Clinical trials: HIV-infection/AIDS
HIV Infections
Pediatric Impact: Promoting Adherence to Medications Among HIV-infected Children
The purpose of the study is to develop and evaluate an intervention to promote adherence to HIV medications among children 5-12 years of age.
- Trial name
- NCT00134602
- Testing
- Needs assessment followed by tailored intervention
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Centers for Disease Control and Prevention
Cytomegalovirus Infections, HIV Infections
A Randomized, Double-Blind Study of the Efficacy and Safety of Oral Ganciclovir for the Prevention of CMV Disease in People Infected With the Human Immunodeficiency Virus
To evaluate the efficacy of oral ganciclovir in preventing progression to cytomegalovirus (CMV) disease (e.g., CMV retinitis, gastrointestinal CMV disease) in CMV-infected people with HIV infection and CD4 lymphocyte counts <=…
- Trial name
- NCT00002095
- Testing
- Ganciclovir
- Where
- 19 sites in United States
- Volunteers
- 700 people
- Sponsor
- Hoffmann-La Roche
HIV, Atherosclerosis
Effect of Extra Virgin Olive Oil on Atherosclerosis Biomarkers in HIV-infected Patients
HIV infection is associated with systemic inflammation that is involved in pathogenesis of atherosclerosis. Treatment of HIV infection may cause lipid profile disturbance and consequently, atherosclerosis progression.
- Conditions
- HIV, Atherosclerosis, HIV Infections
- Trial name
- EVOO_HIV (NCT00925795)
- Testing
- consumption 1. EVOO; 2. ROO, consumption 1. ROO; 2. EVOO
- Where
- Croatia
- Volunteers
- 39 people
- Sponsor
- University Hospital for Infectious Diseases, Croatia
HIV Infections
Safety and Antiviral Study of ACH-126, 443 (Beta-L-Fd4C) in the Treatment of Adults With HIV Infection and Modestly Detectable Viral Load.
To determine safety and efficacy of ACH-126,443 on the treatment of adults with HIV infection who have modestly detectable viral load while on stable triple combination antiretroviral therapy including 3TC.
- Trial name
- NCT00040157
- Testing
- ACH126-443 (Beta-L-Fd4C)
- Where
- 13 sites in United States
- Volunteers
- 60 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
HIV Infection, Heavy Alcoholic Consumption
Pharmacotherapy for HIV Infected Patients With Alcohol Problems
This is a randomized double blind clinical trial to test the effect of Naltrexone on HIV infected heavy drinkers. The study will select 40 HIV positive patients who meet criteria for heavy drinking.
- Conditions
- HIV Infection, Heavy Alcoholic Consumption, HIV Infections
- Trial name
- NCT00854230
- Testing
- Naltrexone
- Sponsor
- VA Connecticut Healthcare System
HIV Infections, Hypercholesterolemia
Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients
The purpose of this study is to evaluate the safety, efficacy, and tolerability of extended-release niacin (Niaspan) in improving the level of fats in the blood of HIV-infected patients.
- Conditions
- HIV Infections, Hypercholesterolemia, Hypertriglyceridemia, Diabetes Mellitus
- Trial name
- NCT00046267
- Testing
- Niacin
- Where
- 16 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bone Marrow Failure Syndrome, Severe Aplastic Anemia
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation
This study's goal is to determine the frequency and severity of acute graft versus host disease, to evaluate incidence of primary and secondary graft rejection, to assess event free survival and overall survival, to determine the…
- Conditions
- Bone Marrow Failure Syndrome, Severe Aplastic Anemia, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia
- Trial name
- NCT01966367
- Testing
- CD34 Stem Cell Selection Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Diane George
HIV Seropositivity
Fluoride Metabolism, Bone Remodelling and Mineral Density in HIV Patients Treated With Tenofovir +/- Emtricitabine
HIV+ patients are considered at risk for excessive bone fragility. Several factors could contribute: age, male sex, low body mass index (BMI), HIV infection per se, vitamin D deficiency, using tenofovir/a protease inhibitor (time…
- Trial name
- NCT01813292
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Hopital Lariboisière
HIV Infection
Pilot Trial of a Synbiotic in HIV+ Patients
The goal of this study is to test the hypothesis that daily ingestion of a 'synbiotic' for 4 weeks will improve intestinal function, ease immune system overactivation, and increase blood CD4 count in HIV-infected individuals.
- Trial name
- NCT00688311
- Testing
- Synbiotic 2000
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, Davis
Acquired Immune Deficiency Syndrome, Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
Correlation Between Cytokines and Hepatic Histology in Patients Infected by HIV-1 and the Hepatitis-C Virus
This study aims at correlating TNF-α, INF-γ, IL-2, IL-4, IL-10 and TGF-β values as dosed by ELISA and mRNA expression by real-time PCR with histopathological hepatic biopsy findings in individuals with HIV/HCV coinfection.
