Clinical trials: HIV Infected Individuals
HIV Infections
Safety and Effectiveness of an Adjuvant in Improving Immune Response to Hepatitis B Virus Vaccine in HIV Infected Individuals
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring substance that is made by the body in response to infection or inflammation, and greatly improves cellular immune responses.
- Trial name
- NCT00272493
- Testing
- Hepatitis B virus vaccine with GM-CSF adjuvant, Hepatitis B virus vaccine
- Where
- 11 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients
HIV vaccines may help the immune systems of HIV infected patients better control the virus. The goal of this study is to determine whether patients on anti-HIV medications can stop taking those medications if they receive an HIV…
- Trial name
- NCT00080106
- Testing
- MRK Ad5 HIV-1 gag vaccine
- Where
- 28 sites in United States, Puerto Rico
- Volunteers
- 114 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus
3BNC117 and 10-1074 in ART-treated Individuals
The proposed study is a phase 1, open label, randomized study to evaluate the safety and antiretroviral activity of seven infusions of 3BNC117 and 10-1074, administered intravenously at 30 mg/kg dose level, in human…
- Trial name
- NCT03526848
- Testing
- 3BNC117, 10-1074, Analytical treatment interruption
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Rockefeller University
HIV, AIDS
Neurocognitive Effects and Tolerability of Efavirenz in Aging HIV-infected Individuals ("SHAC Neuro Study")
Investigators hypothesize that older HIV-infected individuals (i.e., >50 years old) on efavirenz (EFV)-containing antiretroviral therapy (ART) will have significantly worse neurocognitive function than older individuals on…
- Trial name
- NCT01985399
- Testing
- Neuropsychological testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
HIV
Phase I Study of HIV 1 Antigen Expanded Specific T Cell Therapy
This is a phase 1, single-site study is to evaluate the safety and immunologic and virologic efficacy of ex vivo expanded HIV-1 multi-antigen specific T-cell (HXTC) therapy in HIV-infected individuals with viral suppression on…
- Trial name
- HXTC (NCT02208167)
- Testing
- HXTC infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV-infected Participants With Latent TB Infection in High TB Burden Country
Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals
The investigators want to know if ultra-short, effective treatment for latent tuberculosis (TB) infection (LTBI) could dramatically reduce the global incidence of active TB or not.
- Trial name
- NCT03785106
- Testing
- Isoniazid/Rifapentine daily (4 weeks) plus pyridoxine (vitamin B6), Isoniazid/Rifapentine 12-weekly plus pyridoxine (vitamin B6)
- Where
- 16 sites in Thailand
- Volunteers
- 2,500 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Human Immunodeficiency Virus, Herpes Simplex
Can Valacyclovir Attenuate Inflammation in Antiretroviral-Treated HIV-Infected Individuals With Herpes Simplex Virus Type 2?
The purpose of this study is to compare the levels of immune and inflammatory markers among HIV-1, HSV-2 co-infected adults achieving plasma HIV RNA suppression to <50 copies/mL, between those randomized to valacyclovir and…
- Trial name
- VALIANT Pilot (NCT01176409)
- Testing
- Valacyclovir
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Oropharyngeal Candidiasis
Single Dose Versus Two Weeks Course of Fluconazole in the Treatment of Oropharyngeal Candidiasis in HIV Infected Individuals in Tanzania
A prospective randomized double blinded placebo controlled comparative trial will be performed at HIV clinic of the Muhimbili National Hospital/MUCHS where 220 HIV positive patients presenting with oropharyngeal candidiasis (OPC)…
- Trial name
- SDVS2WK (NCT00553137)
- Testing
- fluconazole
- Where
- Tanzania
- Volunteers
- 220 people
- Sponsor
- Netherlands Organisation for Scientific Research
Anal Cancer, Precancerous Condition
Infrared Coagulation in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia
RATIONALE: Infrared coagulation may be effective in preventing the development of anal cancer in patients who have anal neoplasia.
