Clinical trials: HIV Primary Infection
HIV Infections, Cancer, Second Primary
Micronutrient Supplemented Probiotic Yogurt for HIV/AIDS and Other Immunodeficiencies
We hypothesize that micronutrient fortified probiotic yogurt can improve nutritional status and enhance immunity parameters in subjects HIV/AIDS and other immunodeficiencies.
- Trial name
- NCT00517803
- Testing
- Probiotic Yogurt B: with various micronutrients, Probiotic Yogurt A: Kaiser micronutrients, Probiotic yogurt C: with basic micronutrients
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
AIDS-Related Diffuse Large B-cell Lymphoma, AIDS-Related Non-Hodgkin Lymphoma
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
This phase I trial evaluates the side effects and usefulness of axicabtagene clioleucel (a CAR-T therapy) and find out what effect, if any, it has on treating patients with HIV-associated aggressive B-cell non-Hodgkin lymphoma…
- Conditions
- AIDS-Related Diffuse Large B-cell Lymphoma, AIDS-Related Non-Hodgkin Lymphoma, HIV Infection, Recurrent Diffuse Large B-Cell Lymphoma
- Trial name
- NCT05077527
- Testing
- Axicabtagene Ciloleucel, Cyclophosphamide, Fludarabine
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- AIDS Malignancy Consortium
HIV Infections
Impact of a Telenovela/Soap Opera for HIV Prevention in Latinas
Latinas continue to be affected disproportionally by HIV in the United States (US). Often, Latinas are not aware of their HIV status.
- Trial name
- NCT05929482
- Testing
- Infección de Amor (Infectious Love)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus, Alcohol-Related Disorders
Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Africa
The purpose of this study is to evaluate a stepped care behavioral intervention for HIV medication adherence and substance use ("Khanya") integrated into an HIV primary care setting in South Africa.
- Conditions
- Human Immunodeficiency Virus, Alcohol-Related Disorders, Drug Use, Substance Use
- Trial name
- NCT05933226
- Testing
- Khanya
- Where
- South Africa
- Volunteers
- 160 people
- Sponsor
- University of Maryland, College Park
Hiv
Pharmacokinetics and Efficacy of Multiple Dosing of LP-98 for Injection in HIV-infected Patients
A Randomized, Double-Blind, Parallel-Group, Exploratory Clinical Study to Evaluate the Safety, Pharmacodynamic Effects, and Pharmacokinetic Characteristics of Multiple Subcutaneous Injections of LP-98 in Treatment-Naive…
- Trial name
- NCT06560489
- Testing
- Subjects will be randomly assigned to receive 1.25 mg, 2.5 mg, 5 mg, or 10 mg of LP-98.
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanxi Kangbao Biological Product Co., Ltd.
HIV Infections, Primary Acute Infection
Multicentric Trial Comparing Three Therapeutical Strategies in Patients With Acute Primary HIV Infection
Treatment of acute primary HIV infection may improve long-term outcome. However, optimal treatment is still debated. The ANRS 112-INTERPRIM trial evaluates three different therapeutical strategies, combining permanent or…
- Trial name
- NCT00196638
- Testing
- Antiretroviral combination (drugs), Pegylated Interferon alpha (drug)
- Volunteers
- 90 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV-1-Associated Cognitive Motor Complex
The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort -
To determine the prevalence of HIV associated Neurological Disorder (HAND) in a population of HIV positive patients within a primary care setting compared with the HIV negative population.
- Trial name
- CNS HAND (NCT01434563)
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Holdsworth House Medical Practice
Pre-Exposure Prophylaxis, Hiv
Peer-led Social Media Intervention to Prevent HIV Among Young Men Who Have Sex With Men (YMSM)
The aim of this study is to examine the effect of social media intervention on the use of pre-exposure prophylaxis (PrEP) by young men who have sex with men (YMSM) in the greater New Haven area.
- Conditions
- Pre-Exposure Prophylaxis, Hiv, Men
- Trial name
- NCT04417946
- Testing
- PrEP messages, Heath messages
- Where
- 2 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV-1-infection
Primary Infection Cohort
Open, prospective, multicenter French cohort study enrolling subjects aged of 15 years or more, during or immediately after HIV-1 primary infection.
- Trial name
- PRIMO (NCT03148964)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 2,800 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML)
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant
The purpose of this study is to learn more about the effects of (classification determinant) CD34+ stem cell selection on graft versus host disease (GVHD) in children, adolescents, and young adults.
