Clinical trials: HIV Reservoir
HIV-1 Infection
Analytical Treatment Interruption in HIV Positive Patients
HIV-1 infected patients with normal peripheral blood CD4+ T-cell counts and undetectable viral load will be recruited in four Belgian HIV reference centers.
- Trial name
- ISALA (NCT02590354)
- Testing
- ART interruption
- Where
- 4 sites in Belgium
- Volunteers
- 114 people
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV Infection
Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir
The objective of this study is to discover a new approach in which human immunodeficiency virus (HIV) can be eradicated from an infected individual by intensified antiretroviral treatment coupled with immunomodulation.
- Trial name
- EraMune02 (NCT00976404)
- Testing
- DNA + HIV-rAd5 vaccine, ART intensification (raltegravir), ART intensification (maraviroc)
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Robert L. Murphy
HIV-1
A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy
Background: Antiretroviral therapy (ART) can suppress HIV to undetectable levels in people, but the virus rebounds quickly if the drug treatment is stopped; this is because HIV can remain dormant in a pool of blood cells called…
- Trial name
- NCT05612178
- Testing
- 3BNC117-LS, 10-1074-LS, Sterile Saline
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1 Infection
Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 Infected Patients
The purpose of this study is to assess the impact of allogeneic hematopoietic stem cell transplantations (HSCT) in HIV infected patients on the persistence of HIV and the HIV immune response.
- Trial name
- HSCT-HIV (NCT02732457)
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Kirby Institute
HIV
Platelets Target the Circulating HIV Reservoir: Implications for Immunological Failure
HIV/AIDS is a chronic disease that is difficult to eradicate because the virus persists as proviral DNA integrated into the host cells.
- Trial name
- PLAQUAGE (NCT07745530)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Tourcoing Hospital
Hypogonadism, HIV
Study of the Prevalence and Associated Factors With Hypogonadism in HIV + Men
Testosterone deficiency is classically associated with the development of metabolic syndrome, osteoporosis, erectile disorder and / or a reduced libido, a depressive syndrome and alteration of the quality of patients life.
- Trial name
- HYPOG (NCT02665559)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Tourcoing Hospital
HIV
Comprehensive Analysis of HIV Reservoirs in Chronically Infected HIV-1 Treated Patients
HIV infection can be efficiently controlled by antiretroviral therapy (ART), with in 2013 nearly 85 % of patients having a suppressed viremia, but HIV cannot, however, be eradicated with ART alone [1].
- Trial name
- RESACHRON (NCT02628340)
- Testing
- Ex-vivo analysis
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
HIV
Dolutegravir in Reservoirs
The purpose of this study is to find out how well the HIV medication dolutegravir gets into different parts of the body including blood plasma, special blood cells, and rectal tissue.
- Trial name
- NCT02924389
- Testing
- dolutegravir, Triumeq, Truvada
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Human Immunodeficiency Virus Infection (HIV)
Innate-like and NK Signatures in Chronic-Treated HIV Infection INSTINCT-HIV
Infection with the human immunodeficiency virus (HIV) is a chronic condition requiring lifelong antiretroviral therapy (ART). Despite prolonged virological control under suppressive ART, HIV persists in the form of a stable viral…
- Trial name
- INSTINCT-HIV (NCT07849933)
- Testing
- Blood test
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Hiv
LoViReT (Low Viral Reservoir Treated Patients)
The main purpose of this study is to unravel the mechanisms by which the "Low Viral Reservoir Treated" patients (LoViReT) maintain extremely low HIV-1 DNA levels despite having initiated cART during chronic HIV-1 infection.
- Trial name
- LoViReT (NCT02972931)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- IrsiCaixa
HIV Infections, HIV-1-infection
A Prospective Cohort for ex Vivo Cure Studies With Chronic HIV Infected Patients in the Netherlands
A prospective non-interventional cohort study at Erasmus MC of adult chronic HIV infected patients of ≥18 years of age who initiate antiretroviral therapy in routine care.
