Clinical trials: HIV Infection
Candidiasis, Oral, HIV Infections
A Study of Nystatin in the Prevention of Fungal Infections of the Mouth in Patients With AIDS or AIDS-Related Syndromes
To determine a safe, effective, and convenient dosing schedule for nystatin pastilles in the prophylaxis of oral candidiasis in patients with AIDS or AIDS related syndromes (group III or IV, CDC classification)
- Trial name
- NCT00002293
- Testing
- Nystatin
- Where
- 2 sites in United States
- Sponsor
- Bristol-Myers Squibb
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV Infections
Safety and Acceptability Study of the UC-781 Microbicide Gel Applied Rectally
This study is the first to try this product in the rectum of humans. This study is only to find out if the gel is safe for use in the rectum, not to see if the gel works.
- Trial name
- NCT00408538
- Testing
- UC-781 microbicide gel (0.1% and 0.25%)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV-1-infection
Amsterdam UMC Clinical Trial With a Native-like HIV-1 Envelope Vaccine
ACTHIVE-001 is a randomised, open-label, uncontrolled phase 1 clinical trial to determine the safety profile of the native-like HIV-1 envelope vaccine, ConM SOSIP.v7, adjuvanted with monophosphoryl lipid A (MPLA) liposomes.
- Trial name
- ACTHIVE-001 (NCT03961438)
- Testing
- ConM SOSIP.v7 gp140, adjuvanted with MPLA liposomes
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
HIV Infections
Sequential HIV Therapy in Treatment Resistant HIV-1 Infected Patients
This is an open label, crossover pilot study to explore the safety and efficacy of a rapid cycling regimen of antiretroviral combination therapy in HIV-1 infected patients with virus harboring genotypic resistance to at least…
- Trial name
- NCT00128908
- Testing
- Standard Continuous Highly Active Antiretroviral Therapy (HAART), Rapidly Cycled HAART
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Kidney Failure, HIV Infection
Kidney Transplant for HIV-Infected Patients in Renal Failure
This study will examine the safety and effectiveness of renal (kidney) transplantation for HIV-infected patients with end-stage renal disease (kidney failure).
- Trial name
- NCT00009009
- Testing
- immunosuppressive regimen designed to complement HAART
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
HIV Infections
Safety and Blood Levels of Tenofovir Disoproxil Fumarate in HIV Infected Pregnant Women and Their Babies
To prevent mother-to-child transmission (MTCT) of HIV in resource-limited countries, a simple yet effective treatment plan is needed.
- Trial name
- NCT00120471
- Testing
- Tenofovir disoproxil fumarate
- Where
- 5 sites in Brazil, Malawi
- Volunteers
- 122 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, Chronic Obstructive Pulmonary Disease (COPD)
Doxycycline for COPD in HIV-Infected Patients
In the context of improved survival from HIV infection itself, chronic obstructive pulmonary disease (COPD); a form of lung disease that includes emphysema, which makes breathing difficult) is emerging as an important cause of…
- Conditions
- HIV, Chronic Obstructive Pulmonary Disease (COPD), Emphysema
- Trial name
- NCT01744093
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Weill Medical College of Cornell University
HIV Infections, HSV-2 Genital Herpes
Retention and Duration of Activity of SPL7013 (VivaGel®) After Vaginal Dosing.
To assess the retention and anti-viral activity (human immunodeficiency virus (HIV) and herpes simplex virus 2 (genital herpes, HSV-2) of SPL7013 in cervicovaginal samples taken up to 24 hours after administration of 3% SPL7013…
- Trial name
- NCT00740584
- Testing
- 3% SPL7013 Gel (VivaGel)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Starpharma Pty Ltd
Diabetes, HIV/AIDS
Food Assistance, Diabetes, and HIV
Diabetes prevalence is increasing among people living with HIV (PLWH), yet blood glucose control is less successful in this population who are also often food insecure. Food assistance programs often provide nutrient-poor foods.
- Conditions
- Diabetes, HIV/AIDS, FOOD SECURITY
- Trial name
- BFED (NCT04045184)
- Testing
- Food assistance
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
HIV Infections
A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine
To compare the safety, tolerance, and efficacy of saquinavir mesylate (Ro 31-8959) alone, zalcitabine (dideoxycytidine; ddC) alone, and both in combination, in patients discontinuing or unable to take zidovudine (AZT).
- Trial name
- NCT00002333
- Testing
- Saquinavir, Zalcitabine
- Where
- 47 sites in United States, Canada and 1 more
- Volunteers
- 900 people
- Sponsor
- Hoffmann-La Roche
Tuberculosis, Pulmonary
Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence
This is a phase 2, double-blind, randomized (1:1), placebo-controlled trial with two parallel groups. H56:IC31 (investigational vaccine) Placebo 900 HIV-negative adults with a diagnosis of drug susceptible pulmonary TB are…
- Trial name
- NCT03512249
- Testing
- H56:IC31
- Where
- 6 sites in South Africa, Tanzania
- Volunteers
- 831 people
- Sponsor
- International AIDS Vaccine Initiative
HIV-1-infection
The HIV Functional Cure Potential of UB-421 in ART Stabilized HIV-1 Patients
This is a Phase II, randomized, open-label, multi-center, active-controlled study to assess the safety, tolerability, and efficacy of UB-421 administered as an add-on to the standard ART in ART-treated HIV-1 subjects with stably…
- Trial name
- HIV-1 (NCT04404049)
- Testing
- UB-421(25 mg/kg) Q2W, UB-421(25 mg/kg) Q4W
- Volunteers
- 39 people
- Sponsor
- UBP Greater China (Shanghai) Co., Ltd
HIV Infections
A Study to Assess the Safety and Pharmacokinetics of a Human Monoclonal Antibody (VH4527079) in Healthy Adults and Persons With HIV
This study evaluates the safety, tolerability, and pharmacokinetics (PK) of a single dose administration of VH4527079 by subcutaneous (SC) injection or by intravenous (IV) infusion in healthy adult participants and multiple dose…
- Trial name
- NCT06652958
- Testing
- VH4527079
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Acquired Immunodeficiency Syndrome, HIV Infections
A Phase I /II Study of the Protease Inhibitor Indinavir (MK-0639) in Children With HIV Infection
This is a phase I/II study to determine the safety and tolerance of the protease inhibitor indinavir (MK-0639), alone and then in combination with HIV reverse transcriptase inhibitor therapy in children with HIV infection.
- Trial name
- NCT00001443
- Testing
- indinavir (MK-0639)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
HIV (Human Immunodeficiency Virus), Cardiovascular Diseases (CVD)
Reducing Arterial Inflammation Using Eplerenone and Statins in HIV
HIV has transitioned to a chronic disease in which well-treated persons remain at higher risk for heart disease when compared to the general population.
- Conditions
- HIV (Human Immunodeficiency Virus), Cardiovascular Diseases (CVD), Arterial Inflammation, Heart Disease
- Trial name
- SUNRISE HIV (NCT07892664)
- Testing
- Eplerenone
- Where
- 2 sites in United States
- Volunteers
- 124 people
- Sponsor
- Massachusetts General Hospital
Mycobacterium Avium-Intracellulare Infection, HIV Infections
A Study of Azithromycin in the Prevention of Mycobacterium Avium Complex Disease (MAC) in HIV-Infected Patients
To evaluate the efficacy and safety of azithromycin administered once a week in the prevention of disseminated Mycobacterium avium complex (MAC) in severely immunocompromised HIV-infected patients with a CD4 count < 100 cells/mm3.
- Trial name
- NCT00002309
- Testing
- Azithromycin
- Where
- 3 sites in United States
- Sponsor
- Pfizer
Capacity Building, Drug Use
Methadone Maintenance and HIV Prevention: A Window of Opportunity in China
This study is an intervention pilot that integrates the current methadone maintenance treatment (MMT) program in China with psychosocial and behavioral components in order to address the critical link between drug use and…
- Conditions
- Capacity Building, Drug Use, HIV/AIDS
- Trial name
- MMT1 (NCT01532609)
- Testing
- MMT CARE
- Where
- China
- Volunteers
- 220 people
- Sponsor
- University of California, Los Angeles
HIV Infections
BLQ Study: A Study of a Protease Inhibitor With Fuzeon (Enfuvirtide) in Treatment-Experienced Patients With HIV-1.
This single arm study will evaluate the efficacy, safety and tolerability of a new investigational protease inhibitor (PI) plus background antiretrovirals plus Fuzeon (90mg sc bid) in HIV-1 infected, triple-class…
- Trial name
- NCT00326963
- Testing
- Background ARVs, PI, enfuvirtide [Fuzeon]
- Where
- 38 sites in United States, Australia
- Volunteers
- 142 people
- Sponsor
- Hoffmann-La Roche
Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome (AIDS)
Evaluating Rewards-Based Adherence and Electronic Medication Monitoring in HIV-Positive Adolescents
The primary objective of this project is to assess the study population's acceptance of two medication adherence support strategies: incentive-based programs and electronic medication monitoring.
- Trial name
- NCT01849393
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Jude Children's Research Hospital