Clinical trials: HIV Reservoir
HIV Infection
Safety and Effect of The HDAC Inhibitor Panobinostat on HIV-1 Expression in Patients on Suppressive HAART
The purpose of this study is to assess the safety and ability of panobinostat to re-activate HIV transcription in latently infected CD4+ T-cells among HIV-infected patients on stable antiretroviral therapy
- Trial name
- CLEAR (NCT01680094)
- Testing
- Panobinostat
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
HIV-1-infection
Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV
This study is designed to evaluate the safety and efficacy of lefitolimod and 3BNC117/10-1074 in HIV-1-infected individuals on ART and during ATI as intervention to reduce the HIV-1 reservoir
- Trial name
- TITAN (NCT03837756)
- Testing
- Saline, Lefitolimod, 3BNC117 and 10-1074
- Where
- 8 sites in United States, Australia and 2 more
- Volunteers
- 47 people
- Sponsor
- University of Aarhus
HIV
Role of Viral Reservoir, Immune Activation and Depletion in Persistent Viremia Persistent Viremia in People Living With HIV on Antiretroviral Therapy
Low-level HIV replication in a patient on effective antiretroviral therapy is a relatively frequent event, generating stress for both patient and physician, due to the fear of subsequent virological escape with emergence of…
- Trial name
- ViPer (NCT07015164)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV-1 Infection
Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients
Viral eradication in selected HIV-infected patients is possible with intensive antiretroviral therapy plus immunomodulation
- Trial name
- ERAMUNE-01 (NCT01019551)
- Testing
- ART Intensification, Immunomodulation
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 29 people
- Sponsor
- Objectif Recherche Vaccins SIDA
HIV-1-infection
Euphorbia Kansui and HIV/AIDS Functional Cure
The purpose of this study is to determine the safety and bioactivity of Euphorbia kansui, which has been used in traditional Chinese medicine for the treatment of edema, ascites, and asthma.
- Trial name
- NCT04503928
- Testing
- Euphorbia kansui Pill
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai Public Health Clinical Center
Acute HIV Infection, HIV Infections
Analysis of Telmisartan Administered With Antiretroviral Therapy (ART) in Patients With Acute HIV Infection
This research project will study whether the drug telmisartan administered in conjunction with antiretroviral therapy (ART) will help reduce nervous system infection with HIV.
- Trial name
- SEARCH018 (NCT02170246)
- Testing
- Telmisartan
- Where
- 2 sites in Thailand
- Volunteers
- 21 people
- Sponsor
- Yale University
HIV Infections
Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens With or Without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth
Phase I, Proof of Concept, Open-Label, Randomized Clinical Trial to Evaluate the Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens with or without Toll-like Receptor 4 Agonist on HIV Reservoirs in…
- Trial name
- HVRRICANE (NCT04301154)
- Testing
- HIVIS DNA/MVA-CMDR, HIVIS DNA + Cervarix and MVA-CMDR, Cervarix
- Where
- South Africa
- Volunteers
- 25 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
HIV
The Use of Leukapheresis to Support HIV Pathogenesis Studies
Despite the dramatic improvements that have resulted from combination antiretroviral treatment, long-term efficacy, toxicity, cost, and the requirements for life-long adherence remain as formidable challenges.
- Trial name
- NCT01161199
- Testing
- Leukapheresis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
HIV Infection
Exploratory Study of Cellular Reservoirs in Blood From HIV Infected Patients
This study evaluates the impact of highly active antiretroviral therapy on the size of the latent viral reservoirs in resting CD4+ T cells and monocytes in HIV positive patients.
- Trial name
- EURECA (NCT02858414)
- Testing
- additional blood sample
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hiv
Measuring the HIV-1 Reservoir During Cure Interventions Studies (MERCI)
The aim of this study is the gain new insights into HIV latency before and after cure intervention studies through extensive blood and tissue sampling (lymph node and colon biopsies) from 30 individuals.
- Trial name
- NCT05783388
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
HIV Infections
Evolution of HIV Reservoir, Inflammation and Microbiota Footprint of PLWH Switching to Long-acting Injectable Treatment Compared to Patients on Oral Dual or Triple Anti-integrase-based Therapy
In the last 40 years of HIV history, we have managed to attain most of our therapeutic objectives, namely virological suppression of most patients and sufficient immune reconstitution.
- Trial name
- LAMIVIH (NCT05303337)
- Testing
- Stool sampling, Blood plasma collection
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hôpital Européen Marseille
HIV-1 Infections
Optimisation of Primary HIV1 Infection Treatment(ANRS 147 OPTIPRIM)
The purpose of this trial is to assess the impact of raltegravir, maraviroc, darunavir/r, and Truvada® (emtricitabine/tenofovir) vs.
- Trial name
- NCT01033760
- Testing
- raltegravir; maraviroc; darunavir; ritonavir; tenofovir/emtricitabine, darunavir; ritonavir; emtricitabine/tenofovir
- Where
- France
- Volunteers
- 90 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1-infection, HIV Disease Progression
Comparing Immune Activation and Latent HIV Reservoir Size Between People Living With HIV on Tenofovir-containing Versus NRTI-free ART
The goal of the project is to determine the difference in immune activation and HIV reservoir size between People living with HIV (PWH) on tenofovir-containing antiretroviral therapy (ART) versus PWH on nucleoside reverse…
- Conditions
- HIV-1-infection, HIV Disease Progression, Inflammation, HIV
- Trial name
- NCT05584397
- Testing
- Venipuncture, Targeted physical medical exam, Urine pregnancy test
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
HIV Infection
Metformin Immunotherapy in HIV Infection
Anti-HIV drugs cut down the number of serious infections that people with HIV get. However, some subjects taking anti-HIV drugs do not achieve adequate cluster of differentiation 4 (CD4) recovery and decrease in elevated cluster…
- Trial name
- NCT02659306
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
HIV
Imaging the HIV Reservoir
Radiolabelling broadly neutralizing anti-HIV antibody 3BNC117 with a Copper-64 radio isotope for infusion into people with HIV followed by MRI/PET scanning to detect HIV in vivo.
- Trial name
- NCT03063788
- Testing
- 3BNC117-Copper-64
- Where
- Australia
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Human Immunodeficiency Virus
Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy
Background: Antiretroviral viral therapy (ART) allows people with human immunodeficiency (HIV) to live long, healthy lives. But ART is not a cure. HIV can remain in the body, in infected cells called reservoirs.
- Trial name
- NCT06819176
- Testing
- Lenacapavir
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, HIV I Infection
Multi Interventional Approaches to Mitigate HIV Reservoirs for the Sustained HIV Remission Without Antiretrovirals
A modern and urgent challenge in fighting HIV infection is to achieve sustained HIV remission without the use of antiretrovirals.
- Trial name
- NCT06805656
- Testing
- Maraviroc, Dolutegravir, Dendritic Cell Vaccine
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Federal University of São Paulo
HIV-1 Infection, HIV Reservoir
Intestinal Tissue-Resident Memory T Cells and HIV-1 Persistence During Antiretroviral Therapy
The study aims to better characterize intestinal tissue-resident memory T cells (TRM) in people living with HIV-1 receiving suppressive antiretroviral therapy (ART).
- Conditions
- HIV-1 Infection, HIV Reservoir, Antiretroviral Therapy
- Trial name
- ANRSGALT-2 (NCT07656077)
- Testing
- Colonic Mucosal Biopsies
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV
Safety and Impact of Baricitinib on Cell Surivival Pathways, HIV-1 Reservoir and Inflamation in People With HIV-1
The goal of this exploratory clinical trial is to evaluate the safety and tolerability of bariticinib administered at 2 mg once daily during 12 weeks in 30 people living with HIV-1 (PWH) on suppressive antiretroviral therapy…
- Trial name
- NCT07028385
- Testing
- Bariticinib 2 mg
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
HIV Infections
Dasatinib for HIV-1 Reservoir Reduction
This study will test if the medicine dasatinib can lower the hidden amount of HIV in the body, called the HIV "reservoir." It will also check if dasatinib is safe and easy to take for people living with HIV who have a suppressed…
- Trial name
- NCT07342491
- Testing
- Dasatinib
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)