- Conditions
- HIV Infections, HIV-1-infection, HIV-2 Infection
- Trial name
- CHRONO (NCT04888754)
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Erasmus Medical Center
HIV-1
Inhibiting the Anti-apoptotic Factor, BCL-2, at the Time of ART Initiation to Promote Apoptosis of HIV-infected Cells and Restrict the Seeding of the HIV Reservoir (The INITIATE Study)
Combination therapy with antiretroviral medication (ART) has proven effective in keeping HIV suppressed and restoring the immune system, but it cannot cure the infection. Therefore, lifelong treatment is necessary.
- Trial name
- INITIATE (NCT07481175)
- Testing
- Venetoclax
- Where
- 2 sites in Denmark, Spain
- Volunteers
- 38 people
- Sponsor
- Thomas Aagaard Rasmussen
HIV
Small Trial of Alendronate Impact on the Reservoir of HIV
This clinical trial is designed to test the effects of alendronate (ALN) on people living with HIV who are already receiving antiretroviral therapy (ART).
- Trial name
- STAIR-HIV (NCT07216794)
- Testing
- Alendronate
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus I Infection
MMF for HIV Reservoir Reduction
This is an open label, randomized Phase II study to determine whether Mycophenolate mofetil (MMF) given over 22 months meaningfully decreases the size of participants' HIV reservoir.
- Trial name
- NCT03262441
- Testing
- Mycophenolate Mofetil 500Mg Tab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Fred Hutchinson Cancer Center
HIV
Trial to Evaluate the Interest of a Reductive Anti Retroviral Strategy Using Dual Therapy Inspite of Triple Therapy
In the early 2000s, the "TRILEGE©" study was realized to determine if the reductive anti retroviral strategy from an initial triple therapy (based on a protease inhibitor as the third agent) towards a dual therapy of nucleoside…
- Trial name
- TRULIGHT (NCT02302547)
- Testing
- triple therapy, dual therapy
- Where
- 16 sites in France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Tours
HIV Infections
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection
Background: HIV affects millions of people. The disease may "hide" in the brain, even in people with well-controlled HIV without cancer. Then it may "wake up" and continue.
- Trial name
- NCT03239899
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
HIV Reservoirs
IL-23/IL-12 Imbalance and T Lymphocyte Polarization in HIV Infection
Progressive HIV or HIV infection seems to be related to a preferential loss of CD4+ T lymphocytes, especially Th17+, within the mucosal intestinal lymphoid tissue, and with intestinal mucosal damage and bacterial product…
- Trial name
- INTESTIPAX (NCT01942655)
- Testing
- Blood sample and recto-colic biopsies
- Where
- France
- Volunteers
- 26 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infected Individuals, Informed Consent
Analysis of the Persistence, Reservoir and HIV Latency
The APRIL study aims at analyzing HIV reservoirs, latency and persistence on antiretroviral therapy. It enrolls HIV-infected adults providing blood samples of which peripheral blood mononuclear cells are stored.
- Trial name
- APRIL (NCT05752318)
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
HIV Infections
Vedolizumab Treatment in HIV-Infected Subjects Without Previous Antiretroviral Therapy
HIV cannot be eliminated and remains in the body despite the treatment that is used for HIV-infection called antiretroviral treatment (ART). Individuals undergoing ART interruption rapidly experience virus rebound in the blood.
- Trial name
- NCT03577782
- Testing
- Entyvio (Vedolizumab)
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Characterization of HIV Reservoirs in Adolescents
Characterization of HIV-1 Reservoirs in HIV-1 Non-B Infected Adolescents on ART in Cameroon
Background: Combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests and allow a near-normal life expectancy for HIV-infected individuals.
- Trial name
- AVIR (NCT06363500)
- Testing
- non applicable
- Where
- Cameroon
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chantal Biya International Reference Centre for Research on Prevention and Management of HIV/AIDS