Clinical trials: HIV Infection, completed
Human Immunodeficiency Viruses, Kidney Failure
Impact of Drug Therapy and Co-Morbidities on the Development of Renal Impairment in HIV-Infected Patients
Tenofovir (TDF)-containing regimens may be associated with decreasing renal function in HIV-infected patients concurrently treated with boosted PI's and/or have co-morbid conditions including diabetes mellitus, hypertension…
- Conditions
- Human Immunodeficiency Viruses, Kidney Failure, HIV Infections
- Trial name
- NCT00551655
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- AIDS Arms Inc.
HIV Infections, HIV/AIDS
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
This is a randomized clinical trial of doxycycline post-exposure prophylaxis (dPEP) to reduce bacterial STIs among Kenyan women taking pre-exposure prophylaxis (PrEP).
- Conditions
- HIV Infections, HIV/AIDS, Neisseria Gonorrheae Infection, Chlamydia Trachomatis Infection
- Trial name
- dPEP-KE (NCT04050540)
- Testing
- Doxycycline
- Where
- Kenya
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sarcoma
BMS-275291 in Treating Patients With HIV-Related Kaposi's Sarcoma
Phase I/II trial to study the effectiveness of BMS-275291 in treating patients who have HIV-related Kaposi's sarcoma. Drugs such as BMS-275291 may stop the growth of Kaposi's sarcoma by stopping blood flow to the tumor.
- Trial name
- NCT00024024
- Testing
- rebimastat
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infection
A Prospective, Open-label Trial of Two ABC/3TC Based Regimens in Late Presenter naïve Patients (CD4 <200 Cells/µL)
1. PROTOCOL SUMMARY This is a prospective, randomized open-label, 2 arm, 3-phase trial to compare the 48-weeks virological response of two different regimens containing abacavir/lamivudine (abacavir/lamivudine…
- Trial name
- NCT01900106
- Testing
- abacavir/lamivudine + raltegravir, abacavir/lamivudine + darunavir/ritonavir
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Modena and Reggio Emilia
HIV Infections
Experimental Design of Couple Counseling and Testing in Antenatal Clinics in Dar es Salaam, Tanzania
The objective of this research is to evaluate the effectiveness of couples Voluntary Counseling and Testing for HIV (CVCT) compared to individual VCT (IVCT) in preventing MTCT, and in increasing preventive behaviors and…
- Trial name
- CVCT (NCT00631384)
- Testing
- Couples VCT, Individual VCT
- Where
- Tanzania
- Volunteers
- 1,521 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Substance Abuse, Offenders
Effects of Manualized Treatment in a Seamless System
The specific aims of this project are: 1. To conduct a randomized block experiment to test the effectiveness of different models of the seamless supervision/treatment system and traditional criminal justice supervision on…
- Conditions
- Substance Abuse, Offenders, Criminal Thinking, HIV Risk Behaviors
- Trial name
- Man Tx (NCT01372033)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- George Mason University
HIV Infections
The Effects of r-metHuIFN-Gamma on the Lungs of Patients With AIDS
To determine safety and tolerance of administering aerosolized recombinant interferon gamma (IFN-gamma) for 4 weeks in patients with AIDS. To examine activation of alveolar macrophages by aerosolized IFN-gamma administration.
- Trial name
- NCT00002433
- Testing
- Interferon gamma-1b
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Amgen
Human Immunodeficiency Virus
Feasibility of Telerehabilitation in HIV-patients
The aim of this study is to assess the feasibility and the effects of a 6-week telerehabilitation on the three domains of the International Classification of Functioning, Disability and Health in HIV-infected patients under…
- Trial name
- NCT03335176
- Testing
- Endurance ad Resistance Training Exercise
- Volunteers
- 25 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
HIV Infections
FEM-PrEP (Truvada®): Study to Assess the Role of Truvada® in Preventing HIV Acquisition in Women
This Phase III, double-blind, randomized, placebo-controlled trial enrolled HIV-negative women from 4 sites in 3 countries (Kenya, Tanzania, South Africa).
- Trial name
- NCT00625404
- Testing
- Truvada
- Where
- 4 sites in Kenya, South Africa and 1 more
- Volunteers
- 2,120 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Intervention for (Those) Recently Informed of Seropositive Status (IRISS)
An intervention designed to increase positive affect in a population newly diagnosed with HIV will be effective at improving affect and HIV-related outcomes such as mental and physical health, coping and coping resources.
