Clinical trials: HIV Prevention and Care
HIV
Integrated Care Delivery of HIV Prevention and Treatment in AGYW in Zambia
The study team will test a multilevel package of interventions to connect adolescent girls and young women (AGYW) with a source of regular care to provide a sustainable platform for successful implementation of regular human…
- Trial name
- NCT03995953
- Testing
- SHIELD intervention (Support for HIV Integrated Education, Linkages to care, and Destigmatization), Integrated wellness care (IWC) clinics
- Where
- Zambia
- Volunteers
- 2,150 people
- Sponsor
- RTI International
HIV Prevention, Contraceptive Usage
Peer-led Service Delivery Model for Pregnant and Lactating Adolescent Girls and Young Women in Zimbabwe
This is a pilot cluster-randomized control trial co-led by Dr. Valentina Cambiano, Associate Professor of Epidemiology at University College London, UK and Professor Euphemia Sibanda, Research Director at the Centre for Sexual…
- Conditions
- HIV Prevention, Contraceptive Usage, Adherence, Medication
- Trial name
- Ontanga (NCT07546344)
- Testing
- Peers who are stars
- Where
- 3 sites in Zimbabwe
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College, London
HIV Prevention
Project WERK (Wellness Encouragement Respect Kinship)
The Project WERK intervention is a brief, theory based and culturally sensitive intervention designed to capitalize on organic yet underutilized social support networks in the lives of young black men who have sex with men…
- Trial name
- WERK (NCT03148171)
- Testing
- WERK Supportive Contact
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Risk Behavior, HIV/AIDS
Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs
This study will evaluate the efficacy and cost-effectiveness of CHRP-BB - an integrated bio-behavioral approach that incorporates the use of PrEP - with an evidence-based behavioral approach aimed at enhancing PrEP adherence and…
- Conditions
- Risk Behavior, HIV/AIDS, Medication Adherence, Substance Abuse
- Trial name
- CHRP-BB (NCT03282890)
- Testing
- CHRP-BB
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Connecticut
HIV Infections
Acceptability and Feasibility of Injectable Cabotegravir Pre-exposure Prophylaxis (PrEP) Versus Oral PrEP in Routine Care up to 15 Months in Private Pharmacies in South Africa
This is a mixed methods study employing a convergence model triangulation design. Participants in the study will be sexually active young adults starting Pre-exposure Prophylaxis at private pharmacies, who will be offered either…
- Trial name
- AXIS (NCT06138600)
- Testing
- Cabotegravir Injection [Apretude], Tenofovir disoproxil fumarate / emtricitabine (or lamivudine)
- Where
- South Africa
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Patient Acceptance of Health Care
Acceptability of HIV Oral PrEP Among MSM and TGW
The purpose of this study is to determine the factors associated with acceptability to oral HIV pre-exposure prophylaxis (PrEP) among Thai men who have sex with men (MSM) and transgender women (TGW).
- Trial name
- NCT02855606
- Where
- Thailand
- Volunteers
- 105 people
- Sponsor
- Chiang Mai University
HIV Infection, Prep Prescription
Sexual Risks in Prep Users
Primary purpose of the study: to describe sexual behavior of Prep users, whatever mode of intake, ie continuous or on-demand; it has been shown in some studies, an increase of sexual risks in Prep users, and therefore an similar…
- Conditions
- HIV Infection, Prep Prescription, Vaccinations, Sexually Transmitted Diseases
- Trial name
- PREP (NCT03975517)
- Testing
- PrEP
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
HIV/AIDS
Standardized Patient Encounters to Improve PrEP Counseling for Adolescent Girls and Young Women in Kenya
The goal of this study is to facilitate uptake of and adherence to HIV pre-exposure prophylaxis (PrEP) among adolescent girls and young women (AGYW) in Kenya.
- Trial name
- PrIYA-SP (NCT03875950)
- Testing
- Clinician training intervention
- Where
- Kenya
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV, Mental Health
Social Contact-Based Brief Video Interventions To Reduce Stigma and ImproVe Engagement in HIV Prevention and Care and Mental Health Care for Youth Living With and Vulnerable to HIV
HIV stigma, poverty, and racism contribute to high rates of mental health problems and impede treatment for young sexually minoritized men living with and vulnerable to HIV.
