Clinical trials: HIV Infected Individuals
HIV/AIDS
Effects of Maraviroc vs. Efavirenz on CD4/CD8 Ratio
A low CD4/CD8 ratio is considered a surrogate marker of immunosenescence and is an independent predictor of non-AIDS-related morbidity and mortality.
- Trial name
- MeritRate (NCT03178084)
- Testing
- Maraviroc (UK-427,857) QD + Zidovudine/Lamivudine BID, Efavirenz QD + Zidovudine/Lamivudine BID, Maraviroc (UK-427,857) BID + Zidovudine/Lamivudine QD
- Volunteers
- 721 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
COPD, HIV/AIDS
Determining Bacterial Communities in the Lungs of HIV-infected Individuals With COPD in Uganda.
Research question Is there any association between altered lung bacterial communities and HIV-associated Chronic Obstructive Pulmonary Disease (COPD)? Rationale Sub-Saharan Africa has experienced dramatic increases in COPD…
- Trial name
- LMB (NCT04070248)
- Testing
- No intervention
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV Infected Individuals, HIV
The Efficacy and Safety Study of CAR-T Cells for Functional Cure in HIV-1/AIDS Patients
Autologous CAR-T cell therapy in HIV-1/AIDS patients
- Trial name
- HIV-CAR-T (NCT06880380)
- Testing
- HIV-CAR-T
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
HIV
Efficacy of Neuro-HAART in Patients With HIV
Patients infected with Human Immunodeficiency Virus (HIV) are at risk of brain related complications despite the use of highly active antiretroviral therapy (HAART).
- Trial name
- HANDobs (NCT01434654)
- Where
- 2 sites in Australia
- Volunteers
- 19 people
- Sponsor
- St Vincent's Hospital, Sydney
HIV Infections
A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations
The purpose of this study is to compare two different anti-HIV drug combinations, one that contains nelfinavir (NFV) and one that does not. The best dosing schedule for indinavir (IDV) also will be studied.
- Trial name
- NCT00002430
- Testing
- Indinavir sulfate, Nelfinavir mesylate, Lamivudine
- Where
- 46 sites in United States
- Volunteers
- 220 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
A Study of Dementia and Neurological Problems in HIV Infected Patients Who Are Participating in ACTG A5175
The purpose of this study is to determine how often dementia and other neurological problems occur in people with HIV. Participants of ACTG A5175 will enroll in this study.
- Trial name
- NCT00096824
- Testing
- Neurological assessment
- Where
- 11 sites in Brazil, India and 3 more
- Volunteers
- 860 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Cytomegalovirus Infections, HIV Infections
A Study of HIV and Cytomegalovirus (CMV) in HIV-Infected Patients
To define relationships between 1) HIV load and risk of CMV disease, 2) CMV load and the risk of developing CMV disease, and 3) CMV load and HIV load.
- Trial name
- NCT00001089
- Where
- 36 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Hepatitis C
THISTLE - The HIV-HCV Silibinin Trial
Chronic hepatitis C virus (HCV) is a major cause of morbidity and mortality worldwide with an estimated number of 180 million infected patients.
- Trial name
- THISTLE (NCT01816490)
- Testing
- Intravenous Silibinin (iSIL)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
HIV Infections
Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy
This substudy is an open-label, randomised study comparing the uptake of recombinant interleukin-2 (rIL-2) in HIV-1 infected individuals receiving different combinations of antiemetics and analgesic agents during rIL-2 dosing in…
- Trial name
- NCT00147355
- Testing
- ondansetron, ibuprofen, paracetamol, metoclopramide, ibuprofen, paracetamol, Metoclopramide, codeine phosphate, ibuprofen, paracetamol
- Where
- 16 sites in Argentina, Australia and 1 more
- Volunteers
- 28 people
- Sponsor
- Kirby Institute
HIV
Combination Therapy With 3BNC117 and 10-1074 in HIV-Infected Individuals
Background: Human immunodeficiency virus (HIV) affects the immune system. The main function of the immune system is protect you from infections and other diseases such as cancer.