- Conditions
- Chronic Myeloid Leukemia (CML), Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS), Juvenile Myelomonocytic Leukemia (JMML)
- Trial name
- NCT02061800
- Testing
- CliniMACS CD34+ Reagent System, Thiotepa, Cyclophosphamide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Diane George
HIV, Acquired Immunodeficiency Syndrome
Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients
This randomized clinical trial uses a health plan's electronic medical record (EMR) alcohol screen; and examines innovative behavioral interventions, and their cost effectiveness, for hazardous drinking within a large HIV primary…
- Conditions
- HIV, Acquired Immunodeficiency Syndrome, Alcoholism, Alcoholic Intoxication
- Trial name
- NCT01671501
- Testing
- Motivational Interviewing, Email Feedback, Usual Care
- Where
- United States
- Volunteers
- 614 people
- Sponsor
- University of California, San Francisco
Hiv, Chlamydia
Online HIV Prevention for Young Male Couples
Young gay, bisexual, and other men who have sex with men (YMSM) are the only risk group in which rates of new HIV infections are on the rise.
- Conditions
- Hiv, Chlamydia, Gonorrhea
- Trial name
- 2GETHER (NCT03284541)
- Testing
- 2GETHER, Existing Public Health Practice
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Human Immunodeficiency Virus
HIV Prevention in the Primary Care Setting
In the third decade of the HIV pandemic, what was once a uniformly and rapidly fatal disease has been transformed into a chronic illness by advances in the understanding of HIV pathogenesis and therapeutics.
- Trial name
- NCT00381524
- Testing
- Increase condom use
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Alabama at Birmingham
HIV Infections
Improving Identification of Mental Health/Substance Use Disorders in HIV Primary Care: Pilot Clinical Response
This research is a feasibility pilot of an intervention to respond to positive screening tests for mental health(MH) and substance use (SU) captured through the Patient Reported Outcomes questionnaires (PROs).
- Trial name
- PROACT (NCT03067948)
- Testing
- Patient Designated Positive Screen Shared with Provider
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
HIV-1-infection
A HIV Vaccine Trial in Individuals Who Started Antiretrovirals During Primary or Chronic Infection (EHVA T02)
EHVA T02 is an international, phase II, double-blind study to evaluate two experimental arms each compared to placebo control in HIV-1 positive participants to see if either has a clinically relevant impact on viral replication.
- Trial name
- NCT04120415
- Testing
- Vaccine and vedolizumab (Entyvio)
- Where
- 4 sites in France, Switzerland and 1 more
- Volunteers
- 2 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
Workplace-based HIV Self-testing Among Men in Uganda (WISe-Men)
This study seeks to determine whether workplace delivery of HIV self-testing will lead to an increase in uptake of HIV testing and subsequent linkage to care or prevention services among men in Uganda.
- Trial name
- NCT04164433
- Testing
- Oral HIV Self-Test (OraQuick)
- Where
- 2 sites in Uganda
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Makerere University
Opioid-Related Disorders, HIV Infections
Buprenorphine and Integrated HIV Care Evaluation
The purpose of this study is to assess the feasibility, cost and effectiveness of interventions designed to integrate buprenorphine treatment for opioid dependence into HIV primary care in ten HIV care centers in the U.S.
- Conditions
- Opioid-Related Disorders, HIV Infections, AIDS
- Trial name
- NCT00124358
- Testing
- Buprenorphine, Integrated HIV care and office-based opioid dependence treatment
- Where
- 10 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- The New York Academy of Medicine
HIV Positive
RETRIeVE: ReversE TranscRiptase Inhibitor hiV Practice
An observational retrospective study of NNRTI experienced patients who have virologically failed. The study aims to assess resistance profiling and subsequent prescription patterns of patients on NNRTIs
- Trial name
- NCT01154556
- Where
- Australia
- Volunteers
- 2,044 people
- Sponsor
- Holdsworth House Medical Practice
HIV Infections
Motiv82Change: an HIV Prevention Study for Young Latino Men
The purpose of this study is to develop and pilot test a culturally and developmentally tailored Motivational Enhancement Intervention (MEI) to reduce risky sex (unprotected anal sex and multiple partners) among young Hispanic…
- Trial name
- Motiv82Change (NCT00877695)
- Testing
- Entre Culturas: Navigating Culture, Identity, and HIV Risk
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Lymphoma, Non-Hodgkin, HIV Infections
The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer
To determine the safety and toxicity of high-dose systemic methotrexate (MTX) and dexamethasone (DEX) combined with zidovudine (AZT) and brain irradiation in patients with AIDS-related primary central nervous system (CNS)…
- Trial name
- NCT00000723
- Testing
- Methotrexate, Leucovorin calcium, Zidovudine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)