Clinical trials: HSIL, High Grade Squamous Intraepithelial Lesion
Cervical Adenocarcinoma, Cervical Adenocarcinoma In Situ
Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer
This trial studies the prevalence of anal dysplasia and anal cancer in patients with cervical, vaginal, and vulvar dysplasia and cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenocarcinoma In Situ, Cervical Intraepithelial Neoplasia, Cervical Squamous Cell Carcinoma, Not Otherwise Specified
- Trial name
- NCT02140021
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 409 people
- Sponsor
- M.D. Anderson Cancer Center
Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion
Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions
This randomized phase III trial studies imiquimod or fluorouracil to see how well they work compared to observation in treating patients with high-grade anal squamous skin lesions who are human immunodeficiency virus…
- Conditions
- Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion, HIV Infection
- Trial name
- NCT02059499
- Testing
- imiquimod, fluorouracil, questionnaire administration
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 91 people
- Sponsor
- AIDS Malignancy Consortium
Papillomavirus Infections, Cervical Intraepithelial Neoplasia
E7 TCR T Cells for Human Papillomavirus-Associated Cancers
Background: Human papillomavirus (HPV) can cause cervical, throat, anal, and genital cancers. Cancers caused by HPV have an HPV protein called E7 inside of their cells.
- Conditions
- Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Carcinoma In Situ, Vulvar Neoplasms
- Trial name
- NCT02858310
- Testing
- E7 TCR cells, Aldesleukin, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Cancer Institute (NCI)
AIDS-Related Human Papillomavirus Infection, High Grade Cervical Squamous Intraepithelial Neoplasia
HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV
This randomized phase III trial studies how well human papillomavirus (HPV) vaccine therapy works in reducing high-grade cervical lesions in patients with human immunodeficiency virus (HIV) and HPV.
- Conditions
- AIDS-Related Human Papillomavirus Infection, High Grade Cervical Squamous Intraepithelial Neoplasia, HIV Infection
- Trial name
- COVENANT (NCT03284866)
- Testing
- Laboratory Biomarker Analysis, Recombinant Human Papillomavirus Nonavalent Vaccine, Saline
- Where
- 6 sites in Kenya, Malawi and 3 more
- Volunteers
- 535 people
- Sponsor
- AIDS Malignancy Consortium
HSIL, High-Grade Squamous Intraepithelial Lesions, Vaginal Microbiome
Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated with Imiquimod
The goal of this clinical trial is to identify the immunophenotypic profile of the local immune response, the cervicovaginal microenvironment and the microbiological profile of women with CIN 3 treated with imiquimod.
- Conditions
- HSIL, High-Grade Squamous Intraepithelial Lesions, Vaginal Microbiome, Biomarkers
- Trial name
- NCT06356012
- Testing
- Imiquimod, Loop Electrosurgical Excision Procedure
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Cervix Cancer, HPV Infection
Optimization of Cervical Cancer Screening Among Women Living With HIV in Latin American Countries
Cervical cancer is a relatively common cancer among women living with human immunodeficiency virus (HIV). This study will test women for human papillomavirus (HPV) infection of the cervix.
- Conditions
- Cervix Cancer, HPV Infection, Cervical High Grade Squamous Intraepithelial Lesion, HIV Infections
- Trial name
- ULACNet-202 (NCT06002126)
- Testing
- Xpert HPV, QIAsure Methylation Test
- Where
- 2 sites in Brazil, Mexico
- Volunteers
- 1,001 people
- Sponsor
- Weill Medical College of Cornell University
Uterine Cervical Neoplasms, Cervix Intraepithelial Neoplasia
Safety and Tolerability of Cidofovir Gel Applied on Cervix Squamous Lesions
Human Papilloma Virus (HPV) infections induce cervical intraepithelial neoplasia (CIN) of cervix. To reduce incidence of invasive tumor associated with high grade CIN lesions, the standard treatment is the conisation of cervix…
- Trial name
- NCT00989443
- Testing
- Cidofovir gel
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Mithra Pharmaceuticals
Anal Cancer, Precancerous Condition
Infrared Coagulation in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia
RATIONALE: Infrared coagulation may be effective in preventing the development of anal cancer in patients who have anal neoplasia.
- Trial name
- NCT00066430
- Testing
- infrared photocoagulation therapy, Infrared Coagulator
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- AIDS Malignancy Consortium
Aids-related Malignancies, Lymphoma
Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials
RATIONALE: Diagnostic procedures, such as anal swab collection, digital rectal examination, and anal endoscopy and biopsy, may help find and diagnose anal and genital human papillomavirus infection and squamous intraepithelial…
- Conditions
- Aids-related Malignancies, Lymphoma, Precancerous Condition, Sarcoma
- Trial name
- NCT00695422
- Testing
- polymerase chain reaction, cytology specimen collection procedure, histological technique
- Where
- 10 sites in United States
- Volunteers
- 47 people
- Sponsor
- AIDS Malignancy Consortium
High-grade Squamous Intraepithelial Lesion (HSIL)
NWRD09 for HPV-16 Related Cervical HSIL
This is a single-arm, open label, multi-center clinical study to evaluate the safety, tolerability and immunogenicity HPV16 targeted mRNA therapeutic vaccine (NWRD09) in HPV16 related cervical high-grade squamous intraepithelial…
- Trial name
- NCT07047989
- Testing
- NWRD09 injection
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Newish Biotech (Wuxi) Co., Ltd.
Stage 0 Cervical Cancer, High-grade Squamous Intraepithelial Lesion
S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Celecoxib may be effective in preventing cervical cancer.
- Trial name
- NCT00072540
- Testing
- celecoxib, anti-cytokine therapy, antiangiogenesis therapy
- Sponsor
- SWOG Cancer Research Network
Human Papillomavirus, Cancer
Study of the Prevention of Anal Cancer
SPANC stands for Study of the Prevention of Anal Cancer. There are more than 100 types of human papillomavirus (HPV). Some HPV types cause genital warts and other types cause more than 90% of anal cancer.
- Trial name
- SPANC (NCT02007421)
- Testing
- Participants asked questions about recent experiences of anal intercourse in the last six months., High Resolution Anoscopy
- Where
- 2 sites in Australia
- Volunteers
- 617 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
HPV - Anogenital Human Papilloma Virus Infection, HSIL, High Grade Squamous Intraepithelial Lesions
E6/E7 mRNA Performance to Detect HSIL and Cost-effectiveness Analysis of This Screening Strategy in HIV + MSM
This study evaluates the positive and negative predictive value of E6/E7 mRNA expression for anal HSIL and its capacity to predict incident HSIL in HIV + MSM. We also analyse the cost-effectiveness of this new screening strategy.
- Conditions
- HPV - Anogenital Human Papilloma Virus Infection, HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer, Hiv
- Trial name
- ELAVI-67 (NCT03357991)
- Where
- Spain
- Volunteers
- 355 people
- Sponsor
- Hospital Universitari de Bellvitge
Human Immunodeficiency Virus, Human Papillomavirus-Related Anal Squamous Cell Carcinoma
Anal High-risk HPV, HSIL, and Microbiome Among Hispanic Peoples Living With HIV (PLWH)
The study evaluates if there is relationship between the kinds of bacteria living in the anus (also known as the anal microbiome) and the risk of human papillomavirus (HPV) infection or HPV-related pre-cancer (high-grade squamous…
- Conditions
- Human Immunodeficiency Virus, Human Papillomavirus-Related Anal Squamous Cell Carcinoma, High-Grade Squamous Intraepithelial Lesions
- Trial name
- ULACNet-104 (NCT06651957)
- Testing
- Biospecimen Collection, Questionnaires
- Where
- 3 sites in United States, Mexico and 1 more
- Volunteers
- 217 people
- Sponsor
- University of California, San Francisco
High-Grade Squamous Intraepithelial Lesions
Preventing Invasive Cervical Cancer: The Importance of Expectant Management in Young Women With High-grade Pre-cancerous Lesions
Lesions classified as "High Grade Squamous Intra-epithelial Lesions" (HSIL) are pre-cervical lesions of the cervix, induced by infection with the Human Papilloma Virus (HPV).
- Trial name
- NCT03920800
- Testing
- Data extraction from medical files, Immunohistochemistry
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Catherine Vanpachterbeke
High-Grade Squamous Intraepithelial Lesions
Laser Ablation in the Treatment of High-grade Cervical Lesions
Cervical laser ablation is an effective, minimally invasive treatment with a low incidence of perinatal complications and minimal impact on fertility.
- Trial name
- NCT06333743
- Testing
- laser ablation, LEEP or Conization
- Volunteers
- 308 people
- Sponsor
- Peking Union Medical College Hospital
High-Grade Squamous Intraepithelial Lesions, Neoplasm Regression, Spontaneous
Conservative Management in Patients Diagnosed With Grade 2 or Grade 3 CIN
Consecutive inclusion and collection of information for all women attending the Cervical Disease Unit with an histological diagnosis of grade 2 or grade 3 CIN during the last 5 years, from January 2012 to December 2016, which…
- Conditions
- High-Grade Squamous Intraepithelial Lesions, Neoplasm Regression, Spontaneous, Disease Progression, Papillomavirus Infections
- Trial name
- NCT04115787
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cervical High Grade Squamous Intraepithelial Lesion
Randomized, Double Blind Trial of the Quadrivalent HPV Vaccine to Improve Responses to LEEP Treatment of Cervical HSIL
Cervical cancer occurs commonly in HIV-infected women in South Africa. These women have poor response to treatment of cervical cancer precursors.
- Trial name
- NCT01928225
- Testing
- Human Papillomavirus vaccine
- Volunteers
- 180 people
- Sponsor
- University of Witwatersrand, South Africa
Human Papillomavirus
Human Papillomavirus in Menstrual Blood
The investigators tried to know whether a virus causing cervical cancer could be detected in menstrual blood and to set up a experimental setting to detect the virus.
- Trial name
- NCT01506128
- Testing
- Collecting a Pad used at the first menstrual period after enrollment
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul National University Hospital
HSIL, High Grade Squamous Intraepithelial Lesions, Recurrence
Intraoperative HPV Testing Evaluation
High-grade intraepithelial lesion/cervical intraepithelial neoplasia grade 2-3 is a premalignant cervical lesion caused by persistent high-risk human papillomavirus infection.
- Trial name
- NCT04190472
- Testing
- IOP HPV test
- Volunteers
- 1,553 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute