Clinical trials: HIV-infection/AIDS
Human Immunodeficiency Virus Infection
A Drug-drug Interaction Study of SHR2150 on Healthy Chinese Volunteers
The study is a single-centre, open-label, fixed-sequence, self-controlled clinical trial. It is planned to enroll 20 healthy adult subjects. Subjects will take SHR2150 on Day 1 and Day 21, and take efavirenz from Day 7 to Day 26.
- Trial name
- NCT05141422
- Testing
- SHR2150 tablet、efavirenz
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
HIV Infections
First Time in Human Study of Long Acting VH4524184 Formulations
The purpose of this study is to identify 1 or more doses of parenterally administered VH4524184 that are safe, well tolerated and yield a PK drug exposure profile necessary to deliver a long-acting antiretroviral therapy for the…
- Trial name
- NCT06310551
- Testing
- Oral VH4524184, VH4524184 Formulation A SC, rHuPH20
- Where
- 3 sites in United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infections
GEMINI Study - A Study of Saquinavir/Ritonavir in Treatment-Naive Patients With HIV-1 Infection
This 2 arm study will evaluate the efficacy, safety and tolerability of saquinavir/ritonavir or lopinavir/ritonavir in combination with emtricitabine/tenofovir in patients with human immunodeficiency virus type 1 (HIV-1)…
- Trial name
- NCT00105079
- Testing
- saquinavir [Invirase], Lopinavir/ritonavir, Emtricitabine/tenofovir disoproxil fumarate
- Where
- 44 sites in United States, Canada and 3 more
- Volunteers
- 337 people
- Sponsor
- Hoffmann-La Roche
HIV Infections
Evaluating the Safety, Pharmacokinetics, and Antiviral Activity of a Human Monoclonal Antibody (VRC01) in HIV-Infected Adults Undergoing a Brief Treatment Interruption
The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics (PK), and antiviral activity of an antibody (called VRC01) in HIV-infected adults whose HIV was well-controlled with HIV medicines.
- Trial name
- NCT02463227
- Testing
- VRC01
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus
Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng
This trial will assess the potential impact of a vaginal ring on condom use by comparing the performance (total clinical failure, clinical slippage, and clinical breakage) of a standard male lubricated latex condom when the…
- Trial name
- NCT01755741
- Testing
- Condom
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Sexually Transmitted Diseases, Unsafe Sex
Protect and Connect: Couple HIV Prevention for Drug Involved Male Offenders
This study is a randomized controlled trial (RCT) that will rigorously evaluate the implementation, effectiveness and cost-effectiveness of a couple-based integrated human immunodeficiency virus (HIV) and drug abuse prevention…
- Conditions
- Sexually Transmitted Diseases, Unsafe Sex, Substance-Related Disorders
- Trial name
- PACT (NCT01690494)
- Testing
- PACT, TAU
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infection, Aging
My Smart Age With HIV: Smartphone Self-assessment of Frailty
Understanding the complexity of aging and frailty in chronic HIV infection motivated Italian team members to begin to build a frailty index (FI) including 37 health variables at the Modena HIV Metabolic Clinic (MHMC).
- Trial name
- MySAwH (NCT02663856)
- Testing
- observational
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Modena and Reggio Emilia
HIV Infections
Raltegravir One Thousand Two Hundred vs Darunavir-cb in Immnunosupressed Patients: ROTDIP Study
Multicenter, randomized, open label pilot clinical trial with two parallel arms aimed to compare the efficacy of Raltegravir (RAL) 1200mg QD vs Darunavir/Cobicistat (DRV-cb) 800-150mg QD both in combination with…
- Trial name
- ROTDIP (NCT03842488)
- Testing
- Experimental: RAL QD, Active comparator: DRV/cb
- Volunteers
- 75 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Multi-Drug Resistant Hiv-1 Infection, HIV-1 Infection
A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patients With Multi-Drug Resistant HIV-1 Infection
Background: People with HIV usually take a combination of 2 or more anti-HIV drugs daily to help manage their infection. Sometimes, however, HIV becomes resistant to these drugs, and the infection cannot be treated.
- Trial name
- NCT05582694
- Testing
- UB-421
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV (Human Immunodeficiency Virus)
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV
This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.
- Trial name
- SPISE (NCT07461350)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of California, San Francisco
HIV-1 and HSV-2 Coinfection, HIV Infections
Usage of Acyclovir for Suppression of HIV-1 and HSV-2 Coinfected Persons in Cameroon
The study proposed that both clinical and subclinical HSV reactivation is associated with increased HIV shedding from mucosal surfaces, which may increase the infectiousness of HIV-1/HSV-2 coinfected persons.
- Trial name
- NCT00209313
- Testing
- Acyclovir
- Where
- Cameroon
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center
Substance Use, HIV/AIDS
Trauma Informed Prevention for Substance Use and Risky Sex
The purpose of this research study is to determine the usefulness of the TIPS iPad app in the treatment of adolescent patients who qualify for Trauma Focused-Cognitive Behavioral Therapy (TF-CBT).
- Trial name
- TIPS (NCT03710720)
- Testing
- TIPS app, Trauma Focused-Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Infection, Human Immunodeficiency Virus
A Study to Evaluate the Effect of BMS-955176 on Pharmacokinetics of Dolutegravir and the Effect of Dolutegravir on the Pharmacokinetics of BMS-955176
The purpose of this study is to evaluate how BMS955176 affects pharmacokinetics (PK) of Dolutegravir (DTG) and also how DTG administration affects the PK of BMS955176
- Trial name
- NCT02715479
- Testing
- Dolutegravir, BMS955176
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Hiv, Frailty Syndrome
Altering Mechanisms of Frailty in Persons Living With HIV Aged 50 to 65
People living with HIV are living longer as their disease is controlled with antiretroviral medications. Yet they are experiencing frailty more often and more than ten years earlier than those without HIV.
- Trial name
- ALTER (NCT04321603)
- Testing
- Walking
- Sponsor
- University of Maryland, Baltimore
HIV Seropositivity, Lower Urinary Tract Symptoms
Lower Urinary Tract Symptoms in Males Living With HIV
The primary aim of this study is to learn whether the frequency of lower urinary tract symptoms differ between the males with seronegativity for HIV and males living with HIV.
- Trial name
- NCT05964803
- Testing
- Questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Koç University
HIV
Safety and Efficacy of B/F/TAF in Pregnancy
This is a prospective, multicenter, observational study designed to evaluate the effectiveness and safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in pregnant women living with HIV.
- Trial name
- NCT07666386
- Testing
- BIC+FTC+TAF
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shi Zou
HIV Infections, AIDS
Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission
The purposes of this study are to determine whether Carraguard® Gel can prevent the transmission of HIV when used during vaginal intercourse, and to confirm that the gel is safe for vaginal use.
- Conditions
- HIV Infections, AIDS, Sexually Transmitted Diseases, HIV Seroconversion
- Trial name
- NCT00213083
- Testing
- Carraguard (PC-515)
- Where
- 3 sites in South Africa
- Volunteers
- 6,203 people, healthy volunteers welcome
- Sponsor
- Population Council
Sexually Transmitted Diseases, Disease Transmission, Infectious
Eban II: Intervention for HIV Sero-Discordant Couples
This study focuses on the implementation of an evidence-based HIV risk reduction intervention for HIV-serodiscordant, heterosexual African American couples ("Eban II") in two geographic areas (Northern and Southern California …
- Conditions
- Sexually Transmitted Diseases, Disease Transmission, Infectious, Safe Sex, HIV
- Trial name
- NCT01829282
- Testing
- Risk Reduction
- Where
- 8 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Disease Transmission, Vertical, Vertical Human Immunodeficiency Virus Transmission
Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission
Giving anti-HIV medications to babies born of HIV positive mothers right after birth can lower the babies' risk of contracting HIV.
- Conditions
- Disease Transmission, Vertical, Vertical Human Immunodeficiency Virus Transmission, HIV Infections
- Trial name
- NCT00099359
- Testing
- Zidovudine, Nevirapine (NVP), Epivir (3TC)
- Where
- 17 sites in United States, Argentina and 3 more
- Volunteers
- 1,735 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections
Safety Study of UC-781 Vaginal Microbicide
This study will help determine whether UC-781 gel is safe when applied to the vagina twice daily for 14 days, and will assess whether women and men find the gel acceptable to use.
- Trial name
- NCT00446979
- Testing
- UC 781
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
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