- Conditions
- Acquired Immune Deficiency Syndrome, Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted, HIV Infections
- Trial name
- NCT00499434
- Where
- Brazil
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Atherosclerosis
Inflammation, Viral Replication, and Atherosclerosis in Treated HIV Infection
This is a longitudinal observational study of HIV-infected patients and HIV-negative control patients that is being conducted to learn more about immunologic factors, inflammation, and cardiovascular risk in patients with HIV…
- Trial name
- NCT01519141
- Where
- United States
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV, AIDS
The Effects of Anabolic Steroids and Protease Inhibitors on People Living With HIV/AIDS
The main aim of the study is to investigate the combined effects of using anabolic steroids and protease inhibitors on fat metabolism and body composition of People Living with HIV/AIDS.
- Conditions
- HIV, AIDS, Lipodystrophy, Hyperlipidemia
- Trial name
- NCT00202241
- Testing
- testosterone injection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Queen's University
AIDS
Safety & Immunogenicity of HIV Vaccines in Healthy Kenyan Adults
The study is part of a long-term aim to develop an effective HIV-1 vaccine and will evaluate safety and immunogenicity of vaccines focusing T cell responses on the conserved region of the HIV-1 proteome.
- Trial name
- HIV-CORE 004 (NCT02099994)
- Testing
- Ad35-GRIN, MVA.HIVconsv, pSG2.HIVconsv DNA
- Where
- Kenya
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Acquired Immune Deficiency Syndrome Virus
Immune Recovery in Advanced , ARV-naïve, HIV-1-infected Individuals Taking Dolutegravir or Ritonavir-boosted Darunavir
There are few randomized clinical trials in advanced HIV patients. This is a multicenter, randomized, open clinical trial, comparing 2 parallel groups, to compare the immunological reconstitution and the virological efficacy and…
- Trial name
- NCT02337322
- Testing
- Dolutegravir, Darunavir/r
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Juan A. Arnaiz
HIV Infection
Depot Contraception With and Without Lopinavir/Ritonavir
DMPA (depot medroxyprogesterone acetate or the 'depot' injection) is a widely used contraception. It is popular in woman with HIV as it probably still works when you take HIV drugs.
- Trial name
- NCT01231451
- Testing
- DMPA
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- St Stephens Aids Trust
Mycobacterium Avium-Intracellulare Infection, HIV Infections
Evaluation of the Therapeutic Benefit of r-metHuIFN- Gamma in AIDS Patients With Disseminated Mycobacterium Avium-Intracellulare (MAI) Infection: A Multi-Centered Pilot Study
To examine the effectiveness of subcutaneous gamma interferon in reducing severity of Mycobacterium avium- intracellulare (MAI) bacillemia episodes in AIDS patients in an open-label dose-randomized multi-center pilot clinical…
- Trial name
- NCT00002037
- Testing
- Trifluridine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Amgen
Tuberculosis
A Knowledge Translation Intervention for TB/HIV Treatment Adherence, in Zomba District, Malawi
Despite increased emphasis on evidence based practice in recent years a gap remains between evidence and practice, particularly in resource poor countries.
- Trial name
- NCT01356095
- Testing
- Knowledge translation intervention, Palm-Plus
- Where
- Malawi
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dignitas International
Cytomegalovirus Retinitis, HIV Infections
An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients
To evaluate the safety and efficacy of foscarnet induction therapy for treatment of AIDS patients experiencing their first episode of cytomegalovirus (CMV) retinitis.
- Trial name
- NCT00002039
- Testing
- Foscarnet sodium
- Where
- United States
- Sponsor
- Astra USA
Tuberculosis
Safety and Efficacy of High Dose Rifampicin in Tuberculosis (TB)-HIV Co-infected Patients on Efavirenz- or Dolutegravir-based Antiretroviral Therapy
Higher doses of rifampicin has been associated with a faster drop in bacterial load over time, and shorter treatment regimens with high dose rifampicin are being proposed.
- Trial name
- SAEFRIF (NCT03982277)
- Testing
- Rifampin 300 Mg Oral Capsule
- Where
- Uganda
- Volunteers
- 130 people
- Sponsor
- Makerere University
HIV-1-infection
Optimising Cohorts for HIV Cure Interventions
In a recent international substudy of START (Study of Initiation of ART in Early HIV Infection), we found that people with HIV (PHIV) who initiate ART with CD4+ T cells > 800 cells/μL achieve a substantially smaller HIV reservoir…
- Trial name
- HI-ART (NCT05852301)
- Testing
- no intervention
- Where
- Australia
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Bayside Health
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