Clinical trials: HIV Infected Individuals
HIV Infections
Safety, Tolerance, Efficacy and Pharmacokinetics of Multiple Doses of sCD4-PE40 in the Treatment of HIV-Infected Individuals
To investigate the safety and tolerance of an increasing number of infusions per week of alvircept sudotox ( sCD4-PE40; soluble CD4-Pseudomonas exotoxin ) at a fixed dose when administered to HIV-1-infected individuals.
- Trial name
- NCT00002087
- Testing
- Alvircept sudotox
- Where
- United States
- Sponsor
- Pharmacia and Upjohn
HIV
Phase II Comparator Study of Substitution of Tenofovir or Abacavir Receiving Thymidine Analogue as Part of HAART.
This 48 week study is designed to compare the substitution of the thymidine analogues zidovudine (ZDV) or stavudine (D4T) with either tenofovir DF or abacavir, in patients treated with highly active antiretroviral therapy…
- Trial name
- NCT00270556
- Testing
- tenofovir disoproxil fumarate, Abacavir
- Volunteers
- 100 people
- Sponsor
- Gilead Sciences
HIV Infections
A Study of 141W94 Used Alone or in Combination With Zidovudine Plus 3TC in HIV-Infected Patients
To determine the proportion of patients whose plasma HIV-1 RNA level remains below a detectable level (less than 500/ml) after 24 weeks of study therapy with either 141W94 monotherapy or 141W94 plus zidovudine (ZDV) and…
- Trial name
- NCT00001085
- Testing
- Amprenavir, Lamivudine, Zidovudine
- Where
- 15 sites in United States
- Volunteers
- 94 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily
The purpose of this study is to see whether taking indinavir (IDV) plus ritonavir (RTV) plus stavudine (d4T) plus lamivudine (3TC) 2 times each day is safe and can lower the level of HIV in the blood.
- Trial name
- NCT00002241
- Testing
- Indinavir sulfate, Ritonavir, Lamivudine
- Where
- 18 sites in United States
- Volunteers
- 80 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Effect of Vaccination on Turnover of Lamivudine (3TC) Sensitive and Resistant Virus Populations in HIV-1-Infected Individuals
To ascertain whether the origin of plasma HIV-1-RNA following T cell activation represents the activation of latently infected cells or an increase in cells permissive for replacing viral mutants.
- Trial name
- NCT00001080
- Testing
- Influenza Virus Vaccine, Pneumococcal Vaccine, Polyvalent (23-valent), Lamivudine
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
H1N1 Influenza Vaccine Immunogenicity in HIV-1 Infected Patients
The overall goal of this study is to study influenza vaccine responses in HIV infected individuals. Immunocompromised individuals require special protection from influenza, but may not respond appropriately to the standard killed…
- Trial name
- NCT01111162
- Testing
- H1N1 vaccination
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
HIV
BATAR: Individuals Currently Taking Boosted Atazanavir as Part of an HIV Treatment Regimen Will be Evaluated to See if Substituting Raltegravir for Nucleoside Transcriptase Inhibitors Will be Safe and Well Tolerated.
The purpose of this Phase IV pilot study is to evaluate the safety, tolerability, and satisfaction of a nucleoside analog reverse-transcriptase inhibitors (NRTI)sparing regimen for participants fully suppressed on an…
- Trial name
- BATAR (NCT00931801)
- Testing
- atazanavir/raltegravir, atazanavir/tenofovir/emtricitabine
- Where
- 9 sites in United States
- Volunteers
- 43 people
- Sponsor
- Community Research Initiative of New England
Acute HIV Infection
Effects of Intensive cART During Acute/Early HIV Infection
This trial will investigate the efficacy and safety of intensified antiretroviral treatment that includes raltegravir and maraviroc during the early stages of HIV infection.
- Trial name
- NCT01154673
- Testing
- raltegravir, maraviroc, emtricitabine 200mg /tenofovir 300mg
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- University of Toronto
Hypertension
Expanding Health Systems Research to Optimize Hypertension Care Cascade in HIV-Infected Individuals in Mozambique
Undiagnosed and untreated hypertension is a main driver of cardiovascular disease, affecting disproportionately low and middle-income countries, where guidelines to screen and manage hypertension are poorly used.