- Trial name
- NCT00066430
- Testing
- infrared photocoagulation therapy, Infrared Coagulator
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- AIDS Malignancy Consortium
HIV
Elvitegravir (EVG) Cerebrospinal Fluid (CSF) Pharmacokinetics in HIV-Infected Individuals
The project will have two tracks, one for participants who are currently taking elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate or E/C/F/tenofovir alafenamide (E/C/F/TDF or E/C/F/TAF) single-tablet regimen*…
- Trial name
- NCT02251236
- Testing
- Stribild, Genvoya
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Diego
Human Immunodeficiency Virus
3BNC117-LS First-in-Human Phase 1 Study
The proposed study is a phase 1 study of the mAb 3BNC117-LS administered intravenously in HIV uninfected individuals and HIV-infected individuals, and subcutaneously in HIV-uninfected individuals.The objectives of the study are…
- Trial name
- NCT03254277
- Testing
- 3BNC117-LS
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
HIV Infection
Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals
The purpose of this study is to determine the safety, toxicity, dosing, and antiviral effects of epigallocatechin gallate (EGCG) in capsule form (Polyphenon® E), administered orally twice daily at three different doses in…
- Trial name
- NCT01433289
- Testing
- Polyphenon E
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
HIV
Effect of Vitamin B on Plasma Neurofilament Light Protein (NFL) in HIV-infected Individuals With Increased Plasma Homocysteine
The purpose of this study is to investigate if B vitamin substitution have effect on NFL (neurofilament light protein) plasma levels and neurocognitive performance in HIV-infected individuals with increased plasma homocysteine
- Trial name
- NCT02773147
- Testing
- Cyanocobalamin, Folate, Pyridoxine
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
HIV Infected Individuals, Osteopenia
Zoledronic Acid for the Prevention of TDF-sparing ART-induced Bone Mass Density Loss in Treatment-naive HIV Positive Individuals
The goal of this clinical trial is to learn if zolendric acid can prevent the anticipated deterioration of bone mass after antiviral treatment initiation for people that were recently diagnosed with HIV.
- Trial name
- NCT06762730
- Testing
- Zoledronic Acid 5 mg/Bag 100 ml Inj
- Where
- 3 sites in Israel
- Volunteers
- 110 people
- Sponsor
- Hadassah Medical Organization
HIV
Upper Gastrointestinal Endoscopy in HIV-infected Individuals
The aim of this registry is to collect prospectively demographic characteristics and upper gastrointestinal endoscopy diagnoses over a long-term period, in people living with HIV, undergoing upper gastrointestinal endoscopy
- Trial name
- NCT07425067
- Testing
- Gastroscopy
- Where
- Belgium
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
HIV
Combination Therapy With VRC01 and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions
Background: A daily drug combination can keep human immunodeficiency virus (HIV) levels low for a long time. But if this combination antiretroviral therapy (ART) stops, HIV levels go back up.
- Trial name
- NCT03831945
- Testing
- VRC-HIVMAB060-00-AB (VRC01), 10-1074
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Human Immunodeficiency Virus
Immunologic Response to Kansui in Treated HIV+ Individuals: a Dose Escalation Study
The purpose of this study is to determine the safety and bioactivity of an herbal supplement called "kansui," which contains several active ingredients such as ingenols that may have a role in helping clear HIV from the body.
- Trial name
- NCT02531295
- Testing
- Euphorbia kansui extract powder prepared as tea
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco
HIV Infected Individuals, Informed Consent
Analysis of the Persistence, Reservoir and HIV Latency
The APRIL study aims at analyzing HIV reservoirs, latency and persistence on antiretroviral therapy. It enrolls HIV-infected adults providing blood samples of which peripheral blood mononuclear cells are stored.
- Trial name
- APRIL (NCT05752318)
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Hiv, HIV Infections
Changes in Weight, Body Composition and Cardiac Risk After Discontinuing Abacavir Treatment in HIV-infected Individuals
Randomized controlled parallel open-label study in people living with HIV and at least 6 month of treatment with dolutegravir/abacavir/lamivudine prior to inclusion.
- Conditions
- Hiv, HIV Infections, HIV Cardiomyopathy, Weight Change, Body
- Trial name
- AVERTAS (NCT04904406)
- Testing
- Dolutegravir / Lamivudine Oral Tablet
- Where
- 2 sites in Denmark
- Volunteers
- 81 people
- Sponsor
- Thomas Benfield
Cell Function
In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients
Peripheral blood mononuclear cells (PBMC) will be collected from healthy volunteers and patients who present with different diseases that involve or implicate the immune system dysregulation (HIV infection, autoimmune diseases…
- Trial name
- NCT00342485
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)