Clinical trials: HIV Infection, completed
HIV/AIDS, Tuberculosis
Prevent TB: Choice Architecture for TPT Delivery
Background: Clinical guidelines and policies often fail to achieve high levels of delivery of intended clinical interventions. The difference in what the investigators know works and what is actually delivered at the clinic-level…
- Trial name
- NCT04466488
- Testing
- Choice Architecture
- Where
- South Africa
- Volunteers
- 50,798 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV-1 Infections, HIV Infections
Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples
Randomized, blinded, placebo-controlled trial to demonstrate if pre-exposure prophylaxis decreases HIV-1 acquisition among HIV-1 uninfected individuals within HIV-1 discordant couples.
- Trial name
- Partners PrEP (NCT00557245)
- Testing
- Tenofovir Disoproxil Fumarate (TDF), Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF)
- Where
- 9 sites in Kenya, Uganda
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pneumococcal Disease
Safety and Immunogenicity of V116 in Adults Living With Human Immunodeficiency Virus (HIV) (V116-007, STRIDE-7)
This study will evaluate the safety, tolerability, and immunogenicity of a pneumococcal 21-valent conjugate vaccine (V116) in persons living with human immunodeficiency virus (HIV), for the prevention of pneumococcal disease…
- Trial name
- NCT05393037
- Testing
- V116, PCV15, PPSV23
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 313 people
- Sponsor
- Merck Sharp & Dohme LLC
Health Risk Behaviors
Sexually Active Adolescent Focused Education
SAAFE will be pilot tested in 2 geographically distinct areas (Washington, DC and Deep South) with 100 participants from each site to 1) primarily assess the efficacy of improved self-efficacy, knowledge about HIV/STIs and…
- Trial name
- SAAFE (NCT03646032)
- Testing
- SAAFE, Control
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Benten Technologies, Inc.
PML, AIDS
Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS).
- Trial name
- NCT00342602
- Where
- 6 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Alcohol Consumption, HIV
ARCH II Study (Alcohol Research Center on HIV Study II)
This study is being done to learn about the interaction of alcohol consumption and HIV on brain function. The proposed study will have two broad objectives.
- Conditions
- Alcohol Consumption, HIV, Motivation
- Trial name
- NCT02563574
- Testing
- Motivational Interviewing, Questionnaire assessment, Neurocognitive assessments
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Tuberculosis, HIV Infections
Improving HIV/Tuberculosis Outcomes in Irkutsk
The investigators propose to examine the prospective influence of substance use patterns on HIV/tuberculosis adherence, pharmacokinetics and disease progression while developing novel methods for early detection and correction of…
- Conditions
- Tuberculosis, HIV Infections, Substance Use
- Trial name
- NCT03819374
- Where
- Russia
- Volunteers
- 53 people
- Sponsor
- University of Virginia
HIV-1-infection, Antenatal Care
An Integrated Strategy to Support Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence for HIV Prevention in Pregnant and Breastfeeding Women
This study is composed of two parallel, pilot randomized groups that will obtain preliminary data about the the acceptability, fidelity, and clinical outcomes associated with a multi-component adherence support strategy for HIV…
- Trial name
- NCT04330989
- Testing
- iNSC and Adherence supporter training
- Where
- Malawi
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Seropositivity, Pregnancy, High-Risk
Safer Conception Intervention for HIV-1 Serodiscordant Couples
The greatest burden of the HIV-1 epidemic lies in sub-Saharan Africa, where a substantial proportion of infections occur in long-term heterosexual HIV-1 serodiscordant partnerships.
- Trial name
- SCIP (NCT03030768)
- Testing
- PrEP, Counseling on timed condomless sex, ART and PrEP adherence
- Where
- 2 sites in United States, Kenya
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infections, Sexually Transmitted Infections
Uptake of Medical Male Circumcision Among Men With Sexually Transmitted Infections
The intervention includes provision of transport reimbursement for men who will undergo voluntary medical male circumcision (VMMC), intensified health education by a VMMC mobilizer and a male and female VMMC champion and use of a…
- Trial name
- VMMC-RITe (NCT04677374)
- Testing
- Standard of care, Intensified Health Education, SMS/telephonic Tracing
- Where
- Malawi
- Volunteers
- 2,242 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adolescent Behavior, Hiv
Nutritional Therapy Improves Dyslipidemia in HIV Infected Teenagers With Antiretroviral Treatment
Introduction: Prolonged use of antiretroviral therapy is associated with metabolic and bodily changes such as lipodystrophy, diabetes mellitus, insulin resistance and dyslipidemia latter being associated with a higher chance of…
- Conditions
- Adolescent Behavior, Hiv, Dyslipidemias
- Trial name
- NCT03021889
- Testing
- Nutritional therapy, Control group
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Carcinoma, HIV Infections
Molecular Biology of Anal Cancer in HIV-Positive Patients
The molecular mechanisms involved in squamous cell carcinoma of the anus (SCCA) are poorly elucidated. HIV-positive and renal transplant patients are at high risk for developing SCCA, indicating that immune suppression plays a…
- Trial name
- NCT00952874
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
HIV Infections
Safety and Effectiveness of a Combination Anti-HIV Drug Treatment
The purpose of this study is to see if it is safe and effective to give HIV-positive patients a combination of anti-HIV drugs (abacavir [ABC] plus efavirenz [EFV] plus didanosine [ddI]) with and without hydroxyurea (HU).