- Trial name
- SCALESAIAHTN (NCT05002322)
- Testing
- Systems Analysis and Improvement Approach
- Where
- 6 sites in Mozambique
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Eduardo Mondlane University
HIV Infections
Integrase Inhibitor (MK-0518) Viral Decay
The eradication of HIV by antiretroviral therapy has thus far been elusive. It has been consistently demonstrated that a pool of latently infected, resting CD4+ T cells persists in the majority of HIV-infected individuals…
- Trial name
- NCT00520897
- Testing
- Raltegravir (MK0518), Leukopheresis, Sigmoid Biopsy
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Canadian Immunodeficiency Research Collaborative
HIV-1-infection
MGD014 in HIV-Infected Individuals on Suppressive Antiretroviral Therapy
This is a Phase 1, open-label single-center study to determine the safety of MGD014 in participants with human immunodeficiency virus (HIV) infection on stable suppressive antiretroviral therapy (ART).
- Trial name
- NCT03570918
- Testing
- MGD014
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- MacroGenics
HIV/AIDS, Cardiovascular Diseases
The Evaluations of Cardiovascular Changes in Long-term Treated HIV-infected Individuals
The present study aims to evaluate the cardiovascular changes in long-term virologically controlled HIV patients. All the participants have been treated and have been undetected for at least five years.
- Trial name
- NCT04463810
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking Union Medical College Hospital
HIV Infections
Frailty in Older HIV-infected Individuals
Frailty has been proposed as a measure of biological (as opposed to chronological) aging. In this study the investigators plan to: (1) measure frailty in a cohort of older HIV-infected individuals in Hong Kong, and its…
- Trial name
- NCT03413683
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Human Immunodeficiency Virus (HIV)
3BNC117 and 10-1074 in HIV-infected Individuals
This is a phase 1b clinical trial to evaluate the safety, pharmacokinetics and the antiretroviral effects of the combination of two anti-human immunodeficiency virus (HIV) broadly neutralizing antibodies, 3BNC117 and 10-1074…
- Trial name
- NCT02825797
- Testing
- 3BNC117, 10-1074, Analytical treatment interruption
- Where
- 2 sites in United States, Germany
- Volunteers
- 34 people
- Sponsor
- Rockefeller University
HIV Infections, Hepatitis C
Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and Fibrosis
The purpose of this study is to look at how 2 different anti-HIV drug treatments affect the liver. The use of anti-HIV drugs like the nucleoside reverse transcriptase inhibitors (NRTIs) may be linked to liver problems like fatty…
- Trial name
- NCT00023218
- Testing
- Lopinavir/Ritonavir, Efavirenz
- Where
- 3 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy, HIV
A Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 10-1074
This is a phase 1 clinical trial to evaluate the safety, pharmacokinetics and the antiretroviral effects of the highly neutralizing anti-HIV-1 monoclonal antibody 10-1074 in HIV-infected and HIV-uninfected individuals.
- Trial name
- NCT02511990
- Testing
- 3 mg/kg, single dose IV administration of 10-1074, 10 mg/kg, single dose IV administration of 10-1074, 30 mg/kg, single dose IV administration of 10-1074
- Where
- 2 sites in United States, Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
HIV
Improving Memory Performance by Applying Cognitive Training
The proposed study will test the efficacy of a cognitive training program to improve working memory in a sample of HIV-infected persons.
- Trial name
- IMPACT (NCT02216591)
- Testing
- Active Cognitive Training (ACT), Control (CON)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
COPD, HIV Infections
Airway Microbiome and Th17-mediated Inflammation in COPD Among HIV-infected Individuals in a Rural Ugandan Cohort
Rationale: COPD is increasing in prevalence among people living with HIV/AIDS (PLWHA) as widespread use of ART has increased longevity in this population. In rural Ugandan ART clinics, we report COPD prevalence of 6.22%.
- Conditions
- COPD, HIV Infections, Respiratory Disease
- Trial name
- HLM (NCT05223114)
- Testing
- Not applicable (N/A)
- Where
- Uganda
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV
Maraviroc Switch Collaborative Study
MARCH is an international, multicentre trial planning to enroll 380 HIV-1 infected patients who are currently on 2N(t)RTI + PI/r regimen and virologically suppressed.
- Trial name
- MARCH (NCT01384682)
- Testing
- Maraviroc
- Where
- 51 sites in Argentina, Australia and 11 more
- Volunteers
- 399 people
- Sponsor
- Kirby Institute
HIV, Aging
Tenofovir Pharmacology in Older HIV Infected Individuals
Tenofovir continues to play a vital role in the treatment of the human immunodeficiency virus (HIV) and as the age of the HIV-infected population increases in the United States and worldwide, there is an urgent need to understand…
- Trial name
- NCT02304263
- Testing
- iohexol
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver