Clinical trials: HIV Infection, completed
HIV, Metabolic Syndrome
Incidence of HANA Conditions in HIV-infected Individuals
With the availability of effective anti-retroviral therapy, HIV-infected individuals are expected not to die of AIDS and have longer life expectancy.
- Conditions
- HIV, Metabolic Syndrome, Osteopenia, Osteoporosis
- Trial name
- NCT03483584
- Where
- Hong Kong
- Volunteers
- 215 people
- Sponsor
- Chinese University of Hong Kong
HIV Seropositivity, ART
Effects of VSL#3 on Neuro-cognitive Profile of HIV Patients
Aim of the study is to evaluate the effects of a change in the intestinal microflora on the neuro-cognitive profile of patients with HIV infection receiving HAART treatment.
- Trial name
- NCT02276326
- Testing
- VSL#3 sachets
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Policlinico Umberto I
Infections, Human Immunodeficiency Virus and Herpesviridae
Relative Bioavailability Study of a Pediatric Granule Formulation of Dolutegravir
Dolutegravir (DTG, GSK1349572) is an integrase inhibitor currently in Phase 3 clinical trials for the treatment of human immunodeficiency virus (HIV) infection.
- Trial name
- NCT01382238
- Testing
- Dolutegravir 50 mg tablet, Dolutegravir 50 mg oral granules
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Testing
Does Preference-based HIV Testing Increase Uptake in High Risk Populations?
Despite worldwide efforts to promote HIV Counseling and Testing (HCT), rates of testing remain low. Understanding how high risk groups decide to test and adapting available testing options to their preferences has the potential…
- Trial name
- DCE-IMPACT (NCT02714140)
- Testing
- PB-HCT +, PB-HCT -, Economic incentive
- Where
- 3 sites in United States, Tanzania
- Volunteers
- 1,194 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Acquired Immunodeficiency Syndrome
Accuracy Evaluation of the BD FACS Presto System
The enumeration of T lymphocytes positive for the CD4 antigen is used to determine the immune status of patients with, or suspected of developing, immune deficiencies such as AIDS.
- Trial name
- NCT02396355
- Testing
- Investigational BD FACSPresto System, BD FACSCalibur flow cytometer, Sysmex hematology analyzer KX-21
- Where
- 6 sites in United States, India and 2 more
- Volunteers
- 583 people
- Sponsor
- Becton, Dickinson and Company
HIV-1-infection
MGD014 in HIV-Infected Individuals on Suppressive Antiretroviral Therapy
This is a Phase 1, open-label single-center study to determine the safety of MGD014 in participants with human immunodeficiency virus (HIV) infection on stable suppressive antiretroviral therapy (ART).
- Trial name
- NCT03570918
- Testing
- MGD014
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- MacroGenics
Depression, HIV
Neuroinflammation and Modulating Factors in Depression and HIV
Determine if depression, which persists after depression treatment at 26 weeks, is associated with increased innate inflammation in a prospective cohort of HIV-infected Ugandans receiving SSRIs in which group psychotherapy is…
- Trial name
- NCT04286282
- Testing
- Group Pyschotherapy, Depression Standard of Care, HIV Standard of Care
- Where
- Uganda
- Volunteers
- 109 people
- Sponsor
- University of Minnesota
HIV
Research In Viral Eradication of HIV Reservoirs
This study will be a two-arm prospective 1:1 randomised controlled trial comparing: Arm A: cART preferably including raltegravir (combination ART cART - control) Arm B: cART preferably including raltegravir (cART) plus…
- Trial name
- RIVER (NCT02336074)
- Testing
- Combination Antiretroviral Therapy (cART), Raltegravir, Vorinostat
- Where
- 6 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London
HIV
Operational Assessment of Point-of-Care Diagnostics in Primary Healthcare Clinics
Diagnostic point-of-care (POC) tests are being rapidly developed and implemented in resource-limited settings. There has been a rapid rise of HIV and TB POC tests in South Africa during the last 10-15 years.
- Trial name
- NCT02692274
- Where
- South Africa
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
HIV-1-infection
Identification of Barriers and Facilitators of Implementation of the Out-of-Hospital Administration of the Long- Acting Combination Cabotegravir+Rilpivirina.
The study will identify the barriers and facilitators of implementation of the out-of-hospital administration of CAB+RPV LA from the point of view of staff participating in the study.
- Trial name
- NCT06643897
- Testing
- Qualitative Interview
- Where
- 9 sites in Spain
- Volunteers
- 13 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
HIV Infection
Long-Term Clinical, Immunologic, and Virologic Profiles of Children Who Received Early Treatment for HIV
IMPAACT 2028 is an observational prospective study to characterize a cohort of early treated children who may participate in future research related to HIV remission or cure.
- Trial name
- NCT05154513
- Testing
- Cohort 1
- Where
- 28 sites in United States, Botswana and 9 more
- Volunteers
- 163 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
HIV Prevention
Randomized Controlled Trial of Game Changers
The study is a randomized controlled trial (RCT) of Game Changers, an 8-session peer-led group intervention that aims to empower and mobilize people living with HIV (PLWH) to be agents for HIV prevention in their social networks.
- Trial name
- NCT05098015
- Testing
- Game Changers
- Where
- Uganda
- Volunteers
- 809 people
- Sponsor
- RAND
HIV, AIDS
TMC125-TiDP2-C187: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Interaction Between TMC125 and Two Antifungal Agents (Fluconazole and Voriconazole), All at Steady-state in Healthy Subjects.
This is a Phase I, open-label, 3-period crossover trial to investigate the pharmacokinetic interaction (process by which a drug is absorbed, distributed, metabolised and eliminated by the body) between TMC125 and fluconazole, and…
- Conditions
- HIV, AIDS, Fungal Infection
- Trial name
- NCT00740389
- Testing
- TMC125
- Volunteers
- 18 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
HIV Infections
A Study of Ritonavir-Boosted Invirase (Saquinavir) in Treatment-Naïve HIV-1 Infected Patients
This open-label study will evaluate the safety, pharmacokinetics and antiviral activity of a modified Invirase (saquinavir)/ritonavir regimen in treatment-naïve HIV-1 infected patients.
- Trial name
- NCT01638650
- Testing
- Nucleoside Reverse Transcriptase Inhibitor (NRTIs), ritonavir, saquinavir [Invirase]
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Hoffmann-La Roche
Circumcision, Male
Comparison of the Shang Ring With Conventional Surgical Methods
This is a randomized control trial of 400 adult male circumcision procedures with a one to one ratio between Shang Ring and the in-country standard surgical technique (forceps guided in Kenya and dorsal slit in Zambia).
- Trial name
- NCT01300910
- Testing
- Shang Ring, Male circumcision
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections
Study of Effects of Tenofovir on Bone Health and Kidneys During Pregnancy and Breastfeeding
The purpose of this study is to look at the effects of tenofovir disoproxil fumarate (an anti-HIV medication) on the bone health and kidneys of women with HIV during pregnancy and while breastfeeding.
- Trial name
- NCT01066858
- Testing
- Tenofovir disoproxil fumarate (TDF)
- Where
- 11 sites in Malawi, South Africa and 2 more
- Volunteers
- 1,765 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphatic Disease, HIV Infections
The Efficacy and Safety of Retrovir in Patients Infected With HIV Who Are Asymptomatic (CDC Group II) or Have Persistent Generalized Lymphadenopathy (CDC Group III)
To evaluate the safety and tolerance of chronic administration of Retrovir (AZT) in HIV-infected adult patients without clinical manifestations of disease.
- Trial name
- NCT00002048
- Testing
- Zidovudine
- Where
- 22 sites in United States
- Sponsor
- Glaxo Wellcome
HIV
A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines
Treatment of children and infants with HIV requires modification of medication dosing according to a child's specific weight. For lopinavir/ritonavir (LPV/r), a second line treatment option that is increasingly necessary due to…
- Trial name
- NCT01172535
- Testing
- Lopinavir/ritonavir
- Where
- 19 sites in United States, Brazil and 2 more
- Volunteers
- 97 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infection, Human Immunodeficiency Virus I, HIV Infection
Observational Study Of A Protease Inhibitor (PI) Containing Regimen In Subjects With PI Mutations Selected During Prior Treatment With GW433908 (Fosamprenavir)
This study will assess the efficacy of subsequent protease inhibitor (PI)-containing therapy in subjects who have acquired HIV-1 protease mutations whilst receiving a GW433908 (fosamprenavir)-containing regimen.
- Trial name
- NCT00242840
- Testing
- No intervention; Observational study
- Where
- 7 sites in United States, Italy
- Volunteers
- 20 people
- Sponsor
- ViiV Healthcare
Maternal and Child Health, HIV
Pii Ngima: Consequences of Water Insecurity for Maternal and Child Health
This study will implement the validated household-level water insecurity scale developed by study investigators among a cohort of postpartum women in Nyanza, Kenya and will assess a range of outcomes linked to water insecurity…
- Trial name
- PEN (NCT02979418)
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Northwestern University
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