- Trial name
- IRISS (NCT00720733)
- Testing
- Skills-Building Intervention, Personal Interview Group
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of California, San Francisco
HIV Infections
Lopinavir/r Monotherapy as Maintenance Therapy After Long Term Viral Suppression
1. Objectives Primary To investigate the possibility of maintaining virological suppression of HIV in infected patients, switching them to LPV/r as the only antiretroviral agent To assess the immunological response in patients…
- Trial name
- NCT00160849
- Testing
- Lopinavir/r
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal do Rio de Janeiro
HIV Infections
ATV/Ritonavir Nevirapine Interaction (USPAC)
Open-Label, multiple-dose, drug interaction study to assess the effect of nevirapine on the pharmacokinetics of atazanavir in HIV-infected individuals.
- Trial name
- NCT00162149
- Testing
- Nevirapine, Nevirapine + Atazanavir/Ritonavir, Atazanavir + Ritonavir
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 46 people
- Sponsor
- Bristol-Myers Squibb
HIV
IPREP Study #2: Evaluating Enhanced PrEP Packages for Young Female Sex Workers in Kisumu, Kenya
This is an open-label randomized controlled trial (n=200) in which HIV-negative young female sex workers (FSW) will be randomized to receive oral PrEP combined with specific behavioral and structural adherence interventions…
- Trial name
- NCT03988387
- Testing
- Peer Support (PS), Reminder and Resource Transfer (RRT), daily oral PrEP (emtricitabine 200 mg/tenofovir 300 mg) [FTC/TDF]
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Acquired Immunodeficiency Syndrome, HIV Infections
Analysis of Immune Responses to HIV Vaccines
This study will evaluate a test designed to measure immune system responses to HIV and HIV vaccines.
- Trial name
- NCT00068978
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Multicenter Trial To Evaluate Oral Retrovir in the Treatment of Children With Symptomatic HIV Infection
To evaluate the safety and tolerance of oral zidovudine (AZT) when given over a period of 24 weeks to children between 3 months and 12 years of age.
- Trial name
- NCT00000716
- Testing
- Zidovudine
- Where
- 9 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Trial of Maraviroc (UK-427,857) in Combination With Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of HIV-1 Infected Subjects
Maraviroc (UK-427,857), a selective and reversible CCR5 coreceptor antagonist, has been shown to be active in vitro against a wide range of clinical isolates (including those resistant to existing classes).
- Trial name
- MOTIVATE 1 (NCT00098306)
- Testing
- Maraviroc (UK-427,857), Optimized Background Therapy
- Where
- 22 sites in United States, Canada
- Volunteers
- 601 people
- Sponsor
- ViiV Healthcare
HIV Infections
A Study of Ribavirin in the Treatment of Patients With AIDS and AIDS-Related Problems
To determine the maximum long-term dosage of ribavirin (RBV) that is safe and free of serious side effects in patients with AIDS or AIDS related illnesses.
- Trial name
- NCT00001015
- Testing
- Ribavirin
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Depression
Maternal Depression Treatment in HIV
Cluster randomized controlled trial to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the prevention of mother-to-child-transmission (PMTCT) care cascade at 8…
- Trial name
- M-DEPTH (NCT03892915)
- Testing
- evidence-based depression treatment
- Where
- Uganda
- Volunteers
- 391 people
- Sponsor
- RAND
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Phase II Safety and Efficacy Study of Clarithromycin in the Treatment of Disseminated M. Avium Complex (MAC) Infections in Patients With AIDS
This study is designed to evaluate the efficacy and safety of clarithromycin given orally at 1 of 3 doses to treat disseminated Mycobacterium avium complex infections (MAC) in patients with AIDS.
- Trial name
- NCT00000644
- Testing
- Clarithromycin
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Universal Coverage of Antiretroviral Treatment in Senegal
Senegal plans a rapid scale up of HIV treatment for all people living with HIV, regardless of cluster of differentiation 4 (CD4) count or viral suppression.
- Trial name
- NCT03880006
- Testing
- Case management
- Where
- 4 sites in Senegal
- Volunteers
- 596 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
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