NCT02431091)
- Testing
- Optical Coherence Tomography
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
HIV Infections
HIV - Monotherapy in Switzerland (MOST-ch)
The investigators plan to conduct a two arm study, to compare failure rates in the central nervous system (CNS) and genital compartment in virologically fully suppressed patients continuing a highly active antiretroviral therapy…
- Trial name
- MOST (NCT00531986)
- Testing
- Lopinavir-Monotherapy, HAART
- Where
- 6 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Cantonal Hospital of St. Gallen
Telerehabilitation, Neuropsychology
Teleneuropsychological Intervention in Asymptomatic HIV Seropositive Patients: N&C NeuroChange
Currently 37.9 million people are living with human immunodeficiency virus (HIV) around the world (UNAIDS, 2018). Even with antiretroviral treatment (ART), the virus enters the central nervous system and can affect the following…
- Conditions
- Telerehabilitation, Neuropsychology, HIV Dementia
- Trial name
- NCT05571761
- Testing
- Cognitive stimulation program
- Where
- Mexico
- Sponsor
- Universidad Nacional Autonoma de Mexico
AIDS Dementia Complex, HIV Infections
A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex
The purpose of this study is to see if adding stavudine (d4T) to anti-HIV drug regimens (with or without zidovudine, ZDV) can improve symptoms of AIDS Dementia Complex (ADC, problems involving the brain or spinal cord) in…
- Trial name
- NCT00002246
- Testing
- Stavudine
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 20 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections, Central Nervous System Diseases
Clinical Trial of Brain-Penetrating HIV Drugs to Prevent Cognitive Impairment in China
This primary aim of the project is to determine the association between antiretroviral therapy that better distributes into the central nervous system and prevention of HIV-associated neurocognitive impairment.
- Conditions
- HIV Infections, Central Nervous System Diseases, Dementia
- Trial name
- NCT01340950
- Testing
- zidovudine-lamivudine-nevirapine, tenofovir-lamivudine-efavirenz
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- University of California, San Diego
HIV Dementia
A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV
This study is being done to see if a drug called long acting methylphenidate (Concerta) is safe and effective as a treatment for problems with mental function in adults infected with HIV.
- Trial name
- NCT01599975
- Testing
- Long acting methylphenidate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
AIDS, Dementia
Predictors of Neuro-cognitive Decline and Survival in HIV-infected Subjects
Patients will be followed every 6 months for a total of 5 visits (Month 0, 6, 12, 18 and 24). The first visit is the screening and entry visit which can occur at any time after the subject finishes SEARCH 001 study but preferably…
- Trial name
- NCT00864292
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- SEARCH Research Foundation
AIDS Dementia Complex, HIV Infections
Safety and Effectiveness of CPI-1189 in HIV-Infected Males on Combination Anti-HIV Drug Therapy
The purpose of this study is to see if it is safe to give multiple doses of CPI-1189 to HIV-infected, otherwise healthy, males. The study will also look at how CPI-1189 affects the levels of HIV, T cells (cells in the body that…
- Trial name
- NCT00002209
- Testing
- CPI-1189
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Centaur Pharmaceuticals
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's