- Trial name
- NCT00005018
- Testing
- Hydroxyurea, Abacavir sulfate, Efavirenz
- Where
- 23 sites in United States
- Volunteers
- 150 people
- Sponsor
- Glaxo Wellcome
HIV Infections
Regimen Switch to Dolutegravir/Lamivudine Fixed Dose Combination From Current Antiretroviral Regimen in HIV-1 Infected and Virologically Suppressed Adults (SALSA)
The aim of this study is to determine if virologically suppressed Human Immunodeficiency Virus (HIV) Type 1 infected adults on a current antiretroviral regimen (CAR) (including 2 nucleoside reverse transcriptase inhibitors…
- Trial name
- NCT04021290
- Testing
- DTG/3TC FDC, CAR
- Where
- 119 sites in United States, Argentina and 15 more
- Volunteers
- 493 people
- Sponsor
- ViiV Healthcare
HIV
HIV Self-Testing Africa (STAR) Malawi: General Population
The aim of this project is to investigate the feasibility, affordability as well as the health and social impact of introducing HIV self-testing to rural communities through existing community-based volunteer services.
- Trial name
- STAR Malawi (NCT02718274)
- Testing
- OraQuick ADVANCE HIV I/II test kits, packaged for self-use (manufactured in Thailand), Home-based initiation of ARVs
- Where
- Malawi
- Volunteers
- 5,504 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Prevention
ImQuest (IQP) DuoGel Phase 1 Pharmacokinetic Study
The purpose of this study is describe the safety and single-dose pharmacokinetics of rectally-administered IQP (ImQuest Pharmaceuticals)-0528 (DuoGel) in plasma, rectal tissue biopsies, vaginal tissue biopsies, rectal fluid and…
- Trial name
- NCT03082690
- Testing
- DuoGel
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV-1-infection
Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With Other Antiretroviral Agents in People Living With HIV
The primary objective of this study is to evaluate the efficacy of lenacapavir (formerly GS-6207) containing regimens in people living with human immunodeficiency virus (HIV) (PLWH).
- Trial name
- CALIBRATE (NCT04143594)
- Testing
- Oral Lenacapavir, F/TAF, Subcutaneous Lenacapavir
- Where
- 53 sites in United States, Dominican Republic and 1 more
- Volunteers
- 183 people
- Sponsor
- Gilead Sciences
Human Immunodeficiency Virus (HIV)
Study to Assess Adverse Events and How Intravenous (IV) or Subcutaneous (SC) ABBV-382 Moves Through the Body of Adult Participants With Human Immuno-Deficiency Virus (HIV-1)
Human immuno-deficiency virus (HIV) is the virus that causes Acquired Immuno-Deficiency Syndrome (AIDS). HIV infection is considered to be a chronic disease requiring lifelong therapy.
- Trial name
- NCT04554966
- Testing
- ABBV-382
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 54 people
- Sponsor
- AbbVie
HIV Infections
Papuan Indigenous Model of Male Circumcision
The purpose of the study is: AIM 1: To engage Papuan community members to explore acceptability, barriers and facilitators for introducing a school-based age and culturally appropriate, comprehensive VMMC intervention to reduce…
- Trial name
- NCT06212531
- Testing
- Medical male circumcision using standard surgical technique.
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV-1-infection, HIV Associated Neurocognitive Disorder
HIV-1 Infected Adult Subjects With HIV-associated Neurocognitive Disorders Despite Effective Antiretroviral Therapy
Prospective study in HIV-1 infected adult subjects with HIV-associated neurocognitive disorders despite effective antiretroviral therapy in plasma for more than one year, analyzing the evolution of cognitive disorders and markers…
- Trial name
- NCT04266002
- Testing
- Validation of Charter score for the CNS diffusion of antiretroviral drugs
- Where
- 12 sites in France
- Volunteers
- 31 people
- Sponsor
- Hôpital Franco-Britannique-Fondation Cognacq-Jay
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