Clinical trials: HIV Infections, completed
Contraception, HIV
HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC
This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract of healthy women.
- Conditions
- Contraception, HIV, Immune Cells (Mucosal and Systemic), Microbiota
- Trial name
- Zim CHIC (NCT02038335)
- Testing
- DMPA, NET-EN, MPA/E2
- Where
- Zimbabwe
- Volunteers
- 451 people
- Sponsor
- University of Pittsburgh
HIV/AIDS
Behavioural Text Messages to Improve Retention in Care in South Africa
The proportion of South Africans aware of their HIV status and on treatment remains lower than optimal. The goal of this study is to rapidly determine whether text messages framed according to behavioural economics principles…
- Trial name
- NCT05010291
- Testing
- Standard of Care (SOC) text message reminder to attend clinic appointment, Loss aversion framed text message reminder to attend clinic appointment, Social norms framed text message reminder to attend clinic appointment
- Where
- South Africa
- Volunteers
- 1,541 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hiv, Cigarette Smoking
Cultural Adaptation and Piloting of a Smoking Cessation Intervention for Smokers With HIV
One population of tobacco users that is severely affected by the consequences of smoking is people living with HIV (PLWH). Between 40-84% of PLWH smoke, a percentage that has remained constant since the first studies of smoking…
- Trial name
- NCT03580460
- Testing
- Computer delivered smoking cessation counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
HIV Infections
Study of a New Protease Inhibitor, BMS-232632, in Combination With Other Anti-HIV Drugs
The purpose of this study is to evaluate a new protease inhibitor known as BMS-232632. This drug will be given in combination with 2 other anti-HIV drugs (stavudine and didanosine).
- Trial name
- NCT00002240
- Testing
- Atazanavir, Nelfinavir mesylate, Stavudine
- Where
- 17 sites in United States, Canada
- Sponsor
- Bristol-Myers Squibb
HIV/AIDS
The Incidence and Severity of Drug Interactions Before and After Switching Antiretroviral Therapy to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Treatment Experienced Patients
This study will assess changes in the incidence and severity of drug interactions before and after switching antiretroviral therapy to bictegravir/emtricitabine/tenofovir alafenamide-based regimens in treatment experienced…
- Trial name
- NCT03789968
- Testing
- bictegravir/emtricitabine/tenofovir alafenamide
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
AIDS
Efficacy and Safety of GSK Biologicals HIV Vaccine in Antiretroviral Therapy (ART)-naïve HIV-1 Infected Persons
This study is designed to determine whether administration of the GSK Biologicals HIV vaccine 732462 can lead to a reduction in viral load, and impact on the course of human immunodeficiency virus type 1 (HIV-1) infection.
- Trial name
- NCT01218113
- Testing
- GSK Biologicals HIV Vaccine 732462
- Where
- 42 sites in United States, France and 2 more
- Volunteers
- 191 people
- Sponsor
- GlaxoSmithKline
HIV, AIDS
Exploring the Impact of HIV and ART on Knowledge, Attitudes and Practices in Reproductive Health in Lilongwe, Malawi
The aim of this study is to identify reproductive health priorities among individuals living with HIV.This study also seeks to explore factors that influence fertility, family planning, and sexual behavior among individuals with…
- Trial name
- HIV KAP (NCT02667808)
- Testing
- Focus Group, Questionnaire
- Where
- Malawi
- Volunteers
- 562 people
- Sponsor
- Emory University
HIV Infections
Optimisation of Care in Vulnerable HIV Infected Individuals
Antiretroviral therapy is currently the only way to control HIV disease progression in HIV infected subjects and to prevent transmission.
- Trial name
- OPTICARE (NCT03799276)
- Testing
- Opticare study
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
HIV Infection, Drug Use
Linking Infectious and Narcology Care-Part II
This study, "Linking Infectious and Narcology Care - Part II (LINC-II)," will implement and evaluate a multi-faceted intervention (LINC-II), via a two-armed randomized controlled trial among 240 HIV-infected PWID in St.
- Trial name
- LINC-II (NCT03290391)
- Testing
- Rapid ART initiation, Pharmacotherapy for opioid use disorder, Strengths-based HIV case management
- Where
- 2 sites in Russia
- Volunteers
- 225 people
- Sponsor
- Boston Medical Center
Cognitive Dysfunction
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
The goal of this pilot work was to determine if the cognitive dysfunction accommodation strategies help patients retain/utilize more HIV prevention information and increase PrEP adherence.
- Trial name
- NCT05912374
- Testing
- standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB), enhanced Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
HIV/AIDS, Gonorrhea
A Pragmatic Trial of Two Strategies for Implementing an Effective eHealth HIV Prevention Program (Keep It Up! 3.0)
This study evaluates and compares two implementation strategies of an online HIV prevention intervention: Strategy 1 in which community-based organizations apply, and are selected, for funding to deliver Keep It Up! through…
- Conditions
- HIV/AIDS, Gonorrhea, Chlamydia
- Trial name
- NCT03896776
- Testing
- Keep It Up! 3.0
- Where
- United States
- Volunteers
- 2,249 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HIV Infections, Acquired Immunodeficiency Syndrome
Effectiveness of Structured Ecosystems Therapy for Reducing HIV Risk Behaviors and Improving Treatment Adherence in HIV Infected Men Released From Prison
This study will evaluate the effectiveness of Structured Ecosystems Therapy (SET), a form of therapy that includes family and caregivers, at reducing HIV transmission risk behaviors and improving treatment adherence in HIV…
- Trial name
- NCT00344591
- Testing
- Structured Ecosystems Therapy (SET), Individually tailored intervention
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of California, San Francisco
HIV
Optimization of the ex Vivo Challenge: Reproductive Infections and Contraception
The development of surrogates to predict HIV prevention product safety and efficacy is a high priority. An ex vivo challenge model is one such promising surrogate.
- Trial name
- NCT02375425
- Testing
- no intervention
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
HIV Infections
Study of a New Anti-HIV Drug, T-20, in HIV-Infected Children
The purpose of this study is to determine the best dose of T-20, a new anti-HIV drug, to treat HIV-infected children. T-20, unlike other anti-HIV medications, lessens the ability of HIV to infect certain cells (T cells) in the…
- Trial name
- NCT00001118
- Testing
- Enfuvirtide
- Where
- 25 sites in United States, Puerto Rico
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
HIV-1 Resistance at Screening for HIV Prevention Studies
MTN-009 is a multi-site, cross-sectional study that will provide an estimate of the prevalence of ARV resistance in the population of women who present to study sites to be pre-screened or screened for participation in an HIV…
- Trial name
- NCT01204814
- Where
- 7 sites in South Africa
- Volunteers
- 1,074 people, healthy volunteers welcome
- Sponsor
- Microbicide Trials Network
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Human Immunodeficiency Virus
Problems With Immune Recovery in the Gut Tissue
The aim of this study is to find out if the process of HIV replication in the lymph tissue and gut tissue of people taking HIV drugs causes long-term damage to the ability of the gut to protect you from other infections and…
- Trial name
- NCT01460433
- Testing
- Genital and rectal swabbing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma
Bryostatin 1 Plus Vincristine in Treating Patients With Recurrent or Refractory HIV-Related Lymphoma
Phase I trial to study the effectiveness of bryostatin 1 plus vincristine in treating patients who have recurrent or refractory lymphoma.
- Conditions
- AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma, AIDS-related Peripheral/Systemic Lymphoma, AIDS-related Small Noncleaved Cell Lymphoma
- Trial name
- NCT00022555
- Testing
- bryostatin 1, vincristine sulfate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infections
The Safety and Effectiveness of MK-639 and Zidovudine, Used Alone and Together, in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
To compare the effects on CD4 counts and safety of MK-639 (indinavir, IDV) and AZT administered concomitantly to MK-639 alone and AZT alone in HIV-1 seropositive patients.
- Trial name
- NCT00002443
- Testing
- Indinavir sulfate, Zidovudine
- Volunteers
- 780 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Kidney Disease, HIV Infections
Renal Function Assessment in HIV Patient
Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored.
- Trial name
- HIVERS (NCT00821847)
- Testing
- DEXA scan
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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