- Trial name
- STRIVE (NCT07851077)
- Testing
- Brief Videos for HIV Stigma
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- City University of New York, School of Public Health
Reduction in Heavy Drinking in Patients With HIV
Reducing Heavy Drinking to Optimize HIV/AIDS Treatment and Prevention
This is a double-blind placebo-controlled study to evaluate the effect of Naltrexone (NTX) and counseling on highly active antiretroviral treatment (HAART) medication adherence in a cohort of HIV-infected patients who report…
- Trial name
- DAWN (NCT01227044)
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
HIV/AIDS and Infections, Drug Abuse
Preventing HIV/STI in Urban Adolescents Via an mHealth Primary Care Intervention
The study evaluates the preliminary efficacy of an innovative mobile-health (mHealth) intervention (hereon referred to as S4E) to improve human immunodeficiency virus and sexually transmitted infection testing and reduce HIV/STI…
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03368456
- Testing
- S4E, Usual Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Michigan
HIV Infections, Sexually Transmitted Diseases
Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment
The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Stigma, Social
- Trial name
- NCT03678181
- Testing
- Information Resources, Social Support, HIV Testing
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV
Assisted Partner Notification to Augment HIV Treatment and Prevention in Kenya
The main purpose of this implementation science study is to find out if providing aPS at 18 different Ministry of Health (MOH) VCT clinics in Kenya works and is cost-effective.
- Trial name
- APS (NCT01616420)
- Testing
- Assisted-partner notification services
- Where
- 18 sites in Kenya
- Volunteers
- 2,424 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Infection
Evaluating Methods to Increase HIV Testing, Access to HIV Care, and HIV Prevention Strategies
This is a five-part study that will take place in the Bronx, New York (NY), and Washington, District of Columbia (DC). The different components of the study will focus on increasing the number of people being tested for HIV…
- Trial name
- NCT01152918
- Testing
- Linkage-to-Care Component: Financial Incentive (FI), Linkage-to-Care Component: Standard of Care (SOC), Viral Suppression Component: FI
- Where
- 2 sites in United States
- Volunteers
- 18,442 people
- Sponsor
- HIV Prevention Trials Network
HIV Infections
A Simple Intervention to Increase Persistence on PrEP in MSM to Improve Decision Making
Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality that requires individuals to take a daily tablet to prevent themselves acquiring HIV.
- Trial name
- NCT06476847
- Testing
- PrEP persistence
- Where
- 2 sites in United States, South Africa
- Volunteers
- 106 people
- Sponsor
- Boston University
ART Adherence, PMTCT
HIV Self Testing of Male Partners of Women in PMTCT
The investigators will conduct a randomized trial to evaluate whether provision of oral HIV self-test kits (HIVST) to HIV-positive pregnant women to provide to their male partner, increases the proportion of male partners who…
- Conditions
- ART Adherence, PMTCT, Linkage to Care, HIV
- Trial name
- NCT03484533
- Testing
- HIV self-test kit, Standard of Care (invitation letters for fast-track HIV testing in the clinic)
- Where
- Uganda
- Volunteers
- 736 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Counseling and Testing, HIV Risk Behavior
Safe Spaces 4 Sexual Health
In an earlier study, the study team carried out an HIV/Sexually transmitted infection (STI) testing approach which found men who have sex with men (MSM) at-risk of getting or spreading HIV in online spaces and linked them to…
- Conditions
- HIV Counseling and Testing, HIV Risk Behavior, HIV Prevention
- Trial name
- SS4SH (NCT07133555)
- Testing
- Healthcare counseling service
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prevention of Mother-to-child Transmission of HIV, Antenatal Health Care Utilization
Effectiveness of an HIV-adapted IMCI Training and Supervision Programme for Community Health Workers
This is a cluster randomized controlled trial (C-RCT) to evaluate the effectiveness of a Community-Integrated Management of Childhood Illness (C-IMCI) training for community caregivers (CCGs), adapted to include HIV-related…
- Conditions
- Prevention of Mother-to-child Transmission of HIV, Antenatal Health Care Utilization, Postnatal Health Care Utilization, Infant Feeding Practices
- Trial name
- NCT01774136
- Testing
- Enhanced HIV and MCH training for CHW
- Where
- South Africa
- Volunteers
- 1,342 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
HIV Infection
Integrated Care Centers to Improve HIV Outcomes in Vulnerable Indian Populations
This is a cluster randomized trial to evaluate the effectiveness of integrated care centers (ICC) to improve access to HIV testing, prevention services, and treatment among high-risk populations of injection drug users (IDU) and…
- Trial name
- NCT01686750
- Testing
- Integrated care centers
- Where
- India
- Volunteers
- 21,726 people
- Sponsor
- Johns Hopkins University
HIV Infection, Adherence, Medication
Next Generation Ingestible Sensors for Medication Adherence Measurement
This study will investigate the use of a next-generation Reader as part of a digital pill system (DPS; ID-Cap System) to measure adherence to both antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) in people living…
- Conditions
- HIV Infection, Adherence, Medication, Adherence, Treatment, Pre-Exposure Prophylaxis
- Trial name
- NextGen (NCT05592613)
- Testing
- Next-generation Reader and ID-Cap System, Truvada for pre-exposure prophylaxis (PrEP), Biktarvy for antiretroviral therapy (ART)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital