Clinical trials: HIV-infection/AIDS
HIV/AIDS, Cryptococcal Meningitis
Vietnam Cryptococcal Retention in Care Study - Version 2.1
This is a multicenter prospective cohort evaluation of the implementation of a cryptococcal antigen (CrAg) screening program at selected outpatient HIV clinics (OPCs) and network laboratories in Vietnam.
- Conditions
- HIV/AIDS, Cryptococcal Meningitis, Opportunistic Infections, HIV Related, Cryptococcosis
- Trial name
- NCT03267407
- Testing
- Preemptive high-dose Fluconazole
- Where
- Vietnam
- Volunteers
- 1,184 people
- Sponsor
- National Hospital for Tropical Diseases, Hanoi, Vietnam
HIV/AIDS, HIV Infections
Proviral DNA as a Target for HIV-1 Resistance Analysis
In summary, in this project the investigators propose to study the proviral DNA genotyping to implement a lower cost and wider than the commercial systems currently in use, in order to analyze all HIV genes that are therapeutic…
- Conditions
- HIV/AIDS, HIV Infections, HIV Seropositivity, Viral Infection
- Trial name
- HIV (NCT04088916)
- Where
- 2 sites in Chile
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Chile
HIV Infections
Efficacy, Safety, and ToLerability of Switching to A Two-Drug Regimen With DTG/3TC Compared to Maintaining A Three-Drug REgimen With BIC/FTC/TAF or DTG/3TC/ABC in ViroLogically SupprEssed PeopLe Living With HIV After 24 and 48 Weeks of Follow-Up
This is a phase 4, randomized, controlled, open-label, single-center clinical trial conducted at the Hospital de Infectología, National Medical Center "La Raza." The study employs a non-inferiority design with follow-up…
- Trial name
- TLACAELEL (NCT07138144)
- Testing
- Standard Medical Therapy, dual therapy
- Where
- Mexico
- Volunteers
- 156 people
- Sponsor
- José Antonio Mata Marín
Acquired Immunodeficiency Syndrome, HIV Infection
Phase I Study of APL 400-003, a Candidate HIV Vaccine, in HIV-Negative Volunteers
This is a randomized, double blind study of the safety and immunogenicity of APL 400-003, a plasmid DNA vaccine encoding the env and rev genes of HIV-1, in HIV-negative volunteers.
- Trial name
- NCT00001538
- Testing
- APL 400-003
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv
Early Administration of Romidepsin and 3BNC117 in Treatment-naïve HIV Patients Starting ART
To evaluate the effect of early viral reactivation by latency reversing agents (LRA) and/or administration of potent broadly neutralizing antibodies (bNAb) on the size of the latent HIV-1 reservoir in treatment naïve HIV-1…
- Trial name
- eCLEAR (NCT03041012)
- Testing
- Romidepsin, 3BNC117, Antiretrovirals
- Where
- 7 sites in Denmark, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Hiv, Sexually Transmitted Diseases
CAMELLIA Cohort: A Longitudinal Study to Understand Sexual Health and Prevention Among Women in Alabama
Pre-exposure prophylaxis (PrEP) is an important biomedical human immunodeficiency virus (HIV) prevention tool and may particularly benefit black, cis and trans-gender women, who are at an increased risk for HIV and Sexually…
- Trial name
- CAMELLIA (NCT05463692)
- Testing
- Camelia Cohort
- Where
- United States
- Volunteers
- 830 people
- Sponsor
- University of Alabama at Birmingham
HIV Infections
A Study of the Safety and Effectiveness of an HIV Vaccine for HIV-Positive Patients Receiving Anti-HIV Drugs for at Least 2 Years
The purpose of this study is to see if 2 study vaccines, ALVAC-HIV (vCP1452) and gp160 MN/LAI-2, are safe and effective in boosting the body's attacks on HIV in HIV-positive patients.
- Trial name
- NCT00006509
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), gp160 MN/LAI-2
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Glutamine; Metabolic Disorder, Physical Activity
Effect of Supplementation With Glutamine and Exercise in Women With HIV/AIDS
This study aimed to investigate the effect of an exercise session with weights associated with glutamine dipeptide (GLD) supplementation on cognitive function of people living with HIV/ AIDS.
- Trial name
- NCT03236532
- Testing
- Glutamine and exercise, Maltodextrin and exercise
- Volunteers
- 14 people
- Sponsor
- State University of Maringá
HIV Infections
A Randomized, Dose-ranging Study of Alferon LDO in Asymptomatic HIV+ Subjects
To conduct a randomized dose-ranging study to evaluate the safety and activity of orally administered low dose interferon alfa-n3 as an immunomodulator in subjects with asymptomatic HIV-1 infection.