- Trial name
- NCT03571204
- Testing
- 3BNC117 and 10-1074
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1 Infection
A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen
A prospective, multicenter, open, randomized Phase 2a trial to confirm a sustained virological suppression defined as HIV-RNA <50 copies/ml of 3 different doses of Fozivudine in context to a standard Zidovudine based…
- Trial name
- FATI-01 (NCT01714414)
- Testing
- FZD, 3TC, EFV
- Where
- 2 sites in Côte d’Ivoire, Tanzania
- Volunteers
- 120 people
- Sponsor
- Michael Hoelscher
HIV Infections
A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3
To compare nelfinavir (NFV) with ritonavir (RTV) for delaying disease progression or death in HIV-infected patients with CD4+ cell counts less than 100 cells/mm3 [AS PER AMENDMENT 3/11/98: less than or equal to 200 cells/mm3].
- Trial name
- NCT00000859
- Testing
- Indinavir sulfate, Ritonavir, Nelfinavir mesylate
- Where
- 44 sites in United States, Canada
- Volunteers
- 1,300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Visceral Leishmaniasis
Asymptomatic Leishmania Infection in HIV Patients
To collect pilot data on the prevalence and incidence of asymptomatic Leishmania donovani infection in HIV infected individuals in a visceral leishmaniasis (VL)-HIV endemic region to inform the feasibility of a larger study…
- Trial name
- NCT02839603
- Where
- Ethiopia
- Volunteers
- 540 people
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV Infected Individuals
The Influence of Psychological Interventions Upon Disease Progression in HIV-infected Patients Receiving no Medication
This study examines the hypothesis that psychological interventions have beneficial effects on quality of life including psychological well-being and disease progression in early HIV patients recieving no medication.
- Trial name
- NCT00180700
- Testing
- Hypnosis
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Imperial College London
HIV Infection
Study of Recovery of Intestinal CD4+ and Th17 T Cells in HIV-infected Individuals on Short-term Antiretroviral Therapy
HIV infection is associated with a state of chronic, generalized immune activation that has been shown in many studies to be a key predictor of progression to AIDS.
- Trial name
- NCT02097381
- Testing
- Tenofovir-Emtricitabine plus Lopinavir/Ritonavir or Darunavir/Ritonavir
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Roma La Sapienza
HIV Infections
Double Protease Inhibitor to Darunavir Switch Study
The purpose of the study is to study the effects of switching from an antiretroviral combination that includes two ritonavir boosted protease inhibitors to replacement of these two protease inhibitors with a new protease…
- Trial name
- NCT00531557
- Testing
- Darunavir ritonavir
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- St Stephens Aids Trust
HIV
Addition of Raltegravir to Established Antiretroviral Suppressive Therapy
This study will examine whether intensification with raltegravir of a suppressive antiretroviral regimen in HIV infected patients with poor immune restoration has a beneficial effect on cryptic viral replication and the immune…
- Trial name
- NCT01245101
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Miami
Anemia, Intestinal Helminthiasis
A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes
In this study, it is hypothesized that helminth infections modulate immune responses against HIV-1 infection resulting into increased HIV-1 multiplication, faster progression to AIDS and increased episodes of AIDS-related…
- Conditions
- Anemia, Intestinal Helminthiasis, Intestinal Schistosomiasis, Human Immunodeficiency Virus I Infection
- Trial name
- NCT01541631
- Testing
- Praziquantel and Albendazole
- Where
- 2 sites in Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Catholic University of Health and Allied Sciences
HIV-1 Infection
Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals
The purpose of this study is to determine whether a two-week course of disulfiram will reduce the HIV-1 latent reservoir in patients on highly active antiretroviral therapy (HAART).
- Trial name
- NCT01286259
- Testing
- Disulfiram
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Insomnia
Digital Behavioral Therapy for Sleep Problems
Insomnia is very common, especially in HIV population (up to 73%), and contributes to the development of other conditions such as depression, dementia, inflammation, obesity, and heart diseases.
- Trial name
- dBTS (NCT04308499)
- Testing
- Digital cognitive-behavioral therapy for insomnia (dCBTI), Sleep hygiene education (SHE)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Los Angeles