- Trial name
- NCT00215852
- Testing
- Alferon LDO
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- AIM ImmunoTech Inc.
HIV Infections
A Safety Study to Assess the Delivery of Dapivirine From a Matrix Vaginal Ring
The proposed study is a single-center, double-blind, randomised, placebo-controlled trial to evaluate the delivery of dapivirine from matrix vaginal rings over a 56 and 57 day period and to assess the safety as compared to…
- Trial name
- NCT01144676
- Testing
- dapivirine
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
HIV Infections, Sexual Health
Sexual Health of Sub-Saharan African Migrant Women Recently Diagnosed With HIV in Île-de-France: Missed Opportunities for Prevention
This study looks at the sexual health of women from Sub-Saharan Africa who recently found out they have HIV after arriving in Île-de-France.
- Conditions
- HIV Infections, Sexual Health, Migrants, Women's Health
- Trial name
- NCT07011017
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Stress
Mindful Living With Stress for Nurses Caring for HIV/AIDS Patients in China
The primary objective of this proposed one-year (January 01, 2017 to December 31,2017) project is to assess whether a mindfulness based intervention('Mindful Living With Stress') will be effective at helping nurses caring for…
- Trial name
- MLWS (NCT02936310)
- Testing
- Mindful Living With Stress
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Central South University
HIV Infections
Women's Interagency HIV Study (WIHS)
The Women's Interagency HIV Study (WIHS), a multicenter, prospective study, was established in August 1993 to carry out comprehensive investigations of the impact of HIV infection and its clinical, laboratory, and psychosocial…
- Trial name
- NCT00000797
- Where
- 5 sites in United States
- Volunteers
- 4,982 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Therapeutic HIV Vaccine and Interleukin-2 to Increase the Immune System's Response to HIV
This study will evaluate whether the HIV vaccine ALVAC vCP1452 given in combination with interleukin-2 (IL-2), also known as aldesleukin, can increase immune system function in people with HIV infection.
- Trial name
- NCT00056797
- Testing
- ALVAC HIV vaccine (vCP1452), Interleukin-2
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Cytopenias
An Open Label Phase I Study of Subcutaneously Administered Recombinant Human GM-CSF in Patients With AIDS Virus Infection and Leukopenia
To determine the safety, immunogenicity, biological activity, ad pharmacokinetics of sargramostim ( recombinant granulocyte-macrophage colony-stimulating factor; GM-CSF ) human granulocyte-macrophage colony-stimulating factor …
- Trial name
- NCT00002008
- Testing
- Sargramostim
- Where
- 2 sites in United States
- Sponsor
- Sandoz
Infection, Human Immunodeficiency Virus, HIV Infections
A Study to Evaluate the Pharmacokinetics of an Oral Contraceptive When Co-administered With GSK2248761 in Healthy Adult Female Subjects.
This study is a two-period, double-blind study in healthy adult female subjects. Each subject will participate in an oral contraceptive Run-in period prior to the treatment periods.
- Trial name
- NCT01195974
- Testing
- YASMIN, GSK2248761
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Tobacco Use, HIV-1-infection
A Mobile Intervention to Promote Cessation in HIV-infected Smokers
The purpose of this study is to adapt an existing web-based tobacco treatment program for HIV-infected smokers into a mobile intervention delivered via smartphone.
- Trial name
- NCT02432482
- Testing
- mobile Positively Smoke Free (mPSF), Standard care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
HIV Infections
Changes in Lipids and Lipoproteins in HIV Infected Women After Switch From Protease Inhibitor to Raltegravir
This is a 24-week, one arm, open-label, interventional, non-comparative multicenter study to evaluate lipid changes in HIV infected women with hyperlipidemia on boosted PI based regimen after switching their boosted PI to…
- Trial name
- NCT02097108
- Testing
- Raltegravir
- Where
- 3 sites in Austria
- Volunteers
- 11 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
HIV
HIV Eradication Through Cord-blood Transplantation
Allogeneic hematopoietic cell transplantation from a CCR5 Δ32/Δ32 unrelated donor, performed for the first time in the "Berlin patient", provides the only evidence to date of long-term control of HIV infection.
- Trial name
- HIVECT (NCT02923076)
- Testing
- CCR5 delta32/delta32 cord blood transplantation
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Puerta de Hierro University Hospital
HIV, Substance Use
Adherence Intervention for HIV-infected Drug Users
Many people living with HIV use illicit drugs, which leads to worsened health outcomes and increased transmission of HIV due to poor adherence to medication regimens.
- Trial name
- NCT02907697
- Testing
- Life Steps-Drug Use, General Health Education
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Texas